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Neural Regeneration Research 2017年第12期12卷 2021-2024页

作者： Sung ho jang jun Lee Sang Seok Yeo Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Namku Daegu Republic of Korea Department of Neurology College of Medicine Yeungnam University Namku Daegu Republic of Korea Department of Physical Therapy College of Health Sciences Dankook University Chungnam Republic of Korea

Many studies using diffusion tensor tractography（DTT） have demonstrated that injury of the spinothalamic tract（STT） is the pathogenetic mechanism of central post-stroke pain（CPSP） in intracerebral hemorrhage; however, there is no DTT study reporting the pathogenetic mechanism of CPSP in cerebral infarction. In this study, we investigated injury of the STT in patients with CPSP following cerebral infarction, using DTT. Five patients with CPSP following cerebral infarction and eight age-and sex-matched healthy control subjects were recruited for this study. STT was examined using DTT. Among DTT parameters of the affected STT, fractional anisotropy and tract volume were decreased by more than two standard deviations in two patients（patients 1 and 2） and three patients（patients 3, 4, and 5）, respectively, compared with those of the control subjects, while mean diffusivity value was increased by more than two standard deviations in one patient（patient 2）. Regarding DTT configuration, all affected STTs passed through adjacent part of the infarct and three STTs showed narrowing. These findings suggest that injury of the STT might be a pathogenetic etiology of CPSP in patients with cerebral infarction.

关键词： nerve regeneration central post-stroke pain cerebral infarction spinothalamic tract diffusion tensorimaging neural regeneration

Recovery mechanisms of somatosensory function in stroke patients: implications of brain imaging studies

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Neuroscience Bulletin 2013年第3期29卷 366-372页

作者： Sung ho jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

Somatosensory dysfunction is associated with a high incidence of functional impairment and safety in patients with stroke. With developments in brain mapping techniques, many studies have addressed the recovery of various functions in such patients. however, relatively little is known about the mechanisms of recovery of somatosensory function. Based on the previous human studies, a review of 11 relevant studies on the mecha- nisms underlying the recovery of somatosensory function in stroke patients was conducted based on the fol- lowing topics：（1） recovery of an injured somatosensory pathway, （2） peri-lesional reorganization, （3） contribu- tion of the unaffected somatosensory cortex, （4） contribution of the secondary somatosensory cortex, and （5） mechanisms of recovery in patients with thalamic lesions. We believe that further studies in this field using combinations of diffusion tensor imaging, functional neuroimaging, and magnetoencephalography are needed. In addition, the clinical significance, critical period, and facilitatory strategies for each recovery mechanism should be clarified.

关键词： stroke somatosensory recovery brain mapping brain plasticity

Reduced graphene oxide-based materials for electrochemical energy conversion reactions

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Carbon Energy 2019年第1期1卷 85-108页

作者： Seokhoon Choi Changyeon Kim jun Min Suh ho Won jang Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea

There have been ever-growing demands to develop advanced electrocatalysts for renewable energy conversion over the past *** a promising platform for advanced electrocatalysts,reduced graphene oxide(rGO)has attracted substantial research interests in a variety of electrochemical energy conversion *** versatile utility is mainly attributed to unique physical and chemical properties,such as high specific surface area,tunable electronic structure,and the feasibility of structural modification and ***,a comprehensive discussion is provided upon recent advances in the material preparation,characterization,and the catalytic activity of rGO-based electrocatalysts for various electrochemical energy conversion reactions(water splitting,CO2 reduction reaction,N2 reduction reaction,and O2 reduction reaction).Major advantages of rGO and the related challenges for enhancing their catalytic performance are addressed.

关键词： CO2 reduction reaction electrocatalysis N2 reduction reaction O2 reduction reaction reduced graphene oxide water splitting

Perilesional reorganization of motor function in stroke patients

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Neural Regeneration Research 2010年第21期5卷 1668-1672页

作者： Sung ho jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

Perilesional reorganization is an important recovery mechanism for stroke patients because it yields good motor outcomes. however, perilesional reorganization remains poorly understood. The scientific basis for stroke rehabilitation can be established when detailed mechanisms of recovery are clarified. In addition, studies at the subcortical level remain in the early stages. Therefore, the present study suggested that additional investigations should focus on perilesional reorganization at the subcortical level, identifying the critical period for this mechanism and determining treatment strategies and modalities to facilitate development. The present study reviews literature focused on perilesional reorganization in stroke patients with regard to demonstration, clinical characteristics, and rehabilitative aspects, as well as previous studies of perilesional reorganization at cortical and subcortical levels.

关键词： stroke motor recovery functional MRI diffusion tensor imaging brain plasticity reorganization

Isolated corticospinal tract in a patient with intracerebral hemorrhage A diffusion tensor tractography and transcranial magnetic stimulation study

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Neural Regeneration Research 2011年第7期6卷 558-560页

作者： Sung ho jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

Diffusion tensor tractography allows visualization of the corticospinal tract （CST） in three dimensions. Transcranial magnetic stimulation offers a unique advantage in that it can distinguish between the corticospinal tract and the non-CST by analyzing the characteristics of a motor-evoked potential. A 15 year-old female showed right hemiparesis, due to intracerebral hemorrhage in the left corona radiata, and the posterior limb of the internal capsule. Diffusion tensor tractography revealed that the tracts of both hemispheres originated from the precentral gyrus, and descended through the known CST pathway. Specifically, the tract of the affected hemisphere descended through an isolated area in the leukomalactic lesion at the posterior limb level. In addition, the characteristics of the motor-evoked potential obtained from the right hand when stimulating the hot spot of the left motor cortex corresponded to a CST. In conclusion, we report on a patient with intracerebral hemorrhage who showed an isolated CST in a leukomalactic lesion. This result suggests the importance of saving the adjacent area or penumbra around a hematoma after an intracerebral hemorrhage.

关键词： stroke motor recovery corticospinal tract magnetic stimulation diffusion tensor im-aging

Unusual long-term motor recovery in a patient with corona radiata infarct

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Neural Regeneration Research 2010年第17期5卷 1353-1356页

作者： Sung ho jang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityDaegu 705-717Republic of Korea

The majority of motor recovery following stroke occurs within 6 months after *** present study examined a patient with a corona radiata infarct,who exhibited an unusual long-term recovery（24 months after onset）.The patient was a 64-year-old female,who presented with severe paralysis of the left extremities resulting from a corona radiate *** recovery from the weakness progressed slowly over a 24-month period following onset,even at 6-12 months after *** tensor tractography at 2 weeks from onset showed disruption of the corticospinal tract of the affected hemisphere resulting from the ***,at 12 and 24 months after onset,the corticospinal tract was elongated to the cortex level,as shown by diffusion tensor tractography.A 2-week transcranial magnetic stimulation showed no motor-evoked potential for the affected hemisphere,but a motor-evoked potential of the corticospinal tract was observed at12 and 24 *** results suggest that motor function recovery in cerebral infarct patients can occur at least up to 24 months after stroke onset.

关键词： stroke motor recovery cerebral infarct diffusion tensor tractography transcranial magnetic stimulation diffusion tensor imaging

Spared integrity of corticospinal tract within a pontine infarct A diffusion tensor tractography study

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Neural Regeneration Research 2010年第20期5卷 1552-1554页

作者： Sung ho jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Daegu 705-717 Republic of Korea

Integrity of the corticospinal tract is mandatory for good recovery of impaired motor function in patients who have suffered a stroke.A 67-year-old left hemiparetic female showed an infarct in the right *** months after onset,motor function of the affected extremities recovered rapidly to a nearly complete *** tensor tractography of both hemispheres showed that the corticospinal tract originated from the primary sensori-motor cortex and descended through the known corticospinal tract *** tract of the affected（right）hemisphere descended through an area within the pontine *** diffusion tensor tractography results suggest that from the onset,the integrity of the corticospinal tract appears to have been spared within the pontine infarct.

关键词： pontine infarct diffusion tensor imaging corticospinal tract stroke motor recovery

Medial reorganization of motor function in corona radiata following middle cerebral artery infarction A case report

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Neural Regeneration Research 2009年第9期4卷 668-671页

作者： Sung ho jang Department of Physical Medicine & Rehabilitation Yeungnam University College of Medicine

Peri-lesional reorganization is one of the motor recovery mechanisms following stroke. A 23-year-old female who presented with complete paralysis of the right extremities at the onset of infarct in the left middle cerebral artery territory was included. She slowly recovered some function, and could extend the affected knee with resistance after 9 months. Diffusion tensor tractography, functional MRI, and transcranial magnetic stimulation testing were performed at 7 years after onset. Results showed that diffusion tensor tractography of the affected （left） hemisphere passed through the medial corona radiata at, or around, the wall of the lateral ventricle. The contralateral primary sensorimotor cortex was activated during affected knee movements. The motor-evoked potential, which was obtained from the affected leg, exhibited corticospinal tract characteristics. Results indicated that motor function of the affected leg recovered via the corticospinal tract, which descended through the corona radiata medial to the infarct. The motor function of the affected leg was reorganized to the medial corona radiata following infarct to the middle cerebral artery territory.

关键词： functional magnetic resonance imaging stroke cortical reorganization motor recovery diffusion tensor tractography transcranial maanetic stimulation

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天津艺术文化与中外审美融合的服装设计应用

针织工业 2024年第4期 71-74页

作者：许君田萌蒋蕾姜亚明天津工业大学纺织科学与工程学院天津300387 天津工业大学中华优秀传统文化与技艺国际传承创新基地天津300387 天津工业大学国际教育学院天津300387

为深入理解天津艺术文化元素在服装设计上的再创新及其创新设计表达方式,文章采用问卷调查方法,收集来自不同文化背景的人群对艺术文化创新形式、服装款式、色彩搭配和图案运用的看法和偏好。将不同文化背景的人群对时尚的感受转化为服... 详细信息

为深入理解天津艺术文化元素在服装设计上的再创新及其创新设计表达方式,文章采用问卷调查方法,收集来自不同文化背景的人群对艺术文化创新形式、服装款式、色彩搭配和图案运用的看法和偏好。将不同文化背景的人群对时尚的感受转化为服装设计的具体指标,并将其与天津艺术文化元素相结合,旨在通过服装设计探索文化交流的新方式。该研究不仅挖掘了富有文化底蕴的服装设计表达方法,也为将天津艺术文化的精髓融入现代时尚服装设计提供了实践案例和发展路径。

关键词：天津艺术文化问卷调查艺术元素提取服装设计

Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stress

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International Journal of Oral Science 2024年第3期16卷 553-562页

作者： Zhiyao Yuan junjie Li Fuyu Xiao Yu Wu Zhiting Zhang Jiahong Shi jun Qian Xudong Wu Fuhua Yan Department of Periodontology Nanjing Stomatological HospitalAffiliated Hospital of Medical SchoolInstitute of StomatologyState Key Laboratory of Pharmaceutical BiotechnologySchool of Life SciencesNanjing UniversityNanjingChina

Periodontitis is a chronic inflammatory and immune reactive disease induced by the subgingival *** therapeutic effect for susceptible patients is often unsatisfactory due to excessive inflammatory response and oxidative ***(Sin)is a nature polymethoxylated flavonoid with anti-inflammatory and antioxidant *** study aimed to explore the beneficial effect of Sin on periodontitis and the specific molecular *** found that Sin attenuated oxidative stress and inflammatory levels of periodontal ligament cells(PDLCs)under inflammatory *** Sin to rats with ligation-induced periodontitis models exhibited a protective effect against periodontitis in *** molecular docking,we identified Bach1 as a strong binding target of Sin,and this binding was further verified by cellular thermal displacement assay and immunofluorescence *** immunoprecipitation-quantitative polymerase chain reaction results also revealed that Sin obstructed the binding of Bach1 to the HMOX1 promoter,subsequently upregulating the expression of the key antioxidant factor *** functional experiments with Bach1 knocked down and overexpressed verified Bach1 as a key target for Sin to exert its antioxidant ***,we demonstrated that Sin prompted the reduction of Bach1 by potentiating the ubiquitination degradation of Bach1,thereby inducing ho-1 expression and inhibiting oxidative ***,Sin could be a promising drug candidate for the treatment of periodontitis by targeting binding to Bach1.

关键词： Bach1 period prompt