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Frontiers of Materials Science 2024年第1期18卷 1-14页

作者： Qi Zhang Chongyang Liu Xuehong Wu Xueling Zhang jun song School of Energy and Power Engineering Zhengzhou University of Light IndustryZhengzhou 450007China

The biggest challenge for organic phase change materials(PCMs)used in cold energy storage is to maintain high heat storage capacity while reducing the leakage risk of PCMs during the phase transition process.This is crucial for expanding their applications in the more demanding cold storage field.In this study,novel formstable low-temperature composite PCMs are prepared with mesoporous materials,namely SBA-15 and CMK-3(which are prepared using the template method),as supporting matrices and dodecane as the PCM.Owing to the combined effects of capillary forces within mesoporous materials and interactions among dodecane molecules,both dodecane/SBA-15 and dodecane/CMK-3 exhibit outstanding shape stability and thermal cycling stability even after 200 heating/cooling cycles.In comparison to those of dodecane/SBA-15,dodecane/CMK-3 exhibits superior cold storage performance and higher thermal conductivity.Specifically,the phase transition temperature of dodecane/CMK-3 is-8.81℃ with a latent heat of 122.4 J·g^(-1).Additionally,it has a thermal conductivity of 1.21 W·m^(-1)·K^(-1),which is 9.45 times that of dodecane alone.All these highlight its significant potential for applications in the area of cold energy storage.

关键词： cold energy storage phase change material mesoporous molecular sieve CMK-3 SBA-15 cooling energy charging/discharging capacity

Comparative evaluation of commercial Douchi by different molds:biogenic amines,non-volatile and volatile compounds

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Food Science and Human Wellness 2024年第1期13卷 434-443页

作者： Aijun Li Gang Yang Zhirong Wang Shenglan Liao Muying Du jun song Jianquan Kan College of Food Science Southwest UniversityChongqing 400715China Chinese-Hungarian Cooperative Research Centre for Food Science Chongqing 400715China Laboratory of Quality&Safety Risk Assessment for Agri-products on Storage and Preservation(Chongqing) Ministry of Agriculture and Rural Affairs of the People's Republic of ChinaChongqing 400715China Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing Chongqing 400715China Shu Xiang Douchi Food Research Institute Limited Company Chongqing 402160China

To provide new insights into the development and utilization of Douchi artificial starters,three common strains(Aspergillus oryzae,Mucor racemosus,and Rhizopus oligosporus)were used to study their influence on the fermentation of Douchi.The results showed that the biogenic amine contents of the three types of Douchi were all within the safe range and far lower than those of traditional fermented Douchi.Aspergillus-type Douchi produced more free amino acids than the other two types of Douchi,and its umami taste was more prominent in sensory evaluation(P<0.01),while Mucor-type and Rhizopus-type Douchi produced more esters and pyrazines,making the aroma,sauce,and Douchi flavor more abundant.According to the Pearson and PLS analyses results,sweetness was significantly negatively correlated with phenylalanine,cysteine,and acetic acid(P<0.05),bitterness was significantly negatively correlated with malic acid(P<0.05),the sour taste was significantly positively correlated with citric acid and most free amino acids(P<0.05),while astringency was significantly negatively correlated with glucose(P<0.001).Thirteen volatile compounds such as furfuryl alcohol,phenethyl alcohol,and benzaldehyde caused the flavor difference of three types of Douchi.This study provides theoretical basis for the selection of starting strains for commercial Douchi production.

关键词： Douchi Starting strains Non-volatile compounds Volatile compounds Sensory evaluation

Correlation between cerebral neurotransmitters levels by proton magnetic resonance spectroscopy and HbA1c in patients with type 2 diabetes

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World Journal of Diabetes 2024年第6期15卷 1263-1271页

作者： Xiang-Yu Gao Chen-Xia Zhou Hong-Mei Li Min Cheng Da Chen Zi-Yi Li Bo Feng jun song Department of Endocrinology East HospitalTongji University School of MedicineShanghai 200120China Department of Endocrinology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266000Shandong ProvinceChina Department of Immunization Program Huangdao District Center for Disease Prevention and ControlQingdao 266400Shandong ProvinceChina

BACKGROUND Cognitive dysfunction is the main manifestation of central neuropathy.Although cognitive impairments tend to be overlooked in patients with diabetes mellitus(DM),there is a growing body of evidence linking DM to cognitive dysfunction.Hyperglycemia is closely related to neurological abnormalities,while often disregarded in clinical practice.Changes in cerebral neurotransmitter levels are associated with a variety of neurological abnormalities and may be closely related to blood glucose control in patients with type 2 DM(T2DM).AIM To evaluate the concentrations of cerebral neurotransmitters in T2DM patients exhibiting different hemoglobin A1c(HbA1c)levels.METHODS A total of 130 T2DM patients were enrolled at the Department of Endocrinology of Shanghai East Hospital.The participants were divided into four groups according to their HbA1c levels using the interquartile method,namely Q1(<7.875%),Q2(7.875%-9.050%),Q3(9.050%-11.200%)and Q4(≥11.200%).Clinical data were collected and measured,including age,height,weight,neck/waist/hip circumferences,blood pressure,comorbidities,duration of DM,and biochemical indicators.Meanwhile,neurotransmitters in the left hippocampus and left brainstem area were detected by proton magnetic resonance spectroscopy.RESULTS The HbA1c level was significantly associated with urinary microalbumin(mALB),triglyceride,low-density lipoprotein cholesterol(LDL-C),homeostasis model assessment of insulin resistance(HOMA-IR),and beta cell function(HOMA-β),N-acetylaspartate/creatine(NAA/Cr),and NAA/choline(NAA/Cho).Spearman correlation analysis showed that mALB,LDL-C,HOMA-IR and NAA/Cr in the left brainstem area were positively correlated with the level of HbA1c(P<0.05),whereas HOMA-βwas negatively correlated with the HbA1c level(P<0.05).Ordered multiple logistic regression analysis showed that NAA/Cho[Odds ratio(OR):1.608,95%confidence interval(95%CI):1.004-2.578,P<0.05],LDL-C(OR:1.627,95%CI:1.119-2.370,P<0.05),and HOMA-IR(OR:1.107,95%CI:1.031-1.188,P<0.01)were independent predictors of poor

关键词： Type 2 diabetes mellitus Hemoglobin A1c Proton magnetic resonance spectroscopy Neurotransmitters Central neuropathy

Bile acids,gut microbiota,and therapeutic insights in hepatocellular carcinoma

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Cancer Biology & Medicine 2024年第2期21卷 144-162页

作者： Yang song Harry CH Lau Xiang Zhang jun Yu Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongHong KongChina Department of Gastroenterology Zhongshan Hospital Xiamen UniversityXiamen 361004China

Hepatocellular carcinoma(HCC)is a prevalent and aggressive liver malignancy.The interplay between bile acids(BAs)and the gut microbiota has emerged as a critical factor in HCC development and progression.Under normal conditions,BA metabolism is tightly regulated through a bidirectional interplay between gut microorganisms and BAs.The gut microbiota plays a critical role in BA metabolism,and BAs are endogenous signaling molecules that help maintain liver and intestinal homeostasis.Of note,dysbiotic changes in the gut microbiota during pathogenesis and cancer development can disrupt BA homeostasis,thereby leading to liver inflammation and fibrosis,and ultimately contributing to HCC development.Therefore,understanding the intricate interplay between BAs and the gut microbiota is crucial for elucidating the mechanisms underlying hepatocarcinogenesis.In this review,we comprehensively explore the roles and functions of BA metabolism,with a focus on the interactions between BAs and gut microorganisms in HCC.Additionally,therapeutic strategies targeting BA metabolism and the gut microbiota are discussed,including the use of BA agonists/antagonists,probiotic/prebiotic and dietary interventions,fecal microbiota transplantation,and engineered bacteria.In summary,understanding the complex BA-microbiota crosstalk can provide valuable insights into HCC development and facilitate the development of innovative therapeutic approaches for liver malignancy.

关键词： Bile acid gut microbiota hepatocellular carcinoma therapeutics microbiota modulation

Can serum immunoglobulin G4 levels and age serve as reliable predictors of relapse in autoimmune pancreatitis?

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World Journal of Gastroenterology 2024年第5期30卷 512-515页

作者： jun-Min song Si-Yu Sun Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

We are writing in response to the paper published in the World Journal of Gastroenterology by Zhou et al.The authors identified higher serum immunoglobulin(Ig)G4 levels and age over 55 years as independent risk factors for disease relapse.Despite notable strengths,it is crucial to address potential biases.Firstly,the cohort study included 189 patients with autoimmune pancreatitis(AIP)type 1(with higher IgG4 seropositivity and higher relapse)and 24 with type 2(with lower IgG4 seropositivity and lower relapse).Consequently,most,if not all,AIP type 2 patients were assigned to the normal group,possibly inflating the association of higher serum IgG4 levels with relapse and potentially exaggerating the association of older age with relapse.Secondly,the authors did not provide sufficient details regarding AIP diagnosis,such as the ratio of definitive vs probable cases and the proportion of biopsies.In cases where histological evidence is unavailable or indeterminate,AIP type 2 may be misdiagnosed as definitive type 1,and type 1 may also be misdiagnosed as probable type 2,particularly in cases with normal or mildly elevated serum IgG4 levels.Lastly,in this retrospective study,approximately one-third of the consecutive patients initially collected were excluded for various reasons.Accordingly,the impact of nonrandom exclusion on relapse outcomes should be carefully considered.In conclusion,the paper by Zhou et al offers plausible,though not entirely compelling,evidence suggesting a predictive role of elevated serum IgG4 levels and advanced age in AIP relapse.The foundation for future investigations lies in ensuring a reliable diagnosis and accurate disease subtyping,heavily dependent on obtaining histological specimens.In this regard,endoscopic ultrasound-guided fine-needle biopsy emerges as a pivotal component of the diagnostic process,contributing to mitigating biases in future explorations of the disease.

关键词： Autoimmune pancreatitis Immunoglobulin Endoscopic ultrasound Relapse Age

Laparoscopic anatomical liver resection of segment 7 using a sandwich approach to the right hepatic vein (with video)

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 217-220页

作者： song-Feng Yu Wei-Chen Zhang jun Yu Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Full laparoscopic liver resection has been performed widely since it was introduced in the early 1990s.It has been expanded from initial for partial resection of the anterolateral segments to non-restriction of area of the liver[1–3].Anatomical liver resec-tion is considered to have potential superiority than non-anatomic resection in terms of tumor prognosis,thus it is more often rec-ommended in the treatment of hepatocellular carcinoma[4,5].Recently,laparoscopic segmental liver resection according to the Couinaud classification has been widely performed due to its ad-vantages in minimal invasiveness and tumor prognosis.

关键词： resection liver hepatic

Toeplitz Operators and Carleson Measures for Weighted Bergman Spaces Induced by Regular Weights

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1345-1359页

作者： jun Tao DU song Xiao Hasi WULAN Department of Mathematics Guangdong University of Petrochemical TechnologyMaoming 525000P.R.China Department of Mathematics Shantou UniversityShantou 515063P.R.China

In this paper,we give a universal description of the boundedness and compactness of Toeplitz operator T_(μ)^(ω)between Bergman spaces A_(η)^(p)and A_(υ)^(q)whenμis a positive Borel measure,1 详细信息

In this paper,we give a universal description of the boundedness and compactness of Toeplitz operator T_(μ)^(ω)between Bergman spaces A_(η)^(p)and A_(υ)^(q)whenμis a positive Borel measure,1

关键词： Bergman space Carleson measure Toeplitz operator regular weight

Integrability and solutions of a nonsymmetric discrete Korteweg-de Vries equation

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Communications in Theoretical Physics 2024年第2期76卷 45-50页

作者： Maebel Mesfun Da-jun Zhang song-lin Zhao Department of Mathematics Shanghai UniversityShanghai 200444China Newtouch Center for Mathematics of Shanghai University Shanghai 200444China Department of Applied Mathematics Zhejiang University of TechnologyHangzhou 310023China

In this paper,we present Lax pairs and solutions for a nonsymmetric lattice equation,which is a torqued version of the lattice potential Korteweg-de Vries equation.This nonsymmetric equation is special in the sense that it contains only one spacing parameter but consists of two consistent cubes with other integrable lattice equations.Using such a multidimensionally consistent property we are able to derive its two Lax pairs and also construct solutions using B?cklund transformations.

关键词： discrete Korteweg-de Vries equation nonsymmetric multi-dimensional consistency Backlund transformation solution

Complement C1q induces the M2-polarization of tumor-associated macrophages in lung adenocarcinoma

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Genes & Diseases 2024年第4期11卷 145-148页

作者： Yuxiao song Yang Fu jun Wang Jiazhuo Tang Jiaxin Yin Zhimin Zhang Qibin song Bicheng Zhang Cancer Center Renmin Hospital of Wuhan UniversityWuhanHubei 430061China Department of Oncology Xiangyang HospitalHubei University of Chinese MedicineXiangyangHubei 441100China Department of Oncology The First Affiliated Hospital of Shandong First Medical UniversityJinanShandong 250000China

Complement C1q was proved to be able to regulate the polarization of macrophages to the anti-inflammatory phenotype(M2 polarized),acting as an anti-inflammation molecule independent of the classical complement pathway.A high level of C1q expression has been detected in the tumor microenvironment(TME)of diverse tumors,including non-small cell lung cancer,in which C1q could be considered a predictor of poor prognosis.

关键词： C1q lung inflammation

The essential roles of m^(6)A modification in osteogenesis and common bone diseases

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Genes & Diseases 2024年第1期11卷 335-345页

作者： Yuxi Gu Yidan song Yihua Pan jun Liu State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases Department of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041China

N6-methyladenosine(m^(6)A)is the most prevalent modification in the eukaryotic transcriptome and has a wide range of functions in coding and noncoding RNAs.It affects the fate of the modified RNA,including its stability,splicing,and translation,and plays an important role in post-transcriptional regulation.Bones play a key role in supporting and pro-tecting muscles and other organs,facilitating the movement of the organism,ensuring blood production,etc.Bone diseases such as osteoarthritis,osteoporosis,and bone tumors are serious public health problems.The processes of bone development and osteogenic differen-tiation require the precise regulation of gene expression through epigenetic mechanisms including histone,DNA,and RNA modifications.As a reversible dynamic epigenetic mark,m^(6)A modifications affect nearly every important biological process,cellular component,and molecular function,including skeletal development and homeostasis.In recent years,studies have shown that m^(6)A modification is involved in osteogenesis and bone-related diseases.In this review,we summarized the proteins involved in RNA m^(6)A modification and the latest progress in elucidating the regulatory role of m^(6)A modification in bone formation and stem cell direc-tional differentiation.We also discussed the pathological roles and potential molecular mech-anisms of m^(6)A modification in bone-related diseases like osteoporosis and osteosarcoma and suggested potential areas for new strategies that could be used to prevent or treat bone de-fects and bone diseases.

关键词： Bone diseases m^(6)A modification Osteogenesis Regulatory role Stem cells