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Roles of N-cadherin in cerebral cortical development:cooperation with membrane trafficking and actin cytoskeletal regulation

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Neural Regeneration Research 2025年第1期20卷 188-190页

作者： Shiho ito Takeshi Kawauchi Department of Adaptive and Maladaptive Responses in Health and Disease Graduate School of MedicineKyoto UniversityKyotoJapan Department of Physiology Keio University School of MedicineTokyoJapan

Cell adhesion plays pivotal roles in the morphogenesis of multicellular *** cells form several types of cell-to-cell adhesion,including zonula occludens(tight junctions),zonula adhaerens(adherens junctions),and macula adhaerens(desmosomes).Although these adhesion complexes are basically observed only in epithelial cells,cadherins,which are the major cell adhesion molecules of adherens junctions,are expressed in both epithelial and non-epithelial tissues,including neural tissues(Kawauchi,2012).The cadherin superfamily consists of more than 100 members,but classic cadherins.

关键词： cerebral skeletal cooperation

Investigation of transient and heterogeneous micro-climate around a human body in an enclosed personalized work environment

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Energy and Built Environment 2020年第4期1卷 423-431页

作者： Chong Wang Sung-jun Yoo Shin-ichi Tanabe Kazuhide ito Interdisciplinary Graduate School of Engineering Sciences Kyushu UniversityJapan Faculty of Engineering Sciences Kyushu UniversityJapan Faculty of Science and Engineering Waseda UniversityJapan

Heterogeneous distribution of indoor environmental quality is known to have a great impact on human health,comfort,and productivity.A personalized work environment,that creates a localized and independent environ-ment with capsules or partitions,is being developed worldwide to provide workers with a space that enables undisturbed concentration on studying and ***,the minimized interior space of a personalized work environment can immediately cause adverse health impacts for occupant if the air quality and thermal en-vironment in the personalized work environment is not controlled ***,constant breathing can sharply increase the CO 2 concentrations in an interior space with an insufficient ventilation *** order to design a healthy and comfortable indoor environment,especially in a personalized work environment,it is important to predict precisely and comprehensively the transient and heterogeneous structure of the indoor envi-ronment formed around a human *** this background,we have developed an in silico human model that integrates a computational human model(virtual manikin combined with thermoregulation models)and respi-ratory model(virtual airway)for estimating indoor environmental quality,targeting the microclimate around a human body and breathing zone with high *** this study,we report the applicability of a comprehensive in silico human model to estimate the environ-mental quality in a personalized work environment.A coupled analysis of heat and contaminant transfer with computational fluid dynamics was conducted targeting the space around the in silico human model installed in a virtual personalized work *** informative data including human thermal comfort and breathing air quality were obtained,potentially forming the basis for the development of a digital twin of the personalized work environment and contributing to the design of a healthy,comfortable,and productive personalized work environme

关键词： Microclimate Indoor environment Digital twin Personalized work environment Computational fluid dynamics in silico human model

Impact of indoor ventilation efficiency on acetone inhalation exposure concentration and tissue dose in respiratory tract

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Building Simulation 2023年第3期16卷 427-441页

作者： Cong Li Sung-jun Yoo Kazuhide ito College of Ocean and Civil Engineering Dalian Ocean UniversityDalian 116023China Faculty of Engineering Sciences Kyushu UniversityFukuoka816-8580Japan

A significant feature of the indoor environment is the heterogeneity of airflow and pollutant distributions,which are primarily dependent on ventilation *** the case of short-and high-concentration exposures to hazardous chemical pollutants,it may be necessary to precisely determine the concentration in the breathing zone or,more directly,the inhalation exposure concentration in the respiratory tract,rather than the representative room average concentration in an indoor environment,because of the non-uniformity of pollutant concentration *** this study,we developed a computer-simulated person with a detailed respiratory system to predict inhalation exposure concentration and inhalation dose via transient breathing and reported a demonstrative numerical simulation for analyzing acetone concentration distributions in a simplified model *** numerical analysis revealed that the ventilation efficiency distribution in a room could change significantly by changing the design of the ventilation system,and that the inhalation exposure concentration estimated by a computer-simulated person could differ from the representative concentration,such as perfect-mixing or volume-averaged acetone concentration,by a factor of two or more.

关键词： computational fluid dynamics computer simulated person inhalation exposure numerical respiratory tract physiologically based pharmacokinetics tissue dose

A sustainable way of agricultural livelihood:edible bird’s nests in Indonesia

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Ecosystem Health and Sustainability 2021年第1期7卷 332-341页

作者： Yutaka ito Ken’ichi Matsumoto Aswin Usup Yuki Yamamoto Faculty of Regional Policy The University of ShimaneMatsueJapan Faculty of Economics Toyo UniversityTokyoJapan Faculty of Agriculture University of Palangka RayaPalangkarayaIndonesia Graduate School of Fisheries and Environmental Sciences Nagasaki UniversityNagasakiJapan

Edible birds’nests(EBNs)have traditionally been produced in Southeast *** farmers construct buildings for swiftlets and harvest their *** farming does not directly degrade forest resources and is therefore considered a sustainable means of production,whereas the expansion of other agricultural activities often relies on the degradation of natural *** study examines the relationship between natural resources and agricultural livelihoods,focusing on Indonesian EBN *** survey data that we collected in 2017,combined with satellite information on the extent of the forest in Central Kalimantan,Indonesia,we measured production efficiency and identified the natural and social factors that enhance production *** results show that a forest extent ranging between 2,000 and 6,000 meters from nesting building is positively associated with the production efficiency of EBN farming,perhaps because extensive forest could help swiftlets to collect food and build ***,while EBN farming is a sustainable and profitable option,the initial costs of constructing buildings to house swiftlets may deter farmers from participating in the process.

关键词： Edible bird’s nest swiftlet Indonesia forest natural habitat ecosystem services satellite data

Establishment of induced pluripotent stem cells from aged mice using bone marrow-derived myeloid cells

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Journal of Molecular Cell Biology 2011年第2期3卷 91-98页

作者： Zhao Cheng Sachiko ito Naomi Nishio Hengyi Xiao Rong Zhang Haruhiko Suzuki Yayoi Okawa Toyoaki Murohara Ken-ichi Isobe Department of Immunology Nagoya University Graduate School of Medicine65 Turumai-choShowa-kuNagoyaAichi 466-8520Japan Laboratory for Geriatrics State Key Laboratory of BiotherapySichuan UniversityChengdu 610041China Department of Functioning Activation National Institute for Longevity SciencesNational Center for Geriatrics GerontologyAichi 463-0003Japan Department of Cardiology Nagoya University Graduate School of Medicine65 Turumai-choShowa-kuNagoyaAichi 466-8520Japan

If induced pluripotent stem(iPS)cells are to be used to treat damaged tissues or repair organs in elderly patients,it will be necessary to establish iPS cells from their *** determine the feasibility of using this technology with elderly patients,we asked if it was indeed possible to establish iPS cells from the bone marrow(BM)of aged *** cells from aged C57BL/6 mice carrying the green fluorescence protein(GFP)gene were cultured with granulocyte macrophage-colony stimulating factor(GM-CSF)for 4 *** factors(Oct3/4,Sox2,Klf4 and c-Myc)were introduced into the BM-derived myeloid(BM-M)*** efficiency of generating iPS cells from aged BM cultured in GM-CSF was ***,we succeeded in obtaining BM-M-iPS cells from aged C57BL/6 mice,which carried *** BM-M-iPS cells expressed SSEA-1 and Pou5f1 and were positive for alkaline phosphatase *** iPS cells did make teratoma with three germ layers following injection into syngeneic C57BL/6 mice,and can be differentiated to three germ layers in *** co-culturing with OP9,the BM-M-iPS cells can be differentiated to the myeloid *** differentiated BM-M-iPS cells proliferated well in the presence of GM-CSF,and lost expression of Nanog and Pou5f1,at least in part,due to methylation of their *** the contrary,Tnf and Il1b gene expression was upregulated and their promoters were hypomethylated.

关键词： induced pluripotent stem cells aged mouse bone marrow myeloid cells gene expression methylation ChIP assay

Experimental study of oil mist characteristics generated from minimum quantity lubrication and flood cooling

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Energy and Built Environment 2021年第1期2卷 45-55页

作者： Yiwen Wang Alicia Murga Zhengwei Long Sung-jun Yoo Kazuhide ito Tianjin Key Lab.of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityTianjin 300072China Faculty of Engineering Sciences Kyushu UniversityJapan

The use of metalworking fluids during machining can generate oil mist and endanger the health of *** order to study the characteristics and emission laws of oil mist generated by machining,this study constructed a test bench to simulate the turning *** affecting the oil mist generated in the minimum quantity lubrication(MQL)mode and flood cooling mode were studied by means of single-factor experiments,and the formation mechanisms of oil mist were *** results show that the oil mist generated by the MQL system has two main sources,the initial escape of oil mist into the air and the evaporation/condensation of oil *** centrifugation has almost no effect on oil mist formation in the MQL *** mass concentration of oil mist generated by the MQL system is proportional to the cutting oil flow *** the work-piece is at room temperature,increasing the air supply pressure and nozzle distance,increases the oil mist mass *** the flood cooling mode,the concentration of centrifugal aerosol is linearly and positively correlated with the relative centrifugal force generated by the work-piece,and the coefficient of determination(R 2)is above *** oil mist mass concentrations in MQL mode is 8.33 mg/m^(3)~305.88 mg/m^(3).The MMD and SMD are 0.74μm to 4.42μm and 0.31μm to 2.14μm,*** oil mist mass concentrations in flood cooling mode is 0.2 mg/m^(3)~22.42 mg/m^(3).The MMD and SMD are 1.81μm to 6.58μm and 0.45μm to 5.13μm,respectively.

关键词： Oil mist Metalworking fluids Minimum quantity lubrication Flood cooling Turning

Decreasing inhaled contaminant dose of a factory worker through a hybrid Emergency Ventilation System:Performance evaluation in worst-case scenario

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Energy and Built Environment 2020年第3期1卷 319-326页

作者： Alicia Murga Zhengwei Long Sung-jun Yoo Eisaku Sumiyoshi Kazuhide ito Faculty of Engineering Sciences Kyushu UniversityJapan School of Environmental Science and Engineering Tianjin UniversityChina Technical Research Institute Obayashi CorporationJapan

Air pollution is detrimental to human health,causing several human *** industrial microenvironment generates high levels of indoor airborne pollutants,becoming a pervasive issue for *** is essential to im-prove the indoor air quality in this workplace by applying enhanced ventilation systems to minimize inhalation *** ventilation is used in industrial buildings because of its stratified air distribution and low ***,in case of accidental pollutant release,an enhancement is needed to minimize inhalation *** study proposes a hybrid emergency ventilation system using localized push-pull ventilation to improve the installed displacement ventilation system of a representative *** fluid dynamics was ap-plied to calculate steady-state indoor air flow and volume-averaged pollutant *** performance was evaluated in terms of source position;a computer simulated person was integrated to the building to confirm effectiveness against personal *** showed marked improvement in performance when push-pull technique was used:room-averaged concentration diminished up to 91%while ventilation rate only increased 4%.Inhaled pollutant mitigation was achieved but performance dependence against leakage source and personal position was confirmed.

关键词： Computational fluid dynamics Hybrid ventilation Industrial environment Computer simulated person Inhalation exposure

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Research in Astronomy and Astrophysics 2021年第5期21卷 43-70页

作者： Yuta ito Department of Physics The Graduate Center of CUNY365 Fifth AvenueNew YorkNY 10016USA Department of Physics and Astronomy The College of Staten Island of CUNY2800 Victory BoulevardStaten IslandNY 10314USA

Fitting parametric models to globular clusters’structural profiles has been essential for the study of stellar *** provides their important structural parameters,such as the concentrations and core radii of the ***,existing parametric models can apply only to non-collapsing-core clusters in the early relaxation-evolution ***,a single parametric model cannot provide globular clusters’structural parameters in both the early and late evolution *** have recently found an accurate spectral solution for the self-similar orbit-averaged Fokker-Planck(OAFP)equation to model collapsingcore clusters at the late evolution *** present work establishes a new parametric model by combining the self-similar OAFP-and *** it is a single-mass and isotropic model,the new model applies to at least fifty-five Galactic globular clusters with resolved cores in all the evolution *** a main result,we show the characteristics of the relaxation times against the concentrations of the *** also affirm that the structures of low-concentration clusters are polytropic in the Milky Way.

关键词： (Galaxy:)globular clusters:general Galaxy:kinematics and dynamics methods:numerical

Protective effects of oral glutathione on fasting-induced intestinal atrophy through oxidative stress

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World Journal of Gastroenterology 2017年第36期23卷 6650-6664页

作者： Hiroyuki Uchida Yukari Nakajima Kazuo Ohtake junta ito Masahiko Morita Ayako Kamimura jun Kobayashi Division of Pathophysiology Department of Clinical Dietetics and Human NutritionFaculty of Pharmaceutical ScienceJosai University Kyowa Hakko Bio Co. Ltd.Healthcare Products Development Center

AIM To determine whether oral glutathione(GSH)administration can alleviate the effects of fasting-induced intestinal atrophy in the small intestinal mucosa. METHODS Rats were divided into eight *** group was fed ad libitum,another was fed ad libitum and received oral GSH,and six groups were administrated saline(SA)or GSH orally during *** height,apoptosis,and cell proliferation in the jejunum were histologically evaluated.i NOS protein expression(by immunohistochemistry),nitrite levels(by high performance liquid chromatography,as a measure of NO production),8-hydroxydeoxyguanosine formation(by ELISA,indicating ROS levels),glutathione/oxidized glutathione(GSH/GSSG)ratio(by enzymatic colorimetric detection),andγ-glutamyl transpeptidase(Ggt1)mR NA levels in the jejunum(by semi-quantitative RT-PCR)were also estimated. RESULTS O r a l G S H a d m i n i s t r a t i o n w a s d e m o n s t r a t e d t o drastically reduce fasting-induced intestinal atrophy in the *** particular,jejunal mucosal height was enhanced in GSH-treated animals compared to SA-treated animals[527.2±6.9 for 50 mg/kg GSH,567.6±5.4 for 500 mg/kg GSH vs 483.1±4.9(μm),Pjunum[182.5±1.9 for 500 mg/kg GSH vs 155.8±3.4(5-Brd U positive cells/10 crypts),Pjunum were also attenu

关键词： Intestinal atrophy Glutathione Apoptosis Cell proliferation Inducible nitric oxide synthase