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Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis

National Science Review 2022年第7期9卷 17-31页

作者： Yujuan Jin Qiqi Zhao Weikang Zhu Yan Feng Tian xiao Peng Zhang Liyan jiang Yingyong Hou Chenchen Guo Hsinyi huang Yabin Chen Xinyuan Tong Jiayu Cao Fei Li Xueliang Zhu jun Qin Dong Gao Xin-Yuan Liu hua Zhang Luonan Chen Roman K.Thomas Kwok-Kin Wong Lei Zhang Yong wang Liang Hu Hongbin Ji State Key Laboratory of Cell Biology Chinese Academy of Sciences Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Center for Excellence in Molecular Cell Science Chinese Academy of Sciences Center for Excellence in Mathematical Sciences National Center for Mathematics and Interdisciplinary Sciences Key Laboratory of ManagementDecision and Information SystemHua Loo-Keng Center for Mathematical Sciences Academy of Mathematics and Systems ScienceChinese Academy of Sciences Shenzhen Key Laboratory of Translational Medicine of Tumor Department of Cell Biology and Genetics Shenzhen University Health Sciences Center Shanghai Pulmonary Hospital Tongji University Shanghai Chest Hospital Shanghai Jiaotong University Zhongshan Hospital Fudan University Department of Pathology School of Basic Medical Sciences Fudan University School of Life Science and Technology Shanghai Tech University CAS Key Laboratory of Tissue Microenvironment and Tumor CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Nutrition and Health SciencesChinese Academy of Sciences Laura and Isaac Perlmutter Cancer Center New York University Langone Medical Center School of Life Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Department of Translational Genomics Center of Integrated Oncology Cologne-BonnMedical FacultyUniversity of Cologne Department of Pathology University Hospital Cologne

Small-cell lung cancer(SCLC) is a recalcitrant cancer characterized by high ***,the exact cell type contributing to metastasis remains *** a Rb1L/L/Trp53L/Lmouse model,we identify the NCAMhiCD44lo/-subpopulation as the SCLC metastasizing cell(SMC),which is progressively transitioned from the non-metastasizing NCAMloCD44hicell(non-SMC).Integrative chromatin accessibility and gene expression profiling studies reveal the important role of the SWI/SNF complex,and knockout of its central component,Brgl,significantly inhibits such phenotypic transition and ***,TAZ is silenced by the SWI/SNF complex during SCLC malignant progression,and its knockdown promotes SMC transition and ***,ectopic TAZ expression reversely drives SMC-to-non-SMC transition and alleviates ***-cell RNA-se quencing analyses identify SMC as the dominant subpopulation in human SCLC metastasis,and immunostaining data show a positive correlation between TAZ and patient *** data uncover high SCLC plasticity and identify TAZ as the key mole cular switch in orchestrating SCLC phenotypic transition and metastasis.

关键词： small cell lung cancer SWI/SNF complex TAZ phenotypic transition metastasis

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青藏高原西部班公湖岛弧带特提斯洋盆闭合后的地壳伸展作用

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地球科学（中国地质大学学报） 2011年第6期36卷 1021-1032,1028-1032页

作者：江军华王瑞江曲晓明辛洪波王振中中国地质科学院矿产资源研究所北京100037 五矿勘查开发有限公司北京100044 成都理工大学地球科学学院四川成都610059

青藏高原西部班公湖-怒江缝合带西端的班公湖地区分布着一系列南北向和东西向岩脉:花岗斑岩和闪长玢岩.通过岩石地球化学系统分析和锆石U-Pb LA-ICP-MS年龄测定,指出这些岩脉代表了班公湖中特提斯洋盆闭合后的地壳伸展事件.呈南北向产... 详细信息

青藏高原西部班公湖-怒江缝合带西端的班公湖地区分布着一系列南北向和东西向岩脉:花岗斑岩和闪长玢岩.通过岩石地球化学系统分析和锆石U-Pb LA-ICP-MS年龄测定,指出这些岩脉代表了班公湖中特提斯洋盆闭合后的地壳伸展事件.呈南北向产出的花岗斑岩脉13个锆石颗粒测试结果给出了79.59±0.32Ma(MSWD=1.08)的加权平均年龄;既有南北向也有东西向产出的闪长玢岩脉6个锆石颗粒给出了75.9±1.2Ma(MSWD=2.8)的加权平均年龄.这些结果表明班公湖岛弧带发生在晚白垩世的地壳伸展作用一开始只沿东西向进行,稍后南北向也开始伸展.岩石地球化学特征表明,2种脉岩都具有岛弧岩浆特征,这是由于岩浆源区的印度洋MORB型地幔受到了来自俯冲沉积物熔体的交代.处于较深部位的闪长玢岩源区参与交代的沉积物熔体大体在1%～10%之间,部分熔融程度约为8%～15%;处于较浅部位的花岗斑岩源区参与交代的沉积物熔体约在10%～15%之间,部分熔融程度大于15%.

关键词：地壳伸展岩脉岩浆源区班公湖岛弧带青藏高原

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挡土结构墙后黏土主动土压力改进计算

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长江科学院院报 2021年第2期38卷 80-85,91页

作者：蒋峻峰赵其华喻小王谊成都理工大学地质灾害防治与地质环境保护国家重点实验室成都610059 成都理工大学环境与土木工程学院成都610059 华南防灾减灾研究院(深圳)有限公司广东深圳518001

经典的朗肯土压力理论忽略了墙土内摩擦角与挡墙倾角对土压力的影响,计算模型简便,而库伦土压力理论虽考虑因素较多,但没有考虑黏聚力对土压力的影响。为更好地反映挡墙墙后黏性土土压力的变化规律,在库伦土压力理论基础上,推导了一种... 详细信息

经典的朗肯土压力理论忽略了墙土内摩擦角与挡墙倾角对土压力的影响,计算模型简便,而库伦土压力理论虽考虑因素较多,但没有考虑黏聚力对土压力的影响。为更好地反映挡墙墙后黏性土土压力的变化规律,在库伦土压力理论基础上,推导了一种能考虑墙土摩擦角、墙顶张拉裂缝高度、墙体位移状态及折线滑移面的黏性土主动土压力计算方法,采用其他常用理论与模型实测值对比验证,证明了该方法对计算墙后黏性土主动土压力计算的有效性。与其他类似方法相比,该方法计算的墙后黏性主动土压力与模型实测值更为接近,且计算过程更为简便;当黏聚力为0时,该方法可直接化简为库伦主动土压力公式。因此,该法对实际支挡工程具有一定的理论指导意义。

关键词：挡墙黏性土主动土压力摩擦角极限状态滑动面

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湖州市土壤磁化率与重金属元素分布规律及其相关性研究

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吉林大学学报（地球科学版） 2005年第5期35卷 653-660,666页

作者：姜月华殷鸿福王润华康晓钧中国地质大学地球科学学院湖北武汉430074 南京地质矿产研究所江苏南京210016

通过对84个地表土样、17个剖面土样和11个基岩样的磁参数与化学分析测试,对湖州市进行了土壤磁化率与重金属元素分布规律、成因及两者的相关性研究。结果表明:表层土壤磁化率高值异常区与土壤重金属元素高值分布区吻合程度非常高,剖面... 详细信息

通过对84个地表土样、17个剖面土样和11个基岩样的磁参数与化学分析测试,对湖州市进行了土壤磁化率与重金属元素分布规律、成因及两者的相关性研究。结果表明:表层土壤磁化率高值异常区与土壤重金属元素高值分布区吻合程度非常高,剖面土壤磁化率值与重金属元素含量总体上均呈向下递减的相同特点;表层土壤磁化率与重金属元素高值异常均系人类经济工程活动影响所致,主要与当地城镇生活垃圾随意堆放、垃圾施肥、工业粉尘、废气、废物和污水排放、农药和化肥的过量使用等有关;表层土壤磁化率值与重金属元素Cd、Hg、Pb、As和Cr含量之间在不同环境条件下相关性有着明显的差异。在旱地土壤中磁化率与重金属元素Hg、Pb高度相关,与Cd、As和Cr不相关;在水田土壤中磁化率与重金属元素Pb、As高度相关,与Cd显著相关,而与Hg、Cr不相关。

关键词：磁化率重金属元素土壤环境磁学地球化学湖州市

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Nucleic acids analysis

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Science china.Chemistry 2021年第2期64卷 171-203页

作者： Yongxi Zhao xiaolei Zuo Qian Li Feng Chen Yan-Ru Chen Jinqi Deng Da Han Changlong Hao Fujian huang Yanyi huang Guoliang Ke hua Kuang Fan Li jiang Li Min Li Na Li Zhenyu Lin Dingbin Liu Juewen Liu Libing Liu xiaoguo Liu Chunhua Lu Fang Luo Xiuhai Mao Jiashu Sun Bo Tang Fei wang Jianbin wang Lihua wang Shu wang Lingling Wu Zai-Sheng Wu Fan Xia Chuanlai Xu Yang Yang Bi-Feng Yuan Quan Yuan Chao Zhang Zhi Zhu Chaoyong Yang xiao-Bing Zhang huanghao Yang Weihong Tan Chunhai Fan Institute of Analytical Chemistry and Instrument for Life Science The Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and NanomedicineRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesInstitute of Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China Cancer Metastasis Alert and Prevention Center Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and ChemotherapyState Key Laboratory of Photocatalysis on Energy and EnvironmentCollege of ChemistryFuzhou UniversityFuzhou 350108China CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China State Key Lab of Food Science and Technology International Joint Research Laboratory for Biointerface and BiodetectionSchool of Food Science and TechnologyJiangnan UniversityWuxi 214122China faculty of Materials Science and Chemistry Engineering Research Center of Nano-Geomaterials of Ministry of EducationChina University of GeosciencesWuhan 430074China College of Chemistry and Molecular Engineering Biomedical Pioneering Innovation Center(BIOPIC)Beijing Advanced Innovation Center for Genomics(ICG)Peking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Division of Physical Biology CAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China Bioimaging Center Shanghai Synchrotron Radiation FacilityZhangjiang LaboratoryShanghai Advanced

Nucleic acids are natural biopolymers of nucleotides that store, encode, transmit and express genetic information, which play central roles in diverse cellular events and diseases in living things. The analysis of nucleic acids and nucleic acids-based analysis have been widely applied in biological studies, clinical diagnosis, environmental analysis, food safety and forensic *** the past decades, the field of nucleic acids analysis has been rapidly advancing with many technological *** this review, we focus on the methods developed for analyzing nucleic acids, nucleic acids-based analysis, device for nucleic acids analysis, and applications of nucleic acids analysis. The representative strategies for the development of new nucleic acids analysis in this field are summarized, and key advantages and possible limitations are discussed. Finally, a brief perspective on existing challenges and further research development is provided.

关键词： nucleic acids analysis signal amplification DNA nanotechnology aptamer biosensing

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滨里海盆地东南部S区块下二叠统空谷阶盐岩特征及其对盐上层系油气成藏的影响

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吉林大学学报（地球科学版） 2012年第2期42卷 304-311页

作者：刘洛夫尚晓庆孟江辉陈治军宁松华王萍李燕中国石油大学油气资源与探测国家重点实验室/盆地与油藏研究中心北京102249 长江大学地球物理学院湖北荆州434023

S区块位于滨里海盆地的东南部,油气富集,但是近年来勘探工作突破不大。从地震和地质资料及其油气藏解剖入手,系统研究了本区块盐岩特征及其对盐上层系油气成藏的影响。通过研究认为,本区盐岩的特点为:就整个盆地而言,盐岩的形成模式属... 详细信息

S区块位于滨里海盆地的东南部,油气富集,但是近年来勘探工作突破不大。从地震和地质资料及其油气藏解剖入手,系统研究了本区块盐岩特征及其对盐上层系油气成藏的影响。通过研究认为,本区盐岩的特点为:就整个盆地而言,盐岩的形成模式属于深盆浅水成盐模式;S区块盐构造的形成模式主要属差异负荷模式,其次为断层阻挡的顺层流动模式;盐构造活动具有多期次性;S区块盐岩层厚度总体表现为东南薄、西北厚,即从盆地边缘向盆地中心逐渐加厚;S区块盐窗较为发育,总体上表现为东部盐窗面积大,西部盐窗面积小。盐岩对S区块盐上层系(包括盐上地层和盐间地层)油气成藏的影响很大,盐岩控制了S区块盐上层系圈闭的类型及分布,盐窗的规模对周围的油藏或含油气构造的聚集程度产生影响。对比盐上层系各种成藏要素的时空匹配关系,可以推断本区盐上层系的油气藏共有3次成藏期,分别为三叠纪末期至早侏罗世末期、晚侏罗世末期和晚白垩世至古近纪。

关键词：盐岩盐上层系油气成藏下二叠统空谷阶 S区块油气滨里海盆地

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肺癌适应性治疗中国专家共识

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循证医学 2024年第4期24卷 193-200页

作者：吴一龙陆舜程颖周清张嘉涛潘燚汪斌超韩宝惠陈海泉周清华王绿化陈明王洁周彩存刘晓晴马智勇黄诚宋启斌莫树锦钟文昭朱正飞宋勇陈蓉蓉陈克终刘基巍杨帆胡晓桦胡毅杨懿岳东升王群赵军范江陈椿孟庆威闫小龙董晓荣朱波邢力刚李兆澄李子明褚倩陈元林根段建春田攀文范云刘安文刘慧刘哲峰杨农汪步海张同梅信涛刘思阳王志杰马锐于起涛林劼涂海燕姚煜赵明芳王慧娟张海波蔡尚立张绪超李慧杜瀛瀛吴芳严令华崔久嵬王燕邬麟周建娅汪笑男黄媚娟冯卫能周进李力中国抗癌协会肺癌专业委员会广东省临床试验协会/中国胸部肿瘤研究协作组广东省肺癌研究所南方医科大学附属广东省人民医院(广东省医学科学院)广州510080 上海交通大学医学院附属胸科医院上海200030 吉林省肿瘤医院长春130021 复旦大学附属肿瘤医院上海200032 四川大学华西医院成都610041 中国医学科学院肿瘤医院深圳医院广东深圳518116 中山大学肿瘤防治中心广州510060 中国医学科学院肿瘤医院北京100021 同济大学附属上海市肺科医院上海200433 解放军总医院第五医学中心北京100039 郑州大学附属肿瘤医院/河南省肿瘤医院郑州450003 福建省肿瘤医院福州350011 武汉大学人民医院肿瘤中心武汉430060 香港中文大学医学院中国香港东部战区总医院南京210002 北京吉因加科技有限公司北京102206 北京大学人民医院北京100044 大连医科大学附属第一医院辽宁大连116011 广西医科大学第一附属医院南宁530020 解放军总医院北京100071 成都市第三人民医院/西南交通大学医学院成都610031 天津医科大学肿瘤医院天津300060 复旦大学附属中山医院上海200032 北京大学肿瘤医院北京100142 上海交通大学附属上海市第一人民医院上海200025 福建医科大学附属协和医院福州350001 哈尔滨医科大学附属肿瘤医院哈尔滨150081 空军军医大学唐都医院西安710038 华中科技大学同济医学院附属协和医院武汉430022 陆军军医大学第二附属医院-新桥医院重庆400037 山东省肿瘤医院济南250117 华中科技大学同济医学院附属同济医院武汉430030 中国医学科学院肿瘤医院山西医院太原030013 中国科学院大学附属肿瘤医院/浙江省肿瘤医院杭州310022 南昌大学附属第二医院南昌330006 湖南省第二人民医院长沙410035 南京大学医学院附属苏北人民医院江苏扬州225001 首都医科大学附属北京胸科医院北京101149 哈尔滨医科大学附属第二医院哈尔滨150001 暨南大学附属第一医院广州510630 辽宁省肿瘤医院沈阳110042 广西医科大学附属肿瘤医院南宁530012 昆明医科大学第二附属医院昆明650101 西安交通大学第一附属医院西安710061 中国医科大学附属第一医院沈阳110001 广东省中医院广州510120 广州燃石医学检验所有限公司广州510300 安徽医科大学第一附属医院合肥230022 中南大学湘雅二医院长沙410011 上海桐树生物科技有限公司上海200444 吉林大学白求恩第一医院长春130021 湖南省肿瘤医院长沙410013 浙江大学医学院附属第一医院杭州310031 南京世和基因生物技术股份有限公司南京210032 佛山市第一人民医院广东佛山528000 四川省肿瘤医院成都610042 陆军军医大学大坪医院重庆400042 不详

由中国抗癌协会肺癌专业委员会和广东省临床试验协会/中国胸部肿瘤研究协作组主办的“第21届中国肺癌高峰论坛”于2024年3月2日在广州顺利召开。此次论坛以肺癌适应性治疗为主题,从肺癌适应性治疗定义、早中晚期临床应用以及生物标志物... 详细信息

由中国抗癌协会肺癌专业委员会和广东省临床试验协会/中国胸部肿瘤研究协作组主办的“第21届中国肺癌高峰论坛”于2024年3月2日在广州顺利召开。此次论坛以肺癌适应性治疗为主题,从肺癌适应性治疗定义、早中晚期临床应用以及生物标志物对适应性治疗的指导价值等角度展开探讨并达成了专家共识。

关键词：肺癌适应性治疗共识

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滇东北会泽超大型铅锌矿Re-Os同位素特征及喜山期成矿作用动力学背景探讨

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岩矿测试 2018年第4期37卷 448-461页

作者：江小均王忠强李超郭忠林柴建华邱文龙王加昇昆明理工大学国土资源工程学院地球科学系云南昆明650093 国家地质实验测试中心北京100037 云南驰宏锌锗股份有限公司云南曲靖655000

会泽超大型铅锌矿是滇东北铅锌多金属成矿域中典型的密西西比河谷型(MVT)或会泽型(HZT)矿床,因其独特的成矿系统以及矿床中富锗而被地质学者熟知,由于该类型矿床成矿温度较低且缺少合适的定年矿物,其成矿时代一直存在较大的争议。本文... 详细信息

会泽超大型铅锌矿是滇东北铅锌多金属成矿域中典型的密西西比河谷型(MVT)或会泽型(HZT)矿床,因其独特的成矿系统以及矿床中富锗而被地质学者熟知,由于该类型矿床成矿温度较低且缺少合适的定年矿物,其成矿时代一直存在较大的争议。本文在会泽铅锌矿麒麟厂矿区1584中段0-11号穿脉坑道块状铅锌硫化物矿石中挑选了9件硫化物样品(黄铁矿、方铅矿和闪锌矿),采用负离子热表面电离质谱法进行Re-Os同位素分析,获得Re-Os等时线年龄为40.7±2.6 Ma(n=9),与模式年龄加权平均值40.0±2.6Ma(n=8)在误差内完全一致,闪锌矿和方铅矿模式年龄分别为38.24±0.41 Ma和36.57±0.40 Ma。上述同位素年龄揭示了会泽超大型铅锌矿的成矿时代可能为始新世。结合滇东北铅锌矿集区NE向逆冲断层和冲断褶皱控矿构造区域构造解析以及断裂、矿体构造-岩相蚀变特征,提出会泽超大型铅锌矿经历了燕山期、喜山期两阶段构造-流体贯入的成矿作用模型。

关键词：滇东北会泽铅锌矿床区域构造解析 Re-Os同位素年代学

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East Asian VLBI Network observations of active galactic nuclei jets:imaging with KaVA+Tianma+Nanshan

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Research in Astronomy and Astrophysics 2021年第8期21卷 220-234页

作者： Yu-Zhu Cui Kazuhiro Hada Motoki Kino Bong-Won Sohn Jongho Park Hyun-Wook Ro Satoko Sawada-Satoh Wu jiang Lang Cui Mareki Honma Zhi-Qiang Shen Fumie Tazaki Tao An Ilje Cho Guang-Yao Zhao xiao-Peng Cheng Kotaro Niinuma Kiyoaki Wajima Ying-Kang Zhang Noriyuki Kawaguchi Juan-Carlos Algaba Shoko Koyama Tomoya Hirota Yoshinori Yonekura Nobuyuki Sakai Bo Xia Yong-Bin jiang Lin-Feng Yu Wei Gou Ju-Yeon Hwang Yong-Chen jiang Yun-Xia Sun Dong-Kyu jung Hyo-Ryoung Kim Jeong-Sook Kim Hideyuki Kobayashi Jee-Won Lee Jeong-Ae Lee hua Zhang Guang-Hui Li Zhi-Qiang Xu Peng Li jung-Hwan Oh Se-Jin Oh Chung-Sik Oh Tomoaki Oyama Duk-Gyoo Roh Katsunori-M.Shibata Wen Guo Rong-Bing Zhao Wei-Ye Zhong Jin-Qing wang Wen-jun Yang Hao Yan Jae-Hwan Yeom Bin Li xiao-Fei Li Jian-Ping Yuan Jian Dong Zhong Chen Kazunori Akiyama Keiichi Asada Do-Young Byun Yoshiaki Hagiwara Jeffrey Hodgson Tae-Hyun jung Kee-Tae Kim Sang-Sung Lee Kunwoo Yi Qing-Hui Liu Xiang Liu Ru-Sen Lu Masanori Nakamura Sascha Trippe Na wang Xue-Zheng wang Bo Zhang Department of Astronomical Science The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan Mizusawa VLBI Observatory National Astronomical Observatory of Japan2-12 HoshigaokaMizusawaOshuIwate 023-0861Japan Kogakuin university of Technology and Engineering Academic Support Center2665-1 NakanoHachiojiTokyo 192-0015Japan Korea Astronomy and Space Science Institute Yuseong-guDaejeon 34055Korea Department of Astronomy Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Korea Department of Astronomy and Space Science University of Science and Technology217 Gajeong-roDaejeonKorea Institute of Astronomy and Astrophysics Academia Sinica645 N Aohoku PIHiloHI 96720USA Graduate School of Sciences and Technology for Innovation Yamaguchi UniversityYoshida 1677-1YamaguchiYamaguchi 753-8512Japan Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China Institute of Astronomy The University of Tokyo2-21-1 OsawaMitakaTokyo 181-0015Japan Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomia s/nGranada E-18008Spain Department of Physics Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Center for Astronomy Ibaraki University2-1-1 BunkyoMitoIbaraki 310-8512Japan Space Light Laboratory 77Yangjaedae-ro 86 roadGangdong-guSeoulKorea Massachusetts Institute of Technology Haystack Observatory 99 Millstone RoadWestfordMA 01886USA National Radio Astronomy Observatory 520 Edgemont RdCharlottesvilleVA 22903USA Toyo university 5-28-20 HakusanBunkyo-kuTokyo 112-8606Japan Department of Physics and Astronomy Seoul National UniversityGwanak-guSeoul 08826Korea Max Planck Institute for Radio Astronomy Auf dem hiigel 69Bonn 53121Germany SNU Astronomy Research Center Seoul National UniversityGwanak-guSeoul 08826Korea

The East Asian Very Long Baseline Interferometry(VLBI) Network(EAVN) is a rapidly evolving international VLBI array that is currently promoted under joint efforts among china.Japan and *** aims at forming a joint VLBI Network by combining a large number of radio telescopes distributed over East Asian *** the combination of the Korean VLBI Network(KVN) and the VLBI Exploration of Radio Astrometry(VERA) into Ka VA,further expansion with the joint array in East Asia is actively *** we report the first imaging results(at 22 and 43 GHz) of bright radio sources obtained with Ka VA connected to Tianma 65-m and Nanshan 26-m Radio Telescopes in *** test the EAVN imaging performance for different sources,we observed four active galactic nuclei(AGN) having different brightness and *** a result,we confirmed that the Tianma 65-m Radio Telescope(TMRT) significantly enhances the overall array sensitivity,a factor of 4 improvement in baseline sensitivity and 2 in image dynamic range compared to the case of Ka VA *** addition of the Nanshan 26-m Radio Telescope(NSRT) further doubled the east-west angular *** the resulting high-dynamic-range,high-resolution images with EAVN(Ka VA+TMRT+NSRT),various fine-scale structures in our targets,such as the counter-jet in M87,a kink-like morphology of the 3 C 273 jet and the weak emission in other sources are successfully *** demonstrates the powerful capability of EAVN to study AGN jets and to achieve other science goals in *** expansion of EAVN will further enhance the angular resolution,detection sensitivity and frequency coverage of the network.

关键词： galaxies:active galaxies:jets instrumentation:interferometers radio continuum:galaxies

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The DIRECT consortium and the REST-meta-MDD project:towards neuroimaging biomarkers of major depressive disorder

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Psychoradiology 2022年第1期2卷 32-42页

作者： xiao Chen Bin Lu Hui-Xian Li Xue-Ying Li Yu-Wei wang Francisco Xavier Castellanos Li-Ping Cao Ning-Xuan Chen Wei Chen Yu-Qi Cheng Shi-Xian Cui Zhao-Yu Deng Yi-Ru Fang Qi-Yong Gong Wen-Bin Guo Zheng-Jia-Yi Hu Li Kuang Bao-Juan Li Le Li Tao Li Tao Lian Yi-Fan Liao Yan-Song Liu Zhe-Ning Liu Jian-Ping Lu Qing-hua Luo hua-Qing Meng Dai-Hui Peng jiang Qiu Yue-Di Shen Tian-Mei Si Yan-Qing Tang Chuan-Yue wang Fei wang hua-Ning wang Kai wang Xiang wang Ying wang Zi-Han wang xiao-Ping Wu Chun-Ming Xie Guang-Rong Xie Peng Xie Xiu-Feng Xu Hong Yang Jian Yang Shu-Qiao Yao Yong-Qiang Yu Yong-Gui Yuan Ke-Rang Zhang Wei Zhang Zhi-jun Zhang jun-Juan Zhu Xi-Nian Zuo Jing-Ping Zhao Yu-Feng Zang the DIRECT consortium Chao-Gan Yan CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China International Big-Data Center for Depression Research Chinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Graduate University of Chinese Academy of SciencesBeijing 101408China Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew YorkNY 10016USA Nathan Kline Institute for Psychiatric Research OrangeburgNew YorkNY 10962USA 9Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370China Capital Normal university Beijing 100089China Department of Psychiatry Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020ZhejiangChina Department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengduSichuan 610044China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengduSichuan 610052China Department of Psychiatry and National Clinical Research Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011HunanChina Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Xijing Hospital of Air Force Military Medical university Xi’anShaanxi 710032China Center for Cognitive Science of Language Beijing Language and Culture UniversityBeijing 100083China Affiliated Mental Health Center&Hangzhou Seventh People’s Hospital Zhejiang University School of

Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder(MDD),repro-ducible findings are lacking,probably reflecting mostly small sample sizes and heterogeneity in analytic *** address these issues,the Depression Imaging REsearch ConsorTium(DIRECT)was *** REST-meta-MDD project,pooling 2428 functional brain images processed with a standardized pipeline across all participating sites,has been the first effort from *** this review,we present an overview of the moti-vations,rationale,and principal findings of the studies so far from the REST-meta-MDD *** from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network,in whole-brain topological properties,in dynamic features,and in functional *** well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven *** these fruitful explorations,DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations.A state-of-the-art,surface-based preprocessing pipeline has also been introduced to improve *** images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diag-nosis *** addition,large-scale longitudinal studies targeting brain network alterations following antidepressant treatment,aggregation of diffusion tensor images,and the development of functional magnetic resonance imaging-guided neuromodulation approaches are *** these endeavours,we hope to accelerate the translation of functional neuroimaging findings to clinical use,such as evaluating longitudinal effects of antidepressant medications and developing individualized

关键词： major depressive disorder DIRECT R-fMRI database neuroimaging

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