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Two new indole alkaloids from Nauclea officinalis

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Chinese Chemical Letters 2007年第9期18卷 1084-1086页

作者： Jing Yong Sun Hong Xiang Lou Hui Xu Sheng jun dai Ke Liu School of Pharmacy Shandong University Jinan 250042 China School of Pharmacy Yantai University Yantai 264005 China

Two new indole alkaloids, 4-oxo-4,12-dihydroindolo[2,3-a]quinolizine-3-carbaldehyde (1) and 1,6,7-trihydro-indolo- [2,3-a]furan[3,4-g]quinolizine-3,4(13H)-dione (2), were isolated from Nauclea officinalis. Their struc... 详细信息

关键词： Nauclea officinalis Indole alkaloids Indolo[2,3-a]quinolizine Indolo[2,3-a]furan[3,4-g]quinolizine

Iron-catalyzed selective oxidation of 5-hydroxylmethylfurfural in air:A facile synthesis of 2,5-diformylfuran at room temperature

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Chinese Chemical Letters 2015年第10期26卷 1265-1268页

作者： Chi Fang Jian-jun dai Hua-Jian Xu Qing-Xiang Guo Yao Fu Anhui Province Key Laboratory of Biomass Clean Energy Department of Chemistry University of Science and Technology of China School of Medical Engineering Hefei University of Technology

An iron（Ⅲ）-catalyzed selective oxidation of 5-HMF to 2,5-DFF in air at room temperature was *** approach gives 2,5-DFF with good selectivity and yields. Additionally, a two-step process was developed for the oxidation of 2,5-DFF to 2,5-FDCA at remarkably high substrate concentrations. This work demonstrates unequivocally the great potential of iron as a cheap and earth-abundant catalyst for the development of new protocols for the conversion of biomass to value-added chemicals.

关键词： Iron Biomass Oxidation Platform molecules Sustainable chemistry

Microbial transformation of glycyrrhetinic acid and potent neural anti-inflammatory activity of the metabolites

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Chinese Chemical Letters 2017年第6期28卷 1200-1204页

作者： Yuan Ma Ji-Mei Liu Ri-Dao Chen Xi-Qiang An jun-Gui dai State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences & PekingUnion Medical College Beijing 100050 China Xinjiang Institute of Materia Medica Urumqi 830004 China Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study Institute of Materia Medica Chinese Academy of Medical Sciences & PekingUnion Medical College Beijing 100050 China

The microbial transformation of glycyrrhetinic acid（1） by Cunninghamella blakesleana CGMCC 3.970 led to the production of five new metabolites（2-6）.The structures of the metabolites were determined by extensive spectroscopic（HR-ESIMS,1D and 2D NMR） data *** involved reactions exhibited specific hydroxylations at C-24,C-7,and C-15,and oxidation at ***,compounds 2,5,and 6showed significant neural anti-inflammatory activity by inhibiting lipopolysaccharide-induced NO production in mouse microglia BV2 cells with IC（50） values of 0.76,0.94,and 0.16μmol/L,respectively.

关键词： Glycyrrhetinic acid Microbial transformation Anti-inflammatory activity Cunninghamella blakesleana Triterpenoid

Enhanced segmentation of gastrointestinal polyps from capsule endoscopy images with artifacts using ensemble learning

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World Journal of Gastroenterology 2022年第41期28卷 5931-5943页

作者： jun-Xiao Zhou Zhan Yang Ding-Hao Xi Shou-jun dai Zhi-Qiang Feng jun-Yan Li Wei Xu Hong Wang Department of Gastroenterology and Hepatology Guangzhou First People’s HospitalGuangzhou 510180Guangdong ProvinceChina School of Information Renmin University of ChinaBeijing 100872China

BACKGROUND Endoscopy artifacts are widespread in real capsule endoscopy(CE)images but not in high-quality standard *** To improve the segmentation performance of polyps from CE images with artifacts based on ensemble *** We collected 277 polyp images with CE artifacts from 5760 h of videos from 480 patients at Guangzhou First People’s Hospital from January 2016 to December *** public high-quality standard external datasets were retrieved and used for the comparison *** each dataset,we randomly segmented the data into training,validation,and testing sets for model training,selection,and *** compared the performance of the base models and the ensemble model in segmenting polyps from images with *** The performance of the semantic segmentation model was affected by artifacts in the sample images,which also affected the results of polyp detection by CE using a single *** evaluation based on real datasets with artifacts and standard datasets showed that the ensemble model of all state-of-the-art models performed better than the best corresponding base learner on the real dataset with *** with the corresponding optimal base learners,the intersection over union(IoU)and dice of the ensemble learning model increased to different degrees,ranging from 0.08%to 7.01%and 0.61%to 4.93%,***,in the standard datasets without artifacts,most of the ensemble models were slightly better than the base learner,as demonstrated by the IoU and dice increases ranging from-0.28%to 1.20%and-0.61%to 0.76%,*** Ensemble learning can improve the segmentation accuracy of polyps from CE images with *** results demonstrated an improvement in the detection rate of polyps with interference from artifacts.

关键词： Artifacts Capsule endoscopy Polyps Ensemble learning Segmentation Robustness

Parallel detection and quantitative analysis of specific binding of proteins by oblique-incidence reflectivity difference technique in label-free format

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Science China(Physics,Mechanics & Astronomy) 2014年第11期57卷 2039-2042页

作者： dai jun LI Lin HE LiPing RUAN KangCheng LU HuiBin JIN KuiJuan YANG GuoZhen Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of Sciences Key Laboratory of Proteomics Institute of Biochemistry and Cell BiologyShanghai Institute for Biological SciencesChinese Academy of Sciences Collaborative Innovation Center of Quantum Matter

In this work,we parallelly detected the specific binding between microarray targets including 12 different kinds of proteins and the probe solution containing five corresponding antibodies and quantitatively analyzed the interactions between CDH13 and solution phase anti-CDH13 at six different probe concentrations by oblique-incidence reflectivity difference(OIRD)method in label-free *** detection sensitivity reached 10 ng/*** experimental results indicate that the OIRD method is a promising and competing technique not only in research work but also in clinic.

关键词： label format oblique reflectivity incidence spots quantitatively competing challenge finger

Two New Styryllactones from Goniothalamus cheliensis

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Chinese Chemical Letters 2003年第5期14卷 487-488页

作者： Si WANG Sheng jun dai Ruo Yun CHEN Shi Shan YU De Quan YU Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050

Two new styryllactones, iso-goniopypyrone and 8-acetyl-9-deoxygoniopypyrone, were isolated from the roots of Goniothalamus cheliensis. Their structure were elucidated on the basis of spectroscopic and chemical eviden... 详细信息

关键词： Goniothalamus cheliensis iso-goniopypyrone 8-acetyl-9-deoxygoniopypyrone.

Intercalation-deintercalation design in MXenes for high-performance supercapacitors

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Nano Research 2022年第4期15卷 3213-3221页

作者： Zhenjiang Li jun dai Yiran Li Changlong Sun Alan Meng Renfei Cheng Jian Zhao Minmin Hu Xiaohui Wang School of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266061China College of Electromechanical Engineering Qingdao University of Science and TechnologyQingdao 266061China Department of Mechanical Engineering City University of Hong KongHong Kong 999077China State Key Laboratory Base of Eco-chemical Engineering College of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

MXene is a new intercalation pseudocapacitive electrode material for supercapacitor *** fast ion diffusion is significantly essential for MXene to achieve excellent electrochemical *** expansion of interlayer void by traditional spontaneous species intercalation always leads to a slight increase in capacitance due to the existence of species sacrificing the smooth diffusion of electrolyte ***,an effective intercalation-deintercalation interlayer design strategy is proposed to help MXene achieve higher *** cation intercalation leads to the expansion of interlayer *** electrochemical cation extraction,intercalated cations are deintercalated mostly,leaving a small number of cations trapped in the interlayer silt and serving as pillars to maintain the interlayer space,offering an open,unobstructed interlayer space for better ion migration and ***,a preferred surface with more-O terminations for redox reaction is created due to the reaction between cations and-OH *** a result,the processed MXene delivers a much improved capacitance compared to that of the original Ti_(3)C_(2)T_(x)electrode(T stands for the surface termination groups,such as-OH,-F,and-O).This study demonstrates an improvement of electrochemical performance of MXene electrodes by controlling the interlayer structure and surface chemistry.

关键词： MXene electrochemical ion intercalation−deintercalation interlayer design supercapacitor energy storage

Activation of NLRP3 Inflammasome via Drp1 Overexpression in Kupffer Cells Aggravates Ischemia-reperfusion Injury in Hepatic Steatosis

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Journal of Clinical and Translational Hepatology 2023年第5期11卷 1069-1078页

作者： Lu Zhang Mingfu Wang Ran An jun dai Shujun Liu Ming Chen Haoran Ding Department of Hepatobiliary Surgery Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingJiangsuChina Surgery Department I Zhangjiagang Traditional Chinese Medicine HospitalSuzhouJiangsuChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Wannan Medical CollegeWuhuAnhuiChina Department of Hepatobiliary Surgery Nanjing Drum Tower HospitalClinical College of Traditional Chinese and Western MedicineSchool of PharmacyNanjing University of Chinese MedicineNanjingJiangsuChina

Background and Aims:Donors with fatty livers are considered to address the shortage of livers for transplantation,but those livers are particularly sensitive to ischemia-reperfusion injury(IRI),and an increased incidence of graft failure is *** cells account for 20–35%of liver nonparenchymal cells,and have been shown to participate in the process of IRI and inflammatory reactions of hepatic ***-like receptor thermal protein domain-associated protein 3(NLRP3)is an intracellular sensor activated by Kupffer cells to promote generation and participates in ***-associated protein 1(Drp1)is one of the main proteins regulating mitochondrial division and exacerbates IRI by affecting mitochondrial *** mechanism of interaction of Kupffer cells with Drp1 and NLRP3 to aggravate IRI has not been ***:A mouse model of hepatic steatosis was established by feeding the mice with a high-fat *** vitro experiments were performed using AML12 normal mouse liver cells and RAW264.7 mononuclear macrophage cells cultured in medium with palmitate and oleic *** blotting and immunohistochemical(IHC)staining were used to detect the expression of NLRPP3 and Drp1 in IRI in the control and high-fat diet *** expression of F4/80+cells during IRI in hepatic steatosis was verified by IHC staining,and the role of NLRPP3 and Drp1 in Kupffer-cell mediated IRI was investigated by targeting Drp-1 ***:Drp1 and NLRP3 expression was increased during IRI in hepatic steatosis,and the expression of Drp1 and NLRP3 were decreased after the elimination of Kupffer *** indicated Kupffer cells were involved in the process of IRI in hepatic steatosis through the action of Drp1 and *** Drp1 inhibition,liver function was restored and NLRP3 expression level was ***:Kupffer cells aggravated IRI in hepatic steatosis via NLRP3 and ***1 inhibitors might be useful as specific therapeutics to alleviate IRI

关键词： Drp1 Kupffer cells NLRP3 Hepatic steatosis Ischemia-reperfusion

Earthworm biomass and population structure are negatively associated with changes in organic residue nitrogen concentration during vermicomposting

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Pedosphere 2021年第3期31卷 433-439页

作者： Bo ZHOU Yiyong CHEN Chi ZHANG Jianlong LI Hao TANG Jiayu LIU jun dai Jinchi TANG Tea Research Institute Guangdong Academy of Agricultural Sciences/Guangdong Provincial Key Laboratory of Tea Plant Resources Innovation and UtilizationGuangzhou 510640China College of Natural Resources and Environment South China Agricultural University/Key Laboratory of the Ministry of Agriculture for South China Farmland ConservationGuangzhou 510642China

Vermicomposting is an efficient and environmentally friendly technology to dispose of agricultural organic *** efficiency of organic residue decomposition during vermicomposting is directly affected by the biomass and population structure of *** this study,we investigated how the earthworm biomass and population structure responded to changes in the physicochemical properties of six types of organic residue(cattle dung,herbal waste,rice straw,soybean straw,garden waste,and tea residues)during *** type of organic residues was placed in a pot with earthworms Eisenia fetida,and the physicochemical properties of the organic residues and earthworm growth dynamics were recorded at 0,30,60,and 90 d of *** biomass and population structure of earthworms were stable or increased in rice straw,garden waste,and cattle dung within 60 d of vermicomposting,whereas in tea residues and herb waste,very little earthworm activity(3 adults and 2 cocoons)was recorded on day *** the physicochemical parameters,the substrate C/N ratio was negatively correlated with earthworm growth *** organic residues showed higher NH_(4)^(+)-N and NH_(3)^(-)-N concentrations but a lower total organic carbon content,which negatively affected earthworm growth and *** recommend that chemical properties of vermicomposting systems should be monitored *** the threshold levels of decomposing organic residue NH_(4)^(+)-N and NH_(3)^(-)-N concentrations,earthworms should be removed and the vermicompost can be ***-and large-scale farmers thus need to monitor the physicochemical properties of vermicompost to sustain active earthworm populations.

关键词： ammonium nitrogen decomposing earthworm biological traits Eisenia fetida nitrate nitrogen organic residue dispose physicochemical property