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Chinese Journal of Chemistry 2017年第6期35卷 969-976页

作者： Lingxia Zuo Liping Jiang jun-jie zhu State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University Nanjing Jiangsu 210093 China

The preparation of highly active electrocatalysts with good durability and low cost for fuel cells is highly desir- able but still remains a significant challenge. Here we synthesized two dimensional （2D） C3N4 nanosheets supported palladium composites （C3N4/Pd） via a simple and convenient sonochemical approach. We have systematically stud- ied the electrocatalytic performance of as-prepared catalysts. We found that the prepared C3N4/Pd composites pos- sessed excellent catalytic activity and stability for oxygen reduction reaction （ORR） in alkaline media. Encourag- ingly, the C3N4/Pd catalysts exhibit the excellent electrocatalytic activity for methanol oxidation reaction （MOR） in alkaline media, even better than that of the commercial Pt/C catalyst, The excellent electrocatalytic performance of the 2D C3N4 nanosheets supported palladium composites catalysts results from their synergy effect between the ul- trathin substrate material with large surface area and excellent dispersion of palladium nanoparticles. This study demonstrates that sonochemical method opens up a new avenue for the preparation of electrocatalysts for fuel cells. We expect these materials are likely to find uses in a broad range of applications, for example, fuel cells, solar cells, batteries and other electrochemical analysis.

关键词： sonochemical method C3N4/Pd oxygen reduction reaction methanol oxidation reaction

Special Topic:Biomedical Application of DNA-Assembled Nanostructure

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Journal of Analysis and Testing 2021年第2期5卷 93-94页

作者： jun-jie zhu State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Pathological features of diseases are typically accompanied with certain upregulated biomarkers,such as ions,nucleic acids,small molecules and *** sensitive detecting tools with acceptable compatibility are of paramount importance for the precise diagnose of ***,the sensitivity,accuracy and biosafety of probes still remain a challenge,which persuade researchers to explore more applicable materials and platforms to address these issues.

关键词： DNA Biomedical Application of DNA-Assembled Nanostructure Special Topic aptamer

Myoglobin/Gold Nanoparticles/Carbon Spheres 3-D Architecture for the Fabrication of a Novel Biosensor

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Nano Research 2009年第3期2卷 210-219页

作者： Xiao Chen Jing Jing Zhang jie Xuan jun jie zhu Key Laboratory of Analytical Chemistry for Life Science Ministry of EducationSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China

A novel biosensor based on a myoglobin/gold nanoparticles/carbon spheres(Mb AuNPs CNs)3-D architecture bioconjunction has been fabricated for the determination of hydrogen peroxide(H2O2).Cyclic voltammetry(CV),Fourier transform infrared(FT-IR)spectroscopy and scanning electron microscopy(SEM)were used to characterize the bioconjunction of the AuNPs CNs with *** results demonstrate that the AuNPsCNs hybrid material is more effective in facilitating electron transfer of the immobilized enzyme than CNs alone,which can be attributed to the unique nanostructure and larger surface area of the *** biosensor displayed good performance for the detection of H_(2)O_(2)with a wide linear range from 0.28μmol/L to 116.5μmol/L and a detection limit of 0.12μmol/*** Michaelis-Menten constant KMapp value was estimated to be 0.3 mmol/*** resulting biosensor exhibited fast amperometric response,and good stability,reproducibility,and selectivity to H_(2)O_(2).

关键词： Biosensor myoglobin gold nanoparticles carbon spheres hydrogen peroxide direct electron transfer

Deep-Red to Near-Infrared Carbon Dots in Biosensing and Bio-medical Applications

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Chinese Journal of Chemistry 2023年第18期41卷 2354-2370页

作者： Shan Huang Li Yan Xiaojun Chen jun-jie zhu Schoolof Chemistry and Molecular Engineering Nanjing TechUniversityNanjingJiangsu 211816China Schoolof Chemistry and chemical Engineering Nanjing UniversityNanjingJiangsu 210023China

Comprehensive Summary,With the rapid development in the field of biomedical diagnosis and treatment,carbon dots(CDs)with favorable photostability,biocompatibility and high quantum yields for deep-red to near-infrared emission have attracted the attention of a majority of *** enlarging the sp2 domain in the core of CDs,doping them with heteroatoms like nitrogen and sulfur,applying hydrothermal,electrochemical,or microwave-assisted techniques,CDs can be made with the aforementioned photoemission *** view of these excellent properties,CDs are flourishing in biosensing and biomedical applications,so that a thorough description and discussion of this topic is beneficial to capture the up-to-date progress of CDs in this field,providing suggestions and considerations for readers.

关键词： Carbon dots Biosensing Biomedical Biotechnology Cancer therapy Antibacterial

In Vivo Voltammetric Imaging of Metal Nanoparticle-Catalyzed Single-Cell Electron Transfer by Fermi Level-Responsive Graphene

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Research 2024年第1期2023卷 271-280页

作者： Qing Xia Rui Liu Xueqin Chen Zixuan Chen jun-jie zhu State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023P.R.China Shenzhen Research Institute of Nanjing University Shenzhen 518000P.R.China

Metal nanomaterials can facilitate microbial extracellular electron transfer(EET)in the electrochemically active ***,the role of nanomaterials/bacteria interaction in this process is still ***,we reported the single-cell voltammetric imaging of Shewanella oneidensis MR-1 at the single-cell level to elucidate the metal-enhanced EET mechanism in vivo by the Fermi level-responsive graphene *** oxidation currents of~20 fA were observed from single native cells and gold nanoparticle(AuNP)-coated cells in linear sweep voltammetry *** the contrary,the oxidation potential was reduced by up to 100 mV after AuNP *** revealed the mechanism of AuNP-catalyzed direct EET decreasing the oxidation barrier between the outer membrane cytochromes and the *** method offered a promising strategy to understand the nanomaterials/bacteria interaction and guide the rational construction of EET-related microbial fuel cells.

关键词： Fermi voltammetry Electron

DNA Technology-assisted Signal Amplification Strategies in Electrochemiluminescence Bioanalysis

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Journal of Analysis and Testing 2021年第2期5卷 95-111页

作者： Yue Cao Cheng Ma jun-jie zhu State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Sensitive and accurate detection of biological analytes,such as proteins,genes,small molecules,ions,cells,etc.,has been a significant project in life *** amplification is one of the most effective approaches to improve the sensitivity of *** advantage of specific base pairing,programmable operation,and predictable assembly,DNA is flexible and suitable to perform the signal amplification *** recent years,signal amplification strategies by means of DNA technology have been widely integrated into the construction of electrochemiluminescence(ECL)biosensors,achieving desirable analytical performance in clinical diagnosis,biomedical research,and drug *** the best of our knowledge,these DNA signal amplification technologies mainly include classical polymerase chain reaction,and various amplification approaches conducted under mild conditions,such as rolling circle amplification(RCA)or hyperbranched RCA,cleaving enzyme-assisted amplification,DNAzyme-involved amplification,toehold-mediated DNA strand displacement amplification without enzyme participation,and so *** review overviews the recent advancements of DNA signal amplification strategies for bioanalysis in the ECL realm,sketching the creative trajectory from strategies design to ultrasensitive ECL platform construction and resulting applications.

关键词： Electrochemiluminescence DNA technology Signal amplification strategies Bioanalysis

DNA functionalized plasmonic nanoassemblies as SERS sensors for environmental analysis

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Aggregate 2023年第2期4卷 62-82页

作者： Jinxiang Li Xueqin Chen jun-jie zhu School of Chemistry and Chemical Engineering Nanjing UniversityNanjingPR China

Surface-enhanced Raman scattering(SERS)is among the most widely applied analytical techniques due to its easy execution and extreme *** molecules can be detected and distinguished based upon the fingerprint spectra that arise when absorbed on the SERS substrates surface,particularly on the SERS-active ***,rational fabricating the enhancing substrates plays a key role in broadening SERS *** DNA functionalized plasmonic nanoassemblies,where DNA acts as both structure basis and functional unit,combine the specificity of DNA recognition,and modulate the assembly of plasmonic nanoparticles(NPs).Specifically designed DNA not only improves the selectivity to target molecules but also promotes the sensitivity of the optical signals through precisely regulating the distance between the molecule and the substrate.A variety of DNA-functionalized SERS sensors have been reported and obtained well performance in the analysis of heavy metal ions in water,toxins,pesticide residues,antibiotics,hormones,illicit drugs,or other small *** review places an emphasis on the design and sensing strategies of the DNA-functionalized plasmonic nanoassemblies,as well as basic principles of Raman enhancement,and recent advances for environmental *** current challenges and potential trends in the development of DNAfunctionalized SERS sensors for environmental pollutant monitoring in complicated scenarios are subsequently discussed.

关键词： assemblies DNA environmental analysis nanostructures SERS

Third generation biosensor based on myoglobin-TiO_2/MWCNTs modified glassy carbon electrode

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Chinese Chemical Letters 2008年第8期19卷 965-968页

作者： Lei Zhang Dan Bi Tian jun jie zhu College of Science Nanjing University of Technology Nanjing 210009 China Laboratory of Analytical Chemistry for Life Science Department of Chemistry Nanjing University Nanjing 210093 China

TiO2 nanoparticles were homogeneously coated on multi-walled carbon nanotubes by hydrothermal deposition, this nanocomposite may be a promising material for myoglobin immobilization in view of its high biocompatibility and large surface. The glassy carbon electrode modified with Mb-TiO2/MWCNTs films exhibited a pair of weU defined, stable and nearly reversible cycle voltammetric peaks. The electron transfer between Mb and electrode surface, Ks of 3.08 s^-1, was greatly facilitated in the TiO2/ MWCNTs film. The electrocatalytic reductions of hydrogen peroxide were studied, the apparent Michaelis-Menten constant is calculated to be 83.10 μmol/L, which shows a large catalytic activity of Mb in the TiO2/MWCNTs film to H2O2.

关键词： Myoglobin Multi-walled carbon nanotubes TiO2 Electrocatalysis Electrochemistry

Advances of Electrochemical and Electrochemiluminescent Sensors Based on Covalent Organic Frameworks

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Nano-Micro Letters 2024年第2期16卷 395-422页

作者： Yue Cao Ru Wu Yan‑Yan Gao Yang Zhou jun‑jie zhu Key Laboratory for Organic Electronics and Information Displays(KLOEID)and Institute of Advanced Materials(IAM) Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023People’s Republic of China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023People’s Republic of China

Covalent organic frameworks(COFs),a rapidly developing category of crystalline conjugated organic polymers,possess highly ordered structures,large specific surface areas,stable chemical properties,and tunable pore *** the first report of boroxine/boronate ester-linked COFs in 2005,COFs have rapidly gained popularity,showing important application prospects in various fields,such as sensing,catalysis,separation,and energy *** them,COFs-based electrochemical(EC)sensors with upgraded analytical performance are arousing extensive *** this review,therefore,we summarize the basic properties and the general synthesis methods of COFs used in the field of electroanalytical chemistry,with special emphasis on their usages in the fabrication of chemical sensors,ions sensors,immunosensors,and ***,the emerged COFs in the electrochemiluminescence(ECL)realm are thoroughly covered along with their preliminary ***,final conclusions on state-of-the-art COFs are provided in terms of EC and ECL sensors,as well as challenges and prospects for extending and improving the research and applications of COFs in electroanalytical chemistry.

关键词： Covalent organic frameworks Electrochemistry Electrochemiluminescence Sensors

Aqueous-phase synthesis of upconversion metal-organic frameworks for ATP-responsive in situ imaging and targeted combinational cancer therapy

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Chinese Chemical Letters 2022年第1期33卷 314-319页

作者： Lin Yang Shuaidong zhu Zhimei He Xiangli Li Jiangning Chen Sai Bi jun-jie zhu State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringSchool of Life SciencesNanjing UniversityNanjing 210023China College of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071China

Herein,the nanoscaled ATP-responsive upconversion metal-organic frameworks(UCMOFs)are aqueousphase synthesized for co-delivery of therapeutic protein cytochrome c(Cyt c)and chemodrugs doxorubicin(DOX),achieving targeted combinational therapy of human cervical *** UCMOFs are rationally fabricated by growing ZIF-90 on mesoporous silica-coated upconversion nanoparticles(UCNPs),in which the ZIF-90 layer attenuates the upconversion luminescence(UCL)and the rigid frameworks increase the stability of encapsulated *** the UCMOF@DOX/Cyt c are internalized into HeLa cells via specific recognition of sgc8 aptamers,the intracellular ATP triggers the dissolution of ZIF-90 into Zn^(2+),which facilitates not only the release of Cyt c and DOX but also the restoration of UCL for real-time monitoring of drug *** has been demonstrated that the therapeutic efficacy is greatly improved by the combination of caspase-mediated apoptosis activated by Cyt c(protein therapeutics),DNA fragmentation induced by DOX(chemotherapy),and Zn;-promoted generation of reactive oxygen species(ROS)(oxidative stress).Overall,our proposed multifunctional UCMOFs provide an effective platform for targeted combinational cancer therapy and in situ imaging,which hold great promise in biomedical and clinical applications.

关键词： Upconversion nanoparticles Metal-organic frameworks ATP response In situ imaging Targeted combinational therapy