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FPR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition

Current Medical Science 2024年第1期44卷 187-194页

作者： Xiao-mei HUANG E liao jun-qun liao Ya-ling LIU Yong SHAO Department of Obstetrics and Gynecology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070China Medical Laboratory Science The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Yubei Maternity and Child Healthcare HospitalChongqing 400042China

Objective:Premature rupture of membranes(PROM)is a common pregnancy disorder that is closely associated with structural weakening of fetal *** have found that formyl peptide receptor 1(FPR1)activates inflammatory pathways and amniotic epithelial-mesenchymal transition(EMT),stimulates collagen degradation,and leads to membrane weakening and membrane *** purpose of this study was to investigate the anti-inflammatory and EMT inhibitory effects of FPR1 antagonist(BOC-MLF)to provide a basis for clinical prevention of ***:The relationship between PROM,FPR1,and EMT was analyzed in human fetal membrane tissue and plasma samples using Western blotting,PCR,Masson staining,and ELISA ***(LPS)was used to establish a fetal membrane inflammation model in pregnant rats,and BOC-MLF was used to treat the LPS rat *** detected interleukin(IL)-6 in blood from the rat hearts to determine whether the inflammatory model was successful and whether the anti-inflammatory treatment was *** used electron microscopy to analyze the structure and collagen expression of rat fetal ***:Western blotting,PCR and Masson staining indicated that the expression of FPR1 was significantly increased,the expression of collagen was decreased,and EMT appeared in *** rat model indicated that LPS caused the collapse of fetal membrane epithelial cells,increased intercellular gaps,and decreased ***-MLF promoted an increase in fetal membrane collagen,inhibited EMT,and reduced the weakening of fetal ***:The expression of FPR1 in the fetal membrane of PROM was significantly increased,and EMT of the amniotic membrane was ***-MLF can treat inflammation and inhibit amniotic EMT.

关键词： formyl peptide receptor 1 BOC-MLF epithelial-mesenchymal transition premature rupture of membranes

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Insights into photocatalytic mechanism over a novel Cu_(2)WS_(4)/MoS_(2) S-scheme heterojunction

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Rare Metals 2024年第7期43卷 3118-3133页

作者： Wei Zhao Ji-Hui Cao jun-Jie liao Yun Liu Xiao-jun Zeng jun-Yu Shen Xue-Kun Hong Yang Guo He-Hua Zeng Ya-Zi Liu School of Materials Engineering Jiangsu Key Laboratory of Advanced Functional MaterialsSchool of Electronic and Information EngineeringChangshu Institute of TechnologyChangshu215500China School of Chemistry and Chemical Engineering Changji UniversityChangji 831100China State Environmental Protection Key Laboratory of Soil Environmental Management and Pollution Control Ministry of Ecology and EnvironmentNanjing Institute of Environmental SciencesNanjing 210023China School of Environment Jiangsu Engineering Lab of Water and Soil Eco-RemediationNanjing Normal UniversityNanjing 210023China Department of Chemical Engineering Curtin UniversityPerthWA6845Australia

A novel efficient Cu_(2)WS_(4)/MoS_(2) step-scheme(S-scheme)heterojunction photocatalyst was constructed for the first time and applied in the removal of environmental *** the as-prepared photocatalysts,the Cu_(2)WS_(4)/MoS_(2)-8%heterojunc tion photoc atalyst demonstrates the optimal photocatalytic performance,with the catalytic oxidation efficiency of tetracycline(TC)and the catalytic reduction efficiency of Cr^(6+)reaching 93.3%and 82.1%,*** excellent catalytic properties of Cu_(2)WS_(4)/MoS_(2) heterojunction photocatalysts are attributed to the effective separation pathways of charges and the presence of S-scheme heterojunctions,together with stronger redox *** is speculated that the photogenerated carrier migration path of the Cu_(2)WS_(4)/MoS_(2) catalyst follows the typical S-scheme photocatalytic mechanism,which is verified by the in-depth experimental study and simulated calculations including the electron paramagnetic resonance(EPR)analysis,free radical quenching experiments,charge density distribution,and simulated built-in electric field formation at the interface,which acts as driving force to promote the separation of photoinduced electrons and ***,the photocatalytic mechanism of S-scheme photogenerated carrier migration for the Cu_(2)WS_(4)/MoS_(2) catalyst is revealed based on the systematic experimental techniques and simulated calculations,accounting for its superior photocatalytic oxidation and reduction *** study provides inspiring implications to develop high-efficient S-scheme photocatalytic systems for versatile applications in solarenergy conversion.

关键词： Cu_(2)WS_(4)/MoS_(2) S-scheme Heterojunction Photocatalysis

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Controllable image generation based on causal representation learning

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Frontiers of Information Technology & Electronic Engineering 2024年第1期25卷 135-148页

作者： Shanshan HUANG Yuanhao WANG Zhili GONG jun liao Shu WANG Li LIU School of Big Data and Software Engineering Chongqing UniversityChongqing 401331China School of Materials and Energy Southwest UniversityChongqing 400715China

Artificial intelligence generated content(AIGC)has emerged as an indispensable tool for producing large-scale content in various forms,such as images,thanks to the significant role that AI plays in imitation and ***,interpretability and controllability remain *** AI methods often face challenges in producing images that are both flexible and controllable while considering causal relationships within the *** address this issue,we have developed a novel method for causal controllable image generation(CCIG)that combines causal representation learning with bi-directional generative adversarial networks(GANs).This approach enables humans to control image attributes while considering the rationality and interpretability of the generated images and also allows for the generation of counterfactual *** key of our approach,CCIG,lies in the use of a causal structure learning module to learn the causal relationships between image attributes and joint optimization with the encoder,generator,and joint discriminator in the image generation *** doing so,we can learn causal representations in image’s latent space and use causal intervention operations to control image *** conduct extensive experiments on a real-world dataset,*** experimental results illustrate the effectiveness of CCIG.

关键词： Image generation Controllable image editing Causal structure learning Causal representation learning

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Advanced nano drug delivery systems for neuroprotection against ischemic stroke

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Chinese Chemical Letters 2024年第2期35卷 151-162页

作者： Chenchen Xie jun liao Ning Zhang Yuhan Sun Yi Li Liyan Xiong Yingnan Zhang Xiaoyan Liu Wei Su Heming Chen Ping Zeng Xiaoqing Zhang Ying Lu Tingfang Wang Chuan Zhang Shanghai Engineering Research Center of Organ Repair School of MedicineShanghai UniversityShanghai 200444China Department of Pharmaceutical Science School of PharmacyNaval Medical UniversityShanghai 200433China Department of pharmacy the International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200030China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200040China

Ischemic stroke(IS)represents a significant threat to brain health due to its elevated mortality and disability *** efficacy of small-molecule neuroprotective agents has been impeded by challenges associated with traversing the blood-brain barrier(BBB)and limited ***,advanced nano drug delivery systems hold promise for overcoming these obstacles by facilitating efficient transportation across the BBB and maintaining optimal drug *** review aims to explore advanced neuroprotective nano drug delivery systems as a means of effectively administering neuroprotective agents to the brain using pharmaceutical approaches in the treatment of *** examining these systems,researchers and clinicians can gain valuable insights and innovative concepts,illuminating the potential of advanced neuroprotective nano drug delivery *** these advancements can drive the progress of pioneering and efficacious therapeutic interventions for IS.

关键词： Target Blood-brain barrier Ischemic stroke Nano drug delivery Neuroprotection

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《习近平谈治国理政》(第四卷)德文版中的翻译创造性探析

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外国语文 2024年第4期40卷 171-182页

作者：廖峻四川外国语大学德语学院重庆400031

在《习近平谈治国理政》多语种版本中,翻译创造性在语言转换、文化输出、交际效果等方面都有突出的体现,对其进行分析研究有利于深化对政治外宣文本的翻译和研究,契合了“三进”工作对教学改革和人才培养的要求。不论是从宏观层面梳理... 详细信息

在《习近平谈治国理政》多语种版本中,翻译创造性在语言转换、文化输出、交际效果等方面都有突出的体现,对其进行分析研究有利于深化对政治外宣文本的翻译和研究,契合了“三进”工作对教学改革和人才培养的要求。不论是从宏观层面梳理学界对翻译创造性的认识,还是在微观层面以第四卷德文版中译例为对象进行分析,都有助于深化对于创造性在外宣翻译中的产生机制及作用的认识,而“新颖性”“适当性”和“美学性”可以作为考察翻译创造性的三种维度,促使高校在语言和翻译教学中把培养学生的创造力放在更加重要的位置,更好地发挥“三进”对高校外语课程思政建设的引领作用。

关键词：《习近平谈治国理政》(第四卷) 翻译创造性 “三进”

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Relationship between preoperative psychological stress and shortterm prognosis in elderly patients with femoral neck fracture

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World Journal of Psychiatry 2024年第6期14卷 838-847页

作者： Wen-Hui Fu Zhi-Long Hu Yuan-jun liao Ri-Jiang Chen Jian-Bin Qiu Wu-Tang Que Wan-Tao Wang Wei-Hua Li Wei-Bin Lan Department of Orthopedics Longyan First Affiliated Hospital of Fujian Medical UniversityLongyan 361000Fujian ProvinceChina

BACKGROUND Older adults are at high risk of femoral neck fractures(FNFs).Elderly patients face and adapt to significant psychological burdens,resulting in different degrees of psychological stress *** hip replacement is the preferred treatment for FNF in elderly patients;however,some patients have poor postoperative prognoses,and the underlying mechanism is *** speculated that the postoperative prognosis of elderly patients with FNF may be related to preoperative psychological *** To explore the relationship between preoperative psychological stress and the short-term prognosis of elderly patients with *** In this retrospective analysis,the baseline data,preoperative 90-item Symptom Checklist score,and Harris score within 6 months of surgery of 120 elderly patients with FNF who underwent total hip arthroplasty were *** analyzed the indicators of poor short-term postoperative prognosis and the ability of the indicators to predict poor prognosis and compared the correlation between the indicators and the Harris *** Anxiety,depression,garden classification of FNF,cause of fracture,FNF reduction quality,and length of hospital stay were independent influencing factors for poor short-term postoperative prognoses in elderly patients with FNF(P<0.05).The areas under the curve for anxiety,depression,and length of hospital stay were 0.742,0.854,and 0.749,*** sensitivities of anxiety,depression,garden classification of FNF,and prediction of the cause of fracture were 0.857,0.786,0.821,and 0.821,*** specificities of depression,FNF quality reduction,and length of hospital stay were the highest at 0.880,0.783,and 0.761,***,depression,and somatization scores correlated moderately with Harris scores(r=-0.523,-0.625,and-0.554;all P<0.001).CONCLUSION Preoperative anxiety,depression,and somatization are correlated with poor short-term prognosis in elderly patients with FNF and warrant consid

关键词： Psychological stress Old age Femoral neck fracture Hip replacement Short-term prognosis Correlation

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Teffichthys wui sp. nov., a new perleidid fish from the Early Triassic of Jiangsu and Anhui, China

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古脊椎动物学报（中英文） 2024年第3期62卷 165-185页

作者： XU Guang-Hui YUAN Zhi-Wei REN Yi liao jun-Ling ZHAO Li-jun SONG Hai-jun Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044 State Key Laboratory of Biogeology and Environmental Geology School of Earth SciencesChina University of GeosciencesWuhan 430074 University of Chinese Academy of Sciences Beijing 100049 College of Economics and Trade Minzu Normal University of Xingyi XingyiGuizhou 562400 Zhejiang Museum of Natural History Hangzhou 310014

Perleididae is a group of stem neopterygian fishes known only from the ***,we report the discovery of a new perleidid,Teffichthys wui ***.,based on six well-preserved specimens from the late Smithian(Olenekian,Early Triassic)marine deposits of Jurong,Jiangsu and Chaohu,Anhui,*** new discovery documents the third and youngest species of Teffichthys,which is slightly younger than the Dienerian(Induan)*** from Guizhou and the early Smithian *** from *** new species shows diagnostic features of Teffichthys(presence of a spiracular,38-41 lateral line scales,and no more than three epaxial rays in the caudal fin)but differs from *** and *** in some autapomorphies(e.g.,a horizontal opercle/subopercle contact and smooth scales with a nearly straight posterior margin).The diagnostic features for the genus Teffichthys and the family Perleididae are emended based on detailed comparisons of the new taxon with other *** phylogenetic relationships of perleidids with other stem neopterygians are discussed using a cladistic approach,and the results provide new insights into the phylogeny and classification of main stem neopterygian clades.

关键词： Jiangsu Anhui Early Triassic Perleidiformes osteology phylogeny

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地铁车辆牵引电机轴承故障分析及改善措施

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现代城市轨道交通 2024年第2期 57-63页

作者：廖俊广州地铁集团有限公司运营事业总部广东广州510310

文章旨在解决广州地铁2号线A4型车的牵引电机轴承频繁故障问题。通过现场调查和实验测试,详细分析轴承现状、失效模式和损伤类别,发现轴承故障主要由径向力、电蚀、电火花放电和轴向力引起的疲劳失效模式导致。为解决这些问题,研究提出... 详细信息

文章旨在解决广州地铁2号线A4型车的牵引电机轴承频繁故障问题。通过现场调查和实验测试,详细分析轴承现状、失效模式和损伤类别,发现轴承故障主要由径向力、电蚀、电火花放电和轴向力引起的疲劳失效模式导致。为解决这些问题,研究提出一系列解决措施。首先,建议采用新材料改善轴承质量和可靠性。其次,需要改进电腐蚀问题以减少电蚀和电火花放电对轴承的损害。最后,通过轴电压测试结果确定适当的轴向力范围,以避免过大的轴向力对轴承造成疲劳失效。实验结果表明,引入驱动端陶瓷轴承和接地环配套组合的改进方案成功解决A4型车轴承频繁故障问题,且方案实施效果显著。同时将该方案引入广州地铁2号线、广佛线后,运营4年期间未再出现轴承烧损问题。该研究具有一定的理论和实践价值,不仅为类似问题的解决提供有益的借鉴,还有效提高轨道交通列车的可靠性和运行效率,为乘客提供更安全、舒适的出行体验。

关键词：地铁车辆牵引电机轴承陶瓷轴承接地环轴电压

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环境胁迫影响三峡库区消落带草本和木本植物生理生态特征的meta分析

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植物生态学报 2024年第5期48卷 623-637页

作者：邓蓓王晓锋廖君山区生态系统碳循环与碳调控重庆市重点实验室三峡库区地表生态过程重庆市野外科学观测研究站重庆师范大学地理与旅游学院重庆401331

三峡库区消落带适生草本与木本植物对环境胁迫的响应是生态系统结构与功能演变的重要机制。然而,目前对消落带胁迫环境下草本和木本植物的响应特征及是否存在类群差异尚不清楚。该研究基于meta分析,探讨了三峡消落带典型环境胁迫(水淹... 详细信息

三峡库区消落带适生草本与木本植物对环境胁迫的响应是生态系统结构与功能演变的重要机制。然而,目前对消落带胁迫环境下草本和木本植物的响应特征及是否存在类群差异尚不清楚。该研究基于meta分析,探讨了三峡消落带典型环境胁迫(水淹、干旱胁迫)对适生草本和木本植物生理生态特征的影响,从物种和生活型的角度揭示了消落带适生植物类群对水淹、干旱胁迫的响应规律。结果表明:(1)草本植物和木本植物在环境胁迫下均表现出明显的生长发育抑制以及生理生化策略的适应性响应,主要表现在各组织器官生物量、光合速率的下降,丙二醛和脯氨酸含量的增加,以及抗氧化酶(超氧化物歧化酶、过氧化物酶、过氧化氢酶)活性增强。(2)水淹胁迫对草本植物生物量负效应最强,干旱胁迫次之;水淹胁迫对木本植物总叶绿素含量和光合速率负效应最大,干旱胁迫次之,表现出环境胁迫作用的生活型效应;但草本与木本植物的总叶绿素含量均对水淹胁迫响应最敏感,而木本植物对干旱胁迫表现出一定的内稳态。木本植物在生理生化方面对水淹胁迫的响应比草本植物更显著,且主要体现在气孔导度、丙二醛含量、脯氨酸含量和过氧化物酶活性方面的响应与草本植物存在差异;而草本植物对干旱胁迫的响应比木本植物更显著,主要表现为总叶绿素含量、水分利用效率、抗氧化酶(超氧化物歧化酶、过氧化物酶、过氧化氢酶)活性方面的响应与木本植物存在差异。(3)草本和木本植物对不同环境胁迫的形态响应具有组织特异性差异。草本植物主要以根部、茎部和叶片形态的变化适应水淹和干旱胁迫,木本植物则主要以根部形态的变化为主。

关键词：三峡库区植物生理生态环境胁迫 meta分析

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研究生学科竞赛促拔尖创新人才能力培养模式研究

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黑龙江教育（理论与实践） 2024年第7期 95-97页

作者：廖俊李珺中南大学航空航天技术研究院湖南长沙410083

学科竞赛在培养研究生创新思维、实践能力及增强研究生综合素质等方面发挥了重要作用,对拓展研究生知识面、提高研究生独立开展科研工作的能力也具有极大的促进作用。文章对目前研究生学科竞赛存在的一系列问题进行了详细总结和分析,并... 详细信息

学科竞赛在培养研究生创新思维、实践能力及增强研究生综合素质等方面发挥了重要作用,对拓展研究生知识面、提高研究生独立开展科研工作的能力也具有极大的促进作用。文章对目前研究生学科竞赛存在的一系列问题进行了详细总结和分析,并在研究生学科竞赛的组织管理模式、奖励机制、导师工作机制等诸多方面提出了合理化的建议,以期为研究生基于学科竞赛进行综合能力培养的相关工作提供参考。

关键词：研究生教育研究生学科竞赛能力培养创新能力实践环节组织管理

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