检索结果-南通市图书馆

Stage-specific nutritional management and developmental programming to optimize meat production

Journal of Animal Science and Biotechnology 2023年第2期14卷 451-464页

作者： Liang Zhao Xiangdong Liu Noe A Gomez Yao Gao jun seok son song Ah Chae Mei‑jun Zhu Min Du College of Animal Science and Technology Nanjing Agricultural University210095 NanjingPR China Nutrigenomics and Growth Biology Laboratory Department of Animal SciencesWashington State UniversityWA 99164 PullmanUSA Laboratory of Perinatal Kinesioepigenetics Department of ObstetricsGynecology and Reproductive SciencesUniversity of Maryland School of MedicineMD 21201 BaltimoreUSA School of Food Science Washington State UniversityWAPullmanUSA.

Over the past few decades,genetic selection and refined nutritional management have extensively been used to increase the growth rate and lean meat production of ***,the rapid growth rates of modern breeds are often accompanied by a reduction in intramuscular fat deposition and increased occurrences of muscle abnor‑malities,impairing meat quality and processing *** stages of animal development set the long‑term growth trajectory of ***,due to the seasonal reproductive cycles of ruminant livestock,gestational nutrient deficiencies caused by seasonal variations,frequent droughts,and unfavorable geological locations nega‑tively affect fetal development and their subsequent production efficiency and meat ***,enrolling live‑stock in nutritional intervention strategies during gestation is effective for improving the body composition and meat quality of the offspring at *** crucial early developmental stages include embryonic,fetal,and postnatal stages,which have stage‑specific effects on subsequent offspring development,body composition,and meat *** review summarizes contemporary research in the embryonic,fetal,and neonatal development,and the impacts of maternal nutrition on the early development and programming effects on the long‑term growth performance of *** the developmental and metabolic characteristics of skeletal muscle,adipose,and fibrotic tissues will facilitate the development of stage‑specific nutritional management strategies to optimize production efficiency and meat quality.

关键词： Adipose tissue Embryonic development Fetal programming Fibro/adipogenic progenitors Marbling Nutritional regulations Skeletal muscle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Variability and trends of near-surface wind speed over the Tibetan Plateau:The role played by the westerly and Asian monsoon

引用

Advances in Climate Change Research 2024年第3期15卷 525-536页

作者： Gang-Feng ZHANG Cesar AZORIN-MOLINA Deliang CHEN Tim RMCVICAR Jose AGUIJARRO Kai-Qiang DENG Lorenzo MINOLA Jaeyeon LEE seok-Woo son Heng MA Pei-jun SHI State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875China Engineering Center of Desertification and Blown-Sand Control of Ministry of Education Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Key Laboratory of Environmental Change and Natural Disaster of Ministry of Education Beijing Normal UniversityBeijing 100875China Centro de Investigaciones Sobre Desertificaci'on Consejo Superior de Investigaciones Cientı'ficas(CIDECSIC-UV-Generalitat alenciana)ClimateAtmosphere and Ocean Laboratory(Climatoc-Lab)Moncada 46113Spain Regional Climate Group Department of Earth SciencesUniversity of GothenburgGothenburg 40530Sweden CSIRO Environment CanberraACT 2600Australia Australian Research Council Centre of Excellence for Climate Extremes CanberraACT 2600Australia State Meteorological Agency Balearic Islands OfficePalma de Mallorca 07015Spain School of Atmospheric Sciences Sun Yat-sen UniversityZhuhai 519082China Interuniversity Department of Regional and Urban Studies and Planning(DIST) Politecnico and University of TurinTurin 10125Italy School of Earth and Environmental Sciences Seoul National UniversitySeoul 08826South Korea Atmospheric and Oceanic Sciences Program Princeton UniversityPrinceton NJ 08544USA Geophysical Fluid Dynamics Laboratory NOAAPrinceton NJ 08544USA

Near-surface wind speed exerts profound impacts on many environmental issues,while the long-term(≥60 years)trend and multidecadal variability in the wind speed and its underlying causes in global high-elevation and mountainous areas(e.g.,Tibetan Plateau)remain largely ***,by examining homogenized wind speed data from 104 meteorological stations over the Tibetan Plateau for 1961-2020 and ERA5 reanalysis datasets,we investigated the variability and long-term trend in the near-surface wind speed and revealed the role played by the westerly and Asian *** results show that the homogenized annual wind speed displays a decreasing trend(-0.091 m s^(−1)per decade,p<0.05),with the strongest in spring(-0.131 m s^(−1)per decade,p<0.05),and the weakest in autumn(-0.071 m s^(−1)per decade,p<0.05).There is a distinct multidecadal variability of wind speed,which manifested in an prominent increase in 1961-1970,a sustained decrease in 1970-2002,and a consistent increase in *** observed decadal variations are likely linked to large-scale atmospheric circulation,and the correlation analysis unveiled a more important role of westerly and East Asian winter monsoon in modulating near-surface wind changes over the Tibetan *** potential physical processes associated with westerly and Asian monsoon changes are in concordance with wind speed change,in terms of overall weakened horizontal air flow(i.e.,geostrophic wind speed),declined vertical thermal and dynamic momentum transfer(i.e.,atmospheric stratification thermal instability and vertical wind shear),and varied Tibetan Plateau *** indicates that to varying degrees these processes may have contributed to the changes in near-surface wind speed over the Tibetan *** study has implications for wind power production and soil wind erosion prevention in the Tibetan Plateau.

关键词： Tibetan Plateau Wind speed Decadal change Atmospheric circulation Physical processes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

REDD1介导子宫内过量糖皮质激素对棕色脂肪发育和产热功能的抑制

引用

Science Bulletin 2021年第5期66卷 478-489,M0004页

作者：陈彦廷胡云杨启元刘向东 jun seok son Jeanene M.de Avila 朱美君杜敏 Nutrigenomics and Growth Biology Laboratory Department of Animal SciencesWashington State UniversityPullmanWA 99164USA School of Food Sciences Washington State UniversityPullmanWA 99164USA

母体应激导致子宫内糖皮质激素升高,增加后代能量代谢紊乱和肥胖风险.尽管棕色脂肪对于维护机体正常代谢和产热极其重要,但是子宫内过量糖皮质激素是否会影响后代棕色脂肪发育、线粒体解偶联产热及其调控机制,目前缺乏研究.本文通过对... 详细信息

母体应激导致子宫内糖皮质激素升高,增加后代能量代谢紊乱和肥胖风险.尽管棕色脂肪对于维护机体正常代谢和产热极其重要,但是子宫内过量糖皮质激素是否会影响后代棕色脂肪发育、线粒体解偶联产热及其调控机制,目前缺乏研究.本文通过对怀孕老鼠注射与母体应激相同剂量的糖皮质激素,发现伴随着激活棕色脂肪中糖皮质激素受体响应蛋白REDD1,胎儿和新生儿不仅表现出棕色脂肪发育障碍、体温和存活率下降,而且棕色脂肪中Ppargc1a替代性启动子转录水平以及线粒体合成显著降低.在诱导胚胎成纤维细胞分化成棕色脂肪细胞过程中,通过敲降和过表达Redd1和Ppargc1a,进一步发现REDD1会抑制PKA-CREB蛋白磷酸化,降低了CREB蛋白与Ppargc1a替代性启动子cAMP调控元件的结合,导致棕色脂肪细胞分化、线粒体合成和解偶联产热功能受损.本研究揭示了在孕期过量糖皮质激素条件下, Redd1抑制Ppargc1a替代性启动子表达和棕色脂肪细胞分化,引起后代线粒体产热障碍和能量代谢紊乱,为药物研发以促进胎儿正常发育提供了新思路.

关键词：棕色脂肪细胞糖皮质激素子宫内发育障碍蛋白磷酸化胚胎成纤维细胞药物研发解偶联

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

引用

Acta Pharmaceutica Sinica B 2024年第7期14卷 3169-3183页

作者： Ha Eun Shin jun-Hyeok Han Seungyong Shin Ga-Hyun Bae Boram son Tae-Hyung Kim Hee Ho Park Chun Gwon Park Wooram Park Department of Integrative Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea Department of MetaBioHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Department of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea Department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biomedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of Science and Technology(KIST) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel biomaterial-based platform,M1-polarized macrophage-derived cellular nanovesicle-coated LNPs(M1-C-LNPs),specifically engineered for a combined gene-immunotherapy approach against solid *** dual-function system of M1-C-LNPs encapsulates Bcl2-targeting siRNA within LNPs and immune-modulating cytokines within M1 macrophage-derived cellular nanovesicles(M1-NVs),effectively facilitating apoptosis in cancer cells without impacting T and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was observed upon intratumoral administration of M1-C-LNPs,owing to the presence of adhesion molecules on M1-NVs,thereby contributing to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-based cancer genetic-immunotherapy,with significant implications for advancing biomaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy M1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy siRNA Cancer immunotherapy Solid tumor Tumor microenvironment(TME)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein(RNP)electroporation

引用

Journal of Animal Science and Biotechnology 2024年第1期15卷 456-462页

作者： Gyeong-Min Gim Kyeong-Hyeon Eom Dong-Hyeok Kwon Dae-Jin jung Dae-Hyun Kim jun-Koo Yi Jae-jung Ha Ji-Hyun Lee Seong-Beom Lee Woo-Jae son Soo-Young Yum Won-Wu Lee Goo Jang Laboratory of Theriogenology and Biotechnology Department of Veterinary Clinical ScienceCollege of Veterinary Medicine and the Research Institute of Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea LARTBio Co. Ltd.SeoulRepublic of Korea Gyeongsangbukdo Livestock Research Institute YeongjuRepublic of Korea Comparative Medicine Disease Research Center Seoul National UniversitySeoulRepublic of Korea

Background Genome editing has been considered as powerful tool in agricultural ***,genome editing progress in cattle has not been fast as in other mammal species,for some disadvantages including long gestational periods,single pregnancy,and high raising ***,technically demanding methods such as microinjection and somatic cell nuclear transfer(SCNT)are needed for gene editing in *** this point of view,electroporation in embryos has been risen as an *** First,editing efficiency of our electroporation methods were tested for *** of mutation on embryo was confirmed by T7E1 *** first combination,mutation rates for MSTN and PRNP were 57.6%±13.7%and 54.6%±13.5%,*** case of MSTN/BLG,mutation rates were 83.9%±23.6%for MSTN,84.5%±18.0%for ***,the double-KO embryos were transferred to surrogates and mutation rate was identified in resultant calves by targeted deep *** recipients were transferred for MSTN/PRNP,4 calves were delivered,and one calf underwent an induction for double *** surrogates were given double-KO embryos for MSTN/BLG,and four of the six calves that were born had mutations in both *** These data demonstrated that production of genome edited cattle via electroporation of RNP could be effectively ***,MSTN and PRNP from beef cattle and MSTN and BLG from dairy cattle have been born and they will be valuable resources for future precision breeding.

关键词： Beta-lactoglobulin Cattle CRISPR-Cas9 Electroporation Knockout MSTN PRNP

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dimensionality-driven metal to Mott insulator transition in two-dimensional 1T-TaSe2

引用

National Science Review 2024年第3期11卷 108-118页

作者： Ning Tian Zhe Huang Bo Gyu Jang Shuaifei Guo Ya-jun Yan Jingjing Gao Yijun Yu Jinwoong Hwang Cenyao Tang Meixiao Wang Xuan Luo Yu Ping Sun Zhongkai Liu Dong-Lai Feng Xianhui Chen Sung-Kwan Mo Minjae Kim Young-Woo son Dawei Shen Wei Ruan Yuanbo Zhang State Key Laboratory of Surface Physics New Cornerstone Science Laboratory and Department of PhysicsFudan University Shanghai Qi Zhi Institute Shanghai Research Center for Quantum Sciences Institute for Nanoelectronic Devices and Quantum Computing Fudan University Zhangjiang Fudan International Innovation Center Fudan University State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology(SIMIT)Chinese Academy of Sciences School of Physical Science and Technology ShanghaiTech University Korea Institute for Advanced Study School of Emerging Technology and Department of Physics University of Science and Technology of China Advanced Light Source Lawrence Berkeley National Laboratory ShanghaiTech Laboratory for Topological Physics Key Laboratory of Materials Physics Institute of Solid State Physics Hefei Institutes of Physical ScienceChinese Academy of Sciences High Magnetic Field Laboratory Hefei Institutes of Physical Science Chinese Academy of Sciences Collaborative Innovation Centre of Advanced Microstructures Nanjing University Department of Physics University of Science and Technology of China and Key Laboratory of Strongly Coupled Quantum Matter Physics Chinese Academy of Sciences National Synchrotron Radiation Laboratory University of Science and Technology of China

Two-dimensional materials represent a major frontier for research into exotic many-body quantum phenomena. In the extreme two-dimensional limit, electron-electron interaction often dominates over other electronic energy scales, leading to strongly correlated effects such as quantum spin liquid and unconventional *** dominance is conventionally attributed to the lack of electron screening in the third dimension. Here, we discover an intriguing metal to Mott insulator transition in 1T-TaSe2that defies conventional wisdom. Specifically, we find that dimensionality crossover, instead of reduced screening, drives the transition in atomically thin 1T-TaSe2. A dispersive band crossing the Fermi level is found to be responsible for the bulk metallicity in the material. Reducing the dimensionality,however, effectively quenches the kinetic energy of these initially itinerant electrons, and drives the material into a Mott insulating *** dimensionality-driven metal to Mott insulator transition resolves the long-standing dichotomy between metallic bulk and insulating surface of 1T-TaSe2. Our work further reveals a new pathway for modulating two-dimensional materials that enables exploring strongly correlated systems across uncharted parameter space.

关键词： two-dimensional materials 1T-TaSe2 dimensionality crossover metal to Mott insulator transition

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Vomiting-induced pharyngeal perforation during bowel preparation for colonoscopy:A case report

引用

World Journal of Clinical Cases 2024年第18期12卷 3615-3621页

作者： Geonhee Kim Won Hyuk Lee seokin Kang jung Rock Moon Yoon Suk Lee jun Hyuk son Nam-Hoon Kim Jong Wook Kim Department of Internal Medicine Ilsan Paik HospitalInje University College of MedicineGoyang 10380South Korea

BACKGROUND Effective bowel cleansing is essential for a successful ***,such as polyethylene glycol,are commonly used for bowel *** is a frequent complication during bowel preparation,and forceful vomiting can potentially lead to esophageal perforation,as reported in several previous ***,pharyngeal perforation during bowel preparation has not been previously ***,we present a case of pharyngeal perforation induced by forceful vomiting during bowel *** SUMMARY A 38-year-old man with a history of hypertension,dyslipidemia,diabetes mellitus,and end-stage renal disease on hemodialysis was admitted for evaluation of recurrent abdominal *** patient complained of sudden pain in the neck,throat,and anterior chest following forceful vomiting during bowel *** examination revealed crepitus under the skin of the neck and anterior chest on palpation,and upper gastrointestinal endoscopy revealed pharyngeal *** perforation site was located above the upper esophageal sphincter,which distinguished it from Boerhaave’s *** medical management was chosen after consultation with a thoracic surgeon and an otolaryngologist,considering the patient's mild symptoms,stable vital signs,and the small size of the lesion;the perforation resolved without endoscopic or surgical *** patient was discharged from hospital two weeks after the *** Despite its rarity,pharyngeal perforation should be considered a potential complication of bowel preparation for colonoscopy.

关键词： Colonoscopy Pharynx Polyethylene glycols Spontaneous perforation Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

不言之痛:“隐”作为言语方式的深层内涵——从“父子相隐”说起

引用

文史哲 2024年第3期 95-107,166,167页

作者：李俊中国社会科学院大学文学院北京102488

在古代宗法制中,每个人因其特定的伦理角色,都无法以单纯的身份或零度的立场来谈论“君亲”的行为过失,《论语》中的“父为子隐,子为父隐”和《春秋公羊传》中“隐”的书法义例,都说明“隐”有“不言”之“隐”和“不忍”之“痛”两方... 详细信息

在古代宗法制中,每个人因其特定的伦理角色,都无法以单纯的身份或零度的立场来谈论“君亲”的行为过失,《论语》中的“父为子隐,子为父隐”和《春秋公羊传》中“隐”的书法义例,都说明“隐”有“不言”之“隐”和“不忍”之“痛”两方面内涵。因此,“隐”也就成了一种特殊的言语方式,强调伦理情感的内在之诚对言语行为的制约和调节,当孝子和宗臣蒙受君亲的伦理过失和政治过失时,只能通过隐而不发的方式抒发自己的隐忧,表达自己的道德立场和伦理担当,这些现象在《诗经》和相关诗歌作品的内容与抒情方式上也有所反映。

关键词：父子相隐隐讳隐痛言语方式

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Spontaneous rupture of ocular surface squamous neoplasia–a case report

引用

International Journal of Ophthalmology(English edition) 2022年第2期15卷 357-359页

作者： jun Hyuk son Su-Ho Lim Department of Ophthalmology Yeungnam University College of MedicineDaegu 42415Republic of Korea Department of Ophthalmology Daegu Veterans Health Service Medical CenterDaegu 42835Republic of Korea

Dear Editor,Ocular surface squamous neoplasia(OSSN)typically occurs adjacent to limbus or in inter-palpebral fissures,over a preexisting pinguecula[1].The term OSSN includes mild dysplasia at one end of its disease spectrum and invasive squamous cell carcinoma at the other and is the most common non-pigmented malignancy of the ocular surface[2,3].

关键词： ocular squamous rupture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development of a 3D subcutaneous construct containing insulin-producing beta cells using bioprinting

引用

Bio-Design and Manufacturing 2022年第2期5卷 265-276页

作者： Chi B.Ahn Ji-Hyun Lee Joo H.Kim Tae H.Kim Hee-Sook jun Kuk H.son Jin W.Lee Department of Molecular Medicine College of MedicineGachon University155Gaetbeol-roYeonsu-kuIncheonRepublic of Korea Department of Health Sciences and Technology GAIHSTGachon University155Gaetbeol-roYeonsu-kuIncheonRepublic of Korea College of Pharmacy Gachon University191Hambangmoe-roYeonsu-kuIncheonRepublic of Korea Department Thoracic and Cardiovascular Surgery Gachon University Gil Medical CenterCollege of MedicineGachon University21Namdong-daero 774 beon-gilNamdong-guIncheonRepublic of Korea

Type 1 diabetes is caused by insulin deficiency due to the loss of beta cells in the islets of *** severe cases,islet transplantation into the portal vein is ***,due to the loss of transplanted islets and the failure of islet function,the 5-year insulin independence rate of these patients is<50%.In this study,we developed a long-term,insulin-secreting,3 Dbioprinted construct implanted subcutaneously with the aim of preventing islet *** bioprinted construct was fabricated by the multi-layer bioprinting of beta-cell(mouse insulinoma-6:MIN-6)-encapsulated alginate bioink and poly(caprolactone)biodegradable polymer.A glucose response assay revealed that the bioprinted constructs proliferated and released insulin normally during the 4-week in vitro *** MIN-6 generated clusters with a diameter of 100-200μm,similar to the original pancreatic islets in the *** an in vivo study using type 1 diabetes mice,animals implanted with bioprinted constructs showed three times higher insulin secretion and controlled glucose levels at 8 weeks after *** the implanted,bioprinted constructs had a positive effect on insulin secretion in the experimental animals,the survival rate of the implanted group(75%)was three times higher than that of the non-implanted group(25%).The results suggest that the proposed,3 D-bioprinted,subcutaneous construct can be a better alternative to portal vein islet transplantation.

关键词： 3D bioprinting Subcutaneous construct Type 1 diabetes Insulin Beta cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：