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Efficacy of neoadjuvant chemotherapy for initially resectable colorectal liver metastases:A retrospective cohort study

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World Journal of Gastrointestinal Oncology 2022年第7期14卷 1281-1294页

作者： Kazuhisa Takeda Yu Sawada Yasuhiro Yabushita Yuki Honma Takafumi Kumamoto jun watanabe Ryusei Matsuyama Chikara Kunisaki Toshihiro Misumi Itaru Endo Gastroenterological Center Yokohama City University Medical CenterYokohama 232-0024Japan Department of Gastroenterological Surgery Yokohama City University Graduate School of MedicineYokohama 236-0004Jordan Department of Biostatistics Yokohama City University Graduate School of MedicineYokohama 236-0004Japan

BACKGROUND The liver is the most common metastatic site of colorectal cancer.Hepatectomy is the mainstay of treatment for patients with colorectal liver metastases(CRLMs).However,there are cases of early recurrence after upfront hepatectomy alone.In selected high-risk patients,neoadjuvant chemotherapy(NAC)may improve longterm survival.AIM To determine the efficacy of NAC for initially resectable CRLMs.METHODS Among 644 patients who underwent their first hepatectomy for CRLMs at our institution,297 resectable cases were stratified into an upfront hepatectomy group(238 patients)and a NAC group(59 patients).Poor prognostic factors for upfront hepatectomy were identified using multivariate logistic regression analysis.Propensity score matching was used to compare clinical outcomes between the upfront hepatectomy and NAC groups,according to the number of poor prognostic factors.Survival curves were estimated using the Kaplan-Meier method and compared using the log-rank test.RESULTS Preoperative carcinoembryonic antigen levels(≥10 ng/mL)(P=0.003),primary histological type(other than well/moderately differentiated)(P=0.04),and primary lymph node metastases(≥1)(P=0.04)were identified as independent poor prognostic factors for overall survival(OS)in the upfront hepatectomy group.High-risk status was defined as the presence of two or more risk factors.After propensity score matching,50 patients were matched in each group.Among high-risk patients,the 5-year OS rate was significantly higher in the NAC group(13 patients)than in the upfront hepatectomy group(18 patients)(100%vs 34%;P=0.02).CONCLUSION NAC may improve the prognosis of high-risk patients with resectable CRLMs who have two or more risk factors.

关键词： Colorectal neoplasms Neoadjuvant therapy Neoplasm metastasis Prognosis Risk factors Survival

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Clearance of the liver remnant predicts short-term outcome in patients undergoing resection of hepatocellular carcinoma

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World Journal of Gastroenterology 2022年第38期28卷 5614-5625页

作者： Atsushi Miki Yasunaru Sakuma Hideyuki Ohzawa Akira Saito Yoshiyuki Meguro jun watanabe Kazue Morishima Kazuhiro Endo Hideki Sasanuma Atsushi Shimizu Alan Kawarai Lefor Yoshikazu Yasuda Naohiro Sata Department of Surgery Jichi Medical UniversityShimotsuke 329-0498TochigiJapan

BACKGROUND Estimation of the functional reserve of the remnant liver is important to reduce morbidity and mortality.AIM To estimate the functional reserve of the remnant liver in patients with hepatocellular carcinoma(HCC).METHODS We reviewed the medical records of 199 patients who underwent resection of HCC.Hepatic clearance of the remnant liver was calculated using fusion images of 99mTc-labelled galactosyl-human serum albumin liver scintigraphy and computed tomography.Posthepatectomy liver failure(PHLF)was classified according to the International Study Group of Liver Surgery.Complications was classified according to Clavien–Dindo classification.We analyzed by the risk factors for PHLF,morbidity and mortality with multivariate analysis.RESULTS Twenty-seven(30%)patients had major complications and 23(12%)developed PHLF.The incidence of major complications increased with increasing albumin–bilirubin(ALBI)grade.The area under the curve values for hepatic clearance of the remnant liver,liver to heart-plus-liver radioactivity at 15 min(LHL15),and ALBI score predicting PHLF were 0.868,0.629,and 0.655,respectively.The area under the curve for hepatic clearance of the remnant liver,LHL15,and ALBI score predicting major complications were 0.758,0.594,and 0.647,respectively.The risk factors for PHLF and major complications were hepatic clearance of the remnant liver and intraoperative bleeding.CONCLUSION The measurement of hepatic clearance may predict PHLF and major complications for patients undergoing resection of HCC.

关键词： Liver function Hepatectomy Cirrhosis Fusion image Complication Mortality

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Efficacy and safety of distal radial approach for cardiac catheterization: A systematic review and meta-analysis

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World Journal of Cardiology 2021年第5期13卷 144-154页

作者： Toshihide Izumida jun watanabe Ryo Yoshida Kazuhiko Kotani Division of Community Medicine Kanazawa Medical University Himi Municipal HospitalHimi 935-8531ToyamaJapan Center for Community Medicine Jichi Medical UniversityShimotsuke-City 329-0498TochigiJapan Department of Internal Medicine Iwami HospitalIwami-Town 681-0003TottoriJapan

BACKGROUND The traditional radial approach(RA)is recommended as the standard method for coronary angiography(CAG),while a distal RA(DRA)has been recently used for CAG.AIM To assess the efficacy and safety of the DRA vs RA during CAG.METHODS The following databases were searched through December 2020:MEDLINE,the Cochrane Central Register of Controlled Trials,EMBASE,the World Health Organization International Clinical Trials Platform Search Portal,and Clinical-Trials.gov.Individual randomized-controlled trials for adult patients undergoing cardiac catheterization were included.The primary outcomes were the successful cannulation rate and the incidence of radial artery spasm(RAS)and radial artery occlusion(RAO).Study selection,data abstraction and quality assessment were independently performed using the Grading of Recommendations,Assessment,Development,and Evaluation approach.RESULTS Three randomized control trials and 13 registered trials were identified.The two approaches showed similar successful cannulation rates[risk ratio(RR)0.90,95%confidence interval(CI):0.72-1.13].The DRA did not decrease RAS(RR 0.43,95%CI:0.08-2.49)and RAO(RR 0.48,95%CI:0.18-1.29).Patients with the DRA had a shorter hemostasis time in comparison to those with the RA(mean difference-6.64,95%CI:-10.37 to-2.90).The evidence of certainty was low.CONCLUSION For CAG,the DRA would be safer than the RA with comparable cannulation rates.Given the limited data,additional research,including studies with standard protocols,is necessary.

关键词： Radial artery Cardiac catheterization Coronary angiography Snuff box Systematic review Meta-analysis

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Novel technique of abdominal wall nerve block for laparoscopic colostomy: Rectus sheath block with transperitoneal approach

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World Journal of Gastrointestinal Surgery 2017年第8期9卷 182-185页

作者： jun Nagata jun watanabe Yusuke Sawatsubashi Masaki Akiyama Koichi Arase Noritaka Minagawa Takayuki Torigoe Kotaro Hamada Yoshifumi Nakayama Keiji Hirata Department of Gastroenterological and General Surgery Wakamatsu Hospital University of Occupational and Environmental Health Department of Surgery Yokosuka Kyosai Hospital Department of Surgery University of Occupational and Environmental Health Department of Anesthesiology Wakamatsu Hospital University of Occupational and Environmental Health

A 62-year-old man who had acute rectal obstruction due to a large rectal cancer is presented. He underwent emergency laparoscopic colostomy. We used the laparoscopic puncture needle to inject analgesia with the novel transperitoneal approach. In this procedure, both ultrasound and laparoscopic images assisted with the accurate injection of analgesic to the correct layer. The combination of laparoscopic visualization and ultrasound imaging ensured infiltration of analgesic into the correct layer without causing damage to the bowel. Twentyfour hours postoperatively, the patient's pain intensity as assessed by the numeric rating scale was 0-1 during coughing, and a continuous intravenous analgesic was not needed. Colostomy is often necessary in colon obstruction. Epidural anesthesia for postoperative pain cannot be used in patients with a coagulation disorder. We report the use of a novel laparoscopic rectus sheath block for colostomy. There has been no literature described about the nerve block with transperitoneal approach. The laparoscopic rectus sheath block was performed safely and had enough analgesic efficacy for postoperative pain. This technique could be considered as an optional anesthetic regimen in acute situations.

关键词： Colorectal 癌症权利鞘块结肠阻塞手术后的疼痛

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Vonoprazan 20 mg vs lansoprazole 30 mg for endoscopic submucosal dissection-induced gastric ulcers

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World Journal of Gastrointestinal Endoscopy 2016年第19期8卷 716-722页

作者： Kazuya Takahashi Yuichi Sato junji Kohisa jun watanabe Hiroki Sato Kenichi Mizuno Satoru Hashimoto Shuji Terai Department of Endoscopy Niigata University Medical and Dental Hospital Division of Gastroenterology and Hepatology Sado General Hospital Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata University Division of Gastroenterology and Hepatology Nagaoka Red Cross Hospital

AIM To compare the healing effects of vonoprazan and lansoprazole on gastric ulcers induced by endoscopic submucosal dissection(ESD).METHODS Data were obtained from a total of 26 patients.Fourteen patients were randomized to the vonoprazan group and 12 were randomized to the lansoprazole group.Patients were administered either 20 mg vonoprazan or 30 mg lansoprazole per day after ESD.Endoscopic images just after ESD,on day 8,and on day 28 were used for the evaluation of the shrinking rate of ESD ulcers.The shrinking rates and the incidence of delayed bleeding were compared between the 2 groups.RESULTS The shrinking rates of ESD ulcers on day 8 [vonoprazangroup: 61.8%(range: 24.0%-91.1%),lansoprazole group: 71.3%(range: 25.2%-88.6%)] and on day 28 [vonoprazan group: 95.3%(range: 76.2%-100%),lansoprazole group: 97.2%(range: 81.1%-99.8%)] were not statistically different between the 2 groups.On day 28,most of the ulcers in both groups healed to more than 90%,whereas 3 of 14(21.4%) in the vonoprazan group and 1 of 12(8.3%) in the lansoprazole group had delayed ulcer healing,which was not statistically different(P = 0.356).The frequency of delayed bleeding was 0 in the both groups.Taken together,there were no significant differences between the two drug groups.CONCLUSION Our study indicates that vonoprazan is potent for the management of ESD ulcers although lansoprazole is also sufficient and cost-effective.

关键词： Lansoprazole 胃的癌症内视镜的 submucosal 解剖钾竞争的酸 blocker 质子泵禁止者 Vonoprazan

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Antioxidant Capacity and Total Phenol Content of Commonly Consumed Indigenous Foods of Asian Tropical Regions

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Journal of Food Science and Engineering 2012年第4期2卷 187-195页

作者： Nazuma Shaheen Masao Goto jun watanabe Yuko Takano-Ishikawa Institute of Nutrition and Food Science （INFS） University of Dhaka Dhaka 1000 Bangladesh Functional Food Factor Laboratory Functional Food Division National Food Research Institute （NFRI） Tsukuba Ibaraki305-8642 Japan

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薄片干电池—“纸电池”

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电池 1981年第1期 23-27页

作者： jun watanabe 袁树仁 755厂

近来由于电子线路及显示技术的发展导致以电池为电源的器件设备消耗功率减少,并促进发展高比能量的电池(即氧化银电池,汞电池以及锂电池)以使这些器

关键词：纸电池厚度放电容量薄片干电池混合粉薄层电池

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Long-term outcomes and prognostic factors of patients with obstructive colorectal cancer: A multicenter retrospective cohort study

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World Journal of Gastroenterology 2016年第22期22卷 5237-5245页

作者： Ishibe Atsushi Ota Mitsuyoshi Yamaguchi Kazuya Kaida Syuhei Kamiya Noriyuki Momiyama Masashi watanabe Akira Sekizawa Kentaro Kamimukai Nobuyuki Sugimasa Natsuko watanabe jun Ichikawa Yasushi Kunisaki Chikara Endo Itaru Department of Gastroenterological Surgery Graduate School of Medicine Yokohama City University Fukuura Kanazawa-ku Yokohama 236-0004 Japan Department of Surgery Gastroenterological Center Yokohama City University Urafune Minami-ku Yokohama 232-0024 Japan Department of Surgery Yokohama City Hospital Okazawa Hodogaya-ku Yokohama 240-8555 Japan Department of Surgery Yokosuka Kyosai Hospital Maigahamadori Yokosuka 238-8558 Japan Department of Surgery Ito Municipal Hospital Ito 414-0055 Japan Department of Surgery Fujisawa City Hospital Fujisawa 251-8550 Japan Department of Surgery Yokosuka City Hospital Nagasaka Yokosuka 240-0195 Japan Department of Surgery Yokohama Hodogaya Central Hospital Kamadai Hodogaya-ku Yokohama 240-8585 Japan Department of Surgery Saiseikai Yokohamashi Nanbu Hospital Kounandai Kounan-ku Yokohama 234-0054 Japan Department of Oncology Graduate School of Medicine Yokohama City University Yokohama 236-0004 Japan

AIM: To investigate the long-term oncologic outcomes and prognostic factors in patients with obstructive colorectal cancer(CRC) at multiple Japanese institutions.METHODS: We identified 362 patients diagnosed with obstructive colorectal cancer from January 1, 2002 to December 31, 2012 in Yokohama Clinical Oncology Group's department of gastroenterological surgery. Among them, 234 patients with stage Ⅱ/Ⅲ disease who had undergone surgical resection of their primary lesions were analyzed, retrospectively. We report the long-term outcomes, the risk factors for recurrence, and the prognostic factors.RESULTS: The five-year disease free survival and cancer-specific survival were 50.6% and 80.3%, respectively. A multivariate analysis showed the ASAPS(HR = 2.23, P = 0.026), serum Albumin ≤ 4.0 g/d L(HR = 2.96, P = 0.007), T4 tumor(HR = 2.73, P = 0.002) and R1 resection(HR = 6.56, P = 0.02) to be independent risk factors for recurrence. Furthermore, poorly differentiated cancers(HR = 6.28, P = 0.009), a T4 tumor(HR = 3.46, P = 0.011) and R1 resection(HR = 6.16, P = 0.006) were independent prognostic factors in patients with obstructive CRC.CONCLUSION: The outcomes of patients with obstructive CRC was poor. T4 tumor and R1 resection were found to be independent prognostic factors for both recurrence and survival in patients with obstructive CRC.

关键词： Obstructive colorectal cancer Prognostic factor Survival

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Mesenchymal stem cell enhances chondral defects healing in horses

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Stem Cell Discovery 2013年第4期3卷 218-225页

作者： Ana Lucia Miluzzi Yamada Armando de Mattos Carvalho Andrei Moroz Elenice Deffune Marcos jun watanabe Carlos Alberto Hussni Celso Antonio Rodrigues Ana Liz Garcia Alves Department of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science(FMVZ)UNESPUniversidade Estadual PaulistaBotucatuBrazil Faculty of Veterinary Medicine Cuiaba UniversityCuiabaBrazil Department of Morphology Institute of BiosciencesUNESPBotucatuBrazil Blood Center School of MedicineUNESPBotucatuBrazil

The purpose of this study was to evaluate the effect of intralesional Mesenchymal Stem Cells (MSC) on the treatment of experimentally induced articular chondral defects in horses, emphasizing the benefits of this application in veterinary medicine. Chondral defects were induced in the medial femoral trochlea of both hind limbs of four horses. Thirty days post induction;the horses were divided into two groups. The G1 was submitted to treatment with MSC and the G2 was the control group. Clinical evaluations, synovial fluid analysis and synovial Prostaglandin E2 (PGE2) assessment were performed prior to defects and fortnightly up to 120 and 150 days. Macroscopic, histopathological and histochemical evaluations were performed at the end of the experiment. The treatment with MSC reduced the intraarticular inflammatory process. The G1 showed lower PGE2 concentrations in the synovial fluid and greater percentage of mononuclear cells and lower percentages of lymphocytes and neutrophils. The treatment improved the macro and microscopic aspects of repair tissue. No difference was observed in the scores of lameness between the G1 and G2. The use of MSC in the treatment of chondral defects minimized joint inflammation, as confirmed by synovial fluid analysis. The treatment resulted in an improved repair tissue, verified by macroscopic examination, histochemical and histopathological analysis.

关键词： Arthroscopy Cartilage Equine Lameness Mesenchymal Stem Cells

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The Nano Research Young Innovators Awards in bio-inspired nanomaterials

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Nano Research 2024年第2期17卷 417-425页

作者： jun Chen Shuotao Wang Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Nano Research Young Innovators(NR45)Awards are designed to acknowledge and celebrate the achievements of young researchers under 45 years of age.These individuals have made significant contributions to the field of nanoscience and nanotechnology.Since the inaugural NR45 Awards in 2018,the journal's editorial board has recognized over a hundred innovators specializing in nanobiotechnology,nano energy,two-dimensional materials,and nanocatalysis.The focus of the 2023 NR45 Awards is on bioinspired nanomaterials,acknowledging thirty-three outstanding young innovators for their extraordinary contributions in developing these materials with applications spanning clean energy,human healthcare,monitoring,and disease treatments,as shown in Fig.1.We extend our heartfelt congratulations to all the 33 NR45 Awardees in 2023!

关键词： journal materials contributions

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