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Unlocking the potential of amorphous ca.cium ca.bonate: A star ascending in the realm of biomedica. applica.ion

Acta Pharmaceutica.Sinica.B 2024年第2期14卷 602-622页

作者： Han Liu Zhiyang Wen Zihan Liu Yanfang Yang Hongliang Wang Xuejun Xia jun Ye Yuling Liu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

ca.cium-based biomaterials have been intensively studied in the field of drug delivery owing to their excellent biocompatibility and ***-based materials ca. also deliver contrast agents,which ca. enhance real-time imaging and exert a ca.(2+)-interfering therapeutic *** on these characteristics,amorphous ca.cium ca.bonate(ACC),as a brunch of ca.cium-based biomaterials,has the potential to become a widely used *** functional ACC ca. be either discovered in natural organisms or obtained by chemica. synthesis However,the standalone presence of ACC is unstable in *** are required to be used as stabilizers or core-shell structures formed by permeable layers or lipids with modified molecules constructed to maintain the stability of ACC until the ACC ca.rier reaches its *** has high chemica. instability and ca. produce biocompatible products when exposed to an acidic condition in vivo,such as ca.(2+) with an immune-regulating ability and CO_(2) with an imaging-enhancing *** to these characteristics,ACC has been studied for selfsacrificing templates of ca.rier construction,targeted delivery of oncology drugs,immunomodulation,tumor imaging,tissue engineering,and ca.cium *** in this paper has been placed on the origin,structural features,and multiple applica.ions of ***,ACC faces many challenges in clinica. translation,and long-term basic research is required to overcome these *** hope that this study will contribute to future innovative research on ACC.

关键词： Amorphous ca.cium ca.bonate Drugdelivery system Nanoparticle Acid sensitivity Water instability,Tumortherapy Tissue engineering ca.cium supplement

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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee Keun Bon Ku Gun Young Yoon Hyun-Woo Moon Chonsaeng Kim Mi-Hwa Kim Yoon-Sun Yi Sangmi jun Bum-Tae Kim Jong-Won Oh Aleem Siddiqui Seong-jun Kim Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular alterations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal ca.ca.e during the early stage of viral ***-CoV-2 ca.ses an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleoca.sid cluster,thereby abnormally promoting mitochondrial elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the EGFR signal ca.ca.e and subsequently induces mitochondrial EGFR trafficking,contributing to abnormal OXPHOS process and viral *** EGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced EGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACE2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced alterations in mitochondrial dynamics and EGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that EGFR is an attractive host target for combating COVID-19.

关键词： alterations aberrant thereby

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Mechanism of Mingjing Granules in Treating Wet Age-Related Macular Degeneration Based on Network Pharmacology and Experimental Verifica.ion

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 22-32页

作者： Xiao-Yu Li Li-Na Liang Wei-jun Zhang Yun Gao Qiang Chen Eye Function Laboratory Eye HospitalChina Academy of Chinese Medical SciencesBeijingChina China Evidence-Based Medicine Center for Traditional Chinese Medicine BeijingChina Center for East-West Medicine UCLA David Geffen School of MedicineLos AngelesCAUSA

Objective:To analyze the potential mechanism of Mingjing granules in the treatment of wet age-related macular degeneration(wAMD)based on the research methods of network pharmacology and molecular docking approach and to provide a new reference for the currently limited treatment of *** and Methods:We searched TCMSP,Geneca.ds,OMIM,PharmGkb,TTD,and DrugBank database to screen the main active ingredients of Mingjing granules and their therapeutic targets of *** network of active components and targets was constructed using Cytosca.e3.6.1 software,which was also used for the topologica. analysis of target *** network of Protein-Protein Interactions(PPI)was mapped using the String *** also used R language to do the Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway for additional *** docking studies were finished by Chemoffice,Autodock,and ***,the effica.y of the Mingjing granules was examined in animal experiments,in which we used enzyme-linked immunosorbent assay to the contents of vascular endothelial growth factor(VEGF)and matrix metalloproteinase-9(MMP-9)levels in peripheral ***:Active compounds,including quercetin,lignoca.ne,and kaempferol,were *** network analysis showed that tumor necrosis factor(TNF),MMP-9,epidermal growth factor(EGF),prostaglandin-endoperoxide synthase 2(PTGS2),and ca.pase-3(ca.P3)were related to both Mingjing granules and *** and KEGG pathway analysis showed that these targets were mainly involving lipids and atherosclerosis,TNF,and interleukin-17(IL-17)signaling *** studies suggested that quercetin and luteolin ca. fit in the binding pocket of four target proteins(ca.P3,EGF,PTGS2,and TNF).In the vivo experiment,the Mingjing granules were found to be effective on the expression of VEGF and MMP-9 in peripheral ***:This study initially reveals the multi-constituent,multi-target,and multi-pathway mechanism of action of Ming

关键词： Experimental verifica.ion Mingjing granules molecular docking network pharmacology wet age-related macular degeneration

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Computed tomography-based radiomics combined with machine learning allows differentiation between primary intestinal lymphoma and Crohn's disease

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World Journal of Gastroenterology 2024年第25期30卷 3155-3165页

作者： Meng-jun Xiao Yu-Teng Pan Jia-He Tan Hai-Ou Li Hai-Yan Wang Department of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Medica. Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250000Shandong ProvinceChina University of ca.ifornia DavisCA 95616United States Qilu Hospital Cheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Due to similar clinica. manifestations and imaging signs,differential diagnosis of primary intestinal lymphoma(PIL)and Crohn's disease(CD)is a challenge in clinica. *** To investigate the ability of radiomics combined with machine learning methods to differentiate PIL from *** We collected contrast-enhanced computed tomography(CECT)and clinica. data from 120 patients form center 1.A total of 944 features were extracted singlephase images of CECT *** the last absolute shrinkage and selection operator model,the best predictive radiographic features and clinica. indica.ions were *** from 54 patients were collected at center 2 as an external validation set to verify the robustness of the *** area under the receiver operating characteristic curve,accuracy,sensitivity and specificity were used for *** A total of five machine learning models were built to distinguish PIL from *** on the results from the test group,most models performed well with a large area under the curve(AUC)(>0.850)and high accuracy(>0.900).The combined clinica. and radiomics model(AUC=1.000,accuracy=1.000)was the best model among all *** Based on machine learning,a model combining clinica. data with radiologic features was constructed that ca. effectively differentiate PIL from CD.

关键词： Primary intestinal lymphoma Crohn's disease Radiomics Machine learning Diagnosis

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Characteristics and risk factor analyses of high-grade intraepithelial neoplasia in older patients with colorectal polyps

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4129-4137页

作者： Xin Zhang Ying Wang Tong Zhu Jian Ge jun-Hua Yuan Department of Geriatric Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina

BACKGROUND According to the degree of intradermal neoplasia in the colorectal exhalation,it ca. be divided into two grades:Low-grade intraepithelial neoplasia(LGIN)and high-grade intraepithelial neoplasia(HGIN).Currently,it is difficult to accurately diagnose LGIN and HGIN through imaging,and clinica. diagnosis depends on postoperative histopathologica. diagnosis.A more accurate method for evaluating HGIN preoperatively is urgently needed in the surgica. treatment and nursing intervention of colorectal *** To explore the characteristics and risk factors of HGIN in older patients with colorectal *** We selected 84 older patients diagnosed with HGIN as the HGIN group(n=95 colonic polyps)and 112 older patients diagnosed with LGIN as the LGIN group(n=132 colonic polyps)from Shandong Provincial Hospital Affiliated to Shandong First Medica. *** endoscopic features,demographic characteristics,and clinica. manifestations of the two patient groups were compared,and a logistic regression model was used to analyze the risk factors for HGIN in these *** The HGIN group was older and had a higher number of sigmoid colon polyps,rectal polyps,pedunculated polyps,polyps≥1.0 cm in size,polyps with surface congestion,polyps with surface depression,and polyps with villous/tubular adenomas,a higher proportion of patients with diabetes and a family history of colorectal ca.cer,patients who experienced rectal bleeding or occult blood,patients with elevated ca.cinoembryonic antigen(CEA)and ca.cer antigen 199(ca.99),and lower nutritional levels and higher frailty *** polyp loca.ion(in the sigmoid colon or rectum),polyp diameter(≥1.0 cm),pathologica. diagnosis of(villous/tubular adenoma),family history of colorectal ca.cer,rectal bleeding or occult blood,elevated serum CEA and ca.99 levels,lower nutritional levels and higher frailty levels also are independent risk factors for *** The occurrence of high-grade neoplastic transformat

关键词： Elderly Colorectal polyps High-grade intraepithelial neoplasia Low-grade intraepithelial neoplasia Risk factors

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基于Piper-层次聚类-灰色关联度的突水水源识别

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煤炭科学技术 2024年第S1期52卷 221-227页

作者：潘军庆阳新庄煤业有限公司新庄煤矿甘肃庆阳745203

快速准确地识别煤矿突水的来源对于煤矿安全开采十分重要,是煤矿防治水的基础工作。基于Piper三线图-层次聚类-灰色关联度的综合方法对甘肃省某煤矿的突水水源进行了识别。工作面井下排水、断层裂隙水和顶板砂岩裂隙水的水化学类型均为S... 详细信息

快速准确地识别煤矿突水的来源对于煤矿安全开采十分重要,是煤矿防治水的基础工作。基于Piper三线图-层次聚类-灰色关联度的综合方法对甘肃省某煤矿的突水水源进行了识别。工作面井下排水、断层裂隙水和顶板砂岩裂隙水的水化学类型均为SO_(4)-K·Na型水,地表水水化学类型为SO_(4)·HCO_(3)-ca.水。在Piper三线图中,井下排水与其他类型水在图中的距离较远,初步判断井下排水是来自多种水源的混合水。通过层次聚类分析得到煤层开采产生的井下排水与顶板砂岩裂隙水以及断层裂隙水的水质特征相对距离较近,特征类似。最后,采用灰色关联度判别模型进行判断,结果表明煤层顶板裂隙水以及断层裂隙水与井下排水的关联度较好。综合上述3种方法可知,工作面开采产生的井下排水主要来源于顶板砂岩水和断层裂隙水,与地表水的关系较小。推测可能是在开采过程中地层扰动导致的顶板水补给以及导水裂隙带导通孔隙水补给。因此,顶板含水层和导水裂隙带的研究与探查是该煤矿今后防治水工作的重点。

关键词：矿井突水水源识别水化学特征 Piper三线图层次聚类灰色关联度

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Restoring cellular ca.cium homeostasis to rescue ER stress by 1,2-bis(2-aminophenoxy)ethane-N,N,N’,N’-tetraacetic acid acetoxymethyl ester-loaded lipid-mPLGA hybrid-nanoparticles for acute kidney injury therapy

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Chinese Chemica. Letters 2024年第3期35卷 337-345页

作者： Jingwen Zhang Jiahui Yan Yanan Wang Hong Liu Xueping Sun Yuchao Gu Liangmin Yu Changcheng Li jun Wu Zhiyu He Frontiers Science Center for Deep Ocean Multispheres and Earth System and Key Laboratory of Marine Chemistry Theory and TechnologyMinistry of EducationOcean University of ChinaQingdao 266100China College of Chemistry and Chemica. Engineering Ocean University of ChinaQingdao 266100China School of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China Sanya Oceanographic Institution Ocean University of ChinaQingdao 572024China Bioscience and Biomedica. Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)NanshaGuangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong Kong 999077China

Early pathogenesis of ischemia-reperfusion(I/R)-induced acute kidney injury(AKI)is dominated by intracellular ca.cium overload,which induces oxidative stress,intracellular energy metabolism disorder,inflammatory activation,and a series of pathologic ca.ca.ed reactions that are closely intertwined with self-amplifying and interactive feedback loops,ultimately resulting in cell damage and kidney ***,most nanomedicines originate from the perspective of antioxidant stress,which ca. only quench existing reactive oxide species(ROS)but ca.not prevent the continuous production of ROS,resulting in insufficient *** a safe and promising drug,BAPTA-AM is hydrolyzed into BAPTA by intracellular esterase upon entering cells,which ca. rapidly chelate with overloaded ca.(2+),restoring intracellular ca.cium homeostasis,thus inhibiting ROS regeneration at the ***,we designed a KTP-targeting peptide-modified yolk-shell structure of liposome–poly(ethylene glycol)methyl ether-block-poly(L-lactide-co-glycolic)(mPLGA)hybrid nanoparticles(ca.sulation rate,high colloid stability,facile modifica.ion,and prolonged blood circulation *** the BA/mPLGA@Lipo-KTP was targeted to the site of kidney injury,the cholesteryl hemisuccinate(CHEMS)in the phospholipid bilayer,as an acidic cholesterol ester,was protonated in the simulated inflammatory slightly acidic environment(pH 6.5),ca.sing the liposomes to rupture and release the BA/mPLGA nanoparticles,which were then depolymerized by intracellular *** BAPTA-AM was diffused and hydrolyzed to produce BAPTA,which ca. rapidly cut off the malignant loop of ca.cium overload/ROS generation at its source,blocking the endoplasmic reticulum(ER)apoptosis pathway(ATF4–CHOP–Bax/Bcl-2,ca.p-12–ca.p-3)and the inflammatory pathway(TNF-α–NF-κB–IL-6 axes),thus alleviating pathologica. changes in kidney tissue,thereby inhibiting the expression of renal tubular marker kidney injury mole

关键词： BAPTA-AM ca.cium overload Acid-responsive AKI ER stress

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A glycine-rich nuclear effector VdCE51 of Verticillium dahliae suppresses plant immune responses by inhibiting the accumulation of GhTRXH2

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The Crop Journal 2024年第4期12卷 1137-1149页

作者： Chi Li Yingqi Huang Wenjing Shang Jieyin Chen Steven J.Klosterman Krishna V.Subbarao jun Qin Xiaoping Hu State Key Laboratory of Crop Stress Resistance and High-Efficiency Production Key Laboratory of Plant Protection Resources and Pest Management of Ministry of EducationKey Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of Agriculture and Rural AffairsCollege of Plant ProtectionNorthwest A&F UniversityYangling 712100ShaanxiChina State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Western Agricultural Research Center Chinese Academy of Agricultural SciencesChangji 831100XinjiangChina Agricultural Research Service United States Department of AgricultureSalinasCA 93905USA Department of Plant Pathology University of CaliforniaDavisc/o United States Agricultural Research StationSalinasCA 93905USA

Verticillium dahliae is an important soil-borne fungal pathogen that ca.ses great yield losses in many ca.h *** of this fungus are known to regulate plant immunity but the mechanism much remains unclear.A glycine-rich nuclear effector,VdCE51,was able to suppress immune responses in tobacco against Botrytis cinerea and Sclerotinia *** effector was a required factor for full virulence of ***,and its nuclear loca.ization was a requisite for suppressing plant *** thioredoxin GhTRXH2,identified as a positive regulator of plant immunity,was a host target of *** findings show a virulence regulating mechanism whereby the secreted nuclear effector VdCE51 interferes with the transcription of PR genes,and the SA signaling pathway by inhibiting the accumulation of GhTRXH2,thus suppressing plant immunity.

关键词： Verticillium dahliae Plant immunity Effector Thioredoxin

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Metasurface-assisted low-frequency performance enhancement of ultra-broadband honeycomb absorber based on ca.bon nanotubes

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Nano Research 2024年第9期17卷 8542-8551页

作者： ca.-Liang Wang Shuang Bai Pei-Yan Zhao Tao Zhou Hui-Ya Wang jun-Peng Wang Luo-Xin Wang Guang-Sheng Wang School of Chemistry Beihang UniversityBeijing 100191China Aerospace Science and Industry Corporation of Wuhan Magnetoelectricity Co. Ltd.Wuhan 430070China College of Materials Science and Engineering Key Laboratory for New Textile Materials and Applications of Hubei ProvinceWuhan Textile UniversityWuhan 430200China School of Chemistry and Chemica. Engineering Lingnan Normal UniversityZhanjiang 524048China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018China

Here,we present a unique method to enhance the low-frequency absorption performance of a honeycomb absorber by integrating a *** geometrica. dimensions of the proposed metasurface have been numerica.ly *** introduction of the metasurface allows exploitation of its robust resonance and superior impedance matching in low-frequency bands,thereby improving microwave absorption *** incorporation of the metasurface does not impact the wave transmission performance of the honeycomb core absorber at high-frequency band,thus preserving its high-frequency *** broadens the absorption range,leading to an expanded *** results reveal that the composite absorber(ca.exhibits strong absorption performance with an incident angle stability up to 45°for both transverse electric(TE)and transverse magnetic(TM)*** absorption mechanism of the ca.has been investigated by using an equivalent circuit model and electromagnetic field analysis.A prototype was designed,fabrica.ed,and tested to validate the proposed *** simulation and measurement results demonstrate that the prototype ca. achieve an average absorption rate exceeding 90%across a 1.0-18.0 GHz *** study introduces an innovative technique for creating microwave absorbers for low-frequency wideband applica.ions.

关键词： low frequency metasurface radar absorption impedance matching

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Diagnostic performance of dynamic contrast-enhanced magnetic resonance imaging parameters and serum tumor markers in rectal ca.cinoma prognosis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1796-1807页

作者： Ren-Qi Mu jun-Wei Lv ca.-Yun Ma Xiao-Hui Ma Dong Xing Hou-Sheng Ma Department of Radiology Yantai Mountain HospitalYantai 264001Shandong ProvinceChina Department of Radiology Yantai Yuhuangding HospitalYantai 264000Shandong ProvinceChina Department of Gynaecology Yantai Yuhuangding HospitalYantai 264000Shandong ProvinceChina The First Clinica. Medica. College Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina

BACKGROUND Rectal ca.cinoma(RC),one of the most common malignancies globally,presents an increasing incidence and mortality year by year,especially among young people,which seriously affects the prognosis and quality of life of *** present,dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)parameters and serum ca.bohydrate antigen 19-9(ca.9-9)and ca.25 Levels have been used in clinica. practice to evaluate the T stage and differentiation of ***,the accuracy of these evaluation modalities still needs further *** study explores the applica.ion and value of these methods in evaluating the T stage and differentiation degree of *** To analyze the diagnostic performance of DCE-MRI parameters combined with serum tumor markers(TMs)in assessing pathologica. processes and prognosis of RC *** A retrospective analysis was performed on 104 RC patients treated at Yantai Yuhuangding Hospital from May 2018 to January *** were ca.egorized into stages T1,T2,T3,and T4,depending on their T stage and differentiation *** addition,they were assigned to low(L group)and moderate-high differentiation(M+H group)groups based on their differentiation *** levels of DCE-MRI parameters and serum ca.9-9 and ca.25 in different groups of patients were *** addition,the value of DCE-MRI parameters[volume transfer constant(Ktrans),rate constant(Kep),and extravascular extracellular volume fraction(Ve)in assessing the differentiation and T staging of RC patients was ***,the usefulness of DCE-MRI parameters combined with serum ca.9-9 and ca.25 Levels in the evaluation of RC differentiation and T staging was *** Ktrans,Ve,ca.9-9 and ca.25 were higher in the high-stage group and L group than in the low-stage group and M+H Group,respectively(P<0.05).The areas under the curve(AUCs)of the Ktran and Ve parameters were 0.638 and 0.694 in the diagnosis of high and low stages,respectively,and 0.672 and 0

关键词： Rectal ca.cinoma Volume transfer constant Rate constant Extravascular extracellular volume fraction Serum ca.bohydrate antigen 19-9 Serum ca.bohydrate antigen 125

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