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Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells

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science China Life sciences 2025年

作者： shi Chen Yuanyuan He Lejun Lv Bei Liu Cheng Li Hongkui Deng jun Xu Department of Cell Biology School of Basic Medical Sciences Peking University Stem Cell Research Center Peking University Health Science Center Peking University Academy of Advanced Interdisciplinary studies Peking University BeiCell Therapeutics school of Life sciences Center for Bioinformatics Center for Statistical Science Peking University MOE Engineering Research Center of Regenerative Medicine School of Basic Medical Sciences State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and Differentiation College of Life Sciences Peking-Tsinghua Center for Life Sciences Peking University

Human primed pluripotent stem cells are capable of generating all the embryonic ***,their extraembryonic trophectoderm potentials are *** remains unclear how to expand their developmental potential to trophectoderm *** we show that transient treatment with a cocktail of small molecule epigenetic modulators imparts trophectoderm lineage potentials to human primed pluripotent stem cells while preserving their embryonic *** chemically treated cells can generate trophectoderm-like cells and downstream trophoblast stem cells,diverging into s.ncytiotrophoblast and extravillous trophoblast *** and CUT&Tag analyses reveal that these induced cells share transcriptional profiles with in vivo trophectoderm and cytotrophoblast,and exhibit reduced H3K27me3 modification at gene loci specific to trophoblast lineages compared with primed pluripotent *** exploration highlighted the critical roles of epigenetic modulators HDAC2,EZH1/2,and KDM5s in the activation of trophoblast lineage *** findings demonstrate that transient epigenetic resetting activates unrestricted lineage potential in human primed pluripotent stem cells,and offer new mechanistic insights into human trophoblast lineage specification and in vitro models for studying placental development and related disorders.

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Modeling Tensile strength of Concrete on Partial Replacement of Cement and s.nd with Quarry Dust Ground Granulated Blast Furnace and slag silica Fumes

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Journal of Building Material science 2021年第1期3卷 43-50页

作者： Eluozo s.n Dimkpa K. Department of Architecture Faculty of Environmental ScienceRivers State UniversityNkpolu OroworukwoPort HarcourtNigeria Department of Civil Engineering College of EngineeringGregory University Uturu(GUU)Abia StateNigeria

Tensile strength of concrete were examined on its partial replacement of cement and s.nd us.ng ground granulated blast furnace and quarry *** study examines its behaviour at different *** is to monitor the variation effect of these parameters on the growth rates of tensile to the optimum curing *** include non linear conditions of tensile state,non-elastic and its brittle behaviour at all times as it express zero conditions in *** means that it has the ability to with stand pull *** also reflects its weak ability to handle shear stress thus tends to cause deformation in material as it has poor *** reflection of its brittle influence the rate of tensile behaviour from concrete *** are known to be a material on modern mechanics of *** are also considered as quasi brittle *** behaviour was reflected as the system considered evaluating the growth rate of tensile strength that replaced cement and s.nd with these locally sourced *** developed model monitor other reflected influential parameters such as variation of concrete porosity due it compaction in placements,tensile behaviour reflects these effect that subject it to mechanical properties of *** study expressed the reaction of these parameters in the simulation,the evaluation of these affected the details variation of tensile growth rate at different water cement ratios and curing *** tensile behaviour that was monitored are based on these factors in the *** derived model were validated with the a researcher results[24],and both parameters developed best fits *** study is imperative because the system expressed the behaviour of tensile strength from concrete at different *** can applied these concept to monitor tensile behaviour considering these parameters in its growth rates.

关键词： Modeling tensile quarry dust ground granulated Blast furnace slag and silica fumes

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Experimental study on microstructural and corrosion behaviors of friction stir processed steel with CoCrFeCuTi HEA reinforcement and effect of annealing

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science China Technological sciences 2025年第1期 233-250页

作者： s.Aravind KRIs.nA n.RADHIKA Alokesh PRAMAnIK n.JEYAPRAKAsH Department of Mechanical Engineering Amrita School of EngineeringAmrita Vishwa Vidyapeetham school of Civil and Mechanical Engineering Curtin University school of Mechanical and Electrical Engineering China University of Mining and Technology

The ability to perform against extreme corrosion environments in stainless steel depreciates under challenging conditions in industrial applications. This can be resolved by employing surface modification techniques to modify the surface with the required characteristics. The pres.nt study investigates the outcomes of friction stir process.ng of ss304 with CoCrFeCuTi high entropy alloy(HEA) as reinforcement and the property enhancements post-annealing. The s.nthesized CoCrFeCuTi HEA exhibited irregular fragments with 17 μm mean particle size and body centred cubic(BCC) phase. The microstructure of the processed surface revealed ultra-refined grains with a uniform distribution of HEA filler. The microstructures of the samples annealed at 400℃, 550℃, 700℃ and 850℃ for 2 h also showed significant grain growth and grain refinements. The processed sample with HEA reinforcement annealed at 700℃ exhibited enhanced microhardness and tensile strength by 63% and 0.88 times than that of the processed sample with HEA pre-annealing. The subsequent electrochemical corrosion test displayed better corrosion resistance for the HEA-processed and annealed sample. Hot corrosion tests at 900℃ showcased excellent resistance for the HEA processed and annealed samples by 14.92%, 12.75%, and 14.83% against the samples pre-annealed under three different salt mixtures, and the corroded surface was analyzed.

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竞争环境下双目标零售平台销售模式选择

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管理工程学报 2025年第1期39卷 227-242页

作者：张冲朱祎宋君南京邮电大学管理学院

电子商务行业发展迅速,具有“超越利润”战略导向以实现更广泛目标的组织正变得越来越普遍,兼顾消费者利益成为企业凸显竞争优势的方式。为此,本文构建由一个制造商和两个零售平台组成的两级供应链。其中,制造商和其中一个零售平台追求... 详细信息

电子商务行业发展迅速,具有“超越利润”战略导向以实现更广泛目标的组织正变得越来越普遍,兼顾消费者利益成为企业凸显竞争优势的方式。为此,本文构建由一个制造商和两个零售平台组成的两级供应链。其中,制造商和其中一个零售平台追求自身利润最大化,另外一个零售平台追求自身利润和消费者剩余的线性组合最大化,即考虑双目标最优。本文具体考虑两个零售平台分别选择转售模式或代理模式共四种情形,进而研究双目标零售平台销售模式选择问题,及其对供应链成员最优决策和供应链整体绩效的影响。结果表明:(1)在一定条件下,双目标零售平台能获得比竞争对手更高的利润;(2)当双目标零售平台选择转售模式时,无论其竞争对手选择哪种销售模式,其双目标策略都能使供应链总体利润得到优化;(3)当双目标零售平台的竞争对手选择代理模式时,其自身根据不同情况选择转售模式或者代理模式可以使两个零售平台的销售模式选择形成均衡。

关键词：双目标企业社会责任零售平台销售模式双渠道

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Engineering n3C vacancies in hierarchical porous carbon nitride nanosheets for room temperature ultradeep photocatalytic aerobic oxidative desulfurization

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science China Chemistry 2025年

作者： Yina nie Weijie Yang Xin Wang Xiang Li Lele Wei Xiaolin Bai Lin Liu Feng Fu jun Wan College of Chemistry & Chemical Engineering Research Institute of Comprehensive Energy Industrial Technology Shaanxi Key Laboratory of Chemical Reaction Engineering Yan'an University Anhui Engineering Research Center of Carbon neutrality College of Chemistry and Materials Science Anhui Normal University

The production of ultra-low sulfur clean fuels holds global significance for improving energy efficiency and reducing environmental pollution. Photocatalytic aerobic oxidative desulfurization（PODs） offers an attractive approach to efficiently remove refractory heterocyclic aromatic sulfur compounds under mild conditions. However, the sluggish charge dynamics,insufficient molecule activation, and slow mass transfer within photocatalysts restrict the overall desulfurization efficiency,hindering the widespread application of this technology. Herein, we developed a defective g-C3n4（M1U3Cn） photocatalyst with bridged n3Cvacancies and hierarchical porous structures to address these limitations. This catalyst not only demonstrates outstanding dibenzothiophene（DBT） removal efficiency of 99.6% for model oil with high conversion and selectivity but also achieves complete sulfur removal from gasoline as well as 96.7% sulfur removal for distilled diesel at room temperature,successfully achieving ultradeep aerobic oxidative desulfurization. The introduction of rich n3Cvacancies and abundant micromeso-macroporous distribution in M1U3Cn enhances kinetic efficiencies by promoting charge carrier separation, mass transfer,and molecular activation simultaneously; resulting in exceptional PODs performance. This work provides a collaborative strategy to overcome kinetic challenges in aerobic oxidative desulfurization via defect and structural engineering of the catalyst.

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sTUDY OF HOT CORROsIOn REsIsTAnCE MECHAnIsMs OF ARC sPRAYInG COATInGs

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Acta Metallurgica s.nica(English Letters) 1999年第5期12卷 1007-1013页

作者： s.n .Ma, Q.Liu and C.Q. Li surface Engineering Research Institute of CMEs, Beijing 100072, China

According to the working condition of boiler tubes of power station, hot corrosion tests were carried out at two temperatures (650℃ and 800℃) to simulate the environment of coal fired boiler. The hot corrosion resistance and mechanism of three arc spraying coatings (sL30, 45CT and FeCrAl) have been studied. The result showed that coating sL30 and 45CT have a better protection ability against hot corrosion. It indicated that a protective Cr 2O 3 scale formed on the surface of coating sL30 and coating 45CT.

关键词： arc spraying coating hot corrosion

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亡佚的经典:试论《苍颉篇》的经典化及经典地位

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东北师大学报（哲学社会科学版） 2025年第1期 99-106页

作者：白军鹏东北师范大学文学院吉林长春130024

《苍颉篇》的经典地位问题以往学者均未论及,它是秦代“书同文”政策的产物,也是这一活动的重要组成,在文字编排及结构两个方面都深刻地影响了《说文解字》的编纂。在汉代,《苍颉篇》不仅与入仕息息相关,从同墓葬的伴出文献可推知它也... 详细信息

《苍颉篇》的经典地位问题以往学者均未论及,它是秦代“书同文”政策的产物,也是这一活动的重要组成,在文字编排及结构两个方面都深刻地影响了《说文解字》的编纂。在汉代,《苍颉篇》不仅与入仕息息相关,从同墓葬的伴出文献可推知它也是深受贵族重视的典籍,尤其值得重视的是它对汉代辞赋家产生过重要影响。通过官方所组织的两次文字会议均以之为核心来看,除表明《苍颉篇》的特殊地位,还可知其与古文经学有重要的关联。经过扬雄、杜林、张揖、郭璞等的注释工作后,《苍颉篇》的身份在南北朝隋唐时期发生了转换,它开始成为学者注释古书的重要参考。本文所论也提示我们应该重新审视对虽已亡佚却在历史上产生过深远影响的古书的评价。

关键词：《苍颉篇》经典文本注释

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Green ionic metal-organic frameworks as.nanocatalysts for CO_(2)fixation

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nano Research 2025年第1期18卷 260-269页

作者： nuria Martín Miguel Maireles-Porcar Julián s.nchez Velandia Belén Altava Francisco G.Cirujano Eduardo García-Verdugo Departamento de Química Inorgánica y Orgánica Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

Co,ni,and Zn iso-reticular coordination polymers of 2,5-dihydroxyterphthalic acid(H_(2)dot)can be rapidly obtained under room temperature and aqueous conditions us.ng either sodium or ammonium hydroxide as the bases to deprotonate the *** use of metal bromides and tetrabutylammonium hydroxide(TBAOH)as the base allows the green s.nthesis of ionic metal-organic frameworks(MOFs),characterized by X-ray diffraction(XRD),Fourier transform infrared(FTIR),scanning electron microscopy(sEM),thermo gravimetric analysis(TGA),H-nuclear magnetic res.nance(nMR),elemental analysis,and X-ray photoelectron spectroscopy(XPs),and employed in the pressure,solvent,and additive-free CO_(2)fixation to epoxides by its cycloaddition to epichlorohydrin,exhibiting a cooperative behavior between the MOF and the ionic liquid formed within the framework,achieving TOns of the confined tetrabutylammonium bromide(TBABr)up to 700.

关键词： metal-organic frameworks(MOFs) ionic liquids heterogeneous catalysis CO_(2)conversion

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绩效报酬影响创造力的短期效应与长期效应“悖论”

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管理工程学报 2025年第1期39卷 63-77页

作者：马君朱梦霆闫嘉妮上海大学管理学院上海交通大学安泰经济与管理学院

塑造并引导个体着眼长远的激励体系是当前推进科技自强亟待破解的理论难题。现有研究多以横截面研究为主,忽视了动态视角下的时间效应。鉴于绩效报酬激励体系在激发创造力的过程中产生的两种目标导向:着眼于当下追求短期价值的表现目标... 详细信息

塑造并引导个体着眼长远的激励体系是当前推进科技自强亟待破解的理论难题。现有研究多以横截面研究为主,忽视了动态视角下的时间效应。鉴于绩效报酬激励体系在激发创造力的过程中产生的两种目标导向:着眼于当下追求短期价值的表现目标导向(PGO)和着眼于学习发展寻求长期价值的精熟目标导向(MGO)。而目标的选择取决于基于时间折扣的利弊权衡“算计思维”。据此,基于时间动机理论,本文构建了一个有关绩效激励的时间动机模型,并据此设计两项研究,旨在探索考虑时间折扣影响下的短期和长期绩效报酬如何影响个体目标导向的选择进而决定其创造力。研究1的横截面研究揭示,短期内,绩效报酬强度促进个体趋近PGO远离MGO,从而负向预测创造力。研究2通过纵向的潜变量增长模型和HLM模型结果揭示,长期内,绩效报酬强度促进个体趋近MGO远离PGO,从而正向预测创造力。研究揭示了绩效报酬激励效应的时间变化轨迹和目标导向逆转现象,即随着时间的推移,绩效报酬制度引导员工逐渐从趋近PGO远离MGO,转向趋近MGO远离PGO,从而形成一个长短期“悖论”:绩效报酬制度在短期内抑制创造力而在长期内促进创造力。本文的贡献在于创建了一个时间心理计量框架,为完善以绩效报酬为核心的激励制度提供了理论和管理启示。

关键词：绩效报酬创造力时间动机理论成就目标导向时间心理计量框架

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基于2018-2022年国家自然科学基金结题项目分析干细胞研究现状

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中国组织工程研究 2025年第19期29卷 4145-4150页

作者：蒋君张玢中国医学科学院医学信息研究所北京市100005

背景:目前大多数研究从国家自然科学基金资助论文和项目申请角度出发,对干细胞某一方面进行深入分析,或者验证某种评价方法,缺乏对干细胞领域国家自然科学基金已结题项目的全面分析。目的:了解2018-2022年干细胞领域国家自然科学基金结... 详细信息

背景:目前大多数研究从国家自然科学基金资助论文和项目申请角度出发,对干细胞某一方面进行深入分析,或者验证某种评价方法,缺乏对干细胞领域国家自然科学基金已结题项目的全面分析。目的:了解2018-2022年干细胞领域国家自然科学基金结题项目资助情况及研究热点,为后续研究提供参考。

关键词：干细胞国家自然科学基金聚类分析研究热点文献计量学

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