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Local recurrence of hepatocellular carcinoma after radiofrequency ablation

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World Journal of Gastroenterology 2010年第40期16卷 5135-5138页

作者： Wang-jun liao Min Shi Jin-Zhang Chen Ai-Min Li Department of Oncology Nanfang Hospital Southern Medical University 1838 Guangzhou Avenue North Guangzhou 510515 China

A 51-year-old Chinese male with a 20-year history of hepatitis B was diagnosed with hepatocellular carcinoma in the right anterior portion of the liver, sized 3.5 cm × 3.2 cm, and was treated with radiofrequency ablation (RFA) on December 18, 2001. The patient did not receive antiviral therapy for hepatitis B virus after RFA. The treated lesion reduced gradually and reached its minimum size of 1.7 cm × 1.5 cm seven years later on November 18, 2008. However computed tomography findings revealed that a recurrence lesion of 6.0 cm × 4.8 cm which was histologically confirmed overlapped the previous treated lesion at the 8th year on December 3, 2009. Although recurrence at 8 years after curative RFA is a rare event, such a possibility must be kept in mind. To find and treat the recurrence lesion promptly, long-term and close monitoring is warranted after RFA. Meanwhile, the recurrence-prevention therapy is as important as close monitoring for those patients with a history of hepatitis B.

关键词： Hepatocellular carcinoma Radiofrequency ablation Recurrence

Electroacupuncture inhibits annulus fibrosis cell apoptosis in vivo via TNF-α-TNFR1-caspase-8 and integrin β1/Akt signaling pathways

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Journal of Traditional Chinese Medicine 2014年第6期34卷 684-690页

作者： jun liao Le Zhang Jiaxuan Zheng Debiao Yu Meigui Ke Teng Xu Department of Acupuncture and Moxibustion Fujian University of Traditional Chinese Medicine

OBJECTIVE: To examine whether electroacupuncture(EA) treatment inhibited cell apoptosis of intervertebral annulus fibrosis(AF) via tumor necrosis factor-α(TNF-α)-tumor necrosis factor receptor 1(TNFR1)-caspase-8 and integrin β1/Akt signaling pathways in a rat model of cervical intervertebral disc degeneration caused by unbalanced dynamic and static ***: Thirty-two Sprague-Dawley rats were included in this study, of which 24 rats underwent surgery to induce cervical intervertebral disc degeneration, while eight rats received EA treatment at Dazhui(GV 14). Immunohistochemical staining was used to detect TNF-α, TNFR1, and caspase-8Apoptosis of AF cells was examined with terminal deoxynucleotidyl transferase-mediated d UTP-biotin nick end labeling(TUNEL) staining. The m RNA and protein expression levels of integrin β1 andAkt were evaluated with real-time polymerase chain reaction and western blot analysis, ***: Treatment with EA decreased TUNEL-positive AF cells and lowered TNF-α, TNFR1 and caspase-8 positive cells compared with control groups. EA treatment also increased integrin β1and Akt m RNA and protein levels compared with ***: Treatment with EA inhibits AF cell apoptosis through suppression of the TNF-α-TNFR1-caspase-8 signal pathway and increases the expression of integrin β1 and Akt. EA may be a good alternative therapy for treating cervical spondylosis.

关键词： Electroacupuncture Cervical spondylo-sis, Apoptosis, TNF-α-TNFR1-caspase-8 pathway In-tegrin β1/Akt pathway

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延迟交配对皂角豆象寿命及繁殖的影响

应用昆虫学报 2024年第2期61卷 271-278页

作者：黄成艳张升廖俊罗康李猷武承旭徐芳玲杨茂发贵州大学林学院兴仁市农业农村局贵州省植保植检站福建农林大学植物保护学院贵州大学昆虫研究所贵州山地农业病虫害重点实验室贵州大学烟草学院

【目的】为了明确延迟交配对皂角豆象Megabruchidius dorsalis (Fahraeus)(Coleoptera:Bruchinae)寿命及繁殖的影响。【方法】在室内条件下，分别对初羽化未交配的皂角豆象雌雄虫、雄虫、雌虫分别延迟1-7 d后配对饲养，研究延迟交配对... 详细信息

【目的】为了明确延迟交配对皂角豆象Megabruchidius dorsalis (Fahraeus)(Coleoptera:Bruchinae)寿命及繁殖的影响。【方法】在室内条件下，分别对初羽化未交配的皂角豆象雌雄虫、雄虫、雌虫分别延迟1-7 d后配对饲养，研究延迟交配对该虫产卵前期、产卵期、产卵量、卵孵化率、子代性比及雌、雄成虫寿命等参数的影响。【结果】雌、雄同时延迟交配和雌虫延迟交配显著延长雌虫寿命（P0.05）。在3种延迟交配模式下，延迟交配对皂角豆象产卵期、产卵次数、产卵量和孵化率均有不利影响（皮尔森相关系数r0.05），其中皂角豆象雌虫在延迟交配1和2 d时的产卵量最高，在延迟交配6和7 d时的产卵量明显下降；雌、雄同时延迟交配和雄虫延迟交配显著降低卵的孵化率（P<0.05）。【结论】延迟交配会降低皂角豆象的繁殖潜力，结果将为深入探讨田间使用信息素迷向法防治皂角豆象提供依据。

关键词：皂角豆象延迟交配寿命繁殖产卵

High-temperature Thermal Properties and Wear Behavior of Basalt as Heat Storage Material for Concentrated Solar Power Plants

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Journal of Wuhan University of Technology(Materials Science) 2022年第4期37卷 547-553页

作者： liao jun ZHU Xupeng LI Jianan XUE Shuwen ZOU Changwei ZHANG jun School of Physics Scienceand Technology Lingnan Normal UniversityZhanjang 524048China

The microstructures,components,thermal stability,specific heat capacity and thermal conductivity of basalt sample were ***,as a comprehensive result of thermal expansion and contraction process,both the friction coefficient and wear rate of the basalt sample were also *** results indicate that basalt is an excellent candidate to be used as thermal energy storage material for concentrated solar power plants,and also provide a strategy for solar energy utilization in volcanic area with excellent geographical environment.

关键词： thermal energy storage concentrated solar power basalt wear rate

Mo_(2)C添加量对YG6细晶硬质合金组织结构及性能的影响

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稀有金属与硬质合金 2024年第2期52卷 70-75页

作者：董凯林廖军时凯华刁椿珉张钱伟江佳阳自贡硬质合金有限责任公司四川自贡643011

采用传统粉末冶金方法制备了不同Mo_(2)C添加量的YG6细晶硬质合金。通过对合金显微结构的观察及物理力学性能的检测,研究了Mo_(2)C添加量对YG6细晶硬质合金组织结构及性能的影响。结果表明:随着Mo_(2)C添加量的增加,合金中WC晶粒度逐渐... 详细信息

采用传统粉末冶金方法制备了不同Mo_(2)C添加量的YG6细晶硬质合金。通过对合金显微结构的观察及物理力学性能的检测,研究了Mo_(2)C添加量对YG6细晶硬质合金组织结构及性能的影响。结果表明:随着Mo_(2)C添加量的增加,合金中WC晶粒度逐渐细化并趋于稳定。当合金中Mo_(2)C添加量超过3.5%时,Mo_(2)C对WC晶粒形貌具有球化作用。另外,添加Mo_(2)C会降低合金致密度,合金矫顽磁力随Mo_(2)C含量的增加而逐渐增加。Mo_(2)C添加量为5.0%时,合金综合力学性能最好,其硬度达92.7 HRA,抗弯强度为3 600 MPa,磨粒磨损值为0.81 cm^(3)/(10^(5)r)。

关键词：硬质合金 Mo_(2)C 组织结构性能

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极高地应力硬岩隧道变形规律及施工优化研究

公路交通技术 2024年第3期40卷 124-132页

作者：王昆张粒廖峻朱仁景吴胜忠招商局重庆交通科研设计院有限公司重庆400067

依托重庆市巫镇高速宝山隧道工程,采用数值模拟方法开展极高地应力无仰拱硬岩隧道的变形规律和施工优化研究,对不同施工工法、施工步距进行了比选。研究表明:1)不同施工工法隧道变形规律基本一致,竖向位移大于水平位移且基底隆起较拱顶... 详细信息

依托重庆市巫镇高速宝山隧道工程,采用数值模拟方法开展极高地应力无仰拱硬岩隧道的变形规律和施工优化研究,对不同施工工法、施工步距进行了比选。研究表明:1)不同施工工法隧道变形规律基本一致,竖向位移大于水平位移且基底隆起较拱顶沉降更明显,全断面法施工隧道变形收敛速度最快;2)不同施工工法均为基底应力释放程度最大,释放后基底应力仅为初始的55%,且全断面法拱脚处应力集中范围最小;3)隧道周围的岩体以拉伸破坏为主,部分位置存在剪切破坏,施工工法对塑性区的水平影响范围有限;4)该隧道选用全断面法施工可行且较经济。全断面法不同施工步距变形及应力分布基本规律相同,施工步距越大,水平竖向位移越大,拱脚处应力集中越显著,最小主应力值也越大,综合考虑现场施工建设速度、变形收敛情况、应力分布状态,采用1.6 m步距较经济合理。

关键词：极高地应力硬岩隧道变形规律施工工法施工优化

Ultralow platinum-loading PtPdRu@PtRuIr/C catalyst with excellent CO tolerance and high performance for the methanol oxidation reaction

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Rare Metals 2014年第3期33卷 337-342页

作者： Yan-Ni Wu Shi-jun liao Hai-Fu Guo Xiang-Ying Hao Zhen-Xing Liang School of Chemistry and Chemical Engineering Zhaoqing University School of Chemistry and Chemical Engineering South China University of Technology

Carbon-supported PtPdRuIr, Pd@PtRuIr, PtPd@PtRuIr, and PtPdRu@PtRuIr catalysts were prepared by a colloidal method and their catalytic activities to the methanol oxidation reaction in the acidic media were extensively investigated at room temperature. The catalysts were characterized by transmission electron microscopy and X-ray diffraction techniques, and their electrochemical behavior was evaluated by the cyclic voltammetry. The PtPdRu@PtRuIr/C catalyst is found to yield much higher electrocatalytic activity than the other ones and the commercial catalyst. For example, the Pt metal mass-specific activity of this PtPdRu@PtRuIr/C（Pt content 10 wt%,1.7 mAácm-2ámg-1） electrocatalyst is ＊3-fold higher than that of the commercial JM 40 % Pt/C（0.6 mAácm-2ámg-1）electrocatalysts, and the If/Ib ratio of PtPdRu@PtRuIr/C is1.6, which is higher than that of the JM 40 % Pt/C（0.9）. The improvement may result from the high dispersion of the active metal catalyst and the synergistic effect between the PtRuIr and PtPdRu layers. It is thus concluded that the pseudo-core-shell structure could significantly improve the methanol electro-oxidation activity and CO tolerance of the electrocatalyst.

关键词： Catalyst Colloidal approach Methanoloxidation PtPdRu@PtRuIr/C

脑泰方对脑缺血再灌注损伤小胶质细胞极化及胶质瘢痕的影响

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中国中药杂志 2024年第4期49卷 989-999页

作者：刘吉勇张文丽廖君胡立娟王国佐葛金文梅志刚湖南中医药大学中医学院中医诊断学湖南省重点实验室湖南长沙410208 湖南中医药大学药学院湖南长沙410208 湖南中医药大学医学院湖南长沙410208 湖南中医药大学第二附属医院湖南长沙410005 湖南中医药大学中西医结合学院中西医结合心脑疾病防治湖南省重点实验室湖南长沙410208

探讨脑泰方(NTF)对脑缺血再灌注损伤(cerebral ischemia reperfusion injury,CIRI)大鼠小胶质细胞极化及胶质瘢痕相关蛋白的影响。用大脑中动脉阻塞/复灌注方法建立大鼠CIRI模型。将造模成功的48只大鼠随机分为脑缺血再灌注模型7 d组(mo... 详细信息

探讨脑泰方(NTF)对脑缺血再灌注损伤(cerebral ischemia reperfusion injury,CIRI)大鼠小胶质细胞极化及胶质瘢痕相关蛋白的影响。用大脑中动脉阻塞/复灌注方法建立大鼠CIRI模型。将造模成功的48只大鼠随机分为脑缺血再灌注模型7 d组(model 7 d)、脑缺血再灌注模型14 d组(model 14 d)、脑泰方+脑缺血再灌注模型7 d组(NTF 7 d)、脑泰方+脑缺血再灌注模型14 d组(NTF 14 d),每组12只,另设12只SD大鼠为假手术组(sham)。NTF治疗组给予NTF混悬液27 g·kg^(-1)·d^(-1)灌胃,sham与model 7 d、model 14 d每天给予同体积生理盐水,连续灌胃7、14 d。干预结束,各组大鼠进行Longa评分;2,3,5-三苯四唑氯(TTC)染色法检测脑梗死面积;水迷宫实验、旷场实验评估大鼠空间学习记忆和认知功能以及焦虑程度;苏木素-伊红(hematoxylin-eosin,HE)染色观察脑组织形态结构及损伤情况;免疫荧光检测活化星形胶质细胞胶质纤维酸性蛋白(glial fibrillary acidic protein,GFAP)的表达和胶质瘢痕情况;免疫印迹法检测脑皮质瘢痕相关蛋白GFAP、神经蛋白聚糖(neurocan)、磷酸蛋白聚糖(phosphacan),小胶质细胞极化蛋白CD206、精氨酸酶-1(arginase-1,Arg-1)及炎症因子白细胞介素(interleukin,IL)-1β、IL-6、IL-4的表达情况。与sham比较,model 7 d及model 14 d大鼠均出现不同程度的脑梗死,脑皮质及神经元海马组织病理损伤严重,神经功能缺损,空间学习记忆及认知功能障碍及焦虑严重,星形胶质细胞增生及半暗带胶质瘢痕厚度均增加,IL-1β、IL-6表达升高,脑皮质GFAP、neurocan、phosphacan、CD206、Arg-1蛋白表达升高,差异均有统计学意义(P<0.01)。与模型组比较,NTF 7 d及NTF 14 d大鼠空间学习记忆和认知功能改善,焦虑减轻,神经功能改善,脑梗死体积减少,星形胶质细胞增生及半暗带胶质瘢痕厚度均减少,脑皮质组织GFAP、neurocan、phosphacan、IL-6、IL-1β表达降低,IL-4、CD206、Arg-1表达增加,差异均有统计学意义(P<0.05或P<0.01)。NTF对CIRI具有神经保护作用,能诱导小胶质细胞向M2型极化,抑制炎症反应,减轻胶质瘢痕的形成。

关键词：中风脑缺血再灌注胶质瘢痕小胶质细胞脑泰方

Metastasis-associated in colon cancer-1 in gastric cancer: Beyond metastasis

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World Journal of Gastroenterology 2016年第29期22卷 6629-6637页

作者： Zhen-Zhen Wu Li-Shan Chen Rui Zhou Jian-Ping Bin Yu-Lin liao Wang-jun liao Department of Oncology Nanfang Hospital Southern Medical University Medical Center for Overseas patients Nanfang Hospital Southern Medical University Department of Cardiology Nanfang Hospital Southern Medical University

Metastasis-associated in colon cancer-1(MACC1) is an oncogene that was first identified in colon cancer. The upstream and downstream of MACC1 form a delicate regulatory network that supports its tumorigenic role in cancers. Multiple functions of MACC1 have been discovered in many cancers. In gastric cancer(GC), MACC1 has been shown to be involved in oncogenesis and t umor progression. MACC1 overexpression adversely affects the clinical outcomes of GC patients. Regarding the mechanism of action of MACC1 in GC, studies have shown that it promotes the epithelialto-mesenchymal transition and accelerates cancer metastasis. MACC1 is involved in many hallmarks of GC in addition to metastasis. MACC1 promotes vasculogenic mimicry(VM) via TWIST1/2, and VM increases the tumor blood supply, which is necessary for tumor progression. MACC1 also facilitates GC lymphangiogenesis by upregulating extracellular secretion of VEGF-C/D, indicating that MACC1 may be an important player in GC lymphatic dissemination. Additionally, MACC1 supports GC growth under metabolic stress by enhancing the Warburg effect. In conclusion, MACC1 participates in multiple biological processes inside and outside of GC cells, making it an important mediator of the tumor microenvironment.

关键词： Metastasis-associated in colon cancer-1 Gastric cancer Epithelial-to-mesenchymal transition Vasculogenic mimicry Lymphangiogenesis Warburg effect Tumor microenvironment