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From dichotomy to diversity:deciphering the multifaceted roles of tumor-associated macrophages in cancer progression and therapy

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Cancer Biology & Medicine 2024年第2期21卷 132-138页

作者： Xiumei Wang Jun Chen Guangshuai Jia Department of Immunology and Microbiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Jinfeng Laboratory Chongqing 401329China GMU-GIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou 510182China

Macrophages are innate immune cells that are ubiquitously distributed throughout the vertebrate body.Macrophages orchestrate sophisticated processes in development,homeostasis,immunity,and disease1.Macrophages residing in tumor tissues are commonly known as tumor-associated macrophages(TAMs)and promote or inhibit tumor growth depending on the activation state2.

关键词： immunity homeostasis tumor

Integrability and Exact Solutions of the(2+1)-dimensional KdV Equation with Bell Polynomials Approach

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Acta Mathematicae Applicatae Sinica 2022年第4期38卷 861-881页

作者： jun-cai PU Yong chen School of Mathematical Sciences Shanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal UniversityShanghai 200062China College of Mathematics and Systems Science Shandong University of Science and TechnologyQingdao 266590China

In this paper,the bilinear formalism,bilinear B?cklund transformations and Lax pair of the(2+1)-dimensional KdV equation are constructed by the Bell polynomials approach.The N-soliton solution is derived directly from the bilinear form.Especially,based on the two-soliton solution,the lump solution is given out analytically by taking special parameters and using Taylor expansion formula.With the help of the multidimensional Riemann theta function,multiperiodic(quasiperiodic)wave solutions for the(2+1)-dimensional KdV equation are obtained by employing the Hirota bilinear method.Moreover,the asymptotic properties of the one-and two-periodic wave solution,which reveal the relations with the single and two-soliton solution,are presented in detail.

关键词： the bilinear formalism bilinear B?cklund transformations Lax pair lump solution periodic wave solution the asymptotic properties

Revisiting the gravity laws of inter-city mobility in megacity regions

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Science China Earth Sciences 2023年第2期66卷 271-281页

作者： Pengjun ZHAO Haoyu HU Liangen ZENG Jun Chen Xinyue YE College of Urban and Environmental Sciences Peking UniversityBeijing100871China School of Urban Planning and Design Peking University Shenzhen Graduate SchoolShenzhen518055China Laboratory for Laboratory for Earth Surface System and Human-Earth Relations Ministry of Natural Resources of ChinaPeking University Shenzhen Graduate SchoolShenzhen518055China National Geomatics Center of China Beijing100048China Department of Landscape Architecture and Urban Planning Texas A&M UniversityCollege StationTX77843USA

Inter-city mobility is one of the most important issues in the UN Sustainable Development Goals,as it is essential to access the regional labour market,goods and services,and to constrain the spread of infectious diseases.Although the gravity model has been proved to be an effective model to describe mobility among settlements,knowledge is still insufficient in regions where dozens of megacities interact closely and over 100 million people reside.In addition,the existing knowledge is limited to overall population mobility,while the difference in inter-city travel with different purposes is unexplored on such a large geographic scale.We revisited the gravity laws of inter-city mobility using the 2.12 billion trip chains recorded by 40.48 million mobile phone users’trajectories in the Jing-Jin-Ji Region,which contains China’s capital Beijing.Firstly,unlike previous studies,we found that non-commuting rather than commuting is the dominant type of inter-city mobility(89.3%).Noncommuting travellers have a travel distance 42.3%longer than commuting travellers.Secondly,we developed more accurate gravity models for the spatial distribution of inter-city commuting and non-commuting travel.We also found that inter-city mobility has a hierarchical structure,as the distribution of inter-city travel volume follows Zipf’s law.In particular,the hierarchy of non-commuting travel volume among the cities is more in line with an ideal Zipf distribution than commuting travel.Our findings contribute to new knowledge on basic inter-city mobility laws,and they have significant applications for regional policies on human mobility.

关键词： Mobility Inter-city Travel behaviour Megacity region Zipf’s law China

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Photogalvanic effect induced charge and spin photocurrent in group-V monolayer systems

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Frontiers of physics 2023年第6期18卷 253-261页

作者： Li-Wen Zhang Ya-Qing Yang Jun Chen Lei Zhang School of Physics and Information Engineering Shanxi Normal UniversityTaiyuan 030031China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyShanxi UniversityTaiyuan 030006China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Theoretical PhysicsShanxi UniversityTaiyuan 030006China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Photogalvanic effect(PGE)occurs in materials with non-centrosymmetric structures when irradiated by linearly or circularly polarized light.Here,using non-equilibrium Green’s function combined with density functional theory(NEGF-DFT),we investigated the linear photogalvanic effect(LPGE)in monolayers of group-V elements(As,Sb,and Bi)by first-principles calculations.First,by designing a two-probe structure based on the group-V elements,we found a giant anisotropy photoresponse of As between the armchair and zigzag directions.Then,we analyzed Sb and Bi’s charge and spin photocurrent characteristics when considering the spin-orbit coupling(SOC)effect.It is found that when the polarization direction of linearly polarized light is parallel or perpendicular to the transport direction(θ=0°or 90°),the spin up and spin down photoresponse in the armchair direction has the same magnitude and direction,leading to the generation of net charge current.However,in the zigzag direction,the spin up and spin down photoresponse have the same magnitude with opposite directions,leading to the generation of pure spin current.Furthermore,it is understood by analyzing the bulk spin photovoltaic(BSPV)coefficient from the symmetry point of view.Finally,we found that the net charge current generated in the armchair direction and the pure spin current generated in the zigzag direction can be further tuned with the increase of the material’s buckling height.Our results highlight that these group-V monolayers are promising candidates for novel functional materials,which will provide a broad prospect for the realization of ultrathin ferroelectric devices in optoelectronics due to their spontaneous polarization characteristics and high Curie temperature.

关键词： group-V monolayers photogalvanic effect pure spin current

Plant-derived polyphenols in sow nutrition:An update

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Animal Nutrition 2023年第1期12卷 96-107页

作者： Jun Chen Zhouyin Huang Xuehai Cao Tiande Zou Jinming You Wutai Guan Jiangxi Province Key Laboratory of Animal Nutrition College of Animal Science and TechnologyJiangxi Agricultural UniversityNanchang330045China Guangdong Provincial Key Laboratory of Animal Nutrition Control College of Animal ScienceSouth China Agricultural UniversityGuangzhou510642China

Oxidative stress is a potentially critical factor that affects productive performance in gestating and lactating sows.Polyphenols are a large class of plant secondary metabolites that possess robust antioxidant capacity.All polyphenols are structurally characterized by aromatic rings with multiple hydrogen hydroxyl groups;those make polyphenols perfect hydrogen atoms and electron donors to neutralize free radicals and other reactive oxygen species.In the past decade,increasing attention has been paid to polyphenols as functional feed additives for sows.Polyphenols have been found to alleviate inflammation and oxidative stress in sows,boost their reproductivity,and promote offspring growth and development.In this review,we provided a systematical summary of the latest research advances in plant-derived polyphenols in sow nutrition,and mainly focused on the effects of polyphenols on the(1)antioxidant and immune functions of sows,(2)placental functions and the growth and development of fetal piglets,(3)mammary gland functions and the growth and development of suckling piglets,and(4)the long-term growth and development of progeny pigs.The output of this review provides an important foundation,from more than 8,000 identified plant phenols,to screen potential polyphenols(or polyphenol-enriched plants)as functional feed additives suitable for gestating and lactating sows.

关键词： Offspring pig Plant-derived polyphenols Sow nutrition

Graphene-based materials for flexible energy storage devices

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Journal of Energy Chemistry 2018年第1期27卷 12-24页

作者： Kena chen Qingrong Wang Zhiqiang Niu Jun Chen Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education).College of Chemistry.Nankai University Tianjin 300071.China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Nankai UniversityTianjin 300071China

The booming developments in portable and wearable electronics promote the design of flexible energy storage systems. Flexible supercapacitors and batteries as promising energy storage devices have attracted tremendous attention. As the key component of both supercapacitors and batteries, electrode materials with excellent flexibility should be considered to match with highly flexible energy storage devices. Owing to large surface area, good thermal and chemical stability, high conductivity and mechanical flexibility,graphene-based materials have been widely employed to serve as promising electrodes of flexible energy storage devices. Considerable efforts have been devoted to the fabrication of flexible graphene-based electrodes through a variety of strategies. Moreover, different configurations of energy storage devices based on these active materials are designed. This review highlights flexible graphene-based two-dimensional film and one-dimensional fiber supercapacitors and various batteries including lithium-ion, lithium–sulfur and other batteries. The challenges and promising perspectives of the graphene-based materials for flexible energy storage devices are also discussed.

关键词： Graphene Flexible Energy storage device

Degree Conditions on Copies of Forests in Graphs

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Journal of the Operations Research Society of China 2023年第3期11卷 667-672页

作者： Xiao-Dong chen Shuai-Jun Chen Ming-Chu Li School of Mathematics Liaoning Normal UniversityDalian116029LiaoningChina College of Science Liaoning University of TechnologyJinzhou121001LiaoningChina School of Softsware Dalian University of TechnologyDalian116024LiaoningChina

For a graph G,letμ(G)=min{max{d(x),d(y)}:x≠y,xy∉E(G),x,y∈V(G)}if G is non-complete,otherwise,μ(G)=+∞.For a given positive number s,we call that a graph G satisfies Fan-type conditions ifμ(G)≥s.Supposeμ(G)≥s,then a vertex v is called a small vertex if the degree of v in G is less than s.In this paper,we prove that for a forest F with m edges,if G is a graph of order n≥|F|andμ(G)≥m with at most max{n−2m,0}small vertices,then G contains a copy of F.We also give examples to illustrate both the bounds in our result are best possible.

关键词： Fan-type conditions Forest Copy Small vertex

Accurate analysis of limiting human dose of non-lethal laser weapons

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Defence Technology（防务技术） 2022年第4期18卷 678-688页

作者： chen-yang Lyu Ren-jun Zhan College of Equipment Management and Support Chinese People’s Armed Police Force Engineering UniversityXi’an710086ShaanxiChina

In order to maximize the lethality and reversibility of the non-lethal laser weapons(NLLW) at the same time and thus provide a theoretical basis for the R&D of laser weapons in the future,this paper accurately analyzed the limiting biological dose of irreversible damage to human skin caused by the NLLW.Firstly,based on the burn theory in medicine and the actual tactical background,this paper redefines the evaluation criteria of the limiting laser dose of NLLW to the human body.Secondly,on the basis of anatomical knowledge,a 5-layer finite element model(FEM) of superficial skin is proposed,constructed and verified,which can accurately describe the limiting reversible damage.Based on the optimized Pennes bioheat transfer equation,the diffusion approximation theory,the modified Beer-Lambert law,the Arrhenius equation,and combined with dynamic thermophysical parameters,this paper highly restored the temperature distribution and accurately solved the necrotic tissue distribution inside the human skin irradiated by 1064 nm laser.Finally,it is concluded that the maximum human dose of the1064 nm NLLW is 8.93 J/cm^(2),8.29J/cm^(2),and 8.17 J/cm^(2) when the light spots are 5 mm,10 mm and15 mm,respectively,and the corresponding output power of the weapon is 46.74 W,173.72 W and384.77 W.Simultaneously,the temperature and damage distribution in the tissue at the time of ultimate damage are discussed from the axial and radial dimensions,respectively.The conclusions and analysis methods proposed in this paper are of great guiding significance for future research in military,medical and many other related fields.

关键词： Laser weapon Non-lethal Limit dose Tissue optics Bioheat transfer Finite element

Outstanding electromechanical performance in piezoelectric ceramics via synergistic effects of defect engineering and domain miniaturization

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Journal of Materials Science & Technology 2023年第27期158卷 1-8页

作者： Zhifei Zhang Liang chen Huajie Luo Yueyun Zhang Yonghao Yao Guanfu Liu He Qi Jun Chen Beijing Advanced Innovation Center for Materials Genome Engineering Department of Physical ChemistryUniversity of Science and Technology BeijingBeijing 100083China Hainan University Haikou 570228China

Piezoelectric ceramics with high mechanical quality factor Q_(m) and large piezoelectric coefficient d_(33) are urgently required for advanced piezoelectric applications.However,obtaining both of these prop-erties simultaneously remains a difficult challenge due to their mutually restrictive relationship.Here 0.5Pb(Ni_(1/3)Nb_(2/3))O_(3)-0.5Pb(Zr_(0.3)Ti_(0.7))O_(3) piezoceramic with tetragonal(T)-rich MPB is designed as a matrix to construct the defect engineering by doping low-valent Mn ions.The strong coupling of defect dipole and T-rich phase can effectively hinder the rotation of P_(s),restrict domain wall motion and improve Q_(m).At the same time,the substituted Mn ions will introduce local random field,destroying the long-range or-dering of ferroelectric domain and reducing domain size.The miniaturized domain structure can increase poling efficiency and inhibit the reduction of d_(33).Guided by this strategy,Q_(m) has increased by more than 10 times and d_(33) has only decreased by about 25%.The optimized electromechanical performance with Q_(m)=822,d_(33)=502 pC/N,k_(p)=0.55 and tanδ=0.0069 can be obtained in the present study.

关键词： PNN-PZT ceramics Defect engineering Domain miniaturization High mechanical quality factor Q_(m) Large piezoelectric coefficient d_(33)