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Tetrahydrocurcumin-induced apoptosis of hepatocellular carcinoma cells involves the TP53 signaling pathway,as determined by network pharmacology

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 221-236页

作者： Zhuo-Cong Bao Ye Zhang Zhao-Dong Liu Hui-jun dai Fu Ren Ning Li Shang-Yu Lv Yan Zhang Graduate School Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Guangxi Medical University Cancer Hospital Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Human Ethnic Specificity and Phenomics of Critical Illness in Liaoning Province Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Key Laboratory of Phenomics in Shenyang Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Department of Biochemistry School of Basic MedicineShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Department of Clinical Medicine Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina International Education School International Exchange and Cooperation OfficeShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is a malignant disease with high incidence and mortality *** study focuses on the TP53 target protein to investigate the potential therapeutic effect of tetrahydrocurcumin(THC)on HCC and its mechanism of *** research hypothesis is that THC can inhibit the proliferation,migration,and invasion of HCC cells,and promote their apoptosis by regulating the TP53 target *** To explore the mechanism by which THC inhibits HCC cell proliferation via the TP53 signaling *** Potential targets of THC and HCC were identified from multiple *** core targets were subjected to analyses using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases,and visualization processing,using the online platform Metascape to identify the key molecules and signaling pathways involved in the action of THC against *** molecular mechanisms of action of THC against TP53 in the inhibition of HCC cells were verified using cell counting kit-8,Transwell,apoptosis,and western blotting *** Molecular docking results showed that THC had a high score for the TP53 target *** vitro experiments indicated that THC effectively inhibited the proliferation and migration of HCC cells,and affected the expression levels of TP53,MDM2,cyclin B,Bax,Bcl-2,caspase-9,and *** THC induces the apoptosis of HCC cells through the TP53 signaling pathway,thereby inhibiting their proliferation and migration.

关键词： Hepatocellular carcinoma cells Tetrahydrocurcumin TP53 Network pharmacology Molecular docking

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认罪认罚案件中被追诉人自愿性保障问题研究

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哈尔滨师范大学社会科学学报 2025年第1期16卷 78-84页

作者：高勇代俊哈尔滨商业大学法学院黑龙江哈尔滨150028

认罪认罚从宽制度作为协商性司法的中国实践,顺应了案件繁简分流、提高刑事司法效率的司法改革需要。但是,随着该制度在司法实践中适用的增多,其在适用过程中的问题也逐渐显露,其中最突出的问题是被追诉人是否自愿认罪认罚。被追诉人知... 详细信息

认罪认罚从宽制度作为协商性司法的中国实践,顺应了案件繁简分流、提高刑事司法效率的司法改革需要。但是,随着该制度在司法实践中适用的增多,其在适用过程中的问题也逐渐显露,其中最突出的问题是被追诉人是否自愿认罪认罚。被追诉人知悉权保障不足且难以获得有效的法律帮助致使对其合法权利保障不足,审查时间短、方式不合理与审查内容片面等问题导致法院对被追诉人认罪认罚自愿性审查形式化,对被追诉人行使反悔权缺乏必要规定且行使反悔权存在“从重处罚的风险”等诸多问题导致被追诉人认罪认罚自愿性保障不足,进而在司法适用中出现违背该制度设计初衷的问题。针对以上问题,应通过加强对被追诉人权利保障、完善法院审查机制、保障被追诉人反悔权等措施予以解决。

关键词：认罪认罚案件自愿性被追诉人权利保障

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数字经济助推中国体育产业链现代化的作用机制、赋能效应及实现路径

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山东体育学院学报 2025年第1期41卷 62-70页

作者：鲁志琴戴俊何姿颖盐城师范学院体育学院江苏盐城224002 江汉大学体育学院湖北武汉430056

产业链现代化是中国体育产业链高质量发展的必然选择,数字经济为助推中国体育产业链现代化提供了新机遇。该研究运用文献资料和逻辑分析等方法探究了数字经济助推中国体育产业链现代化的作用机制、赋能效应与实现路径。研究发现:数字经... 详细信息

产业链现代化是中国体育产业链高质量发展的必然选择,数字经济为助推中国体育产业链现代化提供了新机遇。该研究运用文献资料和逻辑分析等方法探究了数字经济助推中国体育产业链现代化的作用机制、赋能效应与实现路径。研究发现:数字经济助推体育产业链现代化的作用机制主要表现为优化生产要素组合,拓展供需匹配空间,提升协同治理效率及实现数字化转型;数字经济助推体育产业链现代化的赋能效应表现在创新激励效应、市场调节效应、业态融合效应、要素配置效应及规模经济效应5个方面。据此,提出了实现路径:加大数字基建建设力度,构建体育产业链发展新格局;完善数字平台架构体系,优化体育产业链服务功能;推动数字空间协同治理,营造多链融合创新生态;注重数字技术研发应用,丰富体育产业链应用场景。

关键词：数字经济体育产业链产业链现代化作用机制赋能效应实现路径

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To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 270-290页

作者： Zhuo-Cong Bao Zhao-Dong Liu Ye Zhang Hui-jun dai Hui Jia Fu Ren Ning Li Lu Zhao Yi-Wei Wang Shang-Yu Lv Yan Zhang Graduate School Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Guangxi Medical University Cancer Hospital Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina School of Traditional Chinese Medicine Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Key Laboratory of Human Ethnic Specificity and Phenomics of Critical Illness in Liaoning Province Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Key Laboratory of Phenomics in Shenyang Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Department of Biochemistry School of Basic MedicineShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Molecular Morphology Laboratory College of Basic Medical SciencesShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina Batch 2022 Clinical MedicineShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina International Education School International Exchange and Cooperation OfficeShenyang Medical CollegeShenyang 110034Liaoning ProvinceChina

BACKGROUND Liver cancer has a high incidence and mortality worldwide,especially in ***,we investigated the therapeutic effect and mechanism of tetrahydrocurcumin against hepatocellular carcinoma(HCC),with a focus on the of phosphoinositide 3-kinases(PI3K)/AKT signaling *** To investigate the effects and mechanism of tetrahydrocurcumin in HCC cell lines HepG2 and *** Using Metascape,we analyzed the potential targets of tetrahydrocurcumin in *** docking validation was performed using *** Counting Kit-8,wound healing,and transwell assays were performed to evaluate the effects of tetrahydrocurcumin on HepG2 and Huh7 cell migration,invasion,and *** expression of PI3K/AKT signaling pathway-related proteins was detected by western *** Network pharmacology and molecular docking showed that tetrahydrocurcumin has high binding affinity for phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit *** vitro experiments demonstrated that tetrahydrocurcumin suppressed the migration and invasion of liver cancer cells,promoted their apoptosis,and downregulated the expression of p-PI3K,p-AKT,and B cell leukemia/lymphoma 2,while upregulating caspase-3,p53,and B cell leukemia/lymphoma 2 associated *** In summary,tetrahydrocurcumin suppresses PI3K/AKT signaling,promotes apoptosis,and prevents the migration and invasion of liver cancer cells.

关键词： Hepatocellular carcinoma Tetrahydrocurcumin Network pharmacology Molecular docking PI3K/AKT signaling pathway

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多源流框架下城市公共安全政策的变迁机制--基于改革开放以来226份政策文本分析

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长白学刊 2025年第1期 72-86页

作者：戴均刘家鼎陕西师范大学政法与公共管理学院陕西西安710119

维护城市公共安全是推进中国式现代化的重要一环,分析城市公共安全政策,探究其变迁历程,对我国城市公共安全研究与治理实践具有重要意义。城市公共安全政策变迁的深层次机制是什么?这是亟待探索的问题。本研究基于中国治理场域,将政策... 详细信息

维护城市公共安全是推进中国式现代化的重要一环,分析城市公共安全政策,探究其变迁历程,对我国城市公共安全研究与治理实践具有重要意义。城市公共安全政策变迁的深层次机制是什么?这是亟待探索的问题。本研究基于中国治理场域,将政策源流细分为缓流和湍流,并关注各源流间的互动关系,进一步修正多源流框架;运用文本分析法,梳理改革开放以来的226份政策文件,总结出城市公共安全政策变迁经历了灾害管理、应急管理、风险治理和韧性治理四个阶段,明晰了政策缓流和政策湍流的内容。研究表明,城市公共安全政策变迁机制包括:政治与问题源流以“引领-需求”路径互动、政治与政策源流以“引领-回应”路径互动、问题与政策源流以“需求-回应”路径互动。

关键词：城市公共安全政策多源流框架政策变迁城市公共安全治理

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A synthesizing control model of networked control systems to guarantee QoP and QoS

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控制理论与应用（英文版） 2008年第4期6卷 379-384页

作者： jun KANG Guanzhong dai College of Automation Northwestern Polytechnical University Xi＇an Shannxi 710072 China

The whole performance of the networked control system （NCSs） depends on two interaction factors, namely the quality of control performance （QoP） and quality of network service （QoS）. So, to optimize the whole perfor-mance of NCSs, the problem of guaranteeing QoP and QoS plays an important role in the design of NCSs. However, up to now, little work has been done in this field. In this paper, a synthesizing control model of NCSs to guarantee QoP and QoS is proposed, and a feasible condition of optimizing whole performance of NCSs is also suggested. Finally, the simulation results show that the proposed model is effective.

关键词： Networked control system (NCSs) Synthesizing control Quality of control performance (QoP) Quality of network service (QoS)

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广西特色大横枝杉优树选择

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安徽农业科学 2025年第1期53卷 123-125页

作者：程琳戴俊陈代喜陈晓明广西壮族自治区林业科学研究院广西南宁530002 广西优良用材林资源培育重点实验室广西南宁530002

采用5株优势木对比法,对广西特色大横枝杉展开调查,探索大横枝杉的生长特性,初选优树35株,优势木175株。经统计分析,确定了大横枝杉优树选择范围:胸径和材积分别是优势木均值的207%和569%,树高大于优势木均值。根据该范围,对35株候选优... 详细信息

采用5株优势木对比法,对广西特色大横枝杉展开调查,探索大横枝杉的生长特性,初选优树35株,优势木175株。经统计分析,确定了大横枝杉优树选择范围:胸径和材积分别是优势木均值的207%和569%,树高大于优势木均值。根据该范围,对35株候选优树进行复选,获得大横枝杉Ⅰ级优树19株,Ⅱ级优树6株,入选率分别为54.29%和17.14%,可为大横枝杉无性系种子园营建提供优质种质材料。

关键词：大横枝杉优树选择变异规律

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Interior gradient and Hessian estimates for the Dirichlet problem of semi-linear degenerate elliptic systems: A probabilistic approach

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Science China Mathematics 2019年第10期62卷 1851-1886页

作者： jun dai Shanjian Tang Bingjie Wu School of Mathematical Sciences Fudan University

In this paper, we give interior gradient and Hessian estimates for systems of semi-linear degenerate elliptic partial differential equations on bounded domains, using both tools of backward stochastic differential equ... 详细信息

关键词： semi-linear degenerate elliptic systems quasi-derivatives backward stochastic differential equations Dirichlet problems

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Independent control of harmonic amplitudes and phases via a time-domain digital coding metasurface

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Light(Science & Applications) 2018年第1期7卷 201-210页

作者： jun Yan dai Jie Zhao Qiang Cheng Tie jun Cui State Key Laboratory of Millimeter Waves Southeast University210096 NanjingChina Synergetic Innovation Center of Wireless Communication Technology Southeast University210096 NanjingChina

Harmonic manipulations are important for applications such as wireless communications,radar detection and biological monitoring.A general approach to tailor the harmonics involves the use of additional amplifiers and phase shifters for the precise control of harmonic amplitudes and phases after the mixing process;however,this approach leads to issues of high cost and system *** composed of a periodic array of subwavelength resonators provide additional degrees of freedom to realize customized responses to incident light and highlight the possibility for nonlinear control by taking advantage of time-domain ***,we designed and experimentally characterized a reflective time-domain digital coding metasurface,with independent control of the harmonic amplitude and *** the reflection coefficient is dynamically modulated in a predefined way,a large conversion rate is observed from the carrier signal to the harmonic components,with magnitudes and phases that can be accurately and separately *** addition,by encoding the reflection phases of the meta-atoms,beam scanning for multiple harmonics can be implemented via different digital coding sequences,thus removing the need for intricate phase-shift *** work paves the way for efficient harmonic control for applications in communications,radar,and related areas.

关键词： harmonic harmonics surface

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First Principles Study on FeAs Single Layers

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Chinese Journal of Chemical Physics 2009年第2期22卷 139-142页

作者： jun dai Zhen-yu Li Jin-long Yang Hefei National Laboratory for Physical Sciences at Microscale University of Science and Technology of China Hefei 230026 China

FeAs^- single layer is tested as a simple model for LaFeAsO and BaFe2As2 based on firstprinciples calculations using generalized gradient approximation （GGA） and GGA＋U. The calculated single-layer geometric and electronic structures are inconsistent with that of bulk materials. The bulk collinear antiferromagnetic ground state failed to be obtained in the FeAs^- single layer. The monotonous behavior of the Fe-As distance in z direction upon electron or hole doping is also in contrast with bulk materials. The results indicate that, in LaFeAsO and BaFe2As2, interactions between FeAs layer and other layers beyond simple charge doping are important, and a single FeAs layer may not represent a good model for Fe based superconducting materials.

关键词： Superconductivity FeAs layer Magnetism Density functional theory

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