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Scintillation and optical properties of Ce-doped YAGG transparent ceramics

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Journal of Rare Earths 2016年第8期34卷 763-768页

作者： Masaki Mori Jian Xu Go Okada Takayuki Yanagida jumpei ueda Setsuhisa Tanabe Graduate School of Materials' Science Nara Institute of Science and Technology (NAIST) 8916-5 Takayama-cho Ikoma-shi Nara 630-0192 Japan Graduate School of Human and Environmental Studies Kyoto University Yoshida-nihonmatsu-eho Sakyo-ku Kyoto 606-8501 Japan

We investigated photoluminescence （PL） and scintillation properties of Ce3＋-doped Y3A12Ga3OI2 （Ce：YAGG） trans- parent ceramics synthesized by vacuum sintering with different Ce3＋ concentrations （mol.%） from 0.3% to 1% （0.3%Ce：YAGG, 0.5%Ce：YAGG, 0.8%Ce：YAGG and I%Ce：YAGG）. The samples were synthesized by the vacuum sintering technique. The obtained samples showed a very strong and broad PL emission by the 5dl-4f transition of Ce3＋ in the wavelength range from 470 to 600 nm. The PL decay profiles were approximated by a single exponential decay function with the time constants of around 33-39 ns, Fur- thermore, the scintillation spectra induced by X-rays showed similar features with those observed in PL. The scintillation decay time profiles followed a second-order exponential decay function. The fast component group （ranged 3542 ns） were dominantly contrib- uted by the 5d1-4f transition of Ce3＋. The pulse height spectra utilizing the latter emissions showed a clear photoabsorption peak. Among those samples tested, 0.5%Ce：YAGG sample showed the highest scintillation light yield of 21,400 ph/MeV under 13VCs y-ray irradiation.

关键词： YAGG cerium transparent ceramic scintillation photoluminescence rare earths

Enzyme replacement therapy in two patients with classic Fabry disease from the same family tree:Two case reports

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World Journal of Clinical Cases 2023年第15期11卷 3542-3551页

作者： Yuki Harigane Issei Morimoto O Suzuki jumpei Temmoku Takayuki Sakamoto Kohichiro Nakamura Kazuo Machii Masayuki Miyata Department of Urology Fukushima Medical UniversityFukushima 960-1295Japan Otsuki Sleep Clinic Fukushima 960-8044Japan Department of Diagnostic Pathology Fukushima Medical UniversityFukushima 960-1295Japan Center of Internal Medicine for Rheumatology and Collagen Disease Fukushima Red Cross HospitalFukushima 960-8530Japan Department of Cardiology Fukushima Red Cross HospitalFukushima 960-8530Japan Department of Neurology Fukushima Red Cross HospitalFukushima 960-8530Japan Machii Cardiology and Internal Medicine Clinic Fukushima 960-8530Japan

BACKGROUND The pathophysiology of Fabry disease(FD)-induced progressive vital organ damage is *** progression can be delayed using enzyme replacement therapy(ERT).In patients with classic FD,sporadic accumulation of globotriaosylceramide(GL-3)in the heart and kidney begins in utero;however,until childhood,GL-3 accumulation is mild and reversible and can be restored by *** current consensus is that ERT initiation during early childhood is ***,complete recovery of organs in patients with advanced FD is *** SUMMARY Two related male patients,an uncle(patient 1)and nephew(patient 2),presented with classic *** patients were treated by *** 1 was in his 50s,and ERT was initiated following end-organ damage;this was subsequently *** developed cerebral infarction and died of sudden cardiac *** 2 was in his mid-30s,and ERT was initiated when the patient was diagnosed with FD,during which the damage to vital organs was not overtly *** he had left ventricular hypertrophy at the beginning of this treatment,the degree of hypertrophy progression was limited to a minimal range after>18 years of *** We obtained discouraging ERT outcomes for older patients but encouraging outcomes for younger adults with classic FD.

关键词： Enzyme replacement therapy Fabry disease Pedigree Left ventricular hypertrophy α-galactosidase Case report

Ig SF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95

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Bone Research 2020年第1期8卷 97-106页

作者： Hyunsoo Kim Noriko Takegahara Matthew CWalsh Sarah AMiddleton Jiyeon Yu jumpei Shirakawa Jun ueda Yoshitaka Fujihara Masahito Ikawa Masaru Ishii Junhyong Kim Yongwon Choi Department of Pathology and Laboratory Medicine University of Pennsylvania Perelman School of MedicinePhiladelphiaPA 19104USA Department of Biology Department of Computer and Information ScienceSchool of Arts and SciencesProgram in Single Cell BiologyUniversity of PennsylvaniaPhiladelphiaPA 19104USA Research Institute for Microbial Diseases Osaka UniversitySuitaOsaka 565-0871Japan Department of Immunology and Cell Biology Graduate School of Medicine and Frontier BiosciencesOsaka UniversitySuitaOsaka 565-0871Japan

Osteoclasts are multinucleated, giant cells derived from myeloid progenitors. While receptor activator of NF-κB ligand(RANKL)stimulation is the primary driver of osteoclast differentiation, additional signaling further contributes to osteoclast ***, we demonstrate that immunoglobulin superfamily member 11(Ig SF11), whose expression increases during osteoclast differentiation, regulates osteoclast differentiation through interaction with postsynaptic density protein 95(PSD-95), a scaffold protein with multiple protein interaction domains. Ig SF11 deficiency in vivo results in impaired osteoclast differentiation and bone resorption but no observed defect in bone formation. Consequently, Ig SF11-deficient mice exhibit increased bone *** in vitro osteoclast culture systems, we show that Ig SF11 functions through homophilic interactions. Additionally, we demonstrate that impaired osteoclast differentiation in Ig SF11-deficient cells is rescued by full-length Ig SF11 and that the Ig SF11-PSD-95 interaction requires the 75 C-terminal amino acids of Ig SF11. Our findings reveal a critical role for Ig SF11 during osteoclast differentiation and suggest a role for Ig SF11 in a receptor-and signal transduction molecule-containing protein complex.

关键词： SF11 osteoclast impaired

Possible modulated γ-ray emission from the transitional millisecond pulsar binary PSR J1023+0038

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Research in Astronomy and Astrophysics 2018年第10期18卷 109-116页

作者： Yi Xing Zhong-Xiang Wang jumpei Takata Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics Huazhong University of Science and Technology

We report the results from our analysis of Fermi Large Area Telescope （LAT） data for the transitional millisecond pulsar binary PSR J1023＋0038. The time period of the data is nearly 9 yr, and that after the source＇s transition, in June 2013 from the disk-free state to the active state of having an accretion disk, is approximately 4 yr. We identify a high-energy 〉5.5 GeV component in the source＇s spectrum in the active state, and find this component is only significantly detected in half of the orbital phase centered at the descending node （when the pulsar is moving towards the Earth）. Considering the pulsar scenario proposed for multi-frequency emission from the source, in which the pulsar is still active and a cold-relativistic pulsar wind inverse-Compton scatters the photons from the accretion disk, we discuss the origin of the high-energy component. In order to explain the observed spectrum, a power-law distribution of particles, with an index of ~3, in the pulsar wind is required, while the orbital variations are possibly due to changes in power-law index as a function of orbital phase.

关键词： gamma rays stars - binaries eclipsing - stars neutron

Mechanophore activation enhanced by hydrogen bonding of diarylurea motifs:An efficient supramolecular force-transducing system

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Aggregate 2021年第3期2卷 9-13页

作者： jumpei Kida Daisuke Aoki Hideyuki Otsuka Department of Chemical Science and Engineering Tokyo Institute of TechnologyMeguro-kuTokyoJapan

Macromolecules are efficient as mechanical transducers for mechanically induced chemical bond cleavage *** various classes of polymers have been studied as effective mechanical-force transducers for mechanophores,alternatives to polymer chains,that is,small molecules,have rarely been *** this paper,the role of hydrogen bonding as small-molecule mechanical-force transducers for the activation of mechano-responsive molecular units(mechanophores)in the bulk is *** introduction of diarylurea linkage motifs,which are known as strong hydrogen bonding groups,enhances the mechanochemical activation of the fluorescent mechanophore tetraarylsuccinonitrile(TASN)as effectively as the attachment of a typical macromolecular *** paramagnetic resonance measurements of mechanically activated TASN with diphenyl urea motifs demonstrate its higher carbon–carbon bond dissociation ratio compared to that of TASN without diphenyl urea *** efficient supramolecular-forcetransducing system represents a new concept in the field of mechanochemistry,namely,the enhancement of mechanochemical bond scission by simply changing the substituents of a mechanophore,even in small molecules.

关键词： hydrogen bonding mechanophore radical

Modeling the high-energy emission from the gamma-ray binary 1FGL J1018.6–5856

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Research in Astronomy and Astrophysics 2021年第8期21卷 46-58页

作者： A-Ming Chen Chowing Ng jumpei Takata Yun-Wei Yu School of physics Huazhong University of Science and TechnologyWuhan 430074China Department of Physics The University of Hong KongPokfulam RoadHong KongChina College of Physical Science and Technology Central China Normal UniversityWuhan 430079China

1FGL J1018.6–5856 is a high mass gamma-ray binary containing a compact object orbiting around a massive star with a period of 16.544 *** the compact object is a pulsar,non-thermal emissions are likely produced by electrons accelerated at the termination shock,and may also originate from the magnetosphere and the un-shocked wind of the *** this paper,we investigate the non-thermal emissions from the wind and the shock with different viewing geometries and study the multi-wavelength emissions from 1FGL J1018.6–*** present the analysis results of the Fermi/LAT using nearly 10 years of *** phase-resolved spectra indicate that the Ge V emissions comprise a rather steady component that does not vary with orbital motion and a modulated component that shows flux maximum around inferior *** ke V/Te V light curves of 1FGL J1018.6–5856 also exhibit a sharp peak around inferior conjunction,which are attributed to the boosted emission from the shock,while the broad sinusoidal modulations could be originating from the deflected shock tail at a larger *** modulations of Ge V flux are likely caused by the boosted synchrotron emission from the shock and the IC emission from the unshocked pulsar wind,while the steady component comes from the outer gap of the pulsar ***,we discuss the similarities and differences of 1FGL J1018.6–5856 with other binaries,like LS 5039.

关键词： binaries:close gamma rays:stars X-rays:binaries radiation mechanisms:non-thermal

Global signatures of protein binding on structured RNAs in Saccharomyces cerevisiae

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Science China(Life Sciences) 2014年第1期57卷 22-35页

作者： YANG YuCheng UMETSU jumpei LU Zhi John MOE Key Lab of Bioinformatics School of Life Sciences Tsinghua University Department of Biological Information Tokyo Institute of TechnologyTokyo 152-8850 Japan

Protein binding is essential to the transport,decay and regulation of almost all RNA ***,the structural preference of protein binding on RNAs and their cellular functions and dynamics upon changing environmental conditions are poorly ***,we integrated various high-throughput data and introduced a computational framework to describe the global interactions between RNA binding proteins(RBPs)and structured RNAs in yeast at single-nucleotide *** found that on average,in terms of percent total lengths,~15%of mRNA untranslated regions(UTRs),~37%of canonical non-coding RNAs(ncRNAs)and^11%of long ncRNAs(lncRNAs)are bound by *** RBP binding sites,in general,tend to occur at single-stranded loops,with evolutionarily conserved signatures,and often facilitate a specific RNA structure conformation in *** found that four nucleotide modifications of tRNA are significantly associated with RBP *** also identified various structural motifs bound by RBPs in the UTRs of mRNAs,associated with localization,degradation and stress ***,we identified>200 novel lncRNAs bound by RBPs,and about half of them contain conserved secondary *** present the first ensemble pattern of RBP binding sites in the structured non-coding regions of a eukaryotic genome,emphasizing their structural context and cellular functions.

关键词： RNA binding protein non-coding RNA UTR RNA structure Saccharomyces cerevisiae

Pneumococcal infection transmission between family members with congenital asplenia: A case report

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World Journal of Clinical Cases 2019年第24期7卷 4277-4284页

作者： jumpei Shibata Kazuhiro Hiramatsu Tuneaki Kenzaka Takehito Kato Department of General Surgery Toyohashi Municipal Hospital50 Aza Hachiken NishiAotake-ChoAichi 4418570ToyohashiJapan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineHyogo 6520032KobeJapan

BACKGROUND Asplenia,the lack of a spleen,can be congenital and increases susceptibility to severe infections caused by encapsulated bacteria,such as Streptococcus pneumoniae(***).We report two cases of severe pneumococcal infection in two asplenic family members living in the same *** SUMMARY Patient 1,a 38-year-old man with a history of congenital hepatitis B infection and hypospadias,was brought to our emergency department with complaints of cyanosis,cough,and edema of his *** was clinically diagnosed as hyposplenic with overwhelming pneumococcal *** was admitted to the intensive care unit and was administered antibiotics and catecholaminergic therapy but died 2 h after *** 2,a 63-year-old woman with a history of type 2 diabetes,was brought to our emergency department one month after admission of Patient *** was diagnosed as asplenic with overwhelming pneumococcal ***-taking revealed that she was the mother of Patient 1 and the two had lived in the same *** was admitted to the intensive care unit and was rapidly provided antibiotics and catecholaminergic intervention but died one day after *** Pneumococcal bacteremia caused by virulent *** may be transmitted within *** residents of households where individuals with pneumococcal bacteremia are living should be educated about the risk of *** members of patients with congenital asplenia/hyposplenia,all family members should be examined to assess their splenic function.

关键词： Streptococcus pneumoniae Pneumococcal infection Asplenia Hyposplenia Isolated congenital asplenia Septic shock Case report

Vibrational dynamics of the CN stretching mode of [Ru(CN)_6]^(4-) in D_2O studied by nonlinear infrared spectroscopy

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Science China(Physics,Mechanics & Astronomy) 2010年第6期53卷 1013-1019页

作者： jumpei TAYAMA Motohiro BANNO Kaoru OHTA Keisuke TOMINAGA Graduate School of Science Kobe University Molecular Photoscience Research Center Kobe University PRESTO JST4-1-8 Honcho KawaguchiSaitamaJapan 332-0012Japan

We have studied vibrational dynamics of the T1u mode of the CN stretching mode of [Ru(CN)6 ]4- in D2O by infrared(IR) nonlinear spectroscopy such as an IR three-pulse photon echo experiment and polarization-sensitive IR pump-probe spectroscopy. The isotropic component of the pump-probe signal shows a bi-exponential decay with time constants of 0.8 ps and 20.8 ps. The fast and slow components correspond to the rapid equilibration between the T1u mode and the Raman active modes of the CN stretching mode and the vibrational population relaxation from the v=1 state of the T1u mode,respectively. Anisotropy of the pump-probe signal decays with a time constant of 3.1 ps,which is due to the time evolution of the superposition states of the triply degenerate T1u modes. Three pulse photon echo measurements showed that the time correlation function of the frequency fluctuation decays bi-exponentially with time constants of 80 fs and 1.4 ps. These time constants depend only on the solute and are independent of the solvent,whereas the amplitudes depend on both the solute and solvent.

关键词： nonlinear IR spectroscopy metal complex aqueous solution