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Mechanical and biological properties of Ti–(0–25 wt%)Nb alloys for biomedical implants application

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Regenerative Biomaterials 2020年第1期7卷 119-127页

作者： Yuqing Zhang Danni Sun jun Cheng James kit Hon Tsoi Jiang Chen School and Hospital of Stomatology Fujian Medical UniversityFuzhou 350002FujianChina Stomatological Key Laboratory of Fujian College and University Fujian Medical UniversityFuzhou 350002FujianChina Faculty of Dentistry Dental Materials ScienceDivision of Applied Oral Sciences and Community Dental CareThe University of Hong KongHong Kong SARChina Shaanxi Key Laboratory of Biomedical Metal Materials Northwest Institute for Non-ferrous Metal ResearchXi’an 710016ShaanxiChina

Binary titanium–niobium(Ti–Nb)alloys have recently been attracted due to low Young’s moduli and non-toxic *** study explores the influence of low Nb content(0–25 wt%)on the comprehensive parameters of tensile stress–strain relationships(ultimate strength(rUTS),yield strength(r0.2)and elastic modulus(E)),surfaces properties(Vickers microhardness,surface roughness(Ra),water contact angle(WCA),X-ray diffraction(XRD)and scanning electron microscopy(SEM)),corrosion resistance(in artificial saliva and lactic acid)and biological properties(cytotoxicity and alkaline phosphatase activity of MC3T3-E1 pre-osteoblasts)of Ti–xNb alloys(x紏5,10,15,20 and 25 wt%),with using commercially pure grade 2 titanium(cp-Ti)as *** results shown that all the Ti–xNb alloys comprised atb Ti alloy phases,such that the b phase increased correspondingly with the increased amount of Nb in the alloy,as well as the reduction of E(69–87 GPa).Except Ti–5Nb,all other Ti–xNb alloys showed a significantly higher hardness,increased rUTS and r0.2,and decreased WCA compared with *** corrosion was detected on Ti–xNb alloys and cp-Ti in artificial saliva and lactic acid *** cytotoxicity of Ti–xNb alloys was comparable to that of cp-Ti in MC3T3-E1 pre-osteoblasts without interference from differentiation behaviour,but the proliferation rate of the Ti–5Nb alloy was lower than other *** overall,binary Ti–(10–25 wt%)Nb alloys are promising candidate for orthopaedic and dental implants due to their improved mechanical properties and comparable biological performance,while Ti–5Nb should be used with caution.

关键词： biomaterial titanium-niobium binary titanium alloys low Young’s modulus biocompatibility

Is the advantage of coronary bypass graft surgery over percutaneous coronary intervention in diabetic patients with severe multivessel disease influenced by the status of insulin requirement？

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Journal of Geriatric Cardiology 2014年第1期11卷 83-89页

作者： Beom jun Lee Peter Herbison Cheuk-kit Wong Department of Cardiology Dunedin School of Medicine University of Otago Dunedin Public Hospital Dunedin New Zealand Department Preventive and Social Medicine Dunedin School of Medicine University of Otago Dunedin New Zealand

Several studies have shown that coronary artery bypass graft surgery （CABG） is superior to percutaneous coronary intervention （PCI） in patients with diabetes and multi-vessel disease. Whether this advantage of CABG over PCI is confined to diabetics who require insulin is unknown. We review the published literature comparing CABG with PCI in diabetics including 8 cohorts and 4,786 patients. There was a lower rate for all-cause mortality （Relative risk （RR）： 0.78, 95% confidence interval （CI）： 0.62-0.99）, and for major adverse cardiac and cerebrovascular events （MACCE, RR： 0.59, 95% CI： 0.47-0.75） for CABG compared to PCI. Composite outcome of mortality, myocardial infarction and stoke was similar between CABG and PCI （RR： 0.87, 95% CI： 0.54-1.42）. Visual inspection of the forest plots showed that in most analyses, the point estimates of the RR are similar between the insulin requiring group and non-insulin requiring group. On meta-regression, there was no interaction between status of insulin requirement and revascularization strategies （P 〉 0.05 for all）. The pre- sented data on the still unpublished analysis of the FREEDOM trial showed similar results. Thus, in the current era, CABG is superior to PCI with lower mortality and MACCE rates, but the state of insulin requirement had no effect on the outcomes from the two revascularization strategies.

关键词： Percutaneous coronary intervention Coronary artery bypass graft surgery Diabetes mellims Insulin Multivessel disease

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OFDMA干扰信道资源分布式自优化算法

天津大学学报（自然科学与工程技术版） 2012年第7期45卷 647-650页

作者：任杰侯建军 wong kai-kit 北京交通大学电子信息工程学院北京100044 伦敦大学学院电子工程系

针对多用户正交频分多址(orthogonal frequency division multiple access,OFDMA)干扰信道自优化问题,研究其功率和信道资源分配策略,提出了一种新的分布式的资源优化分配算法.各用户只需要知道自己的信道状态信息就可以通过迭代注水的... 详细信息

针对多用户正交频分多址(orthogonal frequency division multiple access,OFDMA)干扰信道自优化问题,研究其功率和信道资源分配策略,提出了一种新的分布式的资源优化分配算法.各用户只需要知道自己的信道状态信息就可以通过迭代注水的方式对系统资源进行合理分配,实现速率最大化.通过对注水算法增加干扰强度限制条件的方法,优化资源配置,提高系统的效率,并用线性规划理论将其实现.仿真结果表明,该算法在性能上比纳什博弈算法有很大的提高.

关键词：正交频分多址注水算法线性规划

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美国结合医学临床在全科医学领域的发展

中国中西医结合杂志 2015年第4期35卷 394-400页

作者：张卫军许家杰洛杉矶加州大学东西医学中心美国90024

近20年来,美国结合医学临床、科研和教学均得到迅猛发展。民众的热情要求西医师能够了解互补替代医学(complementary and alternative medicine,CAM)的安全性和有效性,并能够提供临床咨询。美国的全科医学,尤其是家庭科,是最早接纳结合... 详细信息

近20年来,美国结合医学临床、科研和教学均得到迅猛发展。民众的热情要求西医师能够了解互补替代医学(complementary and alternative medicine,CAM)的安全性和有效性,并能够提供临床咨询。美国的全科医学,尤其是家庭科,是最早接纳结合医学的专业学科,因为两者诊治的疾病谱存在交叉和重叠,也强调基本相同的核心价值,如以患者为中心、循证医疗、治疗的主动性及连续性。随着结合医学全科医师项目的发展,全科医学的教育人员试图通过加入结合医学的核心要素来提高全科医学的学科能力和建设,如发展出培训课程设计指南和需掌握结合医学核心的可测量的能力指标。当前全美有超过40个全科医学项目宣称其加入CAM和结合医学的内容,同时各结合医学中心根据自己的特点也发展了具有不同特色的全科医师项目。这种以西医师为主体的结合医学从业人员结构与中国的中西医结合医学初创时相似。时值中国在强调基层西医学习中医项目之际,希望本文能提供一定的借鉴。

关键词：全科医学结合医学互补替代医学中医医疗改革

创新的临床科学研究推动全球化背景下的中医发展

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中国中西医结合杂志 2010年第8期30卷 789-792页

作者：许家杰张卫军洛杉矶加州大学东西医学中心

传统医学在中国包括传统中医学以及少数民族医药如蒙医、藏医、苗医等;在美国包括传统中医学、印度医学、阿拉伯医学、本土印地安土著医学等等,又被称为互补替代医学（CAM）。传统医学与当地的文化、社会和历史密切相关;同时,因为传统,... 详细信息

传统医学在中国包括传统中医学以及少数民族医药如蒙医、藏医、苗医等;在美国包括传统中医学、印度医学、阿拉伯医学、本土印地安土著医学等等,又被称为互补替代医学（CAM）。传统医学与当地的文化、社会和历史密切相关;同时,因为传统,所以往往存在与现代医学不一致的概念。

关键词：传统中医学科学研究全球化临床少数民族医药传统医学阿拉伯医学印度医学

中国有可能建立更完善的卫生保健实施系统——中西医结合实施系统

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中国中西医结合杂志 2011年第1期31卷 107-110页

作者：许家杰张卫军美国洛杉矶加州大学东西医学中心美国90024

中美两国的医疗改革均以扩大医药保障体系,达到更广泛的覆盖率以及降低医药服务的成本和提高医疗服务的质量和效率为目标。尽管国情不同,但两国医疗改革的具体措施可以相互借鉴。本文从当前美国医疗系统的两大弊端——失败的慢性病系统... 详细信息

中美两国的医疗改革均以扩大医药保障体系,达到更广泛的覆盖率以及降低医药服务的成本和提高医疗服务的质量和效率为目标。尽管国情不同,但两国医疗改革的具体措施可以相互借鉴。本文从当前美国医疗系统的两大弊端——失败的慢性病系统管理和效率低下的初级卫生保健系统入手,讨论美国医疗改革中采取的解决方案以及结合医学在医疗改革中所能起到的作用;根据我们对双方医疗系统和结合医学的了解,结合中国目前医疗改革中中医参与的相关措施,认为如果这些措施能确切实行,有效借鉴部分美国医疗改革中采取的措施,加上中国中西医结合的固有特色,中国的医疗系统可能成为更完善的医疗实施系统。

关键词：医疗改革医疗费用慢性病管理初级卫生保健结合医学

Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries

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Cellular & Molecular Immunology 2017年第3期14卷 308-318页

作者： Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu kit S Lam Jin jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung School of Life Sciences The Chinese University of Hong Kong Shatin N.T. Hong Kong SAR China Department of Pediatrics and Adolescent Medicine Queen Mary Hospital The University of Heng Kong Pokfulam Hong Kong SAR China Department of Biochemistry and Molecular Medicine University of California Davis CA 95616 USA Division of Rheumatology/Allergy School of Medicine University of California Davis CA 95616 USA

The one-bead-one-compound （OBOC） combinatorial peptide library is a powerful tool to identify ligand and receptor interactions. Here, we applied the OBOC library technology to identify mimotopes specific to the immunoglobulin E （IgE） epitopes of the major shellfish allergen tropomyosin. OBOC peptide libraries with 8-12 amino acid residues were screened with serum samples from patients with shellfish allergy for IgE mimotopes of tropomyosin. Twenty-five mimotopes were identified from the screening and their binding reactivity to tropomyosin-specific IgE was confirmed by peptide ELISA. These mimotopes could be divided into seven clusters based on sequence homology, and epitope mapping by EpiSearch of the clustered mimotopes was performed to characterize and confirm the validity of mimotopes. Five out of six of the predicted epitopes were found to overlap with previously identified epitopes of tropomyosin. To further confirm the mimicry potential of mimotopes, BALB/c mice were immunized with mimotopes conjugated to keyhole limpet hemocyanin and assayed for their capacity to induce tropomyosin-specific antibodies. BALB/c mice that received mimotope immunization were found to have an elevated level of tropomyosin-specific immunoglobulin G, but not mice that received an irrelevant mimotope. This study pioneers the successful application of the OBOC libraries using whole sera to screen and identify multiple shrimp allergen mimotopes and validates their mimicry potential using in vitro, in vivo, and in silico methods.

关键词： epitope mimotope OBOC peptide library tropomyosin

Interpretable learning of voltage for electrode design of multivalent metal-ion batteries

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npj Computational Materials 2022年第1期8卷 1654-1661页

作者： Xiuying Zhang jun Zhou Jing Lu Lei Shen Department of Physics National University of Singapore2 Science Drive 3Singapore117551Singapore State Key Laboratory of Mesoscopic Physics and Department of Physics Peking University100871BeijingPeople’s Republic of China Institute of Materials Research&Engineering A*STAR(Agency for ScienceTechnology and Research)2 Fusionopolis WayInnovisSingapore138634Singapore Collaborative Innovation Center of Quantum Matter 100871BeijingPeople’s Republic of China Department of Mechanical Engineering National University of Singapore9 Engineering Drive 1Singapore117575Singapore

Deep learning(DL)has indeed emerged as a powerful tool for rapidly and accurately predicting materials properties from big data,such as the design of current commercial Li-ion ***,its practical utility for multivalent metal-ion batteries(MIBs),the most promising future solution of large-scale energy storage,is limited due to scarce MIB data availability and poor DL model ***,we develop an interpretable DL model as an effective and accurate method for learning electrode voltages of multivalent MIBs(divalent magnesium,calcium,zinc,and trivalent aluminum)at small dataset limits(150–500).Using the experimental results as validation,our model is much more accurate than machine-learning models,which usually are better than DL in the small dataset *** the high accuracy,our feature-engineering-free DL model is explainable,which automatically extracts the atom covalent radius as the most important feature for the voltage learning by visualizing vectors from the layers of the neural *** presented model potentially accelerates the design and optimization of multivalent MIB materials with fewer data and less domain-knowledge restriction and is implemented into a publicly available online tool kit in http://***/for the battery community.

关键词： electrode magnesium radius

Expression of CTB-human Insulin(BA) Fusion Protein in Gynostemma Pentapyhllum Makino Callus Cells and Its Hypoglycemic Effect in Mice

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Chemical Research in Chinese Universities 2010年第5期26卷 773-779页

作者： WANG Ya-jun QI Feng-chun HAO Shu-mei WANG Chun-yi SUI Bo SHENG jun College of Life Science Jilin University Changchun 130012 P R. China Changchun Institute of Biological Products Changchun 130062 P R. China Changchun University of Science and Technology Changchun 130022 P. R. China Changchun Keygen Biological Products Co. Ltd. Changchun 130021 P R. China Yunnan Agricultural University Kunming 650201 P. R. China

The plant expression vector of choleratoxin B subunit（CTB）-human insulin（BA） fusion protein pBI121/（CTB-BA） was constructed first and then the Gynostemma Pentapyhllum Makino callus cell line that could express CTB-human insulin fusion protein was constructed and its hypoglycemic effect was evaluated in mice. The plant expression vector pBl 121/（CTB-BA） was digested with both BamI and SacI. Agrobacterium tumerfaciens strain LBA4404 was transformed with previously constructed recombinant plasmid pBI121/（CTB-BA） via the freeze thawing method, then CTB-BA gene was integrated to G Pentapyhllum Makino callus cells by co-culturing the cells with the transformed LBA4404 strain. The transformed G Pentapyhllum Makino callus cells were identified by DNA sequence assey and RT-PCR. The expressed product was identified by western-blot and its amount was tested by ELISA kit and its blood sugar decreasing effect was tested in mice. The sequences of synthetic CTB and human insulin genes（BA） were completely identical to those designed. Restriction map proved that the length of gene fragment in- serted into expression vector pBI121 was consistent with that expected. The sequence of genomic DNA of expressed product was completely identical to that designed. The result of RT-PCR was consistent with that expected. The expressed product showed a specific band with a relative molecular mass of 17000 by Western-blot. The human insulin expression amount was 6.03 μIU/mL according to the ELISA result. The animal test showed that only the G Pentapyhllum Makino callus cell line itself showed activity in decreasing the blood sugar of mice, however, the activity of the transformed G Pentapyhllum Makino callus cells was much higher, The plant expression vector pBI121/（CTB-BA） was constructed and expressed in the G Pentapyhllum Makino callus cells successfully for the first time. The trans- formed G Pentapyhllum Makino callus cells showed high activity in decreasing the blood sugar of mice. This stu

关键词： Human insulin peptide without C pcptide Choleratoxin B subunit G Pentapyhllum Makino callus cells