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腹腔镜胆囊切除术的医学伦理学问题

中国医学伦理学 2004年第1期17卷 32-33页

作者：蔡军梁久银武警安徽总队医院安徽合肥230041

腹腔镜胆囊切除术 (LC)作为一项崭新的微创手术技术 ,已成为治疗胆囊结石的标准。作者从医学伦理学的角度出发 ,探讨开展LC技术过程中应遵循的医德原则。医师的高度责任心 ,严格的腹腔镜外科培训 ,医师间的相互配合及正确地对待中转开... 详细信息

腹腔镜胆囊切除术 (LC)作为一项崭新的微创手术技术 ,已成为治疗胆囊结石的标准。作者从医学伦理学的角度出发 ,探讨开展LC技术过程中应遵循的医德原则。医师的高度责任心 ,严格的腹腔镜外科培训 ,医师间的相互配合及正确地对待中转开腹问题是顺利开展LC的重要因素。

关键词：腹腔镜胆囊切除术医学伦理学微创手术胆囊结石医德适应证

Ground State and Single Vortex for Bose-Einstein Condensates in Anisotropic Traps

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Communications in Theoretical Physics 2007年第6期47卷 1053-1057页

作者： XU Zhi-jun cai Ping-Gen Department of Applied Physics Zhejiang University of Technology Hangzhou 310032 China The State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan 430071 China

For Bose-Einstein condensation of neutral atoms in anisotropic traps at zero temperature,we presentsimple analytical methods for computing the properties of ground state and single vortex of Bose-Einstein condensates,and compare those results to extensive numerical simulations.The critical angular velocity for production of vortices iscalculated for both positive and negative scattering lengths a,and find an analytical expression for the large-N limit ofthe vortex critical angular velocity for a>0,and the critical number for condensate population approaches the point ofcollapse for a<0,by using approximate variational method.

关键词：各向异性量子阱玻色-爱因斯坦凝聚态基态波函数涡旋生成

大鼠脑谷氨酸脱羧酶基因的cDNA克隆及序列分析

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生物化学杂志 1996年第5期12卷 544-546页

作者：宋学文赵崇邓彤蔡军何炜张镜宇天津医科大学内分泌研究所

胰岛β－细胞自身抗原蛋白之一是脑中谷氨酸脱羧酶（Ｇｌｕｔａｍｉｃａｃｉｄｄｅｃａｒｂｏｘｙｌａｓｅ，ＧＡＤ，ＥＣ４．１．１．１５）同源物。以双链ｃＤＮＡ为模板，用ＰＣＲ方法快速克隆了Ｗｉｓｔａｒ大鼠脑ＧＡＤ基因的ｃＤ... 详细信息

胰岛β－细胞自身抗原蛋白之一是脑中谷氨酸脱羧酶（Ｇｌｕｔａｍｉｃａｃｉｄｄｅｃａｒｂｏｘｙｌａｓｅ，ＧＡＤ，ＥＣ４．１．１．１５）同源物。以双链ｃＤＮＡ为模板，用ＰＣＲ方法快速克隆了Ｗｉｓｔａｒ大鼠脑ＧＡＤ基因的ｃＤＮＡ，将此包括编码５９３个氨基酸的全长ＤＮＡ片段重组入ｐＵＣ质粒并用双脱氧末端终止法测定了全部序列，证明其全长为１７７９ｂｐ．经比较发现Ｗｉｓｔａｒ大鼠脑与Ｒｕｓｓｅｌｌ报导的大鼠脑ＧＡＤ基因序列，有一处碱基的差别，但并不涉及氨基酸的改变。同时还对用ＰＣＲ扩增长片段ＤＮＡ进行了方法学上的探讨。

关键词：谷氨酸脱羧酶基因 cDNA克隆序列分析

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基于成本和收益的湖北省油菜生产发展研究

湖北农业科学 2018年第7期57卷 125-126,130页

作者：蔡俊松钟燕曾卓杜光耀湖北省油菜办公室武汉430070 湖北生物科技职业学院武汉430070 湖北商贸学院武汉430079 华中农业大学经济管理学院武汉430070

采用2004-2016年湖北省油菜生产成本收益基础数据,系统分析了湖北省油菜生产的总成本、土地成本、人工成本与净利润的变化特征。结果表明,土地成本和人工成本上升已成为推动湖北省油菜生产总成本上升的主要因素;与此同时,油菜产业面临... 详细信息

采用2004-2016年湖北省油菜生产成本收益基础数据,系统分析了湖北省油菜生产的总成本、土地成本、人工成本与净利润的变化特征。结果表明,土地成本和人工成本上升已成为推动湖北省油菜生产总成本上升的主要因素;与此同时,油菜产业面临油料大量进口的冲击,油菜子价格遭遇"天花板"。在此背景下,湖北省油菜产业发展应推动适度规模经营,提升机械化水平和完善补贴政策。

关键词：油菜成本收益建议湖北省

Neoadjuvant transcatheter arterial chemoembolization and systemic chemotherapy for the treatment of undifferentiated embryonal sarcoma of the liver in children

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World Journal of Clinical Cases 2022年第19期10卷 6437-6445页

作者： Min He Jia-Bin cai Can Lai jun-Qing Mao Jie-Ni Xiong Zhong-Hai Guan Lin-Jie Li Qiang Shu Mei-Dan Ying Jin-Hu Wang Department of Surgical Oncology The Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052Zhejiang ProvinceChina Department of Radiology The Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052Zhejiang ProvinceChina Cancer Center Zhejiang UniversityHangzhou 310058Zhejiang ProvinceChina

BACKGROUND Undifferentiated embryonal sarcoma of the liver(UESL)is a rare and aggressive mesenchymal tumor in children.Herein,we describe our experience in neoadjuvant therapy(NAT)and subsequent surgery for the treatment of UESL in children.AIM To evaluate the efficacy of NAT and explore a new choice for successful operation of UESL in children.METHODS We retrospectively analyzed six patients newly diagnosed with unresectable UESL who received NAT and then surgery at our center between January 2004 and December 2019.The tumor was considered unresectable if it involved a large part of both lobes of the liver or had invaded the main hepatic vessels or inferior vena cava.The NAT included preoperative transcatheter arterial chemoembol ization(TACE)and systemic chemotherapy.The patients were 4 boys and 2 girls with a mean age of 7 years.The longest tumor at presentation ranged from 8.6 to 14.8 cm(mean,12 cm).Extrahepatic metastases were present in 2 cases.Preoperative systemic chemotherapy was administered 3 wk after TACE.Tumor resection was performed 3 wk after one or two cycles of NAT.The patients received systemic chemotherapy after surgery.RESULTS All patients successfully underwent NAT and complete resection.The tumor volumes decreased by 18.2%–68.7%,with a mean decrease of 36%after 1 cycle of NAT(t=3.524,P=0.017).According to the Response Evaluation Criteria In Solid Tumors criteria,4 patients had a partial response and underwent surgery,while 2 had stable disease and received another cycle of NAT before surgery.Massive tumor necrosis was seen on pathological examination of the surgical specimen:>90%necrosis in two,>50%necrosis in three,and 25%necrosis in 1,with an average of 71.8%.Post-NAT complications included fever,nausea and vomiting,and mild bone marrow suppression.Elevated alanine transaminase levels occurred in all patients,which returned to normal within 7–10 d after treatment.No cardiac or renal toxicity,severe hepatic dysfunction,bleeding and nontarget embolization were observed in the patients.The me

关键词： Undifferentiated embryonal sarcoma of the liver Unresectable Neoadjuvant therapy Transcatheter arterial chemoembolization Systemic chemotherapy

武汉轨道交通4号线车辆车体尺寸控制的分析及改进

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电力机车与城轨车辆 2014年第4期37卷 42-43,53页

作者：孙瑶陈阿海刘军良李梁黄军才南车株洲电力机车有限公司技术中心湖南株洲412001

文章主要针对武汉轨道交通4号线车辆试制中出现的车体尺寸超差的问题,对尺寸超差原因和车体焊接工艺进行了分析,从车体组焊工装设置、焊接顺序等方面进行了工艺改进和验证,为建立一种使用内藏门的微鼓型断面B型车体制造平台创造条件。

关键词：轨道交通车体反变形尺寸控制

枸杞籽油对亚急性衰老大鼠睾丸Nrf2/ARE通路和氧化损伤的影响

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中国药理学通报 2024年第3期40卷 490-498页

作者：田瑞莹邢莎莎虎娜马文欣刘畅刘自钰马彪李佳阳刘虎军白长财陈冬梅马会明宁夏医科大学生育力保持教育部重点实验室宁夏银川750004 宁夏医科大学基础医学院宁夏银川750004 宁夏医科大学临床医学院宁夏银川750004 宁夏医科大学药学院宁夏银川750004 宁夏医科大学总医院宁夏干细胞与再生医学重点实验室宁夏银川750004

目的探索枸杞籽油对亚急性衰老大鼠睾丸Nrf2/ARE通路和氧化损伤的影响。方法将60只8周龄♂SD大鼠中的50只(空白组10只)颈部皮下注射D-半乳糖125 mg·kg^(-1),持续8周建立亚急性衰老大鼠模型,β-半乳糖苷酶(β-galactosidase,β-gal)观... 详细信息

目的探索枸杞籽油对亚急性衰老大鼠睾丸Nrf2/ARE通路和氧化损伤的影响。方法将60只8周龄♂SD大鼠中的50只(空白组10只)颈部皮下注射D-半乳糖125 mg·kg^(-1),持续8周建立亚急性衰老大鼠模型,β-半乳糖苷酶(β-galactosidase,β-gal)观察衰老细胞,HE观察睾丸形态,ELISA检测血清中睾酮(testosterone,T)、促卵泡激素(follicle stimulating hormone,FSH)和黄体生成素(luteinizing hormone,LH)及超氧化物歧化酶(superoxide dismutase,SOD)、谷胱甘肽(glutathione,GSH)和丙二醛(malondialdehyde,MDA)的水平,免疫组化和Western blot检测衰老、氧化损伤和Nrf2/ARE通路相关因子表达。结果模型鉴定成功后,经枸杞籽油干预,改善了睾丸形态,下调β-gal和γH2AX表达;升高血清中SOD、GSH以及T、FSH水平及降低MDA和LH水平(P<0.05);上调睾丸组织Nrf2、GCLC、NQO1和SOD2蛋白表达水平(P<0.05)以及支持细胞中Nrf2核表达。结论枸杞籽油激活亚急性衰老大鼠睾丸Nrf2/ARE信号通路表达,降低其氧化损伤,改善其激素水平。

关键词：枸杞籽油 Nrf2/ARE信号通路亚急性衰老氧化应激生殖激素睾丸

Comprehensively evaluate the short outcome of small bowel obstruction:A novel medical-economic score system

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World Journal of Gastroenterology 2023年第9期29卷 1509-1522页

作者： Wei-Xuan Xu Qi-Hong Zhong Yong cai Can-Hong Zhan Shuai Chen Hui Wang Peng-Sheng Tu Wen-Xuan Chen Xian-Qiang Chen jun-Rong Zhang Shengli Clinical Medical College Fujian Medical UniversityFuzhou 350122Fujian ProvinceChina Department of General Surgery(Emergency Surgery) Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina

BACKGROUND Small bowel obstruction(SBO)still imposes a substantial burden on the health care system.Traditional evaluation systems for SBO outcomes only focus on a single element.The comprehensive evaluation of outcomes for patients with SBO remains poorly studied.Early intensive clinical care would effectively improve the short-term outcomes for SBO,however,the full spectrum of the potential risk status regarding the high complication-cost burden is undetermined.AIM We aim to construct a novel system for the evaluation of SBO outcomes and the identification of potential risk status.METHODS Patients who were diagnosed with SBO were enrolled and stratified into the simple SBO(SiBO)group and the strangulated SBO(StBO)group.A principal component(PC)analysis was applied for data simplification and the extraction of patient characteristics,followed by separation of the high PC score group and the low PC score group.We identified independent risk status on admission via a binary logistic regression and then constructed predictive models for worsened management outcomes.Receiver operating characteristic curves were drawn,and the areas under the curve(AUCs)were calculated to assess the effectiveness of the predictive models.RESULTS Of the 281 patients,45 patients(16.0%)were found to have StBO,whereas 236 patients(84.0%)had SiBO.Regarding standardized length of stay(LOS),total hospital cost and the presence of severe adverse events(SAEs),a novel principal component was extracted(PC score=0.429×LOS+0.444×total hospital cost+0.291×SAE).In the multivariate analysis,risk statuses related to poor results for SiBO patients,including a low lymphocyte to monocyte ratio(OR=0.656),radiological features of a lack of small bowel feces signs(OR=0.316)and mural thickening(OR=1.338),were identified as risk factors.For the StBO group,higher BUN levels(OR=1.478)and lower lymphocytes levels(OR=0.071)were observed.The AUCs of the predictive models for poor outcomes were 0.715(95%CI:0.635-0.795)and 0.874(95%CI:0.762-0.986)for SiBO and StBO s

关键词： Principal component analysis Small bowel obstruction Outcome evaluation system Risk factors Intensive clinical care Radiomics

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试析武术运动员心理疲劳的产生及其恢复

体育科技文献通报 2009年第6期17卷 122-122,125页

作者：张鹏程蔡俊张忠兴安徽中医学院体育教研究安徽合肥230038 安徽师范大学体育学院安徽芜湖241000

运用文献资料和综述等方法对心理疲劳理论进行了论述,并依据武术项目的特点,总结并提出了武术运动员产生心理疲劳的原因和有效恢复心理疲劳的手段,以期为提高武术运动员的竞技水平提供理论依据。

关键词：武术运动员心理疲劳影响因素恢复手段