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棘皮动物弧菌诱导中间球海胆免疫致敏现象分析

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大连海洋大学学报 2024年第2期39卷 266-274页

作者：殷维骏刘岩松田文卓欧凡江刘雷丁君张伟杰常亚青大连海洋大学农业农村部北方海水增养殖重点实验室辽宁大连116023

为探究中间球海胆(Strongylocentrotus intermedius)是否存在免疫致敏现象,使用棘皮动物弧菌(Vibrio echinoideorum)对中间球海胆进行重复感染(首次、二次菌浓度分别为10^(3)、10^(4) CFU/mL),检测并比较了两次注射感染后不同时间点中... 详细信息

为探究中间球海胆(Strongylocentrotus intermedius)是否存在免疫致敏现象,使用棘皮动物弧菌(Vibrio echinoideorum)对中间球海胆进行重复感染(首次、二次菌浓度分别为10^(3)、10^(4) CFU/mL),检测并比较了两次注射感染后不同时间点中间球海胆体腔细胞密度、吞噬能力、酸性磷酸酶(ACP)活力、活性氧(ROS)含量、总抗氧化能力(T-AOC)等相关免疫指标的变化,以及二次感染后免疫致敏组和对照组间成活率的差异。结果表明:与首次感染相比,二次感染时诱导致敏组的体腔细胞总密度、吞噬细胞密度、ACP、ROS和T-AOC等均出现显著上升(P<0.05),且响应时间明显缩短,达到峰值的时间分别提前了36、36、84、12、36 h,且各指标的峰值均显著高于首次感染(P<0.05);二次感染后,诱导致敏组在6 h时的吞噬率(45.41%±6.39%)显著高于对照组(33.17%±1.94%);经过棘皮动物弧菌低浓度诱导后,诱导致敏组存活率(43.33%±10.00%)显著高于未经诱导的阳性对照组(7.78%±10.71%)(P<0.05)。研究表明,低浓度棘皮动物弧菌能诱导中间球海胆产生免疫致敏现象,此结果可为中间球海胆的疾病防控提供新思路。

关键词：中间球海胆棘皮动物弧菌免疫致敏免疫指标

驱动及负载激励下高速人字齿轮的动态特性分析

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机械传动 2024年第5期48卷 131-137页

作者：丁军职彦锋张翰林张立勇王长路汪凯郑天乐江苏中工高端装备研究院有限公司江苏泰兴225400 江苏省减速机产品质量监督检验中心江苏泰兴225400 郑州机械研究所有限公司河南郑州450001 安徽科技学院安徽蚌埠233100

高速齿轮传动装置中通常采用人字齿轮传动,其高速工况下的动态特性对设备的可靠运行有重要影响。建立了人字齿轮传动的模型,在考虑驱动和负载激励的条件下,分析了人字齿轮增速传动的动态特性,进行了动力学仿真,并对产品进行了实验。结... 详细信息

高速齿轮传动装置中通常采用人字齿轮传动,其高速工况下的动态特性对设备的可靠运行有重要影响。建立了人字齿轮传动的模型,在考虑驱动和负载激励的条件下,分析了人字齿轮增速传动的动态特性,进行了动力学仿真,并对产品进行了实验。结果表明,在负载恒定时,齿轮角速度越大,齿轮所受接触力越大,碰撞频率越高。随着输入转速逐步提高至500、1000、1488 r/min时,其速度波动幅值之差分别为2.27、4.76、9.37 rad/s,后两种工况下最大接触力分别是500 r/min工况下的1.87倍和2.44倍,角速度波动的次数分别增大到500 r/min工况下的1.94倍和2.94倍。负载增大,从动齿轮角速度波动幅度减小,接触力增大。研究为高速齿轮传动装置设计提供了参考。

关键词：人字齿轮动态特性负载激励

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Towards key scientific questions in the diagnosis and treatment of rare diseases: Summary from the 297th Meeting of the Shuangqing Forum

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Zoological Research 2022年第2期43卷 234-236页

作者： Cai-Yun Zhu Wei Hong Lei Wang Li-jun ding Xue Zhang Department of Health Sciences National Natural Science Foundation of ChinaBeijing 100085China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Institute of Pediatrics Children’s Hospital of Fudan University and Shanghai Key Laboratory of Medical EpigeneticsInternational Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and Technology and Institutes of Biomedical SciencesState Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200032China Center for Reproductive Medicine and Obstetrics and Gynecology Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingJiangsu 210008China McKusick-Zhang Center for Genetic Medicine Institute of Basic Medical SciencesChinese Academy of Medical Sciences/School of Basic MedicinePeking Union Medical CollegeBeijing 100005China

In China,rare diseases are defined as having a birth incidence of less than 1/10000,or a prevalence of less than 1/10000 or less than 140000 *** 7000 rare diseases affect more than 20 million people in *** conditions are misdiagnosed or undiagnosed and most have no treatment,resulting in a huge burden on patients,their families,and the national *** the 297th Shuangqing Forum of the National Natural Science Foundation of China,we highlighted the challenges and potential solutions to achieve precision medicine for undiagnosed and rare diseases.

关键词： diagnosis treatment Forum

椎动脉型颈椎病行颈前路椎间盘切除减压植骨融合术的疗效分析

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中国骨伤 2024年第7期37卷 670-675页

作者：艾义翔刘俭涛郝定均龚禧朱以涵李幸橼张熙伟王考孙佳俊张淑媛西安交通大学附属红会医院脊柱外科陕西西安710054 西安交通大学第一附属医院骨科陕西西安710061

目的:探讨颈前路椎间盘切除减压植骨融合术(anterior cervical discectomy and fusion,ACDF)治疗椎动脉型颈椎病(cervical spondylosis of vertebral artery type,CSA)的临床效果。方法:回顾性分析2020年1月至2022年1月42例CSA患者的临床资料,男25例,女17例;年龄30~74(53.9±11.0)岁。单节段病变18例,2个节段病变17例,3个节段病变7例。分别在术前和术后6个月时采用美国耳鼻咽喉头颈外科学会听力及平衡委员会评分(Committee on Hearing and Equilibrium,CHE)、颈椎功能障碍指数(neck disability index,NDI)和颈椎曲度Cobb角进行临床疗效评价。结果:42例患者均获随访,随访时间6~30(14.0±5.2)个月;手术时间95~220(160.38±36.77)min,术中出血量30~85(53.60±18.98)ml。2例术后出现轻度吞咽困难,给予雾化吸入等对症处理后均好转。CHE评分由术前(4.05±0.96)分降低至术后6个月的(2.40±0.70)分(t=12.97,P<0.05)。术后6个月38例眩晕改善,改善率90.5%。NDI评分的由术前的(34.43±8.04)分降低至术后6个月的(20.76±3.91)分(t=11.83,P<0.05)。颈椎曲度Cobb角由术前的(8.04±6.70)°提高至术后6个月的(12.42±5.23)°(t=-15.96,P<0.05)。结论:ACDF术式治疗椎动脉型颈椎病的临床疗效突出,手术通过解除骨性压迫,重建颈椎曲度,可快速缓解患者的发作性眩晕症状。但需要严格把握手术指征,明确患者眩晕原因,对保守治疗无效的CSA患者,ACDF手术可推荐使用。

关键词：椎动脉型颈椎病颈前路椎间盘切除减压植骨融合术颈性眩晕

The effect of surface-free energy and microstructure on the condensation mechanism of water vapor

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Progress in Natural Science:Materials International 2023年第1期33卷 37-46页

作者： Shangsheng Zhang Shuman Xu Yang Liu Ruicheng Lei Tianli Guo Yao Yao Shangyu Gao jun ding Zengzhi Zhang China University of Mining and Technology-Beijing School of Mechanical Electronic & Information Engineering

Obtaining high-water-yield drinking water in arid areas without consuming energy is still a global *** water vapor is ubiquitous, atmospheric water harvesting technologies are undoubtedly one of the most promising candidates. A typical water condensation process is analyzed in this paper(nucleation, self-growth,coalescence and sliding). The mechanisms of interactions between adsorbate and water vapor are *** effect of surface-free energy and microstructure on water vapor condensation is described. Finally, the main problems in developing more efficient, high-water-mass and high-cycle-stability atmospheric water collectors are summarized, and the future development trend has been prospected.

关键词： Water vapor condensation Surface free energy Microstructure Atmospheric water harvesting

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丙烯酸基高吸水性树脂的研究进展

应用化工 2024年第1期53卷 150-155页

作者：王昆伦汤建伟刘咏刘鹏飞丁俊祥王保明郑州大学化工学院河南郑州450001 郑州大学生态与环境学院河南郑州450001 国家钙镁磷复合肥技术研究推广中心河南郑州450001 河南省减污降碳协同工程技术研究中心河南郑州450001

介绍了高吸水性树脂的制备方法以及各种方法的优缺点。概述了不同的改性材料对高吸水性树脂吸水保水性能的影响,并给出了增加比表面积、分子量、活性基团数量、适当的中和度和交联度等方法来提高吸水保水能力。总结了高吸水性树脂在环... 详细信息

介绍了高吸水性树脂的制备方法以及各种方法的优缺点。概述了不同的改性材料对高吸水性树脂吸水保水性能的影响,并给出了增加比表面积、分子量、活性基团数量、适当的中和度和交联度等方法来提高吸水保水能力。总结了高吸水性树脂在环境治理、建筑材料和农林业三个领域的应用。对高吸水性树脂性能的进一步改善进行了展望,开发低成本、可降解的高吸水性树脂仍是亟需解决的难题。

关键词：丙烯酸钠高吸水树脂保水剂聚合物材料

Conservative management of multi-trauma induced peritonitis:Experience,outcomes,and indications

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世界临床病例杂志 2023年第25期11卷 5897-5902页

作者： Qi Chen Tao Zhu Jia-Kang Liu jun ding Lina Chen Department of Surgery Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Laboratory Medicine and Pathobiology University of TorontoToronto M5S 1A8OntarioCanada

BACKGROUND The concept of mandatory laparotomy in treating traumatic peritonitis has been increasingly questioned *** To summarize and share the experience of conservative treatment of patients with multi-trauma induced *** A retrospective review was performed on patients with multiple injury induced traumatic *** A total of 184 patients with multiple injury induced traumatic peritonitis were reviewed.46 of them underwent conservative *** of the 46 patients with conservative treatment switched to surgical treatment,and all of them were cured and discharged after successful conservative *** significant abnormal findings were observed at regular follow-up after *** Conservative management is safe,effective,feasible,and beneficial in hemodynamically stable patients with traumatic peritonitis if there is no definite evidence of severe abdominal visceral organ injury.

关键词： Trauma Peritonitis Damage control Conservative treatment

Integration of ATAC-Seq and RNA-Seq identifies the key genes in myocardial ischemia

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Genes & Diseases 2023年第1期10卷 62-64页

作者： Jing Yuan jun-Meng Wang Zhi-Wei Li Cheng-Shun Zhang Bin Cheng Su-Hao Yang ding-jun Cai Shu-Guang Yu Acupuncture and Tuina School/Third Teaching Hospital Chengdu University of Traditional Chinese MedicineChengduSichuan 610075China

Myocardial ischemia(Ml)is a common disease with high mortality and morbidity *** the pathological process of MI is very complicated,a comprehensive understanding of its pathogenesis is the key to the treatment of *** chromatin plays a crucial role in regulating gene expression,and gene regulation is a fundamental process in developing and disease progression,combined analysis of the chromatin and gene can further reveal the pathological mechanism of Ml.

关键词： ischemia mortality pathogenesis

PTEN inhibitor bisperoxovanadium protects against noise-induced hearing loss

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Neural Regeneration Research 2023年第7期18卷 1601-1606页

作者： Bei Fan Fei Lu Wei-Jia Du jun Chen Xiao-Gang An Ren-Feng Wang Wei Li Yong-Li Song ding-jun Zha Fu-Quan Chen Department of Otolaryngology Head and Neck Surgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Studies have shown that phosphatase and tensin homolog deleted on chromosome ten(PTEN)participates in the regulation of cochlear hair cell *** protects against neurodegeneration by inhibiting PTEN ***,whether bisperoxovanadium can protect against noise-induced hearing loss and the underlying mechanism remains *** this study,we established a mouse model of noise-induced hearing loss by exposure to 105 dB sound for 2 *** found that PTEN expression was increased in the organ of Corti,including outer hair cells,inner hair cells,and lateral wall *** administration of bisperoxovanadium decreased the auditory threshold and the loss of cochlear hair cells and inner hair cell *** addition,noise exposure decreased p-PI3K and p-Akt *** preconditioning or PTEN knockdown upregulated the activity of *** also prevented H_(2)O_(2)-induced hair cell death by reducing mitochondrial reactive oxygen species generation in cochlear *** findings suggest that bisperoxovanadium reduces noise-induced hearing injury and reduces cochlear hair cell loss.

关键词： acoustic trauma Akt oxidative stress bisperoxovanadium cochlear hair cells loss inner hair cell ribbons loss noise exposure permanent threshold shift phosphatase and tensin homologue deleted on chromosome ten phosphatidylinositol 3 kinase siPTEN