检索结果-南通市图书馆

中国新药与临床杂志 2002年第10期21卷 622-627页

作者：田红军冯志颖张新军安定医院天津300074

奥氮平是一种新型非典型抗精神病药 ,对多种神经递质受体具有亲和力。口服吸收迅速完全 ,生物利用度高。血浆T1/2 长 ,每日服药 1次。奥氮平对于多种精神障碍具有良好的临床治疗效果。

关键词：抗精神病药奥氮平临床应用药物代谢动力学精神分裂症

维普期刊数据库

Effect of histamine on regional cerebral blood flow of the parietal lobe in rat

在线全文

学校读者我要写书评

暂无评论

Effect of histamine on regional cerebral blood flow of the p...

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Peng-Bo YANG,Xin-Lin CHEN,Jian-jun ZHAO,Jian-Shui zhang,jun-feng zhang,Yu-Mei TIAN,Yong LIU Institute of Neurobiology,Medicine School,Xi’an Jiao Tong University,Xi’an 710061,China

Objective Histamine is one of the most important neurotransmitters in the brain and cell bodies of the histaminergic neurons are located exclusively in the tuberomammillary nuclei of the *** efferent varicose fibers project predominandy ipsilateraly to the whole central nervous system,including most subcortical nuclei and the cerebral *** previous studies,together with other data,have showed that the H1,H2 receptors have expressed in the intracortical blood vessels of rat brain,suggesting mat histamine could regulate the activity of intracortical microvessels in *** also found that histamine could make the intracortical microvessels contract via the H1 receptor on the rat brain *** this paper,the effect of histamine on regional cerebral blood flow(rCBF) in the rat parietal lobe was detected by the laser-Doppler flowmetry(LDF).Methods The probe of LDF was placed in the parietal lobe after craniotomy of rat parietal *** distinct ways were employed to administer histamine or histidine(a precursor of histamine):(1) infusion of histamine dissolved in artificial cerebralspinal fluid in cranial window;(2) intracerebroventricular injection (ICV) of hitamine;(3) intraperitoneal injection of *** extent of rCBF changes was observed.H1 antagonist (diphenhydramine) or H2 antagonist(cimetidine) was also administered(ICV) before the application of histamine or histidine to determine the type of the receptor involved in the histamine *** The reduction of rCBF in the rat parietal lobe was found in three different administering *** the group of cranial window infusion,effect occurred after 1 min application of *** with PU before drug application,the decreasing percentage of PU was respectively 3.48±0.45(10 mol/L),8.24±1.25(10mol/L),20.73±3.54(10,32.94±5.26(10mol/L),42.65±8.21(10mol/L),and concentration-dependent relationship was detected in this group(P<0.01).Yet the high-concentration(10 mol/L.10 mol/L) of his

关键词： histamine rCBF laser-Doppler flowmetry(LDF)

Insulin Inhibits β-Adrenergic Action in Myocardial Ischemia and Reperfusion:A Novel Mechanism of Insulin in Cardioprotection

在线全文

cnki会议

学校读者我要写书评

暂无评论

Insulin Inhibits β-Adrenergic Action in Myocardial Ischemia...

中国生理学会2007年消化内分泌生殖学术研讨会

作者： Qiu-jun Yu,Hai-feng zhang,Rui Si,Wen-Yi Guo,Hai-Chang Wang,Gao feng (Department of Cardiology,Xijing Hospital,and Department of Physiology,Fourth Military Medical University,Xi''an,710032,China)

＜正＞Objectives:Sympathetic overactivity is closely connected with cell injury and contractile dysfunction during myocardial ischemia/reperfusion（MI/R）.This study aimed to investigate the ability of insulin to modulateβ-adrenergic action on myocardial contractility and postischemic injury in acute MI/R and the underlying mechanisms.

关键词：

A Sandwich Stacking of a Pyrene Derivative for Hg2+-Selective Fluorescent Sensing and Its Application to In Vivo Imaging

在线全文

cnki会议

学校读者我要写书评

暂无评论

A Sandwich Stacking of a Pyrene Derivative for Hg2+-Selectiv...

第八届全国化学生物学学术会议

作者： Guang Ke Wang Qi Li Mi Li Yun Zhao jun Jie Hu Lin E Guo Xiao Ju Zou Bo Liu jun feng zhang Qi Hua Zhao Ying Zhou Key Laboratory of Medicinal Chemistry for Natural Resource School of Chemical Science and TechnologyYunnan University Yunnan Institute of Microbiology Yunnan University Yunnan Academy of Tobacco Science School of Life Sciences Yunnan University College of Chemistry and Chemical Engineering Yunnan Normal University

Compound 1 was synthesized as a fluorescence sensor for Hg,the binding process was indicated by a distinct "off-on" fluorescent *** the results showed that,in the 1-Hgcomplex,a sandwich stacking bind mode was *** sepe... 详细信息

关键词： Fluorescence sensor Mercury In vivo imaging C.elegans zebrafish

Staged dendrite suppression for high safe and stable lithium-sulfur batteries

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao zhang Pan Xiong Xin Wang junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Ductility

Stable copper boron–imidazolate cage as Cu-riched enzyme for highly efficient electrocatalytic CO2 reduction to ethylene

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： jun-Qiang Chen Qiao-Hong Li Qin-Long Hong Ping Shao Hai-Xia zhang Jian zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Single-atom catalyst has garnered widespread attention to mimic mature enzymes due to its well-defined atomic structure and coordination environments. However, since the carbon–carbon（C–C） coupling reactions require synergistic catalysis of multiple sites, single-atom catalysts suffer from insufficient active sites and unclear reaction mechanisms. Controlling the reaction intermediates in a precisely targeted pocket through careful metal–organic cage design is therefore crucial. Here, we prepare a tetrahedral [Cu6L4]-type boron–imidazolate cage integrating highly active Cu sites and optimized cavity, which exhibits enzyme like specific catalytic performance in electrochemical CO2reduction reaction（CO2RR） to enhance the selectivity of *** analyses and computational calculations suggest that the single Cu site together with neighboring boron–imidazolate ligands provides suitably synergistic effects that enable the energetically favorable formation of an *COCHO intermediate, a key step determining selectivity. As a result, the [Cu6L4]-type cage of BIC-145 achieves a Faradaic efficiency of 28% for C2H4maintaining an average current density of -3.54 mA cm-2over a 5-hour electrolysis period. This work represents the first example for studying single-metal site catalysts with ultra-low coordination numbers through the rational design of metal–organic cages.

关键词：

From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua Lu jun Shen Xin zhang Lingcong Chao Liang Chen Ding zhang Tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

维普期刊数据库

The influences of tetramethylpyrazine on region cerebral blood flow temporal cortex after focal cerebral ischemia in rat

在线全文

学校读者我要写书评

暂无评论

The influences of tetramethylpyrazine on region cerebral blo...

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Yu-Mei TIAN,Xin-Lin CHEN,jun-feng zhang,Peng-Bo YANG,Jian-Shui zhang,Lu YAO,Yong LIU Institute of Neurobiology,Medical School of Xi''an Jiaotong University,Xi''an 710061,China

＜正＞Objective Using laser-Doppler flowmetry（LDF）,the influence of tetramethylpyrazine（TMP） on regional cerebral blood flow（rCBF） of temporal cortex in rat after focal cerebral ischemia/reperfusion injury was monitored dynamically. Methods Male SD rats were randomly divided into sham-operation group,ischemia group and TMP treated group with different dose（10 mg/kg,20 mg/kg,40 mg/kg,or 80 mg/kg）.Perfusion Units（PU）,which is the main index of rCBF, Concentration of Moving Blood Cells（CMBC）,Velocity（V） and Total Backscatter（TB） as the observation indexes of LDF were continuously monitored before and after injection of different doses of TMP at different *** cranial window was made and the LDF probe was placed on the surface of the temporal *** the LDF successive monitoring,the ischemia model was made by occlusion of right middle cerebral artery with nylon suture,and the animals then received a single *** of *** hours after the occlusion,the nylon suture was withdrawn to allow *** neurological function was scored according to the improved Bederson score system at 12 h after ***（1） In the cerebral ischemia rats,the rCBF decreased in 70%-80%compared with that of sham-operation animals.（2） In the group of 10 mg/kg TMP treatment,there was a significant increase of PU after 30 min application of *** with PU before drug application,the percentage of PU was increased about（37.18±6.65）%and no decrease was observed until 2 h after drug application.（3） In the group of 20 mg/kg TMP treatment,PU increase was observed after 10min,the increased percentage was（50.94±8.67）%.（4） In the group of 40 mg/kg TMP treatment,the increase was observed after 10 min administration and peak point appeared between 60 min and 90 *** decrease was seen within 2 h.（5） No any significant changes of rCBF were observed in 80 mg/kg TMP group.（6） The blood flow did not increase until 15 min after reperfusion in ischemia group,however,in TMP ad

关键词： tetramethylpyrazine cerebral ischemia laser-Doppler flowmetry(LDF) rCBF

Is it possible to foot reflexology for infants with sensorineural hearing loss?

在线全文

cnki会议

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第2期13卷 1-4页

作者： Min Ai Hang-Hang zhang jun-Bang feng Chuan-Ming Li Wen-Jing Wang Meng-Die Hu Department of Anesthesiology Nanan District People's Hospital of ChongqingChongqing 400060China Department of Breast and Thyroid Surgery Chongqing Bishan District Maternal and Child Health Care HospitalChongqing 402760China Department of Medical Imaging Chongqing University Central HospitalChongqing 400014China

Foot reflexology is a non-invasive and safe complementary therapy that works by massaging the reflex zones of the feet and exerts systemic or whole-body regulation through meridian nerve *** therapy is commonly used in the treatment of various conditions such as autism and Parkinson's ***,there is limited reporting on the use of foot reflexology therapy for infants with sensorineural hearing loss(SNHL).Currently,there is no definitive conclusion on how foot reflexology therapy can influence *** editorial holds some guiding significance regarding this clinical *** aim is to present physiological evidence of how foot reflexology therapy can impact infants with SNHL,thereby enhancing clinician’s awareness of foot reflexology in treating infants with SNHL.

关键词： Foot reflexology Sensorineural Hearing Loss Future perspectives Limitations Neural conduction

成都市工业源重点VOC排放行业排放清单及空间分布特征

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

环境科学学报 2018年第4期38卷 1358-1367页

作者：赵锐黄络萍程军欧阳峰张建强西南交通大学地球科学与环境工程学院成都611756

以2013年为基准,采用排放系数法对成都市区域范围内工业源的VOC排放进行了核算,利用GIS工具构建成都市1 km×1 km网格化排放清单,分析了VOCs的空间分布特征.研究结果表明:2013年成都市工业源VOC排放总量为(5.77±3.35)×10~4t,其中溶剂... 详细信息

以2013年为基准,采用排放系数法对成都市区域范围内工业源的VOC排放进行了核算,利用GIS工具构建成都市1 km×1 km网格化排放清单,分析了VOCs的空间分布特征.研究结果表明:2013年成都市工业源VOC排放总量为(5.77±3.35)×10~4t,其中溶剂使用源排放(3.09±4.93)×10~4t,工艺过程源排放(2.35±3.82)×10~4t,化石燃料燃烧源排放(0.21±0.61)×10~4t,生物质燃烧源排放(0.12±0.48)×10~4t.从工业源VOC排放的空间分布特征上看,都江堰、郫县、温江和崇州是最主要的贡献区县,涉及的排污企业类型主要包括钢铁、化工和水泥行业.

关键词：排放清单 VOC 重点行业空间分布成都

维普期刊数据库