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Current Medical Science 2024年第4期44卷 692-697页

作者： jun-feng zhang feng-qing CAI Xiu-cai zhang Qing YE Department of Laboratory Medicine Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou310052China

Objective Inflammation is involved in the development and progression of nonalcoholic fatty liver disease(NAFLD).The monocyte to high-density lipoprotein cholesterol ratio(MHR)has emerged as a marker for various inflammation-related *** aim of the present study was to investigate the association between the MHR and NAFLD in a population with childhood *** Based on hepatic ultrasound,a total of 504 children with obesity(357 with NAFLD and 147 without NAFLD)were included in the *** correlation between the MHR and NAFLD risk factors was assessed by Pearson’s and Spearman’s *** stepwise logistic regression analyses were conducted to explore the association between the MHR and the risk of *** The MHR in patients with NAFLD was significantly greater than that in patients without NAFLD[0.52(0.44-0.67)versus 0.44(0.34-0.57),P<0.001].Multivariate stepwise logistic regression analysis demonstrated that the MHR[odds ratio(OR):1.033,95%confidence interval(CI):1.015-1.051;P<0.001]was an independent predictor of NAFLD in childhood obesity patients,as were age(OR:1.205,95%CI:1.059-1.371;P=0.005],waist circumference[OR:1.037,95%CI:1.008-1.067;P=0.012],and alanine transaminase[OR:1.067,95%CI:1.045-1.089;P<0.001].Additionally,MHR quartiles showed a significant positive association with the incidence of NAFLD after adjusting for potential confounding *** The present study showed that the MHR may serve as an available and useful indicator of NAFLD in individuals with childhood obesity.

关键词： nonalcoholic fatty liver disease obesity monocyte-to-high-density lipoprotein ratio marker

Drying and preheating processes of iron ore pellets in a traveling grate

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International Journal of Minerals,Metallurgy and Materials 2010年第5期17卷 535-540页

作者： jun-xiao feng Yu zhang Hai-wei Zheng Xiao-yan Xie Cai zhang School of Mechanical Engineering University of Science and Technology B~ijing Beijing 100083 China

A mathematical model of drying and preheating processes in a traveling grate was presented based on the laws of mass, momen- tum, heat transfer, and drying semiempirical relations. A field test was systematically carried out in a traveling grate. The effects of pellet diameter, moisture, grate velocity, and inlet gas temperature on the pellet bed temperature were studied. The average relative error between actual measurements and simulations is less than 7.97%, indicating the validity of the model.

关键词： iron ores pelletizing drying preheating numerical methods field test

CRLB analysis of wireless cognitive location with different short-range measurements

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The Journal of China Universities of Posts and Telecommunications 2008年第2期15卷 1-6页

作者： CUI Qi-mei LIU jun TAO Xiao-feng zhang Ping Key Laboratoryof Universal Wireless Communications Beijing University of Posts and Telecommunications Beijing 100876 China

Because of the wide application and great market potential of location-aware services, the research of wireless location techniques for the fourth generation （4G） mobile communications is being paid more attention. Wireless cognitive location （WCL） techniques for next generation wireless networks have been proposed in recent years. This article investigates the changes of the positioning accuracy of WCL algorithm when different methods are adopted to measure the short-range （SR） information. By fJrst completing Cramer-Rao lower bound （CRLB） analysis of the WCL algorithm with SR measurements based on time of arrival （TOA） and received signal strength （RSS）, it is discovered that TOA-based or time difference of arrival （TDOA） -based SR measurement can make WCL algorithms achieve higher accuracy than RSS mode, which is also verified by numerical simulation in the article. The conclusions can instruct the design of novel WCL-based location algorithms.

关键词： wireless cognitive location short range (SR) longrange (LR) Cramer-Rao lower bound (CRLB)

Event-triggered Control of Positive Switched Systems with Actuator Saturation and Time-delay

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International Journal of Automation and computing 2021年第1期18卷 141-154页

作者： jun-feng zhang Lai-You Liu Shi-Zhou Fu Shuo Li School of Automation Hangzhou Dianzi UniversityHangzhou 310018China Inria University of LilleLille 59000France

This paper investigates the event-triggered control of positive switched systems with randomly occurring actuator saturation and time-delay,where the actuator saturation and time-delay obey different Bernoulli ***,an event-triggering con-dition is constructed based on a 1-norm *** the presented event-triggering scheme,an interval estimation method is utilized to deal with the error term of the *** a co-positive Lyapunov functional,the event-triggered controller and the cone attraction domain gain matrices are designed via matrix decomposition *** positivity and stability of the resulting closed-loop systems are reached by guaranteeing the positivity of the lower bound of the systems and the stability of the upper bound of the systems,*** proposed approach is developed for interval and polytopic uncertain systems,***,two examples are provided to illustrate the effectiveness of the theoretical findings.

关键词： Positive switched systems event-triggered control randomly occurring actuator saturation linear programming time-delay

Prevalence of osteoarthritis and association between smoking patterns and osteoarthritis in China:a cross-sectional study

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Frontiers of Nursing 2018年第2期5卷 111-118页

作者： Qian-Qian He jun-feng zhang School of Management Shanxi Medical UniversityTaiyuanShanxi 030001China The Publishing house Chinese Journal of RheumatologyTaiyuanShanxi 030001China

Objective： The aims of this study were to estimate the prevalence of radiographic osteoarthritis （OA） and to assess the association between smoking patterns and OA prevalence in adults aged 50 years or older belonging to the Shanxi province of ***： A cross-sectional study in the rural regions of the Shanxi province was conducted among 2638 Chinese adults （aged ≥50 years）. Demographic characteristics and behavioral information were collected through epidemiological surveys. All participants with joint pain underwent plain radiographic examination and were diagnosed by a professional orthopedist. Associations between smoking patterns and the prevalence of OA were assessed using binary logistic regression ***： Among 2638 individuals （men, 50.3% and women, 49.7%; mean age, 61.5 years） included in the analysis, 49.8% had radiographic OA and 27.5% had knee OA. The prevalence of radiographic OA was higher in women than in men （P〈0.001）. After adjusting for potential confounding factors, there was a nonsignificant correlation between smoking and OA prevalence in the muttivariate model. Odds ratios （ORs） for all types of OA and knee OA were higher in active and passive smokers than in nonsmoking individuals after adjustments （OR 1.374; 95% confidence interval [CI] 1.049-1.802; OR 1.440; 95% CI 1.059-1.958, respectively）.Conclusions： This study showed th at smoking may not be an independent risk factor for OA; however, there was a positive correlation between active and passive smoking and OA.

关键词： osteoarthritis prevalence smoking patterns correlation radiographic

Synthesis of a new 2,2':6',2''-terpyridine derivative and its coordination property

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Chinese Chemical Letters 2007年第5期18卷 530-532页

作者： Yong Chen Xi Juan Zhao jun feng zhang Wen Fu Fu Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100080 China Graduate University of Chinese Academy of Sciences Beijing 100039 China College of Chemistry and Chemical Engineering Yunnan Normal University Kunming 650092 China

A novel compound, （E）-4′-（4-（but-1-en-3-ynyl）phenyl）-2,2′：6′,2″-terpyridine 1 was synthesized from 4′-（4-bromomethylphenyl）-2,2P：6P,2PP-terpyridine phosphonium salt 2 and propargylaldehyde via Wittig reaction, and characterized by EI-MS and ^1H NMR as well as elemental analysis. The spectral changes of the compound in the presence of transition metal ions, such as Cu（I） or Zn（ID, are investigated.

关键词： Polypyridine ligands Synthesis Coordination

Efficacy evaluation of intravitreal ranibizumab therapy for three types of retinopathy of prematurity

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 753-759页

作者： Qiong Zou Yan-Qiong Zhu feng-jun zhang Qiu-Ping Liu Affiliated Eye Hospital of Nanchang University NanchangJiangxi ProvinceChina

AIM:To evaluate efficacy of intravitreal ranibizumab(IVR)therapy for aggressive posterior retinopathy of prematurity(ROP),threshold ROP disease and type 1 pre-threshold ***:A retrospective analysis was performed on 40 patients(76 eyes)who had IVR as the primary treatment for ROP from April 2017 to January *** to disease pathogenic features,the 76 eyes were divided into three groups:aggressive posterior ROP(AP-ROP)group(16 eyes),threshold ROP group(28 eyes)and type 1 pre-threshold ROP group(32 eyes).The characteristics of patients and lesions situation before the first intravitreal injection,and posttreatment fundus outcomes determined by wide-angle Ret Cam fundus imaging were ***:The birth weight and postmenstrual age of first IVR treatment in AP-ROP,threshold ROP,and type 1 pre-threshold ROP groups were significant difference(1087.50±246.78,1103.75±168.30,1257.03±210.82 g,P=0.005;34.50±1.46,36.89±2.97,36.50±2.36 wk,P=0.008),while the gestational age was not difference(28.00±2.00,28.54±1.90,28.59±1.43 wk,P=0.510).The retina hemorrhage ratio(with/without:14/2,8/20,5/27),iris neovascularization or vascular engorgement ratio(with/without:12/4,11/17,6/26),and the zone I(inside/outside:16/0,2/26,5/27)in AP-ROP,threshold ROP,and type 1 pre-threshold ROP group were difference significantly(all P<0.05).The regression rates were 37.5%,92.86%,and 100%,and the recurrence rates were 62.5%,7.14%,and 0 in AP-ROP,threshold ROP,and type 1 pre-threshold ROP group,respectively(both P<0.05).The recurrence eyes were cured by secondary IVR or retinal laser ***:IVR is an effective treatment for all types of *** regression of AP-ROP is significantly lower than type 1 pre-threshold and threshold *** weight,retinal hemorrhage,iris neovascularization or vascular engorgement and lesions located in zone I may be associated with AP-ROP recurrence and retreatment,which should be noted in follow-up.

关键词： retinopathy of prematurity ranibizumab intravitreal injection

Effect of CD74 on the prognosis of patients with resectable pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 81-86页

作者： jun-feng zhang Rong Hua De-jun Liu Wei Liu Yan-Miao Huo Yong-Wei Sun Department of General Surgery Renji Hospital School of Medicine Shanghai Jiaotong University

BACKGROUND: CD74 is known as a type II transmembrane glycoprotein that is associated with the major histocompatibility complex class II α and β chains. Recent studies have demonstrated that the expression of CD74 is also linked to some forms of tumors. The present study was to assess the effect of CD74 expression on the prognosis of resectable pancreatic ductal adenocarcinoma(PDAC). METHODS: Forty-six patients who had received a curative resection of primary PDAC and postoperative chemotherapy were included in this study. Immunohistochemical staining was conducted of CD74 on paraffin-embedded tumor sample slices. The patients were grouped according to CD74 staining: CD74(-): CD74 positive tumor cells <25%; and CD74(+): CD74 positive tumor cells ≥25%. The correlation of CD74 expression level with clinicopathological features and cumulative survival rate was calculated. RESULTS: The numbers of CD74(+) and(-) patients were 32 and 14, respectively. CD74(+) patients showed a high rate of perineural invasion(P=0.007). The 3- and 5-year cumulative survival rates of CD74(-) patients were significantly higher than those of CD74(+) patients(62% and 41% vs 9% and 0%, P=0.000). Multivariate analysis showed that CD74 expression and lymphatic permeation were the independent prognostic indicators. CONCLUSIONS: The overexpression of CD74 is a key factor associated with perineural invasion. Lower-stage(I and II) PDAC patients with CD74 overexpression have a poor prognosis even if they receive a curative resection. CD74 can be used as a prognostic indicator for resectable PDAC.

关键词： CD74 pancreatic ductal adenocarcinoma perineural invasion cumulative survival rate prognosis

A selective coumarin-based “turn-on” fluorescent sensor for the detection of cysteine and its applications for bioimaging

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Chinese Chemical Letters 2017年第10期28卷 2023-2026页

作者： Yan Yang Huan Wang Yu-Lin Wei Jie Zhou jun-feng zhang Ying Zhou College of Chemical Science and Technology Yunnan University College of Chemistry and Chemical Engineering Yunnan Normal University Department of Safety Evaluation Technology Center of China Tobacco Yunnan Industrial Co. Ltd.

A coumarin-based compound（1） was designed and synthesized as a new turn-on fluorescent probe for the detection of cysteine. The probe exhibited higher selectivity towards the target molecule over other thiol and amino acids at pH 7.2 in aqueous media CH_3CN-HEPES（0.02 mol/L, pH 7.2, 1：9, v/v）. The reaction mechanism is attributed to the cysteine-induced S_NAr substitution-rearrangement reaction. Remarkable enhancement of up to 20-fold in fluorescence intensity was achieved in the detection of cysteine. When applied for the fluorescence imaging of cysteine, the compound 1 emitted a green fluorescence in Hi5 cell cytoplasm. The in vivo imaging of Caenorhabditis elegans had further confirmed the cysteine detection by compound 1.

关键词： Fluorescence Sensor Cysteine Coumarin In vivo imaging

Prostacyclin decreases splanchnic vascular contractility in cirrhotic rats

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Hepatobiliary & Pancreatic Diseases International 2014年第4期13卷 416-422页

作者： De-jun Liu Wei Chen Yan-Miao Huo Wei Liu jun-feng zhang Rong Hua Yong-Wei Sun Department of Biliary-Pancreatic Surgery Renji Hospital School of Medicine Shanghai Jiaotong University

BACKGROUND： Prostacyclin has been shown to increase portal hypertension, but the mechanism is unclear. This study aimed to investigate whether the overproduction of prostacyclin（PGI2） in cirrhosis participates in the splanchnic vascular hyporesponsiveness to vasoconstrictors in cirrhotic ***： Cirrhotic model was created by subcutaneous injection of 60% carbon tetrachloride（CCl4） corn oil solution combined with intermittent drinking of 5% alcohol, and agematched rats served as controls. The isolated third-generation mesenteric arterioles were used to examine the contractile response to norepinephrine. The changes in vascular diameter were observed under a microscope imaging device. The plasma concentration of 6-ketone-prostaglandin F1α（6-keto-PGF1α, a stable metabolite of PGI2） was tested via enzyme immunoassays and the expression of cyclooxygenase（COX） in mesenteric arteries was detected by Western ***： In parallel with the increase of plasma 6-ketoPGF1α, the contractile response of arterioles from cirrhotic rats to norepinephrine was significantly impaired compared with that from controls. Inhibition of PGI2 or protein kinase A with indomethacin or Rp-adenosine 3＇, 5＇-cyclic monophosphothioate（Rp-cAMPS） partially reversed the vascular hypo-contractile response to norepinephrine in arterioles from cirrhotic *** significantly decreased the plasma 6-keto-PGF1α.Furthermore, indomethacin significantly attenuated the effect of Rp-cAMPS on arterioles from cirrhotic rats. COX-1 expression was up-regulated in mesenteric arteries from cirrhotic rats,whereas COX-2 was not detectable in the mesenteric arteries from both cirrhotic and control ***： Enhanced COX-1 expression in cirrhotic rats resulted in elevated PGI2 production which partially contributedto the splanchnic vascular hyporesponsiveness to a vasoconstrictor via the protein kinase A pathway.

关键词： portal hypertension prostacyclin indomethacin protein kinase A vascular hyporesponsiveness