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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum jun Kim Seungyon Koh Hyo Jin c.o Xuelian Jin Byung Gon Kim jun Young c.oi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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Gut mic.obiota in cancer initiation,development and therapy

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Science china Life Sciences 2025年

作者： Ruyi Zhang Xiang Zhang Harry cheuk Hay Lau jun Yu Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong Kong

cancer has long been associated with genetic and environmental fac.ors,but recent studies reveal the important role of gut mic.obiota in its initiation and *** 13%of cancers are linked to infectious agents,highlighting the need to identify the specific mic.oorganisms *** mic.obiota can either promote or inhibit cancer growth by influencing oncogenic signaling pathways and altering immune *** can lead to cancer,while certain probiotics and their metabolites may help reestablish mic.oecological balance and improve anti-tumor immune *** into targeted approaches that enhance therapy with probiotics is ***,the effects of probiotics in humans are complex and not yet fully ***,methods to counteract harmful bacteria are still in *** clinical trials also indicate that modifying gut mic.obiota may help manage side effects of cancer *** research is crucial to understand better how gut mic.obiota can be used to improve cancer prevention and treatment outcomes.

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《沙家浜》阿庆嫂原型演变释读

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东北师大学报（哲学社会科学版） 2025年第1期 107-116页

作者：张均中山大学中文系广东广州510275

现代革命京剧《沙家浜》及其前身沪剧《芦荡火种》中的阿庆嫂形象,系从原型东来茶馆老板胡广兴改换性别而来。在如此“变性记”的背后,是社会主义现实主义与“大众之法”之间反复发生的龃龉、竞争与调适。其中,“新人叙事学”并未主导... 详细信息

现代革命京剧《沙家浜》及其前身沪剧《芦荡火种》中的阿庆嫂形象,系从原型东来茶馆老板胡广兴改换性别而来。在如此“变性记”的背后,是社会主义现实主义与“大众之法”之间反复发生的龃龉、竞争与调适。其中,“新人叙事学”并未主导英雄的叙事建构,江湖风情、义气及“斗”之喜剧机制三重“大众之法”共同介入《芦荡火种》对原型人物的删改与虚构,《沙家浜》则以革命对“大众之法”予以双重再调适。阿庆嫂作为经典形象的形成,孕育了社会主义文艺在英雄叙述方面不可多得的艺术经验。

关键词：《沙家浜》阿庆嫂江湖

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optical Photometric.observations of 7-Ray Loud Blazars

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chinese Journal of Astronomy and Astrophysics 2004年第2期4卷 133-142页

作者： jun-HuiFan o.M.Kurtanidze M.G.Nikolashvili A.c.Gupta centerforAstrophysics GuangzhouUniversityGuangzhou510400 Abstumaniobservatory 383762AbstumaniRepublicofGeorgia Harish-chandraResearchInstitute ChhatnagRoadJhunsiAllahabad-211019India

We report results of our optical photometric.observations of ten gamma-ray loud blazers, namely: 0219+428 (3c66A), PKS 0420-014 (oA 129), S5 0716+714, 0754+100 (oI 090.4), 0827+243 (oJ248), 1652+398 (Mrk 501), 2200+420 (BL Lacertae), 2230+114 (cTA 102), 2251+158 (3c 454.3) and 2344+514. The observations were carried out in September-oc.ober, 2000 using the 70 cm optical telescope at Abstumani observatory, Georgia. We found intra-day variations in 0420-014, S5 0716+714, BL Lacertae and cTA 102. A variation of 0.3 magnitude over a time scale of about 3 hours was observed in the R passband in BL Lacertae on JD 2451827. We did not detect any variation in 3c 66A, Mrk 501, or 3c 454.3 during our observations. Nor did we detect any clear evidence of variation in 1ES 2344+514 during our two weeks' observing run of the TeV gamma-ray source.

关键词： galaxies: active - Blazars: individual: PKS 0219+428 (3c 66A) PKS 0420-014 (oA129) S5 0716+714 0754+100 (oI090.4) 0827+243 (oJ248) 1652+398 (Mrk 501) 2200+420 (BL Lacertae) 2230+114 (cTA102) 2251+158 (3c 454.3) and 1ES 2344+514 - galax

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Stable copper boron–imidazolate cage as cu-riched enzyme for highly efficient electrocatalytic co2 reduction to ethylene

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Science china chemistry 2025年

作者： jun-Qiang chen Qiao-Hong Li Qin-Long Hong Ping Shao Hai-Xia Zhang Jian Zhang State Key Laboratory of Structural chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Single-atom catalyst has garnered widespread attention to mimic mature enzymes due to its well-defined atomic structure and c.ordination environments. However, since the carbon–carbon（c–c） coupling reactions require synergistic catalysis of multiple sites, single-atom catalysts suffer from insufficient active sites and unclear reaction mechanisms. controlling the reaction intermediates in a precisely targeted pocket through careful metal–organic cage design is therefore crucial. Here, we prepare a tetrahedral [cu6L4]-type boron–imidazolate cage integrating highly active cu sites and optimized cavity, which exhibits enzyme like specific catalytic performance in electrochemical co2reduction reaction（co2RR） to enhance the selectivity of *** analyses and computational calculations suggest that the single cu site together with neighboring boron–imidazolate ligands provides suitably synergistic effects that enable the energetically favorable formation of an *coc.o intermediate, a key step determining selectivity. As a result, the [cu6L4]-type cage of BIc-145 achieves a Faradaic efficiency of 28% for c2H4maintaining an average current density of -3.54 mA cm-2over a 5-hour electrolysis period. This work represents the first example for studying single-metal site catalysts with ultra-low c.ordination numbers through the rational design of metal–organic cages.

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Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy chemistry 2025年第1期100卷 674-683页

作者： jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang Pan Xiong Xin Wang junwu Zhu Yongsheng Fu Key Laboratory for Soft chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 c,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Ductility

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Engineering N3c vacancies in hierarchical porous carbon nitride nanosheets for room temperature ultradeep photocatalytic aerobic.oxidative desulfurization

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Science china chemistry 2025年

作者： Yina Nie Weijie Yang Xin Wang Xiang Li Lele Wei Xiaolin Bai Lin Liu Feng Fu jun Wan college of chemistry & chemical Engineering Research Institute of Comprehensive Energy Industrial Technology Shaanxi Key Laboratory of Chemical Reaction Engineering Yan'an University Anhui Engineering Research center of carbon Neutrality College of Chemistry and Materials Science Anhui Normal University

The production of ultra-low sulfur clean fuels holds global significance for improving energy efficiency and reducing environmental pollution. Photocatalytic aerobic.oxidative desulfurization（PoDS） offers an attractive approach to efficiently remove refrac.ory heterocyclic aromatic sulfur compounds under mild conditions. However, the sluggish charge dynamics,insufficient molecule activation, and slow mass transfer within photocatalysts restrict the overall desulfurization efficiency,hindering the widespread application of this technology. Herein, we developed a defective g-c3N4（M1U3cN） photocatalyst with bridged N3cvacancies and hierarchical porous structures to address these limitations. This catalyst not only demonstrates outstanding dibenzothiophene（DBT） removal efficiency of 99.6% for model oil with high conversion and selectivity but also achieves complete sulfur removal from gasoline as well as 96.7% sulfur removal for distilled diesel at room temperature,successfully achieving ultradeep aerobic.oxidative desulfurization. The introduction of rich N3cvacancies and abundant mic.omeso-mac.oporous distribution in M1U3cN enhances kinetic efficiencies by promoting charge carrier separation, mass transfer,and molecular activation simultaneously; resulting in exceptional PoDS performance. This work provides a collaborative strategy to overcome kinetic challenges in aerobic.oxidative desulfurization via defect and structural engineering of the catalyst.

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亡佚的经典:试论《苍颉篇》的经典化及经典地位

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东北师大学报（哲学社会科学版） 2025年第1期 99-106页

作者：白军鹏东北师范大学文学院吉林长春130024

《苍颉篇》的经典地位问题以往学者均未论及,它是秦代“书同文”政策的产物,也是这一活动的重要组成,在文字编排及结构两个方面都深刻地影响了《说文解字》的编纂。在汉代,《苍颉篇》不仅与入仕息息相关,从同墓葬的伴出文献可推知它也... 详细信息

《苍颉篇》的经典地位问题以往学者均未论及,它是秦代“书同文”政策的产物,也是这一活动的重要组成,在文字编排及结构两个方面都深刻地影响了《说文解字》的编纂。在汉代,《苍颉篇》不仅与入仕息息相关,从同墓葬的伴出文献可推知它也是深受贵族重视的典籍,尤其值得重视的是它对汉代辞赋家产生过重要影响。通过官方所组织的两次文字会议均以之为核心来看,除表明《苍颉篇》的特殊地位,还可知其与古文经学有重要的关联。经过扬雄、杜林、张揖、郭璞等的注释工作后,《苍颉篇》的身份在南北朝隋唐时期发生了转换,它开始成为学者注释古书的重要参考。本文所论也提示我们应该重新审视对虽已亡佚却在历史上产生过深远影响的古书的评价。

关键词：《苍颉篇》经典文本注释

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HANGING NoDES IN THE UNIFYING THEoRY oF A PoSTERIoRI FINITE ELEMENT ERRoR coNTRoL

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Journal of computational Mathematics 2009年第2期27卷 215-236页

作者： c. carstensen jun Hu Institut für Mathematik Humboldt Universitaet zu Berlin Rudower Chaussee 25 D -12489 Berlin Germany LMAM and Sc.ool of Mathematical Sciences Peking University Beijing 100871 China

A unified a posteriori error analysis has been developed in [18, 21-23] to analyze the finite element error a posteriori under a universal roof. This paper contributes to the finite element meshes with hanging nodes which are required for local mesh-refining. The twodimensional 1-irregular triangulations into triangles and parallelograms and their combinations are considered with conforming and nonconforming finite element methods named after or by courant, Q1, c.ouzeix-Raviart, Poisson, Stokes and Navier-Lamé equations Han, Rannacher-Turek, and others for the The paper provides a unified a priori and a posteriori error analysis for triangulations with hanging nodes of degree ≤ 1 which are fundamental for local mesh refinement in self-adaptive finite element discretisations.

关键词： A posteriori A priori Finite element Hanging node Adaptive algorithm.

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5-脂氧合酶及其相关产物与心脑血管损伤的研究进展

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中国药理学通报 2025年第1期41卷 13-18页

作者：黄林露彭军中南大学湘雅药学院药理学系湖南长沙410013

5-脂氧合酶(5-lipoxygenase,5-LoX)是生成重要炎性介质白三烯和促炎症消退介质的关键酶。既往研究表明,5-LoX的异常激活和白三烯的过量产生与心肌缺血/再灌注损伤、缺血性脑损伤和动脉粥样硬化等损伤相关性心脑血管疾病的发生与发展密... 详细信息

5-脂氧合酶(5-lipoxygenase,5-LoX)是生成重要炎性介质白三烯和促炎症消退介质的关键酶。既往研究表明,5-LoX的异常激活和白三烯的过量产生与心肌缺血/再灌注损伤、缺血性脑损伤和动脉粥样硬化等损伤相关性心脑血管疾病的发生与发展密切相关。靶向抑制5-LoX及其相关产物级联反应中的酶和受体能够对心脑血管损伤起到保护作用,表明5-LoX及其相关产物可能是治疗心脑血管疾病潜在的靶点。已有的相关抑制剂包括5-LoX/5-LoX激活蛋白抑制剂、白三烯A4水解酶/白三烯c4合成酶抑制剂、白三烯受体拮抗剂,这些抑制剂通过不同的机制减轻炎症,抑制促炎介质白三烯的产生,促进抗炎脂质介质的形成,在心肌缺血/再灌注损伤和动脉粥样硬化的治疗中显示出了潜在的价值。该文综述了5-LoX及其相关产物在心脑血管疾病中的作用,同时总结了相关抑制剂在心脑血管应用中的研究进展。

关键词： 5-脂氧合酶心肌缺血/再灌注心肌梗死缺血性脑损伤动脉粥样硬化 5-脂氧合酶抑制剂

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