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Additive manufacturing of composite materials and functionally graded structures using selective heat melting technique

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Journal of Materials Science & Technology 2020年第12期47卷 243-252页

作者： Kalaimani Markandan Ruijing Lim Pawan Kumar Kanaujia Ian Seetoh Muhammad Raziq bin Mohd Rosdi Zhi Huey Tey jun seng goh Yee Cheong Lam Changquan Lai Temasek Laboratories Nanyang Technological University50 Nanyang Drive637553Singapore School of Physical&Mathematical Sciences Nanyang Technological University21 Nanyang Link637371Singapore School of Mechanical&Aerospace Engineering Nanyang Technological University50 Nanyang Avenue639798Singapore School of Materials Science&Engineering Nanyang Technological University50 Nanyang Avenue639798Singapore

The feasibility of using selective heat melting(SHM) to fabricate composite materials and functionally graded structures was *** report,for the first time,the successful 3 D printing of copper(Cu)-polyethylene(PE) composite,iron(Fe)-polyethylene(PE) composite and functionally graded CuO foams using the SHM *** was found that a low feed rate,high airflow rate and high airflow temperature were required for efficient delivery of heat from the emitted hot air to the powder bed,so that the PE binder particles can melt and form dense composites with smooth *** best mechanical properties were exhibited by composites with 80 vol.% PE,as lower PE concentrations led to deficient binding of the metal particles,while higher PE concentrations meant that very few metal particles were available to strengthen the *** strength exhibited by Cu-PE composites was comparable to engineering plastics such as polycarbonate,with the added advantage of being electrically *** average conductivity of the samples,0.152±0.28 S/m,was on par with physically crosslinked graphene *** subjecting a Cu-PE composite,with Cu concentration graded from 10 vol.% to 30 vol.%,to a high temperature debinding and sintering treatment in air,CuO foam with graded porosity can be *** CuO foam was observed to fail in a layer-by-layer manner under mechanical compression,which is a characteristic of functionally graded *** study shows that,compared to existing 3 D printing techniques,SHM can be cheaper,have wider material compatibility,occupy a smaller footprint and potentially induce less residual stresses in the fabricated ***,it could be a valuable complement to current additive manufacturing techniques for fabricating mechanically strong composite materials and functionally graded structures.

关键词： Selective heat melting Functionally graded materials Additive manufacturing Multimaterial

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Recent advances in graphene-based phase change composites for thermal energy storage and management

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Nano Materials Science 2024年第2期6卷 115-138页

作者： Qiang Zhu Pin Jin Ong Si Hui Angela goh Reuben J.Yeo Suxi Wang Zhiyuan Liu Xian jun Loh Institute of Materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)2 Fusionopolis WayInnovis#08-03138634Singapore Institute of Sustainability for Chemicals Energy and EnvironmentA*STAR(Agency for ScienceTechnology and Research)1 Pesek RoadJurong Island627833Singapore School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological University21 Nanyang Link637371Singapore Shenzhen Institutes of Advanced Technology(SIAT) Chinese Academy of Sciences(CAS)1068 Xueyuan AvenueShenzhen518055China Department of Material Science and Engineering National University of Singapore9 Engineering Drive 1#03-09 EA117575Singapore

Energy storage and conservation are receiving increased attention due to rising global energy ***,the development of energy storage materials is *** energy storage(TES)systems based on phase change materials(PCMs)have increased in prominence over the past two decades,not only because of their outstanding heat storage capacities but also their superior thermal energy regulation ***,issues such as leakage and low thermal conductivity limit their applicability in a variety of ***-based materials such as graphene and its derivatives can be utilized to surmount these *** study examines the recent advancements in graphene-based phase change composites(PCCs),where graphene-based nanostructures such as graphene,graphene oxide(GO),functionalized graphene/GO,and graphene aerogel(GA)are incorporated into PCMs to substantially enhance their shape stability and thermal conductivity that could be translated to better storage capacity,durability,and temperature response,thus boosting their attractiveness for TES *** addition,the applications of these graphene-based PCCs in various TES disciplines,such as energy conservation in buildings,solar utilization,and battery thermal management,are discussed and summarized.

关键词： Phase change material Nanocomposites Solar energy Sustainable energy Thermo-regulation

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Does antiviral therapy reduce complications of cirrhosis?

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World Journal of Gastroenterology 2014年第23期20卷 7306-7311页

作者： goh Eun Chung Jeong-Hoon Lee Yoon jun Kim Department of Internal Medicine Healthcare Research InstituteGangnam Healthcare CenterSeoul National University HospitalSeoul 135-984South Korea Department of Internal Medicine and Liver Research Institute Seoul National College of MedicineSeoul 110-744South Korea

Chronic hepatitis B infection is associated with the development of cirrhosis, hepatocellular carcinoma, and finally liver-related mortality. Each year, approximately, 2%-5% of patients with hepatitis B virus (HBV)-related compensated cirrhosis develop decompensation, with additional clinical manifestations, such as ascites, jaundice, hepatic encephalopathy, and gastrointestinal bleeding. The outcome of decompensated HBV-related cirrhosis is poor, with a 5-year survival of 14%-35% compared to 84% in patients with compensated cirrhosis. Because the risk of disease progression is closely linked to a patient’s serum HBV DNA level, antiviral therapy may suppress viral replication, stabilize liver function and improve survival. This article briefly reviews the role that antiviral therapy plays in cirrhosis complications, particularly, in decompensation and acute-on-chronic liver failure.

关键词： Antiviral therapy Cirrhosis Complication Hepatitis B Decompensation

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Investigation on surface integrity of electron beam melted Ti-6Al-4 V by precision grinding and electropolishing

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Chinese Journal of Aeronautics 2021年第12期34卷 28-38页

作者： Jiang GUO Min Hao goh Pan WANG Rui HUANG Xiaohua LEE Bin WANG Sharon Mui Ling NAI jun WEI Key Laboratory for Precision and Non-traditional Machining Technology of Ministry of Education Dalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of Technology Ningbo 315016China Singapore Institute of Manufacturing Technology Singapore 637662Singapore Harbin Institute of Technology Shenzhen 518055China

Electron beam melting(EBM),as an excellent Additive Manufacturing(AM)technology,enables the printing of Ti-6Al-4V alloy for a wide range of applications such as aerospace and biomechanical *** improves functionality and integrity of components and negates complexities in assembly ***,due to the poor surface and sub-surface integrity represented by the rough surface finish and low dimensional accuracy,achieving a favorable surface condition is quite ***,post processing becomes essential for these electron beam melted(EBM-ed)Ti-6Al-4V *** the most common technique to improve such parts,milling of Ti-6Al-4V alloy is very challenging and resulting tool wear issues,due to its unique material ***,this paper presents a comprehensive study on the surface integrity of EBM-ed Ti-6Al-4V parts processed by precision grinding and electropolishing,aiming to qualitatively and quantitatively clarify the interrelation between process parameters and processed surface *** surface and subsurface characteristics such as profile accuracy,surface roughness,microstructure,defective layer and residual stress before and after post processing were compared and *** results show that by precision grinding,the profile accuracy was improved from over 300μm PV to 7μm PV,while surface roughness(R_(a))was reduced from 30μm to about 2μ*** layer with partially melt particles was removed,but introduced a deformed subsurface layer with more residual *** by applying electropolishing,the residual stress was released and the deformed layer was *** addition,Ra was further reduced to 0.65μ*** research can serve as a reference for the integration of post machining processes with AM.

关键词： Additive Manufacturing(AM) Electron Beam Melting(EBM) Electropolishing Grinding Surface integrity Ti-6Al-4V alloy

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Gamma-glutamyl transferase and cardiovascular risk in nonalcoholic fatty liver disease:The Gut and Obesity Asia initiative

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World Journal of Gastroenterology 2020年第19期26卷 2416-2426页

作者： Panyavee Pitisuttithum Wah-Kheong Chan George Boon-Bee goh Jian-Gao Fan Myeong jun Song Phunchai Charatcharoenwitthaya Ajay Duseja Yock-Young Dan Kento Imajo Atsushi Nakajima Khek-Yu Ho Khean-Lee goh Vincent Wai-Sun Wong Sombat Treeprasertsuk Department of Medicine Faculty of MedicineChulalongkorn UniversityBangkok 10330Thailand Department of Medicine University of MalayaKuala Lumpur 50603Malaysia Department of Gastroenterology&Hepatology Singapore General HospitalSingapore 169608Singapore Department of Gastroenterology Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Internal Medicine The Catholic University of KoreaDaejeon 301-723South Korea Division of Gastroenterology Faculty of Medicine Siriraj HospitalMahidol UniversityBangkok 10700Thailand Department of Hepatology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Medicine National University of Singapore 119228Singapore Department of Gastroenterology and Hepatology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan Department of Medicine and Therapeutics The Chinese University of Hong KongHong Kong 999077China

BACKGROUND Gamma-glutamyl transferase(GGT)is associated with the risk of cardiovascular disease(CVD)in the general *** To identify the association of baseline GGT level and QRISK2 score among patients with biopsy-proven nonalcoholic fatty liver disease(NAFLD).METHODS This was a retrospective study involving 1535 biopsy-proven NAFLD patients from 10 Asian centers in 8 countries using data collected by the Gut and Obesity in Asia(referred to as“GO ASIA”)*** patients with available baseline GGT levels and all 16 variables for the QRISK2 calculation(QRISK2-2017;developed by researchers at the United Kingdom National Health Service;https://***/2017/;10-year cardiovascular risk estimation)were included and compared to healthy controls with the same age,sex,and *** risk was ***2 score>10%was defined as the high-CVD-risk *** stages 3 and 4(F3 and F4)were considered advanced *** A total of 1122 patients(73%)had complete data and were included in the final analysis;314(28%)had advanced *** median age(interquartile range[IQR])of the study population was 53(44-60)years,532(47.4%)were females,and 492(43.9%)were of Chinese *** median 10-year CVD risk(IQR)was 5.9%(2.6-10.9),and the median relative risk of CVD over 10 years(IQR)was 1.65(1.13-2.2)compared to healthy individuals with the same age,sex,and *** high-CVD-risk group was significantly older than the low-risk group(median[IQR]:63[59-67]vs 49[41-55]years;P<0.001).Higher fibrosis stages in biopsy-proven NAFLD patients brought a significantly higher CVD risk(P<0.001).Median GGT level was not different between the two groups(GGT[U/L]:Median[IQR],high risk 60[37-113]vs low risk 66[38-103],P=0.56).There was no correlation between baseline GGT level and 10-year CVD risk based on the QRISK2 score(r=0.02).CONCLUSION The CVD risk of NAFLD patients is higher than that of healthy *** GGT level cannot predict CVD ri

关键词： Nonalcoholic fatty liver disease Gamma glutamyl transferase QRISK Cardiovascular risk Gut and Obesity in Asia

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Combating the Coronavirus Pandemic:Early Detection,Medical Treatment,and a Concerted Effort by the Global Community

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Research 2020年第1期2020卷 1141-1175页

作者： Zichao Luo Melgious Jin Yan Ang Siew Yin Chan Zhigao Yi Yi Yiing goh Shuangqian Yan jun Tao Kai Liu Xiaosong Li Hongjie Zhang Wei Huang Xiaogang Liu Department of Chemistry National University of SingaporeSingapore 117543Singapore NUS Graduate School for Integrative Sciences and Engineering Singapore 117456Singapore Frontiers Science Center for Flexible Electronics&Shaanxi Institute of Flexible Electronics Northwestern Polytechnical UniversityXi’an 710072China Sports Medical Centre The Second Affiliated Hospital of Nanchang UniversityNanchang 330000China State Key Laboratory of Rare Earth Resource Utilization Chang Chun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Department of Oncology The Fourth Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100048China Department of Chemistry Tsinghua UniversityBeijing 100084China Key Laboratory of Flexible Electronics&Institute of Advanced Materials Nanjing Tech UniversityNanjing 211816China The N.1 Institute for Health National University of SingaporeSingapore Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350807China

The World Health Organization(WHO)has declared the outbreak of 2019 novel coronavirus,known as 2019-nCoV,a pandemic,as the coronavirus has now infected over 2.6 million people globally and caused more than 185,000 fatalities as of April 23,*** disease 2019(COVID-19)causes a respiratory illness with symptoms such as dry cough,fever,sudden loss of smell,and,in more severe cases,difficulty *** date,there is no specific vaccine or treatment proven effective against this viral *** and accurate diagnosis of COVID-19 is thus critical to curbing its spread and improving health *** transcription-polymerase chain reaction(RT-PCR)is commonly used to detect the presence of *** techniques,such as recombinase polymerase amplification(RPA),loopmediated isothermal amplification(LAMP),clustered regularly interspaced short palindromic repeats(CRISPR),and microfluidics,have allowed better disease ***,as part of the effort to expand screening capacity,we review advances and challenges in the rapid detection of COVID-19 by targeting nucleic acids,antigens,or *** also summarize potential treatments and vaccines against COVID-19 and discuss ongoing clinical trials of interventions to reduce viral progression.

关键词： diagnosis Early Combat

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Differential risk of 23 site-specific incident cancers and cancer-related mortality among patients withmetabolic dysfunction-associated fatty liver disease:a population-based cohort study with 9.7 million Korean subjects

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Cancer Communications 2023年第8期43卷 863-876页

作者： goh Eun Chung Su Jong Yu Jeong-Ju Yoo Yuri Cho Kyu-na Lee Dong Wook Shin Yoon jun Kim jung-Hwan Yoon Kyungdo Han Eun Ju Cho Department of Internal Medicine and Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam CenterSeoulRepublic of Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoulRepublic of Korea Department of Gastroenterology and Hepatology Soonchunhyang University Bucheon HospitalBucheonGyeonggi-doRepublic of Korea Center for Liver and Pancreatobiliary Cancer National Cancer CenterGoyangGyeonggi-doRepublic of Korea Department of Biomedicine&Health Science Catholic University of KoreaSeoulRepublic of Korea Department of Family Medicine/Supportive care center Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Clinical Research Design and Evaluation/Department of Digital Health Samsung Advanced Institute for Health ScienceSeoulRepublic of Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoulRepublic of Korea

Introduction:Although an association between metabolic dysfunctionassociated fatty liver disease(MAFLD)and cardiovascular disease or overall mortality has been reported,it is unclearwhether there is an association between MAFLD and cancer incidence or *** aimed to investigate the differential risk of all-and site-specific cancer incidence and mortality according to MAFLD subgroups categorized by additional etiologies of liver ***:Using the Korean National Health Insurance Service database,we stratified the participants into three groups:(1)single-etiology MAFLD(SMAFLD)or MAFLD of pure metabolic origin;(2)mixed-etiology MAFLD(M-MAFLD)or MAFLD with additional etiological factor(s)(i.e.,concomitant liver diseases and/or heavy alcohol consumption);and(3)*** steatosis and fibrosiswere defined using the fatty liver index and the BARDscore,*** proportional hazards regression was performed to estimate the risk of cancer ***:Among the 9,718,182 participants,the prevalence of S-MAFLD and M-MAFLD was 29.2%and 6.7%,*** the median 8.3 years of follow-up,510,330(5.3%)individuals were newly diagnosed with cancer,and 122,774(1.3%)cancer-related deaths occurred among the entire *** with the non-MAFLD group,the risk of all-cancer incidence and mortality was slightly higher among patients in the S-MAFLD group(incidence,adjusted hazard ratio[aHR]=1.03;95%confidence interval[CI]:1.02−1.04;mortality,aHR=1.06;95%CI:1.04−1.08)and highest among patients with M-MAFLD group(incidence,aHR=1.31;95%CI:1.29−1.32;mortality,aHR=1.45;95%CI:1.42−1.48,respectively).The M-MAFLD with fibrosis group(BARD score≥2)showed the highest relative risk of all-cancer incidence(aHR=1.38,95%CI=1.36–1.39),followed by the M-MAFLD without fibrosis group(aHR=1.09,95%CI=1.06–1.11).Similar trends were observed for cancer-related ***:MAFLD classification,by applying additional etiologies other than pure metabolic origi

关键词： cancer etiology metabolic mortality steatosis

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Traditional Chinese Medicine in Malaysia:A Brief Historical Overview of the Interactions between China and Malay Peninsula

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Chinese Medicine and Culture 2018年第2期1卷 60-63页

作者： Wen Tien Tan Hon Foong Wong Shih Chau Ng Si Woei goh jun Liu Bao Ling Hoo Chyong En Chai Xun Lin Department of Golden Cabinet International Education CollegeShanghai University of Traditional Chinese MedicineShanghaiChina Department of Chinese Medicine Centre for Complementary and Alternative MedicineInternational Medical UniversityKuala LumpurMalaysia

Chinese Medicine was introduced to the Malay Peninsula during the colonial era circa 18th to 19th *** British imported Chinese immigrants mainly for tin *** early Chinese settlers had brought with them the knowledge of Traditional Chinese Medicine(TCM)to *** time goes by,TCM becomes one of the popular traditional medicines that are accepted by other *** has thus contributed to the welfare of *** 2016,a Traditional and Complementary Medicine(T and CM)Act was passed by the Malaysia *** is one of the T and CM practices that fall under the *** services are now offered in Malaysia’s public hospitals in addition to private *** article aims to provide a brief overview on the development of TCM in the precolonial and postindependent Malaysia.

关键词： Development history Malaysia Traditional Chinese Medicine

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Traditional Chinese Medicine in Malaysia: A Brief Historical Overview of the Institutions

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Chinese Medicine and Culture 2019年第1期2卷 15-18页

作者： Shih Chau Ng Hon Foong Wong Wen Tien Tan jun Liu Huiying Wang Xun Lin Si Woei goh Bao Ling Hoo Chyong En Chai International Education College Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Chinese Medicine Centre for Complementary and Alternative MedicineInternational Medical UniversityKuala LumpurMalaysia

Traditional Chinese Medicine(TCM)in British Malaya developed concurrently with the influx of Chinese *** cater for tins growing community,Chinese medical halls which sell Chinese herbs were established in major *** and various TCM treatments were also offered by contract TCM practitioners in some of these medical *** the needs for TCM services continued to grow,dedicated TCM institutions were set up *** establishment of these institutions marked the beginning of professional TCM services in the history of Malaysia.

关键词： Development history Malaysia medical institutions Traditional Chinese Medicine

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Traditional Chinese Medicine in Malaysia: A Brief Historical Overview of Laws and Regulations

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Chinese Medicine and Culture 2019年第3期2卷 162-165页

作者： Hon Foong Wong Shih Chau Ng Wen Tien Tan Huiying Wang Xun Lin Si Woei goh Bao Ling Hoo Chyong En Chai jun Liu International Education College Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Chinese Medicine Centre for Complementary and Alternative MedicineInternational Medical UniversityKuala LumpurMalaysia

Although traditional Chinese medicine(TCM)has been a part of the Malaya and the Malaysia people’s method of maintaining health and well-being for many centuries,it was never been enrolled in the public health-care ***,the rising cost of Western drugs and the increasing number of people frequenting TCM has driven the government to search for cheaper options and to look into its safe *** 1992,the government mandated all TCM herbal products to be registered with the National Pharmaceutical Control *** TCM products sold in Malaysia are now Good Manufacturing Practice *** government has also established a Traditional and Complementary Medicine Division within the Ministry of *** 2008 and 2014,a traditional and complementary medicine unit was set up in major hospitals in all *** is one of the main services offered by the *** 2016,the government enacted the Traditional and Complementary Medicine Act to regulate the TCM ***,a 10-vear blueprint has been drawn to support the development of all traditional and complementary medicines in *** article aims to provide a brief overview on the regulatory development of TCM in Malaysia.

关键词： Development of traditional Chinese medicine historical overview laws and regulations Malaysia Traditional Chinese medicine

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