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Clinical observation of gastrointestinal function recovery in patients after hepatobiliary surgery

World Journal of Gastrointestinal Surgery 2024年第1期16卷 76-84页

作者： hua-jun Zeng Jing-Jing Liu Ying-Chun Yang Department of General Practice Nanyang First People's HospitalNanyang 473000Henan ProvinceChina Department of Anesthesiology Chinese People’s Armed Police Force Hospital of BeijingBeijing 100027China Department of Anesthesiology Beijing Fengtai HospitalBeijing 100071China

BACKGROUND The liver is an important metabolic and digestive organ in the human body,ca-pable of producing bile,clotting factors,and vitamins.AIM To investigate the recovery of gastrointestinal function in patients after hepato-biliary surgery and identify effective rehabilitation measures.METHODS A total of 200 patients who underwent hepatobiliary surgery in our hospital in 2022 were selected as the study subjects.They were divided into a control group and a study group based on the extent of the surgery,with 100 patients in each group.The control group received routine treatment,while the study group re-ceived targeted interventions,including early enteral nutrition support,drinking water before gas discharge,and large bowel enema,to promote postoperative gastrointestinal function recovery.The recovery of gastrointestinal function was compared between the two groups.RESULTS Compared with the control group,patients in the study group had better recovery of bowel sounds and less accumulation of fluids in the liver bed and gallbladder fossa(P<0.05).They also had shorter time to gas discharge and first meal(P<0.05),higher overall effective rate of gastrointestinal function recovery(P<0.05),and lower incidence of postoperative complications(P<0.05).CONCLUSION Targeted nursing interventions(early nutritional support,drinking water before gas discharge,and enema)can effectively promote gastrointestinal function recovery in patients undergoing hepatobiliary surgery and reduce the incidence of complications,which is worthy of promotion.

关键词： Liver and gallbladder patients Gastrointestinal function Postoperative recovery

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HSP110 aggravates ischemia-reperfusion injury after liver transplantation by promoting NF-κB pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 344-352页

作者： Qing-Zhi Hu Zhen-Rui Cao Wei-Xiong Zheng Min-Jie Zhao jun-hua Gong Cong Chen Zhong-jun Wu Rui Tao Department of Hepatobiliary Surgery Bishan Hospital of Chongqing Medical UniversityChongqing 402760China Department of Cardiothoracic Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China c Department of Hepatobiliary Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Hepatobiliary Surgery the Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

Background:Ischemia-reperfusion injury(IRI)poses a significant challenge to liver transplantation(LT).The underlying mechanism primarily involves overactivation of the immune system.Heat shock protein 110(HSP110)functions as a molecular chaperone that helps stabilize protein structures.Methods:An IRI model was established by performing LT on Sprague-Dawley rats,and HSP110 was silenced using siRNA.Hematoxylin-eosin staining,TUNEL,immunohistochemistry,ELISA and liver enzyme analysis were performed to assess IRI following LT.Western blotting and quantitative reverse transcription-polymerase chain reaction were conducted to investigate the pertinent molecular changes.Results:Our findings revealed a significant increase in the expression of HSP110 at both the mRNA and protein levels in the rat liver following LT(P<0.05).However,when rats were injected with siRNAHSP110,IRI subsequent to LT was notably reduced(P<0.05).Additionally,the levels of liver enzymes and inflammatory chemokines in rat serum were significantly reduced(P<0.05).Silencing HSP110 with siRNA resulted in a marked decrease in M1-type polarization of Kupffer cells in the liver and downregulated the NF-κB pathway in the liver(P<0.05).Conclusions:HSP110 in the liver promotes IRI after LT in rats by activating the NF-κB pathway and inducing M1-type polarization of Kupffer cells.Targeting HSP110 to prevent IRI after LT may represent a promising new approach for the treatment of LT-associated IRI.

关键词： Ischemia-reperfusion injury Liver transplantation Inflammation HSP110 Heat shock proteins NF-κB

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Icariin accelerates bone regeneration by inducing osteogenesisangiogenesis coupling in rats with type 1 diabetes mellitus

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World Journal of Diabetes 2024年第4期15卷 769-782页

作者： Sheng Zheng Guan-Yu Hu jun-hua Li Jia Zheng Yi-Kai Li Department of Traditional Chinese Orthopedics and Traumatology Center for Orthopedic SurgeryThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510630Guangdong ProvinceChina School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Endocrinology Peking University First HospitalBeijing 100034China

BACKGROUND Icariin(ICA),a natural flavonoid compound monomer,has multiple pharmacological activities.However,its effect on bone defect in the context of type 1 diabetes mellitus(T1DM)has not yet been examined.AIM To explore the role and potential mechanism of ICA on bone defect in the context of T1DM.METHODS The effects of ICA on osteogenesis and angiogenesis were evaluated by alkaline phosphatase staining,alizarin red S staining,quantitative real-time polymerase chain reaction,Western blot,and immunofluorescence.Angiogenesis-related assays were conducted to investigate the relationship between osteogenesis and angiogenesis.A bone defect model was established in T1DM rats.The model rats were then treated with ICA or placebo and micron-scale computed tomography,histomorphometry,histology,and sequential fluorescent labeling were used to evaluate the effect of ICA on bone formation in the defect area.RESULTS ICA promoted bone marrow mesenchymal stem cell(BMSC)proliferation and osteogenic differentiation.The ICA treated-BMSCs showed higher expression levels of osteogenesis-related markers(alkaline phosphatase and osteocalcin)and angiogenesis-related markers(vascular endothelial growth factor A and platelet endothelial cell adhesion molecule 1)compared to the untreated group.ICA was also found to induce osteogenesis-angiogenesis coupling of BMSCs.In the bone defect model T1DM rats,ICA facilitated bone formation and CD31hiEMCNhi type H-positive capillary formation.Lastly,ICA effectively accelerated the rate of bone formation in the defect area.CONCLUSION ICA was able to accelerate bone regeneration in a T1DM rat model by inducing osteogenesis-angiogenesis coupling of BMSCs.

关键词： Icariin Osteogenesis-angiogenesis coupling Type 1 diabetes mellitus Bone defect Bone regeneration

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Enhanced thermoelectric performance enabled by compositing ZrO_(2)in n-type SiGe alloy with low thermal conductivity

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Rare Metals 2024年第3期43卷 1167-1176页

作者： Meng-Fei Wang hua-jun Lai Ji-Sheng Liang jun-Liang Chen Wang-Yang Ding Qi Zhou Ying Peng Cheng-Yan Liu Lei Miao Guangxi Key Laboratory for Relativity Astrophysics State Key Laboratory of Featured Metal Materials and Life-Cycle Safety for Composite StructuresSchool of Physical Science and TechnologyGuangxi UniversityNanning530004China Guangxi Academy of Sciences Nanning530007China Key Laboratory of Information Material Engineering Research Center of Electronic Information Materials and DevicesGuilin University of Electronic TechnologyMinistry of EducationGuilin541004China Guangxi Key Laboratory of Precision Navigation Technology and Application School of Information and CommunicationGuilin University of Electronic TechnologyGuilin541004China

SiGe-based thermoelectric(TE)materials have gained increasing interests due to their low maintenance costs,environmental friendliness and long lifespan.However,the intrinsically high thermal conductivity of Si-based materials also results in poor TE properties.In this investigation,a zirconia(ZrO_(2))composite strategy was applied to an n-type SiGe alloy,tremendously elevating its TE performance.After mechanical alloying and spark plasma sintering(SPS)processes,the ZrO_(2)induced the formation of nanopores in the SiGe matrix via phosphorus adsorption.Moreover,such increase in porosity enhanced the phonon scattering and dramatically suppressed lattice thermal conductivity,from 2.83 to 1.59 W·m^(-1)·K^(-1)at 873 K.Additionally,reduced phosphorus doping led to an increase in Seebeck coefficients and a relatively minor decrease in electrical conductivity,The power factor didn't deteriorate significantly,either,as its maximum of~3.43 mW·m^(-1-)K^(-2)was achieved at 873 K with(Si_(0.8)Ge_(0.2))_(0.097)P_(0.03)(ZrO_(2))_(0.003).In short,a peak figure of merit(ZT)of~1.27 at 873 K and an average ZT~0.7 from 323 to 873 K were obtained.This study demonstrates that the electrical and thermal transportation of SiGe material can be synergistically tuned by compositing ZrO_(2),illustrating a novel strategy to optimize the TE properties of bulk materials.

关键词： Thermoelectric SiGe alloy ZrO2 composting P element adsorption nanopores

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Icariin ameliorates viral myocarditis by inhibiting TLR4-mediated ferroptosis

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 106-114,I0002-I0005页

作者： Wei Luo Yi Lu jun-hua Deng Peng Liu Yan huang Wan-Xi Liu Chun-Li huang Laboratory of the Atherosclerosis and Ischemic Cardiovascular Diseases Department of CardiologyAffiliated Hospital of Youjiang Medical University for NationalitiesYoujiang Medical University for NationalitiesBaiseGuangxi 533000China Department of Critical Care Medicine Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxi 533000China Department of Respiratory and Critical Care Medicine Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxi 533000China Postgraduate School of Youjiang Medical University for Nationalities BaiseGuangxi 533000China Department of Neonatology Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxi 533000China Department of Nephrology People’s Hospital of PubeiQinzhouGuangxi 535300China Urban Community Health Service Center of Youjiang District BaiseGuangxi 533000China

Objective:To explore the mechanism by which icariin alleviates viral myocarditis.Methods:CVB3-induced cardiomyocytes were used as an in vitro model of viral myocarditis to assess the effects of icariin treatment on cell viability,inflammation,and apoptosis.Moreover,the effects of icariin on ferroptosis and TLR4 signaling were assessed.After AC16 cells were transfected with TLR4 overexpression plasmids,the role of TLR4 in mediating the regulatory effect of icariin in viral myocarditis was investigated.Results:Icariin significantly elevated cell viability and reduced inflammatory factors TNF-α,IL-1β,IL-6,and IL-18.Flow cytometry revealed that icariin decreased apoptosis rate,and the protein expression of Bax and cleaved caspase 3 and 9 in CVB3-induced cardiomyocytes.Additionally,it suppressed ferroptosis including lipid peroxidation and ferrous ion,as well as the TLR4 signaling.However,TLR4 overexpression abrogated the modulatory effects of icariin.Conclusions:Icariin mitigates CVB3-induced myocardial injury by inhibiting TLR4-mediated ferroptosis.Further animal study is needed to verify its efficacy.

关键词： Viral myocarditis CVB3 TLR4 Ferroptosis Icariin

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基于柔性时间窗的地铁货物车厢配置与装载优化

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交通运输工程学报 2024年第2期24卷 221-231页

作者：石俊刚王松郭军华华东交通大学交通运输工程学院江西南昌330013

为缓解城市道路拥堵,提高城市物流系统周转效率,提出了利用地铁线路在非高峰时段开展货物运输;基于客货共载运输模式,在满足乘客出行需求的前提下,推算了各列车最多可挂载的货物车厢数,在此基础上进行货物车厢配置与装载方案优化;以列... 详细信息

为缓解城市道路拥堵,提高城市物流系统周转效率,提出了利用地铁线路在非高峰时段开展货物运输;基于客货共载运输模式,在满足乘客出行需求的前提下,推算了各列车最多可挂载的货物车厢数,在此基础上进行货物车厢配置与装载方案优化;以列车货物车厢配置计划与货物装载分配方案为决策变量,考虑货物送达柔性时间窗与容量限制的约束条件,以配送服务惩罚和货物车厢挂载成本最低为目标,构建了整数线性规划模型,并利用CPLEX优化软件进行模型求解。试验结果表明:为满足4类不同送达时限货物运输需求,方案共配置货运车厢42节,运营总成本为16970元;随着延迟送达惩罚系数增大,货物延迟送达率呈快速降低趋势,当延迟送达惩罚系数由5元·h^(-1)增加到100元·h^(-1)时,延迟送达率由22.50%降至8.75%,随着提前送达惩罚系数增大,货物提前送达率同样呈现快速降低趋势,当提前送达惩罚系数由0增加到40元·h^(-1)时,提前送达率由37.50%降低至3.75%,说明构建的模型对货物服务时效反应较为灵敏,同时有效满足货物送达服务时限要求;当某类货物惩罚系数增加时,该货物送达的提前率或延迟率会降低,整体表现为货物送达的准点率提高,服务水平得到改善,说明优化模型对不同类型货物的送达惩罚系数反应较为敏感;随着客运满载系数的增大,货物送达的准点率呈现递增趋势,货物送达提前率与延迟率总体上呈下降趋势,方案运营总成本也呈递减趋势,说明适当提高客运满载率阈值可以缓解部分列车运力,进而提高货物送达的准点率。

关键词：铁路运输地铁货运车厢配置装载优化柔性时间窗服务水平

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声学黑洞加筋板结构的声振特性分析

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船舶力学 2024年第3期28卷 442-449页

作者：温华兵黄惠文史自强郭俊华江苏科技大学能源与动力学院江苏镇江212100

基于声学黑洞与加强筋这两种结构设计出声学黑洞加筋板,通过建立声学黑洞加筋板、加强筋的有限元模型,对两种结构的声辐射特性、振动能量分布与传递特性开展研究。仿真结果表明:在高于截止频率时声学黑洞加筋板的辐射声功率级比普通加... 详细信息

基于声学黑洞与加强筋这两种结构设计出声学黑洞加筋板,通过建立声学黑洞加筋板、加强筋的有限元模型,对两种结构的声辐射特性、振动能量分布与传递特性开展研究。仿真结果表明:在高于截止频率时声学黑洞加筋板的辐射声功率级比普通加筋板降低8~20 dB,由于敷设的局部阻尼使聚集在声学黑洞区域的振动能得到有效的耗散,因此其振动水平下降明显且与声场耦合变弱;通过分析振动能量分布特性验证了声学黑洞加筋板结构大部分动能聚集在声学黑洞区域,减弱整体结构的振动水平;振动传递特性揭示了声学黑洞加筋板受声学黑洞聚能与加强筋阻振的叠加效应,相比于普通加筋板,声学黑洞加筋板具有更优的减振降噪性能。

关键词：声学黑洞加强筋减振降噪声辐射功率流

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基于改进SBR的舰船SAR成像快速仿真计算方法

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电子学报 2024年第2期52卷 602-613页

作者：章琪琪张寅范君杰夏翀翔闫钧华南京航空航天大学空间光电探测与感知工业和信息化部重点实验室江苏南京211106 南京航空航天大学航天学院江苏南京211106 上海卫星工程研究所上海200240

针对SAR(Synthetic Aperture Radar)舰船成像仿真应用中电磁散射特性计算效率低下的问题,在现有SBR(Shooting and Bouncing Rays)算法的基础上,本文提出两方面改进.一是基于叶节点空间邻域编码搜索的射线管相交面元检测算法,通过只追踪... 详细信息

针对SAR(Synthetic Aperture Radar)舰船成像仿真应用中电磁散射特性计算效率低下的问题,在现有SBR(Shooting and Bouncing Rays)算法的基础上,本文提出两方面改进.一是基于叶节点空间邻域编码搜索的射线管相交面元检测算法,通过只追踪射线管中心射线并搜索叶节点空间周围潜在相交面元,在有效提升相交检测速度的同时避免遗漏相交面元;二是射线管三角剖分快速分裂算法,将射线管和相交面元投影至射线管虚拟孔径面,利用Delaunay三角剖分算法自适应地将射线管快速分裂成连续的子射线管.对典型舰船目标进行RCS(Radar Cross Section)计算及SAR成像仿真实验,结果表明,在保证计算精度的前提下,本文方法计算效率比Kd树(K-dimension tree)加速SBR方法提升14倍以上,比经典自适应射线管分裂SBR方法提升3倍以上,计算效率显著提高.

关键词： SAR成像仿真 SAR回波仿真舰船RCS计算弹跳射线法自适应射线管分裂

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包覆面料裁片切割机横梁进给系统建模及动态特性分析

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林产工业 2024年第7期61卷 55-60页

作者：花军赵旭刘诚东北林业大学机电工程学院黑龙江哈尔滨150040

包覆面料裁片切割机是用于制作软体家具的主要设备之一,其横梁进给系统存在复杂的机电耦合作用。为在设计阶段研究其横梁进给系统切割定位工况下的动态特性,优化横梁进给伺服驱动控制系统参数,建立了横梁进给系统的机电-刚柔混合模型。... 详细信息

包覆面料裁片切割机是用于制作软体家具的主要设备之一,其横梁进给系统存在复杂的机电耦合作用。为在设计阶段研究其横梁进给系统切割定位工况下的动态特性,优化横梁进给伺服驱动控制系统参数,建立了横梁进给系统的机电-刚柔混合模型。拟定横梁进给系统的响应效率、定位精度和刀尖运动稳定性作为动态特性评价指标,探究了横梁进给伺服驱动控制系统参数对横梁进给系统动态特性的影响。结果表明:建立的横梁进给系统机电-刚柔混合模型,为横梁进给系统动态特性分析奠定了基础。增大位置环比例系数可提高横梁进给系统的响应效率和定位精度,增大速度环比例系数可有效提高横梁进给系统的刀尖运动稳定性。研究结果可为提高软体家具生产效率和制造质量提供技术保障。

关键词：包覆面料裁片切割机横梁进给系统虚拟样机机电-刚柔混合动态特性

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基于纤维解离水曲柳压缩解离特征与能量耗散机制研究

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包装工程 2024年第3期45卷 284-291页

作者：许威曹军花军陈光伟东北林业大学机电工程学院哈尔滨150040 哈尔滨商业大学轻工学院哈尔滨150028

目的以水曲柳为研究对象,研究高应变率压缩载荷作用下水曲柳试件的解离特征和能量耗散机制。方法利用压缩加载试验分析应变率、加载方向对受载水曲柳的形态特征影响和动力学特性,并利用弹塑性基本原理分析其受压解离的能量耗散机制。结... 详细信息

目的以水曲柳为研究对象,研究高应变率压缩载荷作用下水曲柳试件的解离特征和能量耗散机制。方法利用压缩加载试验分析应变率、加载方向对受载水曲柳的形态特征影响和动力学特性,并利用弹塑性基本原理分析其受压解离的能量耗散机制。结果解离后径向加载试件主要呈火柴棍状,弦向加载试件主要呈片状,轴向加载试件主要呈不规则块状,试件的解离程度随应变率的增大而增大;当应变率在400~1000 s^(-1)时,水曲柳试件的应力-应变曲线由弹性阶段和屈服后弱线性强化阶段两部分组成;水曲柳试件的屈服强度随应变率的增大而增大,当应变率从400s^(-1)增加到1000s^(-1)时,径向、弦向和轴向加载试件的屈服强度分别增加了0.45倍、1.34倍和0.71倍;木材原料沿径、弦向解离时主要依靠木材细胞的压缩变形来耗散能量,沿轴向解离时主要依靠木材细胞纵向结构的弯曲来耗散能量。结论弦向最易解离,轴向最难解离;水曲柳是一种应变率敏感材料;木材原料径、弦向解离主要依靠压缩变形来耗散能量,轴向解离主要依靠弯曲变形来耗散能量,木材原料解离能够耗散能量的多少主要受加载方向、木材细胞的结构尺寸和力学性能的影响。

关键词：木材纤维解离应变率解离特征能量耗散机制

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