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Effect of Jianpi Bushen formula for colon cancer patients who underwent adjuvant chemotherapy:Statistical analysis plan for a multicenter trial

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 58-63页

作者： Ruiming Zhao Huijuan Cao Lingyun Sun Tong Zhang Yun Xu Shaohua Yan jun mao Jianping Liu Yutong Fei Yufei Yang Graduate School Beijing University of Chinese MedicineBeijing 100029China Centre for Evidence-Based Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China Department of Oncology Xiyuan Hospital of China Academy of Chinese Medicine SciencesBeijing 100091China Integrative Medicine Service Memorial Sloan Kettering Cancer CenterNew York 10041USA

Background:Patients with colon cancer who receive chemotherapy usually experience various gastrointestinal adverse reactions,including nausea,vomiting,and diarrhea,which make it challenging for them to adhere to treatment.As an effective traditional Chinese medicine,the Jianpi Bushen formula has been widely used to alleviate the side effects of chemotherapy.Objective:To evaluate the efficacy and safety of Jianpi Bushen formulae for patients who undergo chemotherapy.This statistical analysis plan(SAP)is intended to enhance the transparency and research quality of our randomized controlled trial.Methods:Our study is a multicenter,double-blind,randomized controlled clinical trial.This trial aimed to compare the completion rate of chemotherapy in colon cancer patients who are using and not using Jianpi Bushen formula.To attenuate possible selection bias in the final report,we declared the overall trial design,outcome measures,subgroup analyses,and safety measures.Also,we described the data management and statistical analysis methods in detail.Conclusion:The SAP provides more detailed information than the trial protocol for data management and statistical analysis methods.Further post-hoc analyses can be performed by referring to the SAP,and possible selection bias can be attenuated.

关键词： Statistical analysis plan Colon cancer Chemotherapy Randomized controlled trial Traditional Chinese medicine Capecitabine Oxaliplatin Treatment duration

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SYNTHESIS AND PROPERTIES OF BIFUNCTIONAL MAGNETIC-OPTICAL NANOMATERIALS:Fe_2O_3@PDMAEMA-CAPPED Ⅱ－Ⅵ SEMICONDUCTOR QUANTUM DOTS NANOCOMPOSITES

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Chinese Journal of Polymer Science 2013年第9期31卷 1233-1241页

作者： Na-na Zhao Wei Nie jun mao Wei-cai Wang Xiang-ling Ji State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences

A facile route to synthesize a new type of multifunctional nanocomposites is reported. Here, PDMAEMA （poly[2- （dimethylamino）ethyl] methacrylate） is a key macromolecule serving as a bridge between magnetic FeaO3 nanoparticles and luminescent quantum dots. Both Fe203 nanoparticles and II-VI semiconductor quantum dots with a narrow size distribution are synthesized through a two-phase thermal approach. Subsequently, the atom transfer radical polymerization （ATRP） technique was applied to prepare magnetic Fe203@PDMAEMA core-shell nanoparticles. The thickness of PDMAEMA shell can be easily controlled by adjusting the reaction time. Finally, the ligand exchange method was exploited to modify II-VI quantum dot with amine-containing polymer of PDMAEMA, which led to quantum dot securely bound by Fe203@PDMAEMA core-shell nanoparticle to form a multifunctional nanocomposite. The resulting nanocomposite remains variable emission by tuning the II-VI semiconductor type and particle size and shows/arc at 49 kA/m and Tb at 16 K from Fe2O3 nanoparticles. The self-assembled behavior for the resulting samples is also discussed.

关键词： Bifunctional nanocomposite Magnetic-optical PDMAEMA Semiconductor ATRP Two-phase method.

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Status quo and prospect of the development for underground coal mine refuge chamber

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Journal of Coal Science & Engineering(China) 2013年第1期19卷 38-45页

作者： Ming-bo PIAO jun mao Tie-jun WANG School of Mechanical Engineering Liaoning Technical University Fuxin 123000 China Coal Production Department Shenhua Group Corporation Limited Beijing 100011 China

As one form of the energy resources, coal is becoming more and more important. Due to the particularity in coal mine production, mine accidents some time occur in countries all over the world, which result in large casualties and economic losses. As equipment that can provides the miners with an emergency shelter when the coal mine accidents occur, the underground coal mine refuge chamber is paid more and more attention by coal mine enterprises, and the application of the refuge chamber is increasingly widespread. The general functions, the classification, and the successful applications of the underground coal mine refuge chamber are illustrated first, and the research significance on the underground coal mine refuge chamber is stated. Following, the development status quo at home and abroad for the refuge chamber is introduced. Then, the implementation methods for the key functions of the underground coal mine refuge chamber are demonstrated. Finally, the prospect for the development of the underground coal mine refuge chamber is stated.

关键词：煤矿井下发展前景硐室事故发生能量资源煤矿生产经济损失人员伤亡

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Realizing n-type CdSb with promising thermoelectric performance

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Journal of Materials Science & Technology 2023年第13期144卷 54-61页

作者： Peng Zhao Honghao Yao Shizhen Zhi Xiaojing Ma Zuoxu Wu Yijie Liu Xinyu Wang Li Yin Zongwei Zhang Shuaihang Hou Xiaodong Wang Siliang Chen Chen Chen Xi Lin Haoliang Liu Xingjun Liu Feng Cao Qian Zhang jun mao School of Materials Science and Engineering and Institute of Materials Genome&Big DataHarbin Institute of Technology(Shenzhen)Shenzhen 518055China School of Science Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

Realizing high performance in both n-type and p-type materials is essential for designing efficient ther-moelectric devices.However,the doping bottleneck is often encountered,i.e.,only one type of conduction can be realized.As one example,p-type CdSb with high thermoelectric performance has been discovered for several decades,while its n-type counterpart has rarely been reported.In this work,the calculated band structure of CdSb demonstrates that the valley degeneracy is as large as ten for the conduction band,and it is only two for the valence band.Therefore,the n-type CdSb can potentially realize an ex-ceptional thermoelectric performance.Experimentally,the n-type conduction has been successfully real-ized by tuning the stoichiometry of CdSb.By further doping indium at the Cd site,an improved room-temperature electron concentration has been achieved.Band modeling predicts an optimal electron con-centration of∼2.0×1019 cm−3,which is higher than the current experimental values.Therefore,future optimization of the n-type CdSb should mainly focus on identifying practical approaches to optimize the electron concentration.

关键词： Thermoelectric materials n-type CdSb Indium doping Band degeneracy

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DIVERGENT EFFECT OF EXPECTANCY ON TREATMENT RESPONSE BETWEEN REAL AND SHAM ACUPUNCTURE

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Journal of Integrative Medicine 2014年第3期 223-224页

作者： jun mao Perelman School of Medicine at University of Pennsylvania

Background: Expectancy has been hypothesized as a critical component of the placebo response; however, change in expectancy during acupuncture trials has not been previously evaluated.We sought to evaluate the relationship between expectancy and treatment response in both real and sham acupuncture.Methods: We analyzed data from a recently completed randomized controlled trial using real electroacupuncture(EA) and sham acupuncture(SA).The trial was conducted among 67 women with stage I-III breast cancer who experienced joint pain attributable to aromatase inhibitors.Responders were classified as those who reported "much improved" or "very much improved" on the Patient Global Impression of Change instrument at week 8(End of intervention).The Acupuncture Expectancy Scale(AES), a validated instrument, measured expectancy at baseline, week 2, 4, and 8.In this scale, a higher score indicates a greater degree of expectancy.Results: Responders in the SA group had higher expectancy at baseline than non-responders(15.5 vs.12.1, P=0.005).Expectancy remained higher in SA responders through the end of intervention(16.0 vs.11.4, P=0.035).Responders and non-responders in the EA group, by contrast, did not have different expectancy levels at baseline(14.8 vs.15.3, P=0.64).By the end of the intervention, however, EA responders had significantly higher expectancy than non-responders(16.2 vs.11.7, P=0.0038).Conclusion: The relationship between expectancy and treatment response is distinct between real and sham acupuncture.Our findings suggest that while higher outcome expectancy predicts treatment response in sham acupuncture, such a predisposition is not associated with the response to electro-acupuncture.Once patients develop a response to real acupuncture, their expectancy rises significantly.These findings have important implications for both acupuncture research and clinical practice.

关键词： SA DIVERGENT EFFECT OF EXPECTANCY ON TREATMENT RESPONSE BETWEEN REAL AND SHAM ACUPUNCTURE

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A RANDOMIZED TRIAL OF ELECTROACUPUNCTURE FOR FATIGUE, SLEEP, AND PSYCHOLOGICAL DISTRESS IN BREAST CANCER PATIENTS WITH AROMATASE INHIBITOR-RELATED ARTHRALGIA

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Journal of Integrative Medicine 2014年第3期 296-297页

作者： jun mao Perelman School of Medicine at University of Pennsylvania

Background: While fatigue, sleep disturbance, depression and anxiety are associated with pain in breast cancer patients, it is unknown if acupuncture can decrease these co-morbid symptoms in cancer patients with pain.This study aimed at evaluating the effects of electroacupuncture(EA) on fatigue, sleep and psychological distress in breast cancer survivors who experience joint pain related to aromatase inhibitors(AIs).Methods: We performed a randomized controlled trial of an eight-week EA as compared to waitlist control(WLC) and sham acupuncture(SA) in postmenopausal women with breast cancer who self-reported joint pain attributable to AIs.Acupuncturists performed 10 EA/SA treatments over eight weeks using a manual protocol with 2 Hz electro-stimulation delivered by a TENS unit.Acupuncturists administered SA using Streitberger(nonpenetrating) needles at non-acupuncture points without electrostimulation.Fatigue, sleep disturbance, anxiety and depression were measured by the Brief Fatigue Inventory(BFI), Pittsburgh Sleep Quality Index(PSQI), and Hospital Anxiety and Depression Scale(HADS).The effects of EA and SA vs.WLC on these outcomes were evaluated using mixed-effects models.Results: Of the 67 randomly assigned patients, baseline paininterference was associated with fatigue(Pearson correlation coefficient r=0.75, P<0.001), sleep(r=0.38, P=0.002 6), and depression(r=0.58, P<0.001).Compared to the WLC, EA produced significant improvement in fatigue(P=0.009 5), anxiety(P=0.044), and depression(P=0.015) and marginal improvement in sleep(P=0.058) during the 12-week intervention and followup period.In contrast, SA only produced significant improvement in depression compared with WLC(P=0.008 8).Conclusion: Among women who experienced AI-related arthralgia, EA produced significant improvement in fatigue, anxiety and depression, while SA improved only depression.These findings provide initial evidence to suggest that EA may reduce pain-related symptom clusters in breast cancer survivors.

关键词： WLC SLEEP AND PSYCHOLOGICAL DISTRESS IN BREAST CANCER PATIENTS WITH AROMATASE INHIBITOR-RELATED ARTHRALGIA SA A RANDOMIZED TRIAL OF ELECTROACUPUNCTURE FOR FATIGUE

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课程思政与心理健康教育下的中学体育与健康教学创新实践研究

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体育科技文献通报 2024年第6期32卷 172-174页

作者：徐良毛军安徽省蚌埠第五中学安徽蚌埠233000 蚌埠市龙子湖实验学校安徽蚌埠233000

本文采用文献资料法、归纳总结法等研究方法,在分析中学体育与健康教学现状的基础上,探讨了以课程思政与心理健康教育为导向的中学体育与健康教学创新实践的意义,并提出了相应的创新实践路径,旨在提升中学生的身心素质,促进中学生的全... 详细信息

本文采用文献资料法、归纳总结法等研究方法,在分析中学体育与健康教学现状的基础上,探讨了以课程思政与心理健康教育为导向的中学体育与健康教学创新实践的意义,并提出了相应的创新实践路径,旨在提升中学生的身心素质,促进中学生的全面发展,提高中学体育与健康教学的效果。

关键词：课程思政心理健康教育中学体育与健康

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基于U型线圈的弹链信息交联信号获取方法

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兵器装备工程学报 2024年第1期45卷 305-310页

作者：张南符超群毛俊王秋生西安机电信息技术研究所西安710065

弹链运动轨迹中感应装定引信无法穿过圆形结构的装定线圈、随着引信数据量增大,用于信息感应装定的窗口在装定时间不变的情况下就显得仓促、甚至不足以满足现状。另外装定的操作程序复杂导致反应时间过长。针对这些问题,提出了基于U型... 详细信息

弹链运动轨迹中感应装定引信无法穿过圆形结构的装定线圈、随着引信数据量增大,用于信息感应装定的窗口在装定时间不变的情况下就显得仓促、甚至不足以满足现状。另外装定的操作程序复杂导致反应时间过长。针对这些问题,提出了基于U型线圈感应装定装置的弹链信息交联信号获取方法。该方法利用U型线圈磁力线的垂直方向与引信的水平方向运动路径有效交集,分析了感应窗口内的磁场均匀性、信号波形的幅度余量和空间的特征,通过调整复杂的发射线圈形状,采用多匝、多组线圈,组合发送信号;增大线圈的发射空间获取最大感应信号,从而改变了接收线圈上感应信号电压曲线的混合叠加形状。研究结果表明:通过线圈的U型结构变化,极大改善了线圈的耦合效果,U型线圈形成的有限感应装定空间最大幅度变化在±20%、达到均匀一致性,装定窗口明显增大到[±10 mm,±10 mm,±5 mm];感应装定时间余量满足±20%变化。数据量在1 s内达到4 k字节;U型的发射线圈满足弹链上引信的特殊运动轨迹,U型的装定电压门限设置为14V,发射线圈产生的更大的装定窗口。

关键词：信息交联感应装定能量传输

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煤矿智能快速掘进关键技术研究现状及展望

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煤炭学报 2024年第2期49卷 1214-1229页

作者：毛君杨润坤谢苗卢进南王贺刘治翔王帅辽宁工程技术大学机械工程学院辽宁阜新123000

针对煤矿巷道掘进智能化建设情况,探讨了现阶段分别以连采机、掘锚一体机、全断面掘进系统、掘锚机为核心的四大类智能快速掘进成套装备发展现状,分析了四大类智能快掘装备与地质条件适用性,提出了实现煤矿智能化掘进需要解决的关键技... 详细信息

针对煤矿巷道掘进智能化建设情况,探讨了现阶段分别以连采机、掘锚一体机、全断面掘进系统、掘锚机为核心的四大类智能快速掘进成套装备发展现状,分析了四大类智能快掘装备与地质条件适用性,提出了实现煤矿智能化掘进需要解决的关键技术的问题,探讨了以信息传输与智能分析技术、智能感知技术、精确定位导航技术,自主定型定向截割技术、掘进机远程自主截割控制技术以及多级多工序智能协同控制技术为基础的智能化掘进实现途径;基于复杂地质条件下煤矿巷道掘进亟待解决的关键问题,提出了以掘进作业功能需求、掘进工艺要求为依据的系统化分析、模块化设计、功能优化组合的设计方法;研究了以虚控实、虚实结合的多级数字孪生构架,基于掘进巷道设备、环境、地质构造多维信息再现实现掘进机远程控制;提出了单机智能化、系统协同化、井下智控与地面远程监控相协同的控制方法。开发了新型的无重复碾压柔性超前支护技术、截割部多级伸缩截割技术、智能锚固机组多钻机并行作业等技术,研制了具有掘、支、锚、运、探多工序并行作业的新型快速掘进作业联合机组,提出了掘进机器人、超前支护机器人、锚固机器人、辅助运输机器人组柔性并行作业技术;提出了基于数据驱动的多机多工序协同控制行为规划决策方法。提出构建完整的煤矿井下跨系统全时空信息数字感知体系,构建集井下现场生产状态、掘进巷道空间信息、掘进装备状态、风险信息等多参量、多尺度、全时空特性的数据感知智能化监控平台,实现虚拟系统与实际掘进系统实时通信,通过数据驱动规划分析实现智能化、少人化掘进。

关键词：智能掘进自主定性定向截割柔性并行作业多级多工序协同控制数字孪生

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黄芩素调控NLRP3炎性小体对痤疮的保护作用

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中国临床药理学杂志 2024年第7期40卷 1039-1043页

作者：毛俊涛徐丽梅曹牧薛慧河北省中医院医疗美容科河北石家庄050011 河北中医学院护理学院河北石家庄050011

目的探究黄芩素调控NOD样受体热蛋白结构域相关蛋白3(NLRP3)炎性小体对痤疮的保护机制。方法用耳郭皮内注射痤疮丙酸杆菌菌液制备复合痤疮模型。将大鼠随机分为对照组(正常大鼠灌胃0.9%NaCl)模型组(痤疮模型大鼠灌胃0.9%NaCl),低、中、... 详细信息

目的探究黄芩素调控NOD样受体热蛋白结构域相关蛋白3(NLRP3)炎性小体对痤疮的保护机制。方法用耳郭皮内注射痤疮丙酸杆菌菌液制备复合痤疮模型。将大鼠随机分为对照组(正常大鼠灌胃0.9%NaCl)模型组(痤疮模型大鼠灌胃0.9%NaCl),低、中、高剂量实验组(痤疮模型大鼠分别灌胃25、50和100mg·kg^(-1)的黄芩素),阳性对照组(痤疮模型大鼠灌胃3.125mg·kg^(-1)异维A酸),每组10只。观察大鼠耳郭形态,用酶联免疫吸附试验法检测血清中炎症水平,用苏木精-伊红染色检测大鼠耳郭组织病理学变化,用蛋白质印迹法检测耳郭组织蛋白表达水平。结果药物处理后,对照组、模型组、高剂量实验组和阳性对照组的耳郭厚度分别为(0.42±0.05)、(0.75±0.10)、(0.49±0.05)和(0.50±0.05)mm,血清中肿瘤坏死因子-α含量分别为(20.46±2.13)、(62.32±5.47)、(23.27±2.26)和(25.41±2.28)pg·mL^(-1),白细胞介素-1β含量分别为(11.38±1.26)、(31.62±2.58)、(15.61±1.35)和(16.72±1.38)pg·mL^(-1),白细胞介素-6含量分别为(10.62±1.02)、(25.43±2.51)、(13.27±1.15)和(14.01±1.17)pg·mL^(-1),耳郭组织中NLRP3蛋白相对表达水平分别为0.23±0.03、0.81±0.08、0.30±0.04和0.32±0.04,半胱氨酸蛋白酶-1蛋白相对表达水平分别为0.31±0.04、0.76±0.08、0.39±0.04和0.41±0.04,基质金属蛋白酶-2蛋白相对表达水平分别为0.35±0.04、0.86±0.***.0.40±0.05和0.42±0.05。高剂量实验组的上述指标与模型组比较,在统计学上差异均有统计学意义(均P<0.05)。结论黄芩素可抑制痤疮大鼠炎症反应,其作用机制可能与抑制NLRP3炎性小体信号通路相关。

关键词：黄芩素痤疮 NOD样受体热蛋白结构域相关蛋白3炎性小体炎症反应基质金属蛋白酶-2蛋白

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