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The effectiveness and safety of thyroxine replacement therapy for children with down syndrome and subclinical or congenital hypothyroidism—A systematic review

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Health 2012年第8期4卷 452-456页

作者： Ashwaq H. al-Sabban Saleem Ahmed jumana Y. al-aama Department of Genetic Medicine Faculty of Medicine King Abdulaziz University Jeddah KSA Princess al-Jawhara Center of Excellence in Research of Hereditary Disorders (PACER.HD) Department of Genetic Medicine Faculty of Medicine King Abdulaziz University Jeddah KSA

Introduction: Down syndrome (DS) is the most common chromosomal abnormality causing mental handicap in humans. Children with DS have significant medical problems and developmental delay which are further impaired by hypothyroidism. Those clinical features are potentially improved by using thyroxine replacement therapy. Objectives: To examine the evidence of effectiveness (motor & mental development) and safety of thyroxine supplementation in the treatment of SH and CH in children with DS. Methods: Several medical data bases (MEDLINE, EMBASE, CINAHL, Cochrane, Clinical Trials Gov, Essential Evidence and Google) were searched until 20 October, 2011, for randomized control trials (RCTs) that had examined thyroxine’s effectiveness and safety in the treatment of SH or CH in children with DS. Results: There were two high quality RCTs that examined thyroxine in the treatment of CH in children with DS, and no RCTs were found to have examined the effectiveness of thyroxine for SH in children with DS. Conclusion: The RCT which met our inclusion criteria provides the reliable evidence in recommending thyroxine for the treatment of CH in children with DS which is similar to the guidelines for general population. The absence of RCTs examining the treatment of SH in Children with DS indicates the need to conduct such trials.

关键词： Down Syndrome Children Subclinical Hypothyroidism Hypothyroidism Congenital Hypothyroidism Thyroxine

对250位成年双胞胎的宏基因组鸟枪法测序发现影响肠道菌群的遗传与环境因素

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科学新闻 2017年第4期 186-186页

作者： Hailiang Xie Ruijin Guo Huanzi Zhong Qiang Feng Zhou Lan Bingcai Qin Kirsten J.Ward Matthew A.Jackson Yan Xia Xu Chen Bing Chen Huihua Xia Changlu Xu Fei Li Xun Xu jumana yousuf al-aama Huanming Yang Jian Wang Karsten Kristiansen Jun Wang Claire J.Steves Jordana T.Bell 李俊桦 Timothy D.Spector 贾慧珏深圳华大基因研究院宏基因组研究所霍华德休斯医学研究所北卡罗来纳大学教堂山分校

文章简介肠道菌群通常被看作是影响人体健康的环境因素。双胞胎这一群体是系统地解析塑造肠道菌群的遗传与环境因素的绝佳对象。本研究首次对较大规模的双胞胎人群(取自Twin UK队列的250人)的粪便样品进行宏基因组鸟枪法测序,并构建最... 详细信息

文章简介肠道菌群通常被看作是影响人体健康的环境因素。双胞胎这一群体是系统地解析塑造肠道菌群的遗传与环境因素的绝佳对象。本研究首次对较大规模的双胞胎人群(取自Twin UK队列的250人)的粪便样品进行宏基因组鸟枪法测序,并构建最完整参考基因集。研究发现肠道菌群

关键词：肠道菌群双胞胎深圳华大基因研究院宏基因组测序

The Relationship between ABO Blood Group Type and the COVID-19 Susceptibility in Qatif Central Hospital, Eastern Province, Saudi Arabia: A Retrospective Cohort Study

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Open Journal of Internal Medicine 2020年第2期10卷 232-238页

作者： Ghada ali aljanobi alya Hassan alhajjaj Fatimah Lateef alkhabbaz jumana Mansour al-Jishi Internal Medicine Department Qatif Central Hospital Qatif KSA

Introduction: It has been found that the viral infection is linked to the ABO blood group. Limited studies investigated the relationship of the ABO blood group and susceptibility to COVID-19 infection. Objective: To investigate the association between the ABO blood group and the COVID-19 susceptibility. Material & Methods: The study is a retrospective cohort study. It included all hospitalized confirmed COVID-19 patients in Qatif central hospital, Eastern province, Saudi Arabia. We included both genders and people who are older than 14 years of age. The study was conducted in the period between 15th March, and 15th April, 2020. Results: Our sample consists of 72 patients;we found a percentage distribution of 23.62%, 33.33%, 9.72%, and 33.33% for blood groups A, B, AB and O, respectively. Our results showed significantly increased risk for AB blood groups (P although there was a higher percentage distribution of the B blood group among COVID-19 patients as compared to the blood donors’ groups, this difference did not reach statistical significance. There was no significant difference in the risk of COVID-19 in blood group A with a distribution of 23.60% in blood donors’ group, and 23.62% in COVID-19 patients. Conclusion: Our findings suggest that among confirmed COVID-19 patients, patients with AB blood group have higher susceptibility while patients with O blood group have lower susceptibility to COVID-19 infection. Our study has limitations and further studies are needed.

关键词： ABO Group Saudi Qatif COVID-19

Characterization of Natural Antimicrobials in Food System

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Advances in Microbiology 2018年第11期8卷 894-916页

作者： jumana Mahmud Ruhul A. Khan Institute of Radiation and Polymer Technology Bangladesh Atomic Energy Commission Dhaka Bangladesh

There has been a rising interest in using natural antimicrobial compounds in food industry due to current trend of giving value to natural and renewable resources. These antimicrobials provide new modalities to ensure microbial safety and extend the shelf-life of foodstuffs. Natural antimicrobials can be directly added into the food, but several efforts have been made to find alternative solutions to the aim of avoiding undesirable inactivation. Some different ways such as, dipping, spraying, and coating treatment of food are currently applied to product before packaging considered as valid options. The present paper aims to review the use of natural compounds to control microbiological and physicochemical shelf life of major food categories such as, meat, fish, dairy-based products, fruit and vegetables, and cereal-based products.

关键词： Natural Antimicrobial Compounds Food Preservation Shelf-Life Extension

Psychological and Mental Health among Isolated Hospitalized Suspected and Confirmed COVID-19 Patients, Qatif Central Hospital, Eastern Province, Saudi Arabia: A Single-Center Descriptive Study

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Open Journal of Internal Medicine 2020年第3期10卷 245-255页

作者： alya Hassan alhajjaj Taaweel Hussain al Abduljaber Zainab ali alsadeq Fatimah Lateef alkhabbaz Hoor Hussain alobaidan Fatimah ali al Saeed jumana Mansour al-Jishi Ghada ali aljanobi Internal Medicine Department Qatif Central Hospital Al Qatīf Saudi Arabia Psychiatry Department Erada Complex for Mental Health Al Dammam Saudi Arabia

Introduction: During COVID-19 pandemic, isolation and quarantine as preventive measures have been implemented. Isolation is often a bad experience for isolated people and it could affect the psychological and mental health. Objectives: To study the impact of isolation on the psychological and mental health of isolated hospitalized suspected and confirmed COVID-19 patients. Material & Methods: A single-center cohort, descriptive survey involving isolated confirmed and suspected COVID-19 patients in Qatif central hospital, Eastern province, Saudi Arabia. The study was conducted between March 22 and April 18, 2020. Information was collected through an online Arabic-language questionnaire. Our sample included both male and female. Anxiety and depression symptoms during hospitalization were evaluated with the Hospital Anxiety and Depression Scale. Results: A total of 52 questionnaires were returned completed. The majority of the respondents were females (65.4%). Most of the participants were less than 60 years of age (90.4%). Three patients were known to have previous mental illness. About two-thirds of the participants were isolated in shared rooms. The duration of isolation was less than 10 days in 72.3% of our sample. Borderline and abnormal scores for depression and anxiety were observed in about 38.4%, and 17.3% of patients, respectively. Three patients had both abnormal depression and anxiety scores. Conclusion: Isolation for contagious infections such as COVID-19 could cause severe psychological health problems, though this was not supported by our study due to the small sample size. Further studies are needed to address this important issue which results from isolation during infectious outbreaks.

关键词： COVID-19 Psychological Isolation Qatif Saudi

Serum Caspase-3 and Caspase-7 as Predictive Factors of Response in Locally Advanced and Metastatic Breast Carcinoma

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Journal of Cancer Therapy 2014年第6期5卷 584-590页

作者： Hayma Hammoud jumana Saleh Marroan Bachour Maher Salamoon Department of Medical Oncology Al Bairouni University Hospital Damascus Syria Faculty of Pharmacy Damascus University Damascus Syria

Introduction: Breast cancer is the most common cancer in women and the second most frequent cause of cancer death. Several factors affect response to chemotherapy including nodal status, hormonal status and human epidermal growth factor receptor (Her-2). Aim of Study: The study is aiming at evaluating Caspase-3, 7 levels in serum of patients with locally advanced and metastatic breast cancer and establishing the relation between Casepase level and response to chemotherapy. Patients and Methods: The study was performed at al Bairouni University Hospital and the Faculty of Pharmacy (Damascus-Syria). We have included 60 patients with histologic confirmation of invasive ductal carcinoma of the breast treated with the combination (Docetaxel + Doxorubicin) with Caspase-3, 7 levels to be evaluated before treatment and 24 hours after the first and third cycle. Results: Caspase-3 level increases in serum 24 hours after the 1st cycle correlated with different kinds of response in 39 patients (P value 0.0002) with better results in those with Estrogen Receptors (ER) positive patients (P 0.005). In a similar manner, Caspase-7 level increases 24 hours after the 1st cycle correlated with response in 40 patients (P 0.005). However, ER status had no impact on response in Caspase-7 group (P 0.2). Conclusion: Caspase-3 and 7 levels in serum are useful as a predictive marker of response to chemotherapy in both locally advanced and metastatic breast cancer especially when tittered 24 hours after the first chemotherapy.

关键词： Caspase-3 7 Metastatic Breast Cancer Response

Serum CK18 as a Predictive Factor of Response to Chemotherapy in Locally Advanced and Metastatic Breast Cancer

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Advances in Breast Cancer Research 2014年第3期3卷 79-83页

作者： Basem Battah jumana Saleh Marroan Bachour Maher Salamoon al Bairouni University Hospital Damascus Damascus Syria Faculty of Pharmacy Damascus University Damascus Syria

Introduction: Breast cancer is the most common cancer in women and the second most frequent cause of cancer death. Several factors affect response to chemotherapy including nodal status, hormonal status and human epidermal growth factor receptor (Her-2). Aim of Study: The study is aiming at evaluating M30 antigen in serum of patients with locally advanced and metastatic breast cancer and establishing the relation between M30 level and response to chemotherapy. Patients and Methods: The study was performed at al Bairouni University Hospital and the Faculty of Pharmacy (Damascus-Syria). We have included 60 patients with histologic confirmation of invasive ductal carcinoma of the breast treated with the combination (Docetaxel + Doxorubicin) with M30 levels to be evaluated before treatment and 24 hours after the first and third cycle. Results: M30 level increase in serum 24 hours after the 1st cycle correlated with different kinds of response in 39 patients (P value less than 0.03) with better results in those with Estrogen Receptors (ER) positive patients (P value 0.05). There was no correlation between Her-2 status and response (P value 0.3). Conclusion: M30 level in serum is a useful predictor marker of response to chemotherapy in both locally advanced and metastatic breast cancer.

关键词： CK18 Metastatic Breast Cancer Response

Causes of gastrointestinal bleeding in children based on endoscopic evaluation at a tertiary care center in Bahrain

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World Journal of Gastrointestinal Endoscopy 2023年第4期15卷 297-308页

作者： Hasan M Isa Fatema A alkharsi Hana A Ebrahim Kamel J Walwil jumana A Diab Nafelah M alkowari Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Department of Pediatrics Royal College of Surgeons in Ireland-Medical University of BahrainBusaiteen 15503Bahrain Department of Pediatrics King Hamad University HospitalMuharraq 24343Bahrain

BACKGROUND Gastrointestinal bleeding(GIB)is a serious health problem worldwide,particularly during *** can be an alarming sign of an underlying *** endoscopy(GIE)is a safe method for the diagnosis and treatment of GIB in most *** To determine the incidence,clinical presentation,and outcomes of GIB in children in Bahrain over the last two *** This was a retrospective cohort review of the medical records of children with GIB who underwent endoscopic procedures in the Pediatric Department at Salmaniya Medical Complex,Bahrain,between 1995 and *** data,clinical presentation,endoscopic findings,and clinical outcomes were *** was classified into upper(UGIB)and lower(LGIB)GIB according to the site of *** were compared with respect to patients’sex,age,and nationality using the Fisher’s exact,Pearson’sχ2,or the Mann-Whitney U *** A total of 250 patients were included in this *** median incidence was 2.6/100000 per year(interquartile range,1.4-3.7)with a significantly increasing trend over the last two decades (P ales (n = 144, 57.6%). Themedian age at diagnosis was 9 years (5-11). Ninety-eight (39.2%) patients required upper GIEalone, 41 (16.4%) required colonoscopy alone, and 111 (44.4%) required both. LGIB was morefrequent (n = 151, 60.4%) than UGIB (n = 119, 47.6%). There were no significant differences in sex (P = 0.710), age (P = 0.185), or nationality (P = 0.525) between the two groups. Abnormalendoscopic findings were detected in 226 (90.4%) patients. The common cause of LGIB was inflammatorybowel disease (IBD) (n = 77, 30.8%). The common cause of UGIB was gastritis (n = 70, 28%).IBD and undetermined cause for bleeding were higher in the 10-18 years group (P = 0.026 and P =0.017, respectively). Intestinal nodular lymphoid hyperplasia, foreign body ingestion, andesophageal varices were more common in the 0-4 years group (P = 0.034, P < 0.0001

关键词： Pediatric Gastrointestinal bleeding Endoscopy Causes Outcome Bahrain

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伦敦的金融业——时髦产业

英语知识 2009年第1期 13-16页

作者：朱明元 jumana Farouky

在伦敦宁静而豪华的肯辛顿区有一幢帝国气派的维多利亚住宅，尽管业主并非皇族，而是一个在金融领域谋生的瑞士人家庭。此住宅超过6层，共8个卧室、6个浴室、1部电梯和1个花园。他们不想继续为这幢很少使用的房屋支付维修费，于是以185... 详细信息

在伦敦宁静而豪华的肯辛顿区有一幢帝国气派的维多利亚住宅，尽管业主并非皇族，而是一个在金融领域谋生的瑞士人家庭。此住宅超过6层，共8个卧室、6个浴室、1部电梯和1个花园。他们不想继续为这幢很少使用的房屋支付维修费，于是以1850万美元的要价投入市场。就这个价位，奈特·弗兰克住宅研究所经纪人汤姆·唐尼说：“我想买主也一定是个外国人”。

关键词：伦敦金融业产业时髦维多利亚金融领域投入市场住宅