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World Journal of Gastrointestinal Oncology 2023年第11期15卷 2033-2040页

作者： Wen-Hui Luo shao-jun Li Xue-Feng Wang The Second Department of Hepatobiliary Surgery Yantai Yuhuangding HospitalYantai 264000Shandong ProvinceChina

BACKGROUND Cholangiocarcinoma(CCA)poses a significant clinical challenge due to its low radical resection rate and a propensity for high postoperative recurrence,resulting in a poor *** the combination of targeted therapy and immunotherapy has demonstrated notable efficacy in several solid tumors recently,however,its application in CCA remains underexplored and poorly *** SUMMARY This case report describes a patient diagnosed with stage IV CCA,accompanied by liver and abdominal wall metastases,who underwent palliative ***,the patient received two cycles of treatment combining lenvatinib with sintilimab,which resulted in a reduction in abdominal wall metastasis,while intrahepatic metastasis displayed *** unexpected observation illustrates different responses of intrahepatic and extrahepatic metastases to the same *** Lenvatinib combined with sintilimab shows promise as a potential treatment strategy for advanced *** testing for related driver and/or passenger mutations,as well as an analysis of tumor immune microenvironment analysis,is crucial for optimizing drug combinations and eventually addressing the issue of non-response in specific metastatic sites.

关键词： Cholangiocarcinoma Immune-checkpoint-inhibitor Lenvatinib Sintilimab Epigastric metastasis Immunotherapy Case report

Central projections and connections of lumbar primary afferent fibers in adult rats:effectively revealed using Texas red-dextran amine tracing

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Neural Regeneration Research 2017年第10期12卷 1695-1702页

作者： Shi-de Lin Tao Tang Ting-bao Zhao shao-jun Liu State Key Laboratory of Proteomics Department of NeurobiologyBeijing Institute of Basic Medical Sciences Department of Spinal Cord Injury the General Hospital of Jinan Military Command

Signals from lumbar primary afferent fibers are important for modulating locomotion of the ***,silver impregnation techniques,autoradiography,wheat germ agglutinin-horseradish peroxidase and cholera toxin B subunit-horseradish peroxidase cannot image the central projections and connections of the dorsal root in ***,we injected 3-k Da Texas red-dextran amine into the proximal trunks of L4 dorsal roots in adult *** microscopy results revealed that numerous labeled arborizations and varicosities extended to the dorsal horn from T12–S4,to Clarke＇s column from T10–L2,and to the ventral horn from L1–*** labeled varicosities at the L4 cord level were very dense,particularly in laminae I–Ⅲ,and the density decreased gradually in more rostral and caudal *** addition,they were predominately distributed in laminae I–IV,moderately in laminae V–VⅡ and sparsely in laminae VⅢ–***,direct contacts of lumbar afferent fibers with propriospinal neurons were widespread in gray *** conclusion,the projection and connection patterns of L4 afferents were illustrated in detail by Texas red-dextran amine-dorsal root tracing.

关键词： nerve regeneration spinal cord injury dorsal root central projection connection Texas red-dextran amine neural regeneration

Efficient and flexible memory architecture to alleviate data and context bandwidth bottlenecks of coarse-grained reconfigurable arrays

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Science China(Physics,Mechanics & Astronomy) 2014年第12期57卷 2214-2227页

作者： YANG Chen LIU Lei Bo YIN Shou Yi WEI shao jun Institute of Microelectronics Tsinghua University

The computational capability of a coarse-grained reconfigurable array(CGRA)can be significantly restrained due to data and context memory bandwidth ***,two methods have been used to resolve this *** method loads the context into the CGRA at run *** method occupies very small on-chip memory but induces very large latency,which leads to low computational *** other method adopts a multi-context *** method loads the context into the on-chip context memory at the boot *** the pointer of a set of contexts changes the hardware configuration on a cycle-by-cycle *** size of the context memory induces a large area overhead in multi-context structures,which results in major restrictions on application *** paper proposes a Predictable Context Cache(PCC)architecture to address the above context issues by buffering the context inside a *** this architecture,context is dynamically transferred into the *** a PCC significantly reduces the on-chip context memory and the complexity of the applications running on the CGRA is no longer restricted by the size of the on-chip context *** preloading is the most frequently used approach to hide input data latency and speed up the data transmission process for the data bandwidth *** than fundamentally reducing the amount of input data,the transferred data and computations are processed in ***,the data preloading method cannot work efficiently because data transmission becomes the critical path as the reconfigurable array scale *** paper also presents a Hierarchical Data Memory(HDM)architecture as a solution to the efficiency *** this architecture,high internal bandwidth is provided to buffer both reused input data and intermediate *** HDM architecture relieves the external memory from the data transfer burden so that the performance is significantly *** a result of using PCC and

关键词： memory architecture CGRA context cache cache prefetch data memory

The Effect of Boron on the Properties of Glucomannan: An Experimental and Molecular Dynamics Simulation Study

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Chinese Journal of Structural Chemistry 2005年第12期24卷 1397-1402页

作者： PANG Jie SUN Yu-Jing LI Bin TIAN Shi-Ping CHEN shao-jun College of Food Science Fu Jian Agriculture And Forestry University Fuzhou Fujian 350002 China Key Laboratory of Photosynthesis and Environmental Molecular Physiology Institute of Botany The Chinese Academy of Sciences Beijing 100093 China College of Food Science and Technology Agriculture University of Middle China Wuhan Hubei 430070 China

The effect of boron on the properties of Konjac Glucomanan （KGM） has been investigated by the method of experiment and molecular dynamic simulation. Upon analysis, the property and structure of KGM are apt to be affected by boron and structural reasons for property change were discussed. In detail, the addition low concentration borax can increase the systematic inherent viscosity, by contrast, high concentration borax has opposite effect on the viscosity. When adding borax, the micropores on KGM film surface decrease or disappear, leading to more compact and uniform on the film surface. The structure of KGM-Boron complex is described as the coordination reaction between KGM and boron. The main reaction points are hydroxyl group on C（6） position of sugar as well as those on C（2） and C（3） positions of mannose with two kinds of complexes formation： B-K2 and KB-K. And KB-K mainly consists of g-b-m.

关键词： glucomannan boron NMR molecular dynamics

Direct Z-scheme CdFe_(2)O_(4)/g-C3N4 hybrid photocatalysts for highly efficient ceftiofur sodium photodegradation

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Journal of Materials Science & Technology 2020年第21期56卷 133-142页

作者： Miao-Miao Fang jun-Xia shao Xiang-Gang Huang Jin-Yi Wang Wei Chen School of Pharmaceutical and Materials Engineering Taizhou UniversityTaizhou 318000China

A direct Z-scheme CdFe_(2)O_(4)/g-C3N4 hybrid systems with different weight ratios of CdFe2O4 nanoparticles were successfully designed and constructed for ceftiofur sodium *** as-obtained CdFe_(2)O_(4)/g-C_(3)N_(4) hybrid samples composed of CdFe_(2)O_(4) nanoparticles and g-C3N4 nanosheets were systematically characterized by different techniques including X-ray diffraction,scanning electron microscope,transmission electron microscope,Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,UV–vis DRS,chemical oxygen demand,inductively coupled plasma mass spectrometer,photochemical test and electron spin resonance spectrometer *** optimal photocatalytic activity for ceftiofur sodium photodegradation was achieved by modulating the weight ration between CdFe_(2)O_(4) nanoparticles and g-C_(3)N_(4) *** result from photocatalytic tests indicate that Cd Fe_(2)O_(4)/g-C_(3)N_(4)-2 hybrid sample exhibit highly efficient photocatalytic activity towards ceftiofur sodium removal in comparison with pristine CdFe_(2)O_(4) nanoparticles and pure g-C_(3)N_(4) *** the excellent photocatalytic stability of CdFe_(2)O_(4)/g-C_(3)N_(4)-2 hybrid sample was also verified during recycling runs towards photocatalytic ceftiofur sodium *** significant enhancement of photocatalytic activity was attributed to the Z-scheme charge separation and transfer based on the construction of tight heterogeneous interface and well-matched band *** expect this research to provide a new insight into the design and preparation of direct Z-scheme hybrid photocatalysts for environmental remediation.

关键词： CdFe2O4 g-C3N4 Z-scheme Photodegradation

A comparative study on proliferating activity between HBV-related and HCV-related small HCC

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World Journal of Gastroenterology 1997年第4期3卷 38-39页

作者： YU shaojun

IM To compare the proliferating activity between HBVrelated small hepatocellular carcinoma (HCC) and HCVrelated small HCC.METHODS Sixty liver biopsy specimens from patients with small HCC (≤3cm in diameter) were examined immunohistochemically using antiproliferating cell nuclear antigen monoclonal antibody, of them 30 were HBVrelated HCC and 30 HCVrelated HCC with matched sex and morphologic features.RESULTS The labeling index of proliferating cell nuclear antigen was 79% in HBVrelated HCC and 125% in HCVrelated HCC. There was no statistically significant differences between the two groups (P>005).CONCLUSION In the early phase or small stage of hepatocellular carcinoma, HBVrelated HCC showed similar proliferating activity to that of HCVrelated HCC which suggested that in the early phase, HBVrelated HCC has similar malignancy to HCVrelated HCC.

关键词： liver neoplasms carcinoma hepatocellular hepatitis B virus proliferating cell nuclear antigen

Geochemical and Nd-Hf Isotopic Constraints on the Petrogenesis of an Archean Granitoid in the Erguna Massif, NE China

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Acta Geologica Sinica(English Edition) 2021年第6期95卷 2033-2044页

作者： shao jun LI Yinglei WANG Deli SONG Wanbing WU Xinwei LIU Hongzhang Shenyang Institute of Geology and Mineral Resources Shenyang CenterChina Geological SurveyShenyang 110034China Key Laboratory of Orogen and Crust Evolution Department of GeologyPeking UniversityBeijing 100871China Institute of Mineral Resources Chinese Academy of Geological SciencesBeijing 100037China Inner Mongolia 115th Geological Mineral Exploration and Development Co.Ltd. Huhhot 137100China Inner Mongolia 6th Geological Mineral Exploration and Development Co.Ltd. HulunbuirInner Mongolia 021008China Hebei Regional Geological Survey Institute Hebei 065000China

Crystalline basement and Precambrian crustal growth of the continental massifs within the Central Asian Orogenic Belt(CAOB) are still pending problems. Our geological and geochemical investigations identified an Archean(2606 Ma) granitic pluton in the Biliya area of the Erguna Massif. The Neoarchean granitoids show high and positive in-situ zircon ε_(Ht)(t)(+0.3 to +10.0), whole-rock ε_(Nd)(t)(+4.8) and whole-rock ε_(Ht)(t) values(+2.1). They are characterized by high Y + Ce + Zr + Nb(> 220 ppm) and Zr contents and could be classified as A-type granites. These granitoids are characterized by high Zr saturation temperatures(T;)(796–836°C). They were derived from partial re-melting of juvenile mafic lower crust in an intracontinental back-arc extensional environment. This newly identified Neoarchean granitic pluton may represent the crystalline basement of the several continent massifs within the CAOB, and their high ε_(Ht)(t)–ε_(Nd)(t) values may also indicate the occurrence of lateral crustal growth events in these massifs during the Neoarchean.

关键词： crystalline basement A-type granite Neoarchean crustal growth Neoarchean Central Asian Orogenic Belt

Optimal AK composite estimators in current population survey

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Statistical Theory and Related Fields 2017年第2期1卷 257-264页

作者： Yang Cheng jun shao Zhou Yu U.S.Census Bureau SuitlandMDUSA

The Current Population Survey(CPS)is a monthly household sample survey with a sample consisting of eight rotation *** individuals of a rotation group are interviewed four consecutive months and another four consecutive months after resting eight consecutive months.A composite-type estimator is adopted in the CPS for the estimation of the monthly population total,which combines sample information from the current month’s survey and previous months using the fact that 75%households have data for two consecutive *** are two values,A and K,in the composite estimator to decide how to combine the available information,and thus this estimator is called the AK composite *** this paper,we use a formula of the meansquared error of AK composite estimator and propose an easy-to-use method of choosing A and K based on data,which evolves the estimation of some population quantities using the method of moments and *** numerical studies are conducted to illustrate the effectiveness of the proposed method.

关键词： Composite estimator current population survey mean-squared error quadratic form sample notation

Treatment recommendation and parameter estimation under single-index contrast function

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Statistical Theory and Related Fields 2017年第2期1卷 171-181页

作者： Cui Xiong Menggang Yu jun shao School of Statistics East China Normal UniversityShanghaiChina Department of Biostatistics and Medical Informatics University of Wisconsin-MadisonMadisonWIUSA Department of Statistics University of Wisconsin-MadisonMadisonWIUSA

In this article, we consider a semiparametric model for contrast function which is defined asthe conditional expected outcome difference under comparative treatments. The contrast function can be used to recommend treatment for better average outcomes. Existing approachesmodel the contrast function either parametrically or nonparametrically. We believe our approachimproves interpretability over the non-parametric approach while enhancing robustness overthe parametric approach. Without explicit estimation of the nonparametric part of our model,we show that a kernel-based method can identify the parametric part up to a multiplying constant. Such identification suffices for treatment recommendation. Our method is also extendedto high-dimensional settings. We study the asymptotics of the resulting estimation procedure inboth low- and high-dimensional cases. We also evaluate our method in simulation studies andreal data analyses.

关键词： Kernel weighting LASSO penalty personalised medicine semiparametric model

Advances in research on molecular markers in immune checkpoint inhibitor-associated myocarditis

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Cancer Innovation 2023年第6期2卷 439-447页

作者： jun shao Chuanbin Liu Jing Wang Department of General Medicine First Medical Center of PLA General HospitalBeijingChina 2 Western Medical Branch of PLA General Hospital BeijingChina

Immune checkpoint inhibitors(ICIs)play a crucial role in the immunotherapy of malignant tumors,preventing immune evasion by tumor cells and activating autoimmune cells to eliminate the *** their proven effectiveness in antitumor therapy,potential immune-related adverse effects must be recognized,particularly ICI-associated myocarditis(ICIAM).ICIAM is the most lethal form of organ immunotoxicity,with a significant impact on short-term ***,ICIAM is predominantly asymptomatic or mildly *** is difficult to diagnose,especially due to the lack of unique molecular *** article aims to provide a comprehensive overview of the progress made in identifying molecular markers for ICIAM.

关键词： immune checkpoint inhibitors molecular marker myocarditis tumor immunotherapy