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Protein & Cell 2011年第11期2卷 899-905页

作者： Zheng Zhou jun-Ming Liao Peng Zhang jun-bao fan Jie Chen Yi Liang State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhan 430072China

Parkinson’s disease is the second most common neurodegenerative disease in the ***-arrestin-2 has been reported to be an important protein involved in D2 dopamine receptor desensitization,which is essential to Parkinson’s ***,the potential value of pharmacological inactivation of G protein-coupled receptor kinase or arrestin in the treatment of patients with Parkinson’s disease has recently been *** studied the interaction between D2 dopamine receptor and beta-arrestin-2 and the pharmacological regulation of chemical compounds on such interaction using capillary zone *** results from screening more than 40 compounds revealed three compounds that remarkably inhibit the beta-arrestin-2/D2 dopamine receptor interaction among *** compounds are promising therapies for Parkinson’s disease,and the method used in this study has great potential for application in large-scale drug screening and evaluation.

关键词： drug screening D2 dopamine receptor beta-arrestin-2 capillary zone electrophoresis proteinprotein interaction Parkinson’s disease

Common bile duct morphology is associated with recurrence of common bile duct stones in Billroth II anatomy patients

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World Journal of Clinical Cases 2021年第26期9卷 7671-7681页

作者： Xu Ji Wen Jia Qian Zhao Yao Wang Shu-Ren Ma Lu Xu Ying Kan Yang Cao bao-jun fan Zhuo Yang Department of Digestive Endoscopy General Hospital of Northern Theater CommandShenyang 110840Liaoning ProvinceChina Postgraduate College Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Postgraduate College Liaoning University of Traditional Chinese MedicineShenyang 110847Liaoning ProvinceChina Postgraduate College Jinzhou Medical UniversityJinzhou 121001Liaoning ProvinceChina

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is the primary choice for removing common bile duct(CBD)stones in Billroth II anatomy *** recurrence of CBD stones is still a challenging *** To evaluate CBD morphology and other predictors affecting CBD stone *** A retrospective case-control analysis was performed on 138 CBD stones patients with a history of Billroth II gastrectomy,who underwent therapeutic ERCP for stone extraction at our center from January 2011 to October *** morphology and other predictors affecting CBD stone recurrence were examined by univariate analysis and multivariate logistic regression *** CBD morphology(P<0.01)and CBD diameter≥1.5 cm(odds ratio[OR]=6.15,95%confidence interval[CI]:1.87-20.24,P<0.01)were the two independent risk *** multivariate analysis,the recurrence rate of patients with S type was 16.79 times that of patients with straight type(OR=16.79,95%CI:4.26-66.09,P<0.01),the recurrence rate of patients with polyline type was 4.97 times that of patients with straight type(OR=4.97,95%CI:1.42-17.38,P=0.01),and the recurrence rate of S type patients was 3.38 times that of patients with polyline type(OR=3.38,95%CI:1.07-10.72,P=0.04).CONCLUSION CBD morphology,especially S type and polyline type,is associated with increased recurrence of CBD stones in Billroth II anatomy patients.

关键词： Endoscopic retrograde cholangiopancreatography Common bile duct stones Recurrence Billroth II anatomy Common bile duct morphology Risk factors

New common bile duct morphological subtypes:Risk predictors of common bile duct stone recurrence

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World Journal of Gastrointestinal Surgery 2022年第3期14卷 236-246页

作者： Xu Ji Zhuo Yang Shu-Ren Ma Wen Jia Qian Zhao Lu Xu Ying Kan Yang Cao Yao Wang bao-jun fan Department of Digestive Endoscopy General Hospital of Northern Theater CommandShenyang 110840Liaoning ProvinceChina Postgraduate College Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is the primary treatment for removing common bile duct(CBD)*** risk factors for CBD stone recurrence after ERCP have been discussed for many ***,the influence of CBD morphology has never been *** To evaluate CBD morphology and other predictors affecting CBD stone recurrence in average *** A retrospective analysis of 502 CBD stone patients who underwent successful therapeutic ERCP for stone extraction at our centre from February 2020 to January 2021 was *** morphology and other predictors affecting CBD stone recurrence were examined by univariate analysis and multivariate logistic regression *** CBD morphology(P<0.01),CBD diameter≥1.5 cm[odds ratio(OR)=2.20,95%CI:1.08-4.46,P=0.03],and endoscopic biliary sphincterotomy with balloon dilation(ESBD)(OR=0.35,95%CI:0.17-0.75,P<0.01)are three independent risk factors for CBD stone ***,the recurrence rate of patients with the S type was 6.61-fold that of patients with the straight type(OR=6.61,95%CI:2.61-16.77,P<0.01).The recurrence rate of patients with the polyline type was 2.45-fold that of patients with the straight type(OR=2.45,95%CI:1.14-5.26,P=0.02).The recurrence rate of S type patients was 2.70-fold that of patients with the polyline type(OR=2.70,95%CI:1.08-6.73,P=0.03).Compared with no-ESBD,ESBD could decrease the risk of *** CBD diameter≥1.5 cm and CBD morphology,especially S type and polyline type,were associated with increased recurrence of CBD *** addition,ESBD was related to decreased *** with these risk factors should undergo periodic surveillance and standard prophylactic therapy.

关键词： Endoscopic retrograde cholangiopancreatography Common bile duct stones Recurrence Common bile duct morphology Risk factors

Immuno-protective effect of tumor cell vaccine on Kunming mice bearing Ehrlich ascites tumor

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World Journal of Gastroenterology 1998年第5期4卷 41-45页

作者： MA Zheng, ZHOU Shao Juan, WU Kai Chun, PAN Bo Rong, QIAO Tai Dong, CHEN bao jun and fan Dai Ming

AIM To evaluate the immunity of chemically modified tumor cell *** Tumor cell vaccines (TCV) were prepared by incubating the live Ehrlich ascites tumor cells with concanavalin A-mitomycin C (ConA-MMC), mitomycin C (MMC), concanavalin A-glutaraldehyde (ConA-Glu), glutaraldehyde (Glu), or paraformaldehyde (Para), respectively. The whole cell or soluble forms of the vaccines were administered intraperitoneally into Kunming mice once a week for three times prior to the intraperitoneal inoculation of a lethal dose of live tumor cells. A second challenge with live tumor cells was given four weeks later. Survival and antibody production of the mice were *** After the first challenge, the mice, received whole TCV of ConA-MMC, MMC (P＜0.01) and Glu (P＜0.05) promoted survival incidence than the controls. All the treated mice had the survival time prolonged. ConA-MMC vaccine treated mice had longer survival days than that of ConA-Glu ones (P＜0.05). For the soluble TCV immunized mice, those treated with vaccines of Para (P＜0.01), ConA-Para and ConA-Glu (P＜0.05) had longer survival periods compared with that of the controls. Following the second challenge, survival incidence of the mice received vaccines of ConA-MMC, MMC, ConA-Glu or Glu was significantly increased (P＜0.01). Moreover, all the treated mice had the survival time prolonged, and ConA-MMC vaccine treated mice had longer survival days than that of Para treated ones (P＜0.05). Antibodies against Ehrlich ascites tumor cells were found to be positive in sera of the mice treated with whole TCV of *** Ehrlich ascites tumor cells are immunogenic when treated with ConA-MMC, MMC, ConA-Glu, Glu or Para, which might act as safe and effective tumor vaccines with safety and effectiveness.

关键词： Ehrlich ascites tumor tumor cell vaccine Kunming mice antigen, neoplasm

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第01期 174-180页

作者： fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-Song Yang Fu-Min Zhang Ai-jun Ma bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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Oxidative refolding of reduced,denatured lysozyme in AOT reverse micelles

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Oxidative refolding of reduced,denatured lysozyme in AOT rev...

第九届全国酶学学术讨论会暨邹承鲁诞辰85周年纪念会

作者： jun-bao fan Jie Chen Yi Liang State Key Laboratory of Virology,College of Life Sciences,Wuhan University,Wuhan 430072,China

Hen egg white lysozyme has been widely studied in order to enhance our understanding of how proteins fold in their intracellular *** micelles are geometrically restricted spaces and have been employed as chaperone-lik... 详细信息

关键词： Lysozyme Protein refolding Reverse micelles Protein aggregation Fluorescence spectroscopy Kinetics

The Matthew effect of macromolecular crowding on protein misfolding

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The Matthew effect of macromolecular crowding on protein mis...

第九届全国酶学学术讨论会暨邹承鲁诞辰85周年纪念会

作者： jun-bao fan Zheng Zhou Hai-Li Zhu jun-Zhi Sh Geng-Fu Xiao Jie Chen Yi Liang State Key Laboratory of Virology,College of Life Sciences,Wuhan University,Wuhan 430072,China.

Protein misfolding is of intense medical interest because it is associated with neurodegenerative diseases such as Alzheimer’s disease and transmissible spongiform encephalopathy (TSE).Amyloid fibrils associated with... 详细信息

关键词： Macromolecular crowding Protein misfolding Tau proteins Glycogen synthase kinase-3β Prion proteins Kinetics

The Contrasting Effect of Macromolecular Crowding on Protein Misfolding

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The Contrasting Effect of Macromolecular Crowding on Protein...

2008年全国生物化学与分子生物学学术大会

作者： jun-bao fan Zheng Zhou Hai-li Zhu jun-ming Liao Hong-tao Li Xu Yan Jie Chen Geng-fu Xiao Yi Liang (State Key Laboratory of Virology,College of Life Sciences,Wuhan University,Wuhan 430072,China)

Amyloid fibrils associated with neurodegenerative diseases as Alzheimer’s disease and transmissible spongiform encephalopathy can be considered biologically relevant failures of posttranslational quality control main...

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Studies on the Binding of Sodium Dodecyl Sulfate to Cellulase

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Studies on the Binding of Sodium Dodecyl Sulfate to Cellulas...

第七届全国酶学学术讨论会

作者： Jin Xiang, jun-bao fan, Nan Chen, Hong Xu, Yi Liang (Laboratory of Structural Biology, College of Life Sciences, Wuhan University, Wuhan 430072, China, E-mail: liangyi@***)

Lipid-protein interaction is an important and inevitable biological *** low solubility of lipids in water,however,restricts studies on lipid-proteininteraction,and therefore model studies are designed using detergents in place *** are indispensable as solubilizing agents in the isolation andpurification of *** the correct use of detergents it is necessary to have an

关键词： isothermal titration calorimetry fluorescence titration cellulase sodium dodecyl sulfate binding affinity protein unfolding

Analysis of DNA Cytosine Methylation on Cotton under Salt Stress

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棉花学报 2008年第S1期20卷 106-页

作者： ZHAO Yun-le,YE Wu-wei,WANG jun-juan,fan bao-xiang(Cotton Research Institute,Chinese Academy of Agricultural Sciences Key Laboratory of Cotton Genetic Improvement,Ministry of Agriculture,Anyang,Henan 455000,China) Cotton Research Institute Chinese Academy of Agricultural Sciences Key Laboratory of Cotton Genetic Improvement Ministry of AgricultureAnyangHenan 455000China

DNA methylation,especially methylation of cytosine in eukaryotic organisms,has been implicated in gene regulation,genomic imprinting,the timing of DNA replication,and determination of chromatin *** was reported that 6... 详细信息

关键词： DNA Analysis of DNA Cytosine Methylation on Cotton under Salt Stress