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The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions:insights from a single-arm,phase II trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2202-2214页

作者： Bo Cheng Caichen Li Jianfu Li Longlong Gong Peng Liang Ying Chen Shuting Zhan Shan Xiong Ran Zhong Hengrui Liang Yi Feng Runchen Wang Haixuan Wang Hongbo Zheng jun Liu Chengzhi Zhou Wenlong shao Yuan Qiu Jiancong Sun Zhanhong Xie Zhu Liang Chenglin Yang Xiuyu Cai Chunxia Su Wei Wang Jianxing He Wenhua Liang Department of Thoracic Surgery and Oncology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory HealthState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhouChina Medical Department Genecast Biotechnology Co.LtdWuxiChina Department of Radiation Oncology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Respiratory Medicine the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory HealthState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhouChina Department of Cardiothoracic Surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiangChina Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenChina Department of VIP Inpatient Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaSun Yat-sen UniversityGuangzhouChina Department of Medical Oncology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina

Immune checkpoint inhibitors targeting the programmed cell death-1(PD-1)protein significantly improve survival in patients with advanced non-small-cell lung cancer(NSCLC),but its impact on early-stage ground-glass opacity(GGO)lesions remains unclear.This is a single-arm,phase II trial(NCT04026841)using Simon’s optimal two-stage design,of which 4 doses of sintilimab(200 mg per 3 weeks)were administrated in 36 enrolled multiple primary lung cancer(MPLC)patients with persistent high-risk(Lung-RADS category 4 or had progressed within 6 months)GGOs.The primary endpoint was objective response rate(ORR).T/B/NK-cell subpopulations,TCR-seq,cytokines,exosomal RNA,and multiplexed immunohistochemistry(mIHC)were monitored and compared between responders and non-responders.Finally,two intent-to-treat(ITT)lesions(pure-GGO or GGO-predominant)showed responses(ORR:5.6%,2/36),and no patients had progressive disease(PD).No grade 3-5 TRAEs occurred.The total response rate considering two ITT lesions and three non-intent-to-treat(NITT)lesions(pure-solid or solid-predominant)was 13.9%(5/36).The proportion of CD8^(+)T cells,the ratio of CD8^(+)/CD4^(+),and the TCR clonality value were significantly higher in the peripheral blood of responders before treatment and decreased over time.Correspondingly,the mIHC analysis showed more CD8^(+)T cells infiltrated in responders.Besides,responders’cytokine concentrations of EGF and CTLA-4 increased during treatment.The exosomal expression of fatty acid metabolism and oxidative phosphorylation gene signatures were down-regulated among responders.Collectively,PD-1 inhibitor showed certain activity on high-risk pulmonary GGO lesions without safety concerns.Such effects were associated with specific T-cell re-distribution,EGF/CTLA-4 cytokine compensation,and regulation of metabolism pathways.

关键词： lesions metabolism doses

钨丝增强非晶复合材料弹芯高速侵彻熔化快凝层研究

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塑性工程学报 2024年第1期31卷 240-246页

作者：祝理君杨少增赵洁浙江工商职业技术学院机电工程学院浙江宁波315012 中国兵器科学研究院宁波分院浙江宁波315103 浙江省模塑制品表面装饰与智能成型技术协同创新中心浙江宁波315699

对钨丝增强非晶复合材料弹芯高速侵彻靶板时产生的熔化快凝层进行了扫描电镜观察、能谱分析和X衍射分析,研究了弹靶作用下界面温升机理。结果表明,与传统钨合金相比,钨丝增强非晶复合材料具有更好的“自锐”效应,侵彻能力得到了有效提升... 详细信息

对钨丝增强非晶复合材料弹芯高速侵彻靶板时产生的熔化快凝层进行了扫描电镜观察、能谱分析和X衍射分析,研究了弹靶作用下界面温升机理。结果表明,与传统钨合金相比,钨丝增强非晶复合材料具有更好的“自锐”效应,侵彻能力得到了有效提升;熔化快凝层生成温度应高于1670℃,高温效应有助于提升其侵彻能力;熔化快凝层成分包含靶板材料(Fe、Cr、Mn)和弹芯材料(Zr、Ti、Cu、Ni、W)。其中W的原子分数仅有3.15%,且W元素主要以熔化或熔解方式存在于熔化快凝层中;非晶复合材料弹芯侵彻靶板时反喷物中存在TiW相。弹靶作用界面巨大的冲击导致弹靶材料受到冲击压缩并发生塑性变形、断裂等,引起弹靶作用界面温度急剧升高。

关键词：非晶复合材料熔化快凝层温升机理高速侵彻

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基于协调度的海上专业救助力量部署决策研究

中国航海 2024年第1期47卷 62-70页

作者：邵年骏宁君田辉交通运输部南海救助局广东广州510235 大连海事大学航海学院辽宁大连116026 大连海事大学辽宁省海上应急技术重点实验室辽宁大连116026 交通运输部救助打捞局北京100736

针对当前海洋生产结构调整带来的海上救助需求变化和缺少救助力量部署决策工具等问题,提出一种基于协调度的海上救助力量部署复合决策方法。通过建立协调度评价模型对救助单元救助能力和海上救助需求进行协调性分析,运用层次分析法(AHP... 详细信息

针对当前海洋生产结构调整带来的海上救助需求变化和缺少救助力量部署决策工具等问题,提出一种基于协调度的海上救助力量部署复合决策方法。通过建立协调度评价模型对救助单元救助能力和海上救助需求进行协调性分析,运用层次分析法(AHP)对海洋经济发展中存在的海上救助需求进行评价,使用基本图形分析法建立各海洋产业对不同等级的专业海洋救助船的需求模型,构造空间分布。运用此方法对专业救助力量实际值守海域进行计算及分析,进一步优化部署方案。结果表明:通过此方法得到的部署决策意见与多数可查的海上救助应急处置情况十分接近,验证了该方法的有效性。

关键词：水路运输部署决策协调度海上专业救助力量层次分析法

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高性能箱型复合结构增韧模型与优化计算

工程力学 2024年第S1期41卷 38-49页

作者：喻江胡少伟范向前陆俊水科学与水工程国际联合研究中心江苏南京210029 南京水利科学研究院江苏南京210024 郑州大学水利与土木工程学院河南郑州450001

为了深入揭示高性能箱型复合结构受力机理并有效提升结构整体性能,通过定义四种混凝土翼板模式开展高性能箱型复合结构增韧模型理论研究。通过建立剪力滞翘曲位移模型和界面滑移模式,推导出考虑剪力滞行为与界面滑移相互影响的控制微分... 详细信息

为了深入揭示高性能箱型复合结构受力机理并有效提升结构整体性能,通过定义四种混凝土翼板模式开展高性能箱型复合结构增韧模型理论研究。通过建立剪力滞翘曲位移模型和界面滑移模式,推导出考虑剪力滞行为与界面滑移相互影响的控制微分方程,求得在均布荷载作用下的增韧模型理论解析解,进一步以界面滑移量、剪力滞系数、混凝土材料为韧性指标,对提出的增韧模型进行优化计算分析表明:II型增韧模型受剪力滞影响程度仅为0.04%~0.05%,混凝土材料用量节约35.00%,为四种模型中基于剪力滞与滑移耦合行为的最优高性能箱型复合结构增韧模型,便于为水利、土木工程韧性指标设计提供技术支撑。

关键词：高性能复合结构增韧模型韧性指标优化计算

抽象技术及其在蒙特卡洛树搜索中的应用研究综述

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控制与决策 2024年第4期39卷 1075-1094页

作者：邵天浩程恺张宏军张可陆军工程大学指挥控制工程学院南京210007

抽象技术作为人工智能研究中高效拓展决策的重要组成部分,已广泛应用于大规模的决策问题.蒙特卡洛树搜索虽然在众多决策领域取得了卓越成就,但是在现实决策问题中面临着决策空间巨大和规划周期很长的问题.鉴于此,研究抽象技术及其在蒙... 详细信息

抽象技术作为人工智能研究中高效拓展决策的重要组成部分,已广泛应用于大规模的决策问题.蒙特卡洛树搜索虽然在众多决策领域取得了卓越成就,但是在现实决策问题中面临着决策空间巨大和规划周期很长的问题.鉴于此,研究抽象技术及其在蒙特卡洛树搜索中的应用,从状态空间和动作空间两个角度出发分析抽象技术如何提升蒙特卡洛树搜索的决策能力,并对抽象蒙特卡洛树搜索研究中仍需要解决的问题和未来的研究方向作进一步展望.

关键词：状态抽象动作抽象蒙特卡洛树搜索决策

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高校艺术设计教育与区域经济发展

山西财经大学学报 2024年第S1期46卷 40-42页

作者：杨绍骏罗杰西昌学院艺术学院四川西昌615000 四川美术学院设计学院重庆401331

随着人们物质生活水平的提升,对精神层面艺术设计的要求越来越高,高等教育的艺术设计专业需要与时俱进,而艺术设计作为一种独特的非物质文化形式,它的规模与区域经济发展水平息息相关。深入探讨艺术设计教育与地区经济之间的联系,以及... 详细信息

随着人们物质生活水平的提升,对精神层面艺术设计的要求越来越高,高等教育的艺术设计专业需要与时俱进,而艺术设计作为一种独特的非物质文化形式,它的规模与区域经济发展水平息息相关。深入探讨艺术设计教育与地区经济之间的联系,以及如何平衡高等艺术设计教育和区域经济协调发展因素,对于提升艺术的社会价值和经济价值都至关重要。本文旨在深入研究高等艺术设计教育中艺术与区域经济之间的复杂关联,以期提出有效的解决方案。

关键词：高等艺术设计教育区域经济关联机制

Establishment of a Multiplex Detection Method for Common Bacteria in Blood Based on Human Mannan-Binding Lectin Protein-Conjugated Magnetic Bead Enrichment Combined with Recombinase-Aided PCR Technology

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Biomedical and Environmental Sciences 2024年第4期37卷 387-398页

作者： ZHAO Zi Jin CHEN Xiao Ping HUA shao Wei LI Feng Yu ZHAO Meng XING Chen Hao WANG Jie TIAN Feng Yu ZHANG Rui Qing LYU Xiao Na HAN Zhi Qiang WANG Yu Xin LI Hong Yi SHEN Xin Xin MA Xue jun TIE Yan Qing Graduate School Hebei North UniversityZhangjiakou 075000HebeiChina Department of Clinical Laboratory Hebei General HospitalShijiazhuang 050051HebeiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases NHC Key Laboratory of Medical Virology and Viral DiseasesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Department of Clinical Laboratory Pathology Diagnostic Center Shiyan General HospitalShiyan 442000HubeiChina Graduate School Hebei Medical University Shijiazhuang 050031HebeiChina

Objective Recombinase-aided polymerase chain reaction(RAP)is a sensitive,single-tube,two-stage nucleic acid amplification method.This study aimed to develop an assay that can be used for the early diagnosis of three types of bacteremia caused by Staphylococcus aureus(SA),Pseudomonas aeruginosa(PA),and Acinetobacter baumannii(AB)in the bloodstream based on recombinant human mannanbinding lectin protein(M1 protein)-conjugated magnetic bead(M1 bead)enrichment of pathogens combined with RAP.Methods Recombinant plasmids were used to evaluate the assay sensitivity.Common blood influenza bacteria were used for the specific detection.Simulated and clinical plasma samples were enriched with M1 beads and then subjected to multiple recombinase-aided PCR(M-RAP)and quantitative PCR(qPCR)assays.Kappa analysis was used to evaluate the consistency between the two assays.Results The M-RAP method had sensitivity rates of 1,10,and 1 copies/μL for the detection of SA,PA,and AB plasmids,respectively,without cross-reaction to other bacterial species.The M-RAP assay obtained results for<10 CFU/mL pathogens in the blood within 4 h,with higher sensitivity than qPCR.M-RAP and qPCR for SA,PA,and AB yielded Kappa values of 0.839,0.815,and 0.856,respectively(P<0.05).Conclusion An M-RAP assay for SA,PA,and AB in blood samples utilizing M1 bead enrichment has been developed and can be potentially used for the early detection of bacteremia.

关键词： Staphylococcus aureus Pseudomonas aeruginosa Acinetobacter baumannii Human Mannan-binding lectin protein Bloodstream infection Recombinase-aided PCR assay Multiple detection

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宋元时期墓室壁画“六鹤图”考论

河北大学学报（哲学社会科学版） 2024年第3期49卷 13-24页

作者：邵军王怀志中国传媒大学美术系北京100024

宋元时期几处墓葬中所遗存的屏风鹤画,是以唐薛稷“屏风六扇鹤样”为祖源,主要传写五代黄筌“六鹤图”而成的。墓葬中鹤画的丰富反映了宋元时期“六鹤图”的流变脉络。宋元时期墓葬中鹤画的流行以及各种“六鹤图”的绘制,是重道修道时... 详细信息

宋元时期几处墓葬中所遗存的屏风鹤画,是以唐薛稷“屏风六扇鹤样”为祖源,主要传写五代黄筌“六鹤图”而成的。墓葬中鹤画的丰富反映了宋元时期“六鹤图”的流变脉络。宋元时期墓葬中鹤画的流行以及各种“六鹤图”的绘制,是重道修道时代风气和丧葬观念影响的产物。在墓室壁画中,“六鹤图”被视为一种祥瑞及胎仙,通过屏风鹤画及相关空间营构,寄寓了宋元社会世人升仙重生的思想观念。

关键词：六鹤图屏风六扇鹤样墓室壁画瑞鸟仙禽

Meta-analysis of independent datasets using constrained generalised method of moments

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Statistical Theory and Related Fields 2020年第1期4卷 109-116页

作者： Menghao Xu jun shao KLATASDS-MOE School of StatisticsEast China Normal UniversityShanghaiPeople’s Republic of China Department of Statistics University of Wisconsin-MadisonMadisonWIUSA

Wepropose a constrained generalised method of moments(CGMM)for enhancing the efficiency of estimators in meta-analysis in which some studies do not measure all covariates associated with the response or outcome.Under some assumptions,weshow that the proposedCGMMestimators have good asymptotic properties.Wealso demonstrate the effectiveness of the proposed method through simulation studies with fixed sample sizes.

关键词： Meta-analysis generalised method of moments efficiency