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Approximate Conditional Likelihood for Generalized Linear Models with General Missing Data Mechanism

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Journal of Systems Science & Complexity 2017年第1期30卷 139-153页

作者： ZHAO Jiwei shao jun Department of Biostatistics State University of New York at Buffalo School of Statistics East China Normal University

The generalized linear model is an indispensable tool for analyzing non-Gaussian response data, with both canonical and non-canonical link functions comprehensively used. When missing values are present, many existing methods in the literature heavily depend on an unverifiable assumption of the missing data mechanism, and they fail when the assumption is violated. This paper proposes a missing data mechanism that is as generally applicable as possible, which includes both ignorable and nonignorable missing data cases, as well as both scenarios of missing values in response and *** this general missing data mechanism, the authors adopt an approximate conditional likelihood method to estimate unknown parameters. The authors rigorously establish the regularity conditions under which the unknown parameters are identifiable under the approximate conditional likelihood approach. For parameters that are identifiable, the authors prove the asymptotic normality of the estimators obtained by maximizing the approximate conditional likelihood. Some simulation studies are conducted to evaluate finite sample performance of the proposed estimators as well as estimators from some existing methods. Finally, the authors present a biomarker analysis in prostate cancer study to illustrate the proposed method.

关键词： Asymptotic normality generalized linear model identifiability missing data mechanism,non-canonical link function nonignorable missingness.

Structural Change of SiO_(2) Glass Under High Pressure - a Molecular Dynamics Study

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Chinese Physics Letters 1993年第11期10卷 669-672页

作者： shao jun Department of Chemistry Shanghai University of Science and Technology Shanghai 201800

Pressure-induced structural transition in SiOa glass at 300 *** been investigated by molecular dynamics simulation,The compression of SiO_(2) glass appears to be accommodated by three processes occuring in our calcul&*** 10 GPa,the Si-Ot O-O and Si-Si bond dist&nces decrease with *** in this pressure,region the O-Si-O angle is always peaked at about 109°.Above 10 GPa,the Si-O bond distance increase quickly with compression and the O-Si-O angle deviates from 109°.At about 46 GPa,the structural information shows that the coordination number of Si becones ***,the structural behavior of SiO_(2) glass becomes normal with further compression.

关键词： glass structural angle

Drug-target networks for Tanshinone IIA identified by data mining

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Chinese Journal of Natural Medicines 2015年第10期13卷 751-759页

作者： CHEN shao-jun Department of Traditional Chinese Medicine Zhejiang Pharmaceutical College

Tanshinone IIA is a pharmacologically active compound isolated from Danshen(Salvia miltiorrhiza), a traditional Chinese herbal medicine for the management of cardiac diseases and other disorders. But its underlying molecular mechanisms of action are still unclear. The present investigation utilized a data mining approach based on network pharmacology to uncover the potential protein targets of Tanshinone IIA. Network pharmacology, an integrated multidisciplinary study, incorporates systems biology, network analysis, connectivity, redundancy, and pleiotropy, providing powerful new tools and insights into elucidating the fine details of drug-target interactions. In the present study, two separate drug-target networks for Tanshinone IIA were constructed using the Agilent Literature Search(ALS) and STITCH(search tool for interactions of chemicals) methods. Analysis of the ALS-constructed network revealed a target network with a scale-free topology and five top nodes(protein targets) corresponding to Fos, jun, Src, phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha(PIK3CA), and mitogen-activated protein kinase kinase 1(MAP2K1), whereas analysis of the STITCH-constructed network revealed three top nodes corresponding to cytochrome P450 3A4(CYP3A4), cytochrome P450 A1(CYP1A1), and nuclear factor kappa B1(NFκB1). The discrepancies were probably due to the differences in the divergent computer mining tools and databases employed by the two methods. However, it is conceivable that all eight proteins mediate important biological functions of Tanshinone IIA, contributing to its overall drug-target network. In conclusion, the current results may assist in developing a comprehensive understanding of the molecular mechanisms and signaling pathways of in a simple, compact, and visual manner.

关键词： Data mining Network analysis Network pharmacology Tanshinone IIA

A repetitive DNA-directed program of chromosome packaging during mitosis

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Journal of Genetics and Genomics 2016年第8期43卷 471-476页

作者： shao-jun Tang Department of Neuroscience and Cell Biology University of Texas Medical Branch

Chromosomes, the longest molecular fiber that stores genetic information in eukaryotic cells, must be orderly packaged during mitosis for their proper segregation into daughter cells. Although the morphological changes of chromosomes during mitosis have been described in detail, how mitosis progression programs the transformation of seemingly amorphous and loose interphase .

关键词： A repetitive DNA-directed program of chromosome packaging during mitosis DNA cycle

DISTRIBUTION OF MICROSCOPIC HOLES WITH DIFFERENT RADII IN MOLTEN LiCl

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Chinese Physics Letters 1990年第4期7卷 181-183页

作者： TANG Zhengquan shao jun Shanghai University of Science and Technology Shanghai201800

The method of molecular dynamics to study the distribution of microscopic holes and the calculated results of molten LiCl are reported,and the distribution of microscopic holes with different radii in molten LICl is a... 详细信息

关键词： distribution molten LiCl

HARTEN SOLUTION FOR ONE-DIMENSIONAL UNSTEADY EQUATION

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Applied Mathematics and Mechanics(English Edition) 1993年第6期14卷 545-554页

作者： Chen shao-jun Shanghai University of Technology Shanghai

In order to use the second-order 5-point difference scheme mentioned to compute the solution of one dimension unsteady equations of the direct reflection of the strong plane detonation wave meeting a solid wall barrier,in this paper,we technically construct the difference schemes of the boundary and sub-boundary of the problem,and deduce the auto-analogue analytic solutions of the initial value problem,and at the same time,we present a method for the singular property of the initial value problem,from which we can get a satisfactory computation result of this difficult *** difference scheme used in this paper to deal with the discontinuity problems of the shock wave are valuable and worth generalization.

关键词： one-dimensional unsteady Harten solution difference scheme

Repression of retinal microvascular endothelial cells by transthyretin under simulated diabetic retinopathy conditions

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International Journal of Ophthalmology(English edition) 2016年第6期9卷 809-815页

作者： jun shao Yong Yao Department of Ophthalmology Wuxi People's Hospital Affiliated to Nanjing Medical University

AIM： To investigate biological effects of transthyretin （TTR） on the development of neovascularization under simulated diabetic retinopathy （DR） condition associated with high glucose and hypoxia. METHODS： Human retinal microvascular endothelial cells （hRECs） were cultured in normal and simulated DR environments with high glucose and hypoxia. The normal serum glucose concentration is approximately 5.5 mmol/L; thus, hyperglycemia was simulated with 25 mmol/L glucose, while hypoxia was induced using 200 μmol/L CoCI. The influence of TTR on hRECs and human retinal pigment epithelial cells （hRPECs） was determined by incubating the cells with 4μmol/L TTR in normal and abnormal media. A co -culture system was then employed to evaluate the effects of hRPECs on hRECs. RESULTS： Decreased hRECs and hRPECs were observed under abnormal conditions, including high- glucose and hypoxic media. In addition, hRECs were significantly inhibited by 4 pmol/L exogenous TTR during hyperglycemic culture. During co-culture, hRPECs inhibited hRECs in both the normal and abnormal environments. CONCLUSION： hREC growth is inhibited by exogenous TTR under simulated DR environments with highglucose and hypoxic, particularly in the medium containing 25 mmol/L glucose, hRPECs, which manufacture TTR in the eye, also represses hRECs in the same environment. TTR is predicted to inhibit the proliferation of hRECs and neovascularization.

关键词： transthyretin diabetic retinal human retinalmicrovascular endothelial cells human retinal pigmentepithelial cells hyperglycemia hypoxia

Negative effects of transthyretin in high myopic vitreous on diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1864-1869页

作者： jun shao Yong Yao Departm ent of Ophthalmology W uxi People’s Hospital Aflicted to Nanjing Medical UniversityWuxi 214023Jiangsu ProvinceChina

AIM：To analyze the relationship between vitreous transthyretin（TTR） levels,high myopia and diabetic retinopathy（DR）.METHODS：We selected 6722 individuals from the southern Jiangsu Province for diabetes and ophthalmic *** TTR concentration in the vitreous of 50 patients with high myopia and diabetes,50 patients with only DR,and 20 healthy controls were determined by *** factors in Tie2 pathway in DR development including vascular endothecial growth factor（VEGF）,Tie2,Angpt1,Angpt2,vascular endothelial growth factor receptor（VEGFR） 1 and VEGFR2 were also detected by ***：The prevalence of DR in patients with diabetes and myopia [〈6.00 diopter（D）],diabetes and high myopia（〉6.00 D）,and diabetes without myopia were 11.1%,2.5%,and 60.0%,*** vitreous TTR concentration of patients with diabetes and high myopia was approximately 6.5-and 4.2-times higher than those of patients with DR and healthy controls,respectively（P〈0.05）.Following the vitreous TTR concentration,the levels of VEGF,Tie2,Angpt1,Angpt2,VEGFR1 and VEGFR2 in vitreous of diabetes and high myopia patients,DR patients and healthy controls were detected as dramatically ***：The results suggest that TTR can affect the vitreous contents of key factors in Tie2 pathway for neovascularization,and there should be a protective association between abundant TTR levels in the vitreous of highly myopic patients and a decreased risk of DR.

关键词： transthyretin diabetic retinopathy highmyopia protective

Organic/inorganic nanocomposite polymer electrolyte

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Chinese Chemical Letters 2007年第2期18卷 185-188页

作者： Li Qi shao jun Dong State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

The organic/inorganic nanocomposites polymer electrolytes were designed and synthesized. The organic/inorganic nanocomposites membrane materials and their lithium salt complexes have been found thermally stable below 200 °C. The conductivity of the organic/inorganic nanocomposites polymer electrolytes prepared at room temperature was at magnitude range of 10(?6) S/cm.

关键词： Organic/inorganic nanocomposites Polymer electrolyte Polymer lithium battery Conductivity Characterization Thermal stability