检索结果-南通市图书馆

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第10期11卷 792-800页

作者： jun-mei wang Jian-ming YANG Jing-huan ZHU Qiao-jun JIA Yue-zhi TAO Institute of Crop and Nuclear Technology Utilization Zhejiang Academy of Agricultural Sciences Hangzhou 310021 China

The genetic diversity and relationship among 40 elite barley varieties were analyzed based on simple sequence repeat （SSR） genotyping data. The amplified fragments from SSR primers were highly polymorphic in the badey accessions investigated. A total of 85 alleles were detected at 35 SSR loci, and allelic variations existed at 29 SSR loci. The allele number per locus ranged from 1 to 5 with an average of 2.4 alleles per locus detected from the 40 badey accessions. A cluster analysis based on the genetic similarity coefficients was conducted and the 40 varieties were classified into two groups. Seven malting barley varieties from China fell into the same subgroup. It was found that the genetic diversity within the Chinese malting barley varieties was narrower than that in other barley germplasm sources, suggesting the importance and feasibility of introducing elite genotypes from different origins for malting barley breeding in China.

关键词： Barley (Hordeum vu/gare L.) Genetic similarity Simple sequence repeat (SSR) marker Cluster analysis Genetic diversity

Mitochondrial protective and anti-apoptotic effects of Rhodiola crenulata extract on hippocampal neurons in a rat model of Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第12期12卷 2025-2034页

作者： jun-mei wang Ze-qiang Qu Jin-lang Wu Peter Chung Yuan-shan Zeng Department of Histology and Embryology Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong Province China Department of Electron Microscope Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong Province China Shanghai Ninth People's Hospital Shanghai liao Tong University School of Medicine Shanghai China Institute of Spinal Cord In)ury Sun Yat-sen University Guangzhou Guangdong Province China Co-innovation Center of Neuroregeneration Nantong University Nantong Jiangsu Province China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong Province China

In our previous study, we found that the edible alcohol extract of the root of the medicinal plant Rhodiola crenulata（RCE） improved spatial cognition in a rat model of Alzheimer＇s disease. Another study from our laboratory showed that RCE enhanced neural cell proliferation in the dentate gyrus of the hippocampus and prevented damage to hippocampal neurons in a rat model of chronic stress-induced depression. However, the mechanisms underlying the neuroprotective effects of RCE are unclear. In the present study, we investigated the anti-apoptotic effect of RCE and its neuroprotective mechanism of action in a rat model of Alzheimer＇s disease established by intracerebroventricular injection of streptozotocin. The rats were pre-administered RCE at doses of 1.5, 3.0 or 6.0 g/kg for 21 days before model establishment. ATP and cytochrome c oxidase levels were significantly decreased in rats with Alzheimer＇s disease. Furthermore, neuronal injury was obvious in the hippocampus, with the presence of a large number of apoptotic neurons. In comparison, in rats given RCE pretreatment, ATP and cytochrome c oxidase levels were markedly increased, the number of apoptotic neurons was reduced, and mitochondrial injury was mitigated. The 3.0 g/kg dose of RCE had the optimal effect. These findings suggest that pretreatment with RCE prevents mitochondrial dysfunction and protects hippocampal neurons from apoptosis in rats with Alzheimer＇s disease.

关键词： nerve regeneration Alzheimer's disease intracerebroventricular injection streptozotocin neuronal apoptosis neuroprotection cytochrome c oxidase adenosine triphosphate caspase-3 NeuN neural regeneration

Synthesis of protected (2S,4R)-2-amino-4-methyldecanoic acid, a proposed component of culicinins

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2008年第9期19卷 1068-1070页

作者： Wei Zhang Tian Tian Sun Duo mei jun Fei wang Ying Xia Li Key laboratory of Marine Drugs The Ministry of Education of China School of Pharmacy Ocean University of China Qingdao 266003 China

The protected （2S,4R）-2-amino-4-methyldecanoic acid, a proposed component of culicinins has been synthesized over 10 steps and in total 28% yields using Wittig reaction and Schollkopf amino acid synthesis as key steps.

关键词： Synthesis Amino acid Schollkopf methodology Culicinins

Recent progress of in-situ characterization of LiNi_(1−x−y)Co_(x)Mn_(y)O_(2) cathodes for lithium metal batteries: A mini review

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第3期17卷 1384-1401页

作者： Huanzhu Lv Xiaoqi Zhu jun mei Yuanhua Xia Bin wang Institute of Fundamental and Frontier Science University of Electronic Science and Technology of ChinaChengdu 611731China Chengdu Development Center of Science and Technology China Academy of Engineering PhysicsChengdu 610200China Key Laboratory of Neutron Physics and Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics(CAEP)Mianyang 621999China

In the context of the gradual popularity of electric vehicles(EVs),the development of lithium battery systems with high energy density and power density is regarded as the foremost way to improve the range of ***_(1-x-y)Co_(x)Mn_(y)O_(2)(NCM)cathodes have been the focus of researchers due to their high energy density,excellent power performance,and low-temperature ***,the elaboration of the decay mechanism of NCM cathode based on lithium metal batteries(LMBs)is still being restricted to the primary *** the past decades,the development and application of advanced in-situ characterization tools have facilitated researchers'understanding of the internal operation mechanism of batteries during charging and *** this minireview,the latest progress of in-situ observation of the NCM cathode by X-ray diffraction(XRD),fourier transform infrared(FT-IR)spectroscopy,Raman spectroscopy,atomic force microscopy(AFM),transmission electron microscope(TEM),optical microscope,and other characterization tools is *** mechanisms of structural degradation,cathode-electrolyte interfaces(CEIs)composition,and dynamic changes of NCM,electrolyte breakdown,and gas production are ***,based on the existing research progress,the opportunities and challenges for future in-situ characterization technology in the study of the mechanism of LMBs are discussed in ***,the purpose of this minireview is to summarize recent work that focuses on the outstanding application of in-situ characterization techniques in the mechanistic study of LMBs,and pointing the way to the future development of high energy density and power density LMBs systems.

关键词： lithium metal batteries(LMBs) In-situ characterization LiNi_(1-x-y)Co_(x)Mn_(y)O_(2)(NCM)

Incidence,predictors,and prognosis of thrombocytopenia among patients undergoing intra-aortic balloon pumping in the intensive care unit:a propensity score analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2021年第2期18卷 123-134,I0002页

作者： Wei TONG jun-mei wang Jia-Yue LI Pei-Yao LI Yun-Dai CHEN Zheng-Bo ZHANG Wei DONG Department of Cardiology the Sixth Medical CentreChinese PLA General HospitalBeijingChina Center for Artificial Intelligence in Medicine Chinese PLA General HospitalBeijingChina CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of SciencesChina National Center for BioinformationBeijingChina Global Health Drug Discovery Institute BeijingChina

OBJECTIVE To explore the incidence,predictors,and prognosis of intra-aortic balloon pumping(IABP)-related thrombocytopenia in critically ill *** This multi-center study used the eICU Collaborative Research Database V1.2,comprising data on>130,000 patients from multiple intensive care units(ICUs)in America between 2014 and 2015.A total of 710 patients undergoing IABP were *** was defined as a drop in platelet count>50%from *** the cohort,167 patients who developed thrombocytopenia were matched 1:1 with 167 patients who did not,after propensity score(PS)*** associations between IABP-related thrombocytopenia and clinical outcomes were examined by multivariable logistic *** Among 710 patients undergoing IABP,249 patients(35.07%)developed *** APACHE IVa score was a predictor of thrombocytopenia[adjusted odds ratio(OR)=1.09,95%confidence interval(CI):1.02−1.15].After 1:1 PS matching,in-hospital mortality(adjusted OR=0.76,95%CI:0.37−1.56)and in-ICU mortality(adjusted OR=0.74,95%CI:0.34−1.63)were similar between the thrombocytopenia and non-thrombocytopenia ***,major bleeding occurred more frequently in the thrombocytopenia group(adjusted OR=2.54,95%CI:1.54−4.17).In-hospital length of stay(LOS)and in-ICU LOS were significantly longer in patients who developed thrombocytopenia than in those who did not(9.71 vs.7.36,P<0.001;5.13 vs.2.83,P<0.001).CONCLUSIONS Among patients undergoing IABP in the ICUs,thrombocytopenia was not associated with a difference in inhospital mortality or in-ICU mortality;however,thrombocytopenia was significantly associated with a greater risk of major bleeding and increased in-ICU and in-hospital LOS.

关键词： patients balloon thrombocytopenia

Reinforcement of High Impact Polystyrene by Aramid Nanoparticle Fillers Prepared via an In situ Bottom-up Approach

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第8期42卷 1167-1176页

作者： Xiang-jun Gong Zhi-Ping Zhao Chang-mei Sun Ying Zhang Rong-jun Qu Ying wang School of Chemistry and Materials Science Ludong UniversityYantai 264025China

In this work,aramid nanoparticles(ANPs)were prepared in dimethyl formamide(DMF)solution containing high impact polystyrene(HIPS)via a bottom-up *** electron microscopy(TEM)images showed that the obtained ANPs were evenly distributed in the HIPS matrix without any *** composition of the ANPs,i.e.,poly(p-phenyl-p-phenylenediamine)(PPTA),was confirmed by Fourier transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS)and X-ray diffractometer(XRD).The ANP/HIPS composites,obtained after ethanol precipitation,were added to neat HIPS as fillers to fabricate ANP/HIPS composite *** surface roughness and the glass transition temperature(T_g)of the sheets were characterized by atomic force microscope(AFM)and differential scanning calorimetry(DSC),*** with neat HIPS,the mechanical properties of the composite sheet were significantly improved,and the Young's modulus increased from 246.55 MPa to 2025.12 MPa,the tensile strength increased from 3.07 MPa to 29.76 MPa,and the toughness increased from 0.32 N/mm^2 to 3.92 N/mm^2,with an increase rate of 721%,869%and 1125%,***,the thermal stability of the composites improved with the increase in ANP content.

关键词： High impact polystyrene PPTA nanoparticle Reinforce Mechanical property

A Comparison of Three Heuristic Algorithms for Molecular Docking

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1999年第7期10卷 615-618页

作者： Ting jun HOU jun mei wang Xiao Jie XU(Department of Chemistry. Beida-Jiuyuan Molecular Design Laboratory. Peking University.Beijing 100871) Department of Chemistry Beida-Jiuyuan Molec. Des. Laboratory Peking University Beijing 100871 China

Three heuristic algorithms: simulated annealing, genetic algorithm, and Tabu search were compared to molecular docking procedure using 3 protein-ligand systems. Statistical analysis of the results indicated that the Tabu search showed the best performance in terms of locating solutions close to the crystallographic ligand conformation. From the comparisons, a hybrid search algorithm was proposed, which gave superior results compared with any one of the algorithms alone.

关键词： molecular docking genetic algorithm tabu search simulated annealing

Application of Genetic Algorithm to the QSAR Research of Pyrrolobenzothiazepinones and Pyrrolobenzoxazepinones-Novel and Specific Non-Nucleoside HIV-1 Reverse Transcription Inhibitors

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1998年第7期9卷 651-654页

作者： Ting jun HOU jun mei wang You Yong LI Xiao Jie XU(Chemistry department, Beida-Jiuyuan Molecular Design Laboratory, Peking University,Beijing 100871) Chemistry Department Beida-Jiuyuan Molec. Des. Laboratory Peking University Beijing 100871 China

Genetic Algorithm (GA) was used to study the quantitative structural parameters and activity relationship of pyrrolobenzothizepinones and pyrrolobenzoxazepinones's inhibitory activities with non-nucleoside HIV-1 reverse transcriptase (RT). A group of linear polynomial models with good relationship have been built to get some useful information that other methods can not offer.

关键词： QSAR GA(genetic algorithm) HIV

Glycated albumin as a biomarker for diagnosis of diabetes mellitus:A systematic review and meta-analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第31期9卷 9520-9534页

作者： Jia-Yao Xiong jun-mei wang Xiao-Lan Zhao Chao Yang Xian-Shu Jiang Yan-mei Chen Chang-Qin Chen Zhi-Yong Li Department of Endocrinology Yongchuan Hospital of Chongqing Medical UniversityChongqing 402160China

BACKGROUND Glycated albumin(GA),the non-enzymatic glycation product of albumin in plasma,became a glycemic marker in the beginning of the 21st *** assay is not affected by hemoglobin levels and reflects the glycemic status over a shorter period as compared to HbA1c ***,GA may contributes as an intermediate glucose index in the current diabetes mellitus(DM)diagnostic *** To search and summarize the available data on glycated albumin measurements required for the diagnosis of diabetes *** Databases,including PubMed,Embase,Web of Science,and Cochrane Central Register of Controlled Trials(CENTRAL),among others,were systematically *** Quality Assessment of Diagnostic Accuracy Studies-2 tool was applied for the assessment of quality,and the bivariate model was used to pool the sensitivity and *** hierarchical summary receiver operator characteristic curves(HSROC)model was utilized to estimate the summary receiver operating characteristics curve(SROC).Sensitivity analysis was performed to investigate the association of the study design and patient characteristics with the test accuracy and meta-regression to find the source of *** Three studies regarding gestational diabetes mellitus(GDM)and a meta-analysis of 16 non-GDM studies,comprising a total sample size of 12876,were included in the *** reveal that the average cut-off values of GA reported for the diagnosis of GDM diagnosis was much lower than those for *** non-GDM cases,diagnosing DM with a circulating GA cut-off of 14.0%had a sensitivity of 0.766(95%CI:0.539,0.901),specificity of 0.687(95%CI:0.364,0.894),and area under the curve of 0.80(95%CI:0.76,0.83)for the *** estimated SROC at different GA cut-off values for non-GDM exhibited that the average location parameter lambda of 16 non-GDM studies was 2.354(95%CI:2.002,2.707),and the scale parameter beta was-0.163(95%CI:-0.614,0.288).These non-GDM studies with variou

关键词： Glycated albumin Diabetes mellitus Diagnosis Sensitivity and Specificity Systematic review Meta-analysis

Outcomes of endoscopic sclerotherapy for jejunal varices at the site of choledochojejunostomy (with video): Three case reports

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第14期30卷 2059-2067页

作者： jun Liu Peng wang Li-mei wang Jing Guo Ning Zhong Department of Gastroenterology Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Hemorrhage associated with varices at the site of choledochojejunostomy is an unusual,difficult to treat,and often fatal manifestation of portal *** far,no treatment guidelines have been *** SUMMARY We reported three patients with jejunal varices at the site of choledochojejun-ostomy managed by endoscopic sclerotherapy with lauromacrogol/α-butyl cyanoacrylate injection at our institution between june 2021 and August *** reviewed all patient records,clinical presentation,endoscopic findings and treatment,outcomes and *** patients who underwent pancre-aticoduodenectomy with a Whipple anastomosis were examined using conven-tional upper gastrointestinal endoscopy for suspected hemorrhage from the afferent jejunal *** with stigmata of recent hemorrhage or active he-morrhage were observed around the choledochojejunostomy site in all three *** injection of lauromacrogol/α-butyl cyanoacrylate was carried out at jejunal varices for all three *** bleeding ceased and patency was observed for 26 and 2 months in two *** one patient with multiorgan failure and internal environment disturbance,rebleeding occurred 1 month after endoscopic sclerotherapy,and despite a second endoscopic sclero-therapy,repeated episodes of bleeding and multiorgan failure resulted in eventual *** We conclude that endoscopic sclerotherapy with lauromacrogol/α-butyl cyanoac-rylate injection can be an easy,effective,safe and low-cost treatment option for jejunal varicose bleeding at the site of choledochojejunostomy.

关键词： Endoscopic sclerotherapy Jejunal varices Choledochojejunostomy Portal vein hypertension Case report