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World Journal of Clinical Cases 2020年第19期8卷 4380-4387页

作者： Yan-Hua Zhang Bo Su Pei Sun Ru-Meng Li Xiao-Chun Peng jun cai Department of Oncology First Affiliated HospitalYangtze UniversityJingzhou 434023Hubei ProvinceChina Laboratory of Oncology Center for Molecular MedicineSchool of Basic MedicineYangtze UniversityJingzhou 434023Hubei ProvinceChina

BACKGROUND It is not known whether percutaneous radiofrequency ablation(PRFA)has the same treatment efficacy and fewer complications than laparoscopic resection in patients with small centrally located hepatocellular carcinoma(HCC).AIM To compare the effectiveness of PRFA with classical laparoscopic resection in patients with small HCC and document the safety parameters.METHODS In this retrospective study,85 patients treated with hepatic resection(HR)and 90 PRFA-treated patients were enrolled in our hospital from July 2016 to July 2019.Treatment outcomes,including major complications and survival data,were evaluated.RESULTS The results showed that minor differences existed in the baseline characteristics between the patients in the two groups.PRFA significantly increased cumulative recurrence-free survival(hazard ratio 1.048,95%CI:0.265-3.268)and overall survival(hazard ratio 0.126,95%CI:0.025-0.973);PRFA had a lower rate of major complications than HR(7.78%vs 20.0%,P<0.05),and hospital stay was shorter in the PRFA group than in the HR group(7.8±0.2 d vs 9.5±0.3 d,P<0.001).CONCLUSION Based on the data obtained,we conclude that PRFA was superior to HR and may reduce complications and hospital stay in patients with small HCC.

关键词： Percutaneous radiofrequency ablation Hepatic resection Hepatocellular carcinoma Efficacy Safety Cancer

Etiology spectrum and clinical characteristics of renal artery stenosis in a Chinese cohort

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Journal of Geriatric Cardiology 2021年第2期18卷 104-113,I0001页

作者： Xu MENG Yi ZHOU Xiong-Jing JIANG jun cai Hui-Min ZHANG Hai-Ying WU Wen-jun MA Ying LOU Ya-Xin LIU Xian-Liang ZHOU Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Emergency and Critical Care Center Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVE To analyze the causes of renal artery stenosis(RAS)and compare the clinical characteristics in accordance with the primary disease among patients aged from 30 to 50.METHODS Patients were grouped by etiologies of RAS.Groups were retrospectively examined and compared regarding demographic data,clinical manifestations,laboratory findings,and imaging findings.RESULTS A total of 152 patients(74 females,78 males;mean age:40.70±6.01 years)were enrolled,including 84 patients(55.3%)with atherosclerosis(AS),46 patients(30.3%)with Takayasu arteritis(TA),18 patients(11.8%)with fibromuscular dysplasia(FMD),and four patients(2.6%)with other etiologies.Patients in AS group had greater body mass index,higher prevalence of comorbidities and higher rate of smoking and drinking history.TA patients showed more constitutional symptoms and vascular findings,and higher erythrocyte sedimentation rate.RAS in both AS group and TA group mainly located on ostia and proximal segments,but RAS in FMD group mainly involved middle to distal segment of renal artery.The AS group had significantly lesser stenosis than the other groups.Although renal function evaluated by the estimated glomerular filtration rate did not significantly differ among the groups,the incidence of kidney shrinkage was significantly higher in the TA and FMD groups(39.1%and 50%,respectively)than in the AS group(8.3%).The FMD group had milder cardiac damage than other groups.CONCLUSIONS AS was the most common cause of RAS in patients aged from 30 to 50,followed by TA and FMD.The etiology of RAS should be carefully distinguished based on clinical manifestations,laboratory findings,and imaging to ensure that proper treatment is provided.

关键词： clinical stenosis finding

Tuberculosis in Takayasu arteritis: a retrospective study in 1105 Chinese patients

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Journal of Geriatric Cardiology 2019年第8期16卷 648-655页

作者： Ying ZHANG Peng FAN Fang LUO Hui-Min ZHANG Lei SONG Wen-jun MA Hai-Ying WU jun cai Lin-Ping WANG Xian-Liang ZHOU Department of Cardiology Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College

Background Tuberculosis (TB) infection has been reported to have a possible relationship with the occurrence and clinical course of Takayasu arteritis (TA). We aimed to describe the characteristics of TB in a large population of TA patients. Methods We included a total of 1105 patients with TA, who were hospitalized between January 1992 and December 2017. Comparisons of clinical features were made according to the presence of TB. Results Among the 1105 patients, 109 (9.9%) had TB, including 53 patients (48.6%) diagnosed with TB before the onset of TA, 23 (21.1%) with a concurrent diagnosis of TB and TA, and 24 patients (22.0%) who developed TB after TA. Pulmonary TB was the most frequently identified (97 patients, 89.0%). Patients with TB had more frequent involvement of the pulmonary artery and experienced more chest discomfort and constitutional symptoms but had less interventional treatment. Demographic characteristics, comorbid diseases, and use of steroids were similar between patients with and without TB. Conclusions The proportion of Chinese TA patients with TB was not low, and about half of the patients had TB before TA. Pulmonary TB was the most common. Pulmonary artery involvement and pulmonary hypertension was more frequent in TA patients with TB.

关键词： Immunosuppressive agents Mycobacterium tuberculosis Pulmonary artery Takayasu arteritis

TERT基因在非小细胞肺癌易感性及预后中的研究进展

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现代肿瘤医学 2024年第1期32卷 193-196页

作者：杨柳蔡君长江大学附属第一医院湖北荆州434023 公安县人民医院湖北荆州434300

肺癌是世界上最常见的恶性肿瘤之一,具有很高的死亡率,85%的肺癌患者组织学类型为非小细胞肺癌(non-small cell lung cancer,NSCLC)。非小细胞肺癌的预后较差,与诊断晚、复发风险高、药物耐药等有关。端粒酶是细胞存活的关键酶,它能维... 详细信息

肺癌是世界上最常见的恶性肿瘤之一,具有很高的死亡率,85%的肺癌患者组织学类型为非小细胞肺癌(non-small cell lung cancer,NSCLC)。非小细胞肺癌的预后较差,与诊断晚、复发风险高、药物耐药等有关。端粒酶是细胞存活的关键酶,它能维持细胞端粒的长度,使细胞具有无限增殖和永生化的潜能。端粒酶逆转录酶(TERT基因编码)是端粒酶的催化亚基,能激活端粒酶,为细胞提供癌变的可能。TERT启动子突变被证明是激活端粒酶的一种新的遗传机制,并存在于多种人类肿瘤中。端粒酶激活和端粒损伤与人类肺癌的发生有关,且TERT基因多态性与非小细胞肺癌的易感性及预后有关。本文总结了TERT启动子突变及TERT多态性在非小细胞肺癌中的研究,以及它对非小细胞肺癌预后的影响及靶向治疗前景。

关键词：非小细胞肺癌 TERT启动子突变端粒酶逆转录酶预后

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一种宽输入范围高PSRR线性稳压器设计

兰州工业学院学报 2024年第1期31卷 40-44页

作者：蔡俊王勇安徽理工大学电气与信息工程学院安徽淮南232001

针对一般线性稳压器输入电压范围较窄,对电源纹波抑制能力较差的问题,设计了一款宽输入范围、高电源抑制比的线性稳压器。采用折叠式共源共栅结构的误差放大器提升环路增益,与负载相关的零点移动频率补偿结构保证整个环路的稳定性。结... 详细信息

针对一般线性稳压器输入电压范围较窄,对电源纹波抑制能力较差的问题,设计了一款宽输入范围、高电源抑制比的线性稳压器。采用折叠式共源共栅结构的误差放大器提升环路增益,与负载相关的零点移动频率补偿结构保证整个环路的稳定性。结果表明:基于180 nm 45 V BCD工艺完成电路设计,在输入电压范围为6~45 V,负载电流范围0~100 mA的条件下,能够稳定输出5 V电压,具有良好的线性调整率。当输入电压为24 V,负载电流为50 mA时,低频段下电源抑制比为85.5 dB。

关键词：线性稳压器电源抑制比频率补偿

Combination of anti-PD-1 antibody with P-GEMOX as apotentially effective immunochemotherapy for advancednatural killer/T cell lymphoma

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Signal Transduction and Targeted Therapy 2021年第1期6卷 184-192页

作者： jun cai Panpan Liu Huiqiang Huang Yajun Li Shuyun Ma Hui Zhou Xiaopeng Tian Yuchen Zhang Yan Gao Yi Xia Xuanye Zhang Hang Yang Lirong Li Qingqing cai State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060P.R.China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060P.R.China Department of Lymphoma and Hematology Hunan Cancer HospitalChangsha 410013P.R.China Department of Lymphoma and Hematology The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013P.R.China

Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available therapies.Here,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcitabine,and oxaliplatin)regimen in advanced NKTL.Nine patients underwent six 21-day cycles of anti-PD-1 antibody(day 1),pegaspargase 2000 U/m^(2)(day 1),gemcitabine 1 g/m^(2)(days 1 and 8)and oxaliplatin 130 mg/m^(2)(day 1),followed by anti-PD-1 antibody maintenance every 3 weeks.Programmed death-ligand 1(PD-L1)expression and genetic alterations were determined in paraffin-embedded pretreatment tissue samples using immunohistochemistry and next-generation sequencing(NGS)analysis.Responses were assessed using ^(18)F-fluorodeoxyglucose positron emission tomography(^(18)FDG-PET)and computed tomography or magnetic resonance imaging.Eight patients exhibited significant responses,comprising of seven complete remissions and one partial remission(overall response rate:88.9%).After a median follow-up of 10.6 months,6/9 patients(66.7%)remained in complete remission.The most common grade 3/4 adverse events were anemia(33.3%),neutropenia(33.3%),and thrombocytopenia(33.3%);all of which were manageable and resolved.Immunochemotherapy produced a high response rate in patients with positive PD-L1 expression(5/6,83.3%).NGS analysis suggested that STAT3/JAK3/PD-L1 alterations and ARID1A mutation were associated with immunochemotherapy efficacy.Mutation in DDX3X and alteration in epigenetic modifiers of KMT2D,TET2,and BCORL1 might indicate a poor response to immunochemotherapy.In conclusion,the anti-PD-1 antibody plus P-GEMOX regimen demonstrated promising efficacy in advanced NKTL.PD-L1 expression combined with specific genetic alterations could be used as potential biomarkers to predict therapeutic responses to immunochemotherapy.

关键词： alterations killer lymphoma

基于可达性分析的游憩服务流与服务级联研究——以秦皇岛碣石山风景区为例

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中国城市林业 2024年第2期22卷 72-78页

作者：李光子蔡君北京工业职业技术学院北京100042 北京林业大学园林学院北京100083

理解游憩服务流动机制与服务级联对于实现生态系统服务与社会福祉协同提升具有促进作用。文章在明确游憩服务流与服务级联产生机制的基础上,提出游憩服务级联模式,即以游憩资源-服务潜力-游憩服务-使用者受益-福祉形成5个阶段来理解从... 详细信息

理解游憩服务流动机制与服务级联对于实现生态系统服务与社会福祉协同提升具有促进作用。文章在明确游憩服务流与服务级联产生机制的基础上,提出游憩服务级联模式,即以游憩资源-服务潜力-游憩服务-使用者受益-福祉形成5个阶段来理解从游憩服务供给到人类福祉的过程;应用成本距离法和栅格耗费距离法,结合问卷调查与可达性和人口密度分析,对秦皇岛市碣石山风景区的市域尺度和区域尺度游憩服务流形态特征和流动机制进行研究,结果表明:不同空间尺度上的服务流模式主要有3种,即碣石山—秦皇岛模式,通过田园观光等游憩服务提供身心放松等最直接的收益形式;碣石山—秦皇岛—京津冀模式,作用于从身心健康到自我实现各个层级的福祉;碣石山—京津冀模式,以放松解压、锻炼身体为主要的游客受益形式。

关键词：游憩服务流服务级联生态系统文化服务风景区可达性碣石山

Radiological environmental impact analysis of a 2-MW thorium molten salt reactor during an accident

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Nuclear Science and Techniques 2019年第5期30卷 70-81页

作者： Chang-Qi Chen Xiao-Bin Xia Zhi-Hong Zhang jun cai Chang-Yuan Li Shanghai Institute of Applied Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

The thorium molten salt reactor–liquid fuel(TMSR-LF1) has inherent safety features. The accident occurrence possibility and their consequences are much lower for the TMSR-LF1 than that of traditional reactors.Based on accident analysis, the maximum credible accident and the radioactive source terms of the TMSR-LF1 were first estimated. Then, the total effective dose of the maximum credible accident was calculated. Based on calculations, the cover gas flow rate can significantly affect the radiation consequences of the maximum credible accident when it changes from 0 to 10 L/min. If no cover gas is flowing, a site-area emergency would be required within the range of 50–73 m from the reactor. In the case of cover gas flow, only an abnormal notification and an alert two emergency class would be required within the range of 50 m.

关键词： TMSR-LF1 Accident classification and description Maximum credible accident Emergency class

销钉固定FRP加固钢筋混凝土梁受弯性能研究

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建筑机械 2024年第6期 207-211页

作者：白君才中铁十九局集团华东工程有限公司浙江宁波315499

文章基于ABAQUS软件建立了FRP加固钢筋混凝土梁的精细化有限元模型,首先对比了栓钉固定FRP与外部粘结两种加固方式下梁的承载能力与破坏模式,发现FRP布与加固区表面的粘结性能是影响承载能力的关键,栓钉固定FRP加固方式下梁体破坏时钢... 详细信息

文章基于ABAQUS软件建立了FRP加固钢筋混凝土梁的精细化有限元模型,首先对比了栓钉固定FRP与外部粘结两种加固方式下梁的承载能力与破坏模式,发现FRP布与加固区表面的粘结性能是影响承载能力的关键,栓钉固定FRP加固方式下梁体破坏时钢筋完全屈服、FRP布全界面拉断,材料强度得到了充分利用。对试件进行参数化分析后发现,钢筋配筋率与混凝土强度等级对试件极限承载能力的影响较小;销钉固定FRP比增加FRP布层数对试件承载能力的提升更大,销钉固定FRP加固模式的本质是加强FRP布与加固区的粘结强度,延缓界面剥离出现的时间,提升粘结强度是提高梁承载能力的关键所在。因此为提升FRP加固钢筋混凝土梁的承载能力,应通过销钉加固等方式提升连接部位的粘结强度。

关键词： FRP 钢筋混凝土梁粘结强度受弯性能承载能力

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Liac arterial fibromuscular dysplasia:a systematic review

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中国循环杂志 2018年第S1期33卷 162-163页

作者： Luyun Fan Huimin Zhang jun cai National Center for Cardiovascular Diseases Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background liac arterial fibromuscular dysplasia(FMD)were rarely reported and their demographic,clinical and imaging features have not been precisely described resulting in uncertain therapeutic methods.Methods A literature review was performed using Pubmed,Web of Science and Embase database.Original articles in English published since 1990 with full-text and detailed demographic,clinical,imaging and therapeutic information regarding iliac arterial FMD were included.

关键词： fibromuscular dysplasia uncertain therapeutic methods precisely described