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Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang Jin-Jie Yu Feng Su Tian Jiang Shao-Yuan Zhang Lu Lv Tao Long Hui-Wen Pan jun-qing qi qiang Zhou Wei-Feng Tang Guo-Wen Ding Li-Ming Wang Li-Jie Tan jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

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Theoretical Study on the Structures and Electronic Spectra of the Derivatives of C_(60)-P-2,4,6-Triphenyl Borazinc

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Chinese Journal of Structural Chemistry 2005年第10期24卷 1140-1144页

作者： JIANG qi-jun Department of Chemistry Xiaogan University Xiaogan 432000 China

The structures and electronic spectra of the derivatives of C60-P-2,4,6-triphenyl borazinc have been studied by using AM 1 method. The calculated results indicate that this kind of compounds has a lower energy difference between HOMO and LUMO. It is found that the electron cloud on unoccupied frontier orbital mainly comes from the contribution of C60, while that on occupied frontier orbital mainly concentrates on the side chain. A long-lived charge-separated state may occur in the objective compounds.

关键词： derivatives of C60-P-2,4,6-triphenyl borazinc electronic spectra charge-separated state AM1

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Dynamic phase transition theory

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Science China(Physics,Mechanics & Astronomy) 2023年第2期66卷 102-108页

作者： qi-jun Ye Xin-Zheng Li State Key Laboratory for Artificial Microstructure and Mesoscopic Physics Frontier Science Center for Nano-optoelectronics and School of PhysicsPeking UniversityBeijing 100871China Interdisciplinary Institute of Light-Element Quantum Materials Research Center for Light-Element Advanced Materialsand Collaborative Innovation Center of Quantum MatterPeking UniversityBeijing 100871China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China

Thermodynamic conventions suffer from describing dynamical distinctions,especially when the structural and energetic changes induced by rare events are *** using the ensemble theory in the trajectory space,we present a statistical approach to address this *** than spatial particle-particle interaction which dominates thermodynamics,the temporal correlation of events dominates the *** zeros of dynamic partition function mark phase transitions in the space-time,i.e.,dynamic phase transition(DPT),as Yang and Lee formulate traditional phase transitions,and hence determine dynamic phases on both sides of the *** to the role of temperature(pressure) as thermal(mechanical) potential,we interpret the controlling variable of DPT,i.e., dynamic field,as the dynamical *** findings offer possibility towards a unified picture of phase and phase transition.

关键词： transition phase transition

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Application of Wavelets Transform to Fault Detection in Rotorcraft UAV Sensor Failure

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Journal of Bionic Engineering 2007年第4期4卷 265-270页

作者： jun-tong qi Jian-da Han Shenyang Institute of Automation Chinese Academy of Sciences Shenyang 110016 P. R. China Graduate School Chinese Academy of Sciences Beijing 100049 P. R. China

This paper describes a novel wavelet-based approach to the detection of abrupt fault of Rotorcrafi Unmanned Aerial Vehicle （RUAV） sensor system. By use of wavelet transforms that accurately localize the characteristics of a signal both in the time and frequency domains, the occurring instants of abnormal status of a sensor in the output signal can be identified by the multi-scale representation of the signal. Once the instants are detected, the distribution differences of the signal energy on all decomposed wavelet scales of the signal before and after the instants are used to claim and classify the sensor faults.

关键词： RUAV wavelet transform fault detection sensor failure

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PV Array Reconfiguration Based on the Shaded Cells'Number for PV Modules

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CSEE Journal of Power and Energy Systems 2023年第2期9卷 733-742页

作者： jun qi Xun Huang Beijia Ye Dan Zhou College of Information Engineering Zhejiang University of TechnologyHangzhou 310014China

Reconfiguration can increase the output power for a PV array under partial ***,traditional reconfiguration methods consider the PV module as either totally shaded or totally unshaded,and module-based simulation is employed to evaluate the reconfiguration ***,there is an unneglectable error when treating a partially shaded PV module as totally shaded,through using a more accurate cellbased *** on the analysis of the determinant factors on MPPs’power of a PV array,a new reconfiguration method is proposed based on the exact partial shadow shape projected on the PV *** method restructures the electrical connection among PV modules of a PV array according to the shaded cells’number(SCN)of every PV *** cell-based simulations are carried out on a PV array to verify the effectiveness of the proposed SCN-based reconfiguration *** comparisons among various reconfiguration methods and shadow distributions clearly show its suitability to different irregular shadows and its superiority in PV output power enhancement.

关键词： Maximum power point(MPP) partial shadow PV array PV module reconfiguration

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Effect of Water Absorption on the Impact Properties of Carbon Fiber/Epoxy Composites

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Chinese Journal of Aeronautics 2006年第B12期19卷 14-18页

作者： LU Xiao-jun ZHANG qi School of Materials Science and Engineering Bejing University of Aeronautics and Astronautics Beijing 100083 China

In this paper, the effects of test temperatures and time on the impact damage behavior of unidirectional carbon fiber reinforced epoxy resin composites, immersed in pure water, on a pendulum impact tester, was studied. The results show that immersion in liquids has a significant effect on the impact resistance of the unidirectional composite material. It is obvious that after immersion, the mass of the material increases. The fracture initiation forces as well as the fracture initiation energy decrease as the immersion time lengthens. Moreover, the higher the temperature and the longer the time are, the more the crack propagation energy and the ductility index will be. Immersion makes the fracture mode change from the dominant fiber fracture into dominant delamination. All in all, immersion decreases the impact resistance of the composites and causes the fracture mode to change.

关键词： carbon fiber composites impact damage immersion fracture mechanisms

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Kinetic Monte Carlo simulation of physical vapor deposition of thin Cu film

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中国有色金属学会会刊：英文版 2004年第z1期14卷 463-467页

作者： WANG jun CHEN Chang-qi ZHU Wu School of Mechanical and Automobile Hefei University of Technology Hefei 230009 China School of Mechanical and Automobile Hefei University of Technology Hefei 230009 China School of Mechanical and Automobile Hefei University of Technology Hefei 230009 China

A two-dimensional Kinetic Monte Carlo method has been developed for simulating the physical vapor deposition of thin Cu films on Cu substrate. An improved embedded atom method was used to calculate the interatomic potential and determine the diffusion barrier energy and residence time. Parameters, including incident angle,deposition rate and substrate temperature, were investigated and discussed in order to find their influences on the thin film morphology.

关键词： physical vapor deposition Kinetic Monte Carlo method embedded atom method thin film growth simulation morphology

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Agrobacterium-mediated delivery of CRISPR/Cas reagents for genome editing in plants enters an era of ternary vector systems

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Science China(Life Sciences) 2020年第10期63卷 1491-1498页

作者： Yu Zhang qiang Zhang qi-jun Chen State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Center for Crop Functional Genomics and Molecular Breeding China Agricultural UniversityBeijing 100193China

Lack of appropriate methods for delivery of genome-editing reagents is a major barrier to CRISPR/Cas-mediated genome editing in ***-mediated genetic transformation(AMGT)is the preferred method of CRISPR/Cas reagent delivery,and researchers have recently made great improvements to this *** this article,we review the development of AMGT and AMGT-based delivery of CRISPR/Cas *** give an overview of the development of AMGT vectors including binary vector,superbinary vector,dual binary vector,and ternary vector *** also review the progress in Agrobacterium genomics and Agrobacterium genetic engineering for optimal *** focus in particular on the ternary vector system and the resources we *** summary,it is our opinion that Agrobacterium-mediated CRISPR/Cas genome editing in plants is entering an era of ternary vector systems,which are often integrated with morphogenic *** new vectors described in this article are available from Addgene and/or MolecularCloud for sharing with academic investigators for noncommercial research.

关键词： genome editing CRISPR/Cas ternary vector system delivery Agrobacterium-mediated transformation

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The “Bi-drifting” Subpulses of PSR J0815+0939 Observed with the Fivehundred-meter Aperture Spherical Radio Telescope

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Research in Astronomy and Astrophysics 2022年第2期22卷 195-203页

作者： Lun-Hua Shang jun-Tao Bai Shi-jun Dang qi-jun Zhi School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China School of Electronic and Optical Engineering Nanjing University of Science and TechnologyNanjing 210094China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China

We report the "Bi-drifting" subpulses observed in PSR J0815+0939 using the Five-hundred-meter Aperture Spherical radio Telescope(FAST). The observation at band from 1050 to 1450 MHz is evenly divided into two bands, i.e., the bands at center frequencies of 1150 and 1350 MHz. The mean pulse profiles and the "Bi-drifting"subpulses at these two bands are investigated. It is found that the pulse profiles at these two frequencies show four emission components, and the peak separations between four emission components decrease with the increase of frequency. In addition, the ratio of peak intensity of each component to the intensity of component Ⅳ at 1150 MHz is larger than that at 1350 MHz. We carry out an analysis of the longitude-resolved fluctuation spectrum and twodimensional fluctuation spectrum for each emission component, and find that the P3 of components Ⅰ,Ⅱ and Ⅲ is about 10.56, 10.57 and 10.59 s at 1150 and 1350 MHz. However, the reliable measurements of P3 of component IV and P2 for these four components were not obtained due to the low signal-to-noise ratio of observation *** pulse energy distributions at frequencies 1150 and 1350 MHz are presented, and it is found that no nulling phenomenon has been found in this pulsar. With our observation from the FAST, the "Bi-drifting" subpulse phenomenon of PSR J0815+0939 is expanded from 400 to 1350 MHz, which is helpful for the relevant researchers to test and constrain the pulsar emission model, especially the model of "Bi-drifting" subpulse.

关键词： (stars:)pulsars:general (stars:)pulsars:individual(PSR J0815+0939) radiation mechanisms:nonthermal

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ANALYSIS OF METHOD FOR DETERMINING AZIMUTH OF PRINCIPAL AXIS OF INERTIA BASED ON DYNAMIC BALANCE MEASUREMENT

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Chinese Journal of Mechanical Engineering 2006年第4期19卷 530-533页

作者： ZHAO jun GUAN Yingzi qi Naiming College of Astronautics Harbin Institute of Technology Harbin 150001 China

The dynamic balance quality of a rotating object is an important factor to maintain the stability and accuracy for motion. The azimuth of the principal axis of inertia is a major sign of dynamic balance. A usual method is measuring moment of inertia matrix relative to some base coordinates on a rotary inertia machine so as to calculate the azimuth of principal axis of inertia, By using the measured unbalance results on the two trimmed planes on a vertical hard bearing double-plane dynamic balancing machine, the dimension and direction of couple unbalance can be found. An azimuth angle formula for the principal axis of inertia is derived and is solved by using unbalance quantities. The experiments indicate that method based on dynamic balancing measurement is proved rational and effective and has a fine precision.

关键词： Dynamic balance machine Principal axis of inertia Azimuth

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