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Validation of a novel animal model for sciatic nerve repair with an adipose-derived stem cell loaded fibrin conduit

Neural Regeneration Research 2018年第5期13卷 854-861页

作者： maximilian m.Saller Rosa-Eva Huettl julius m.mayer Annette Feuchtinger Christian Krug Thomas Holzbach Elias Volkmer Experimental Surgery and Regenerative medicine (Experimed) Department of General Trauma and Reconstructive SurgeryLudwig-Maximilians-University (LMU) max-Planck-Institute of Psychiatry Department of Stress Neurobiology and Neurogenetics Department of Hand- Plastic-and Aesthetic Surgery Ludwig-Maximilians-University (LMU) Research Unit Analytical Pathology Munich Helmholtz Zentrum Muenchen-German Research Center for Environmental Health (GmbH) Department of Hand and Plastic Surgery Spital Thurgau AG

Despite the regenerative capabilities of peripheral nerves, severe injuries or neuronal trauma of critical size impose immense hurdles for proper restoration of neuro-muscular circuitry. Autologous nerve grafts improve re-establishment of connectivity, but also comprise substantial donor site morbidity. We developed a rat model which allows the testing of different cell applications, i.e., mesenchymal stem cells, to improve nerve regeneration in vivo. To mimic inaccurate alignment of autologous nerve grafts with the injured nerve, a 20 mm portion of the sciatic nerve was excised, and sutured back in place in reversed direction. To validate the feasibility of our novel model, a fibrin gel conduit containing autologous undifferentiated adipose-derived stem cells was applied around the coaptation sites and compared to autologous nerve grafts. After evaluating sciatic nerve function for 16 weeks postoperatively, animals were sacrificed, and gastrocnemius muscle weight was determined along with morphological parameters（g-ratio, axon density ＆ diameter） of regenerating axons. Interestingly, the addition of undifferentiated adipose-derived stem cells resulted in a significantly improved re-myelination, axon ingrowth and functional outcome, when compared to animals without a cell seeded conduit. The presented model thus displays several intriguing features： it imitates a certain mismatch in size, distribution and orientation of axons within the nerve coaptation site. The fibrin conduit itself allows for an easy application of cells and, as a true critical-size defect model, any observed improvement relates directly to the performed intervention. Since fibrin and adipose-derived stem cells have been approved for human applications, the technique can theoretically be performed on humans. Thus, we suggest that the model is a powerful tool to investigate cell mediated assistance of peripheral nerve regeneration.

关键词： critical-size nerve defect fibrin conduit autologous nerve transplant peripheral nerve regeneration adipose-derived stem/progenitor cells sciatic function index sciatic nerve re-innervation axon guidance peripheral circuitry

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Hypoxic pre-conditioned adipose-derived stem/progenitor cells embedded in fibrin conduits promote peripheral nerve regeneration in a sciatic nerve graft model

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Neural Regeneration Research 2023年第3期18卷 652-656页

作者： julius m.mayer Christian Krug maximilian m.Saller Annette Feuchtinger Riccardo E.Giunta Elias Volkmer Thomas Holzbach Department of Hand-and Plastic Surgery Spital ThurgauFrauenfeldSwitzerland musculoskeletal University Center munich(mUm) Department of Orthopedics and Trauma SurgeryLudwig-Maximilians-University(LMU)Planegg-MartinsriedGermany Research Unit Analytical Pathology MunichHelmholtz Zentrum München-German Research Center for Environmental Health(GmbH)NeuherbergGermany Division of Hand- Plastic-and Aesthetic SurgeryLudwig-Maximilians-University(LMU)MunichGermany Division of Hand Surgery Helios Klinikum München WestMunichGermany

Recent results emphasize the supportive effects of adipose-derived multipotent stem/progenitor cells(ADSPCs)in peripheral nerve *** under hypoxia is considered to enhance the release of the regenerative potential of *** study aimed to examine whether peripheral nerve regeneration in a rat model of autologous sciatic nerve graft benefits from an additional custom-made fibrin conduit seeded with hypoxic pre-conditioned(2%oxygen for 72 hours)autologous ADSPCs(n=9).This treatment mode was compared with three others:fibrin conduit seeded with ADSPCs cultivated under normoxic conditions(n=9);non-cell-carrying conduit(n=9);and nerve autograft only(n=9).A 16-week follow-up included functional testing(sciatic functional index and static sciatic index)as well as postmortem muscle mass analyses and morphometric nerve evaluations(histology,g-ratio,axon density,and diameter).At 8 weeks,the hypoxic pre-conditioned group achieved significantly higher sciatic functional index/static sciatic index scores than the other three groups,indicating faster functional ***,histologic evaluation showed significantly increased axon outgrowth/branching,axon density,remyelination,and a reduced relative connective tissue *** pre-conditioned ADSPCs seeded in fibrin conduits are a promising adjunct to current nerve *** studies are needed to understand the underlying cellular mechanism and to investigate a potential application in clinical practice.

关键词： adipose-derived progenitor cells adipose-derived multipotent stem/progenitor cell autologous nerve graft fibrin conduit hypoxia hypoxic pre-conditioning nerve defect nerve tissue engineering peripheral nerve regeneration regenerative medicine

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Anorectal hemangioma, a rare cause of lower gastrointestinal bleeding, treated with selective embolization: A case report

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2735-2741页

作者： Barbora Pospisilova Jaromir Frydrych Antonin Krajina juliusÖrhalmi Ivana m Kajzrlikova Petr Vitek Department of Internal medicine Hospital in Frydek-MistekFrydek-Mistek 73801Czech Republic Department of Radiodiagnostic Hospital in Jablonec nad NisouJablonec nad Nisou 46601Czech Republic Department of Radiology University Hospital Hradec KraloveHradec Kralove 50005Czech Republic Department of Surgery Hospital HoroviceHorovice 26831Czech Republic Faculty of medicine University of OstravaOstrava 70300Czech Republic

BACKGROUND Anorectal hemangioma is a rare and frequently misdiagnosed cause of lower gastrointestinal(GI)***,we present a minimally invasive therapy with selective *** SUmmARY A 21-year-old male patient experienced painless rectal bleeding since childhood and was treated for ulcerative *** studies later revealed specific characteristics for vascular lesions-anorectal *** severity of rectal bleeding caused symptomatic anemia and possible surgical treatment was asso-ciated with a high risk of fecal ***,we present selective emboli-zation,a minimally invasive therapeutic approach that is proven as an alternative therapeutic method of *** patient significantly improved temporarily and had a small ischemic ulcer,which healed with a control colonoscopy and deve-loped no *** Awareness of the clinical and radiological features of GI hemangiomas may help improve diagnostics and avoid inappropriate therapeutic procedures.

关键词： Hemangioma Vascular malformation Gastrointestinal hemorrhage Rectal bleeding Phlebolith Selective embolization Case report

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A cross-sectional analysis of the effectiveness of a nutritional support programme for people with tuberculosis in Southern madagascar using secondary data from a non-governmental organisation

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Infectious Diseases of Poverty 2024年第1期13卷 101-102页

作者： mara Anna Franke julius Valentin Emmrich Fierenantsoa Ranjaharinony Onja GbrilleRavololohanitra Harizaka Emmanuel Andriamasy Samuel Knauss Nadine muller Global Digital Health Lab at Charité Center for Global Health Charité – Universitätsmedizin Berlin Berlin Germany London School of Hygiene and Tropical medicine London UK Ärzte Für madagaskar E.V. Leipzig Germany Heidelberg Institute of Global Health Heidelberg University Heidelberg Germany Berlin Institute of Health at Charité - Universitätsmedizin Berlin Berlin Germany Doctors for madagascar Antananarivo Madagascar Speciality Network: Infectious Diseases and Respiratory medicine Charité - Universitätsmedizin Berlin Berlin Germany

Background There is a strong,bi-directional link between tuberculosis(TB)and undernutrition:TB often causes undernutrition,and undernourished people are more likely to contract TB and experience worse ***,several TB nutritional support programmes exist;however,evidence on their effectiveness is limited and *** study evaluates the effect of a nutritional support programme implemented for people with TB in the Atsimo-Andrefana region,madagascar in *** this programme,undernourished people with TB[with a body mass index(BmI)ofm]receive 0.6 L of vegetable oil and 6.0 kg of a soy-wheat blend per month throughout their TB *** We analysed secondary non-governmental organisation data collected between January and Novem-ber 2022 in the Atsimo-Andrefana region,Southern madagascar,including information on an individual's medical conditions(e.g.,type of TB,treatment outcomes)and nutritional status measured prior to,during,and after comple-tion of treatment(e.g.,height,weight,mid-upper arm circumference).We conducted descriptive analyses of patient baseline characteristics and outcomes to assess the impact of the provided nutritional support on the BmI of people With *** A total of 1310 people with TB were included in the study[9.9%(130)children under the age of 5,32.1%(420)children between 5 and 18 years,58.0%(760)adults].55.4% of children under 5,28.1% of children between ages 5 and 18,and 81.3%of adults were undernourished at treatment initiation.42.3%(55/130)of children under 5 experi-enced severe acute malnutrition at treatment *** the average Bml of adults with TB receiving food support increased over time,from 17.1 kg/m^(2)(interquartile range:15.8-18.3,range:10.3-22.5)to 17.9 kg/m^(2)(interquartile range:16.6-19.1,range:11.9-24.1),most adults remained undernourished even after completing TB *** The current TB nutritional support programme falls short of sufficiently increasing the Bm

关键词： Tuberculosis Sub-Saharan Africa Undernutrition Nutritional support

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Highly efficient and stable organic solar cells with SnO_(2)electron transport layer enabled by UV-curing acrylate oligomers

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Journal of Energy Chemistry 2024年第5期92卷 124-131页

作者： mwende mbilo Du Hyeon Ryu Seungjin Lee muhammad Haris julius mwakondo mwabora Robinson Juma musembi Hang Ken Lee Sang Kyu Lee Chang Eun Song Won Suk Shin Department of Physics Faculty of Science and TechnologyUniversity of Nairobi(UoN)P.O.Box 30197-00100NairobiKenya Advanced Energy materials Research Center Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Republic of Korea Advanced materials and Chemical Engineering University of Science and Technology(UST)Daejeon 34113Republic of Korea

The interfaces between the inorganic metal oxide and organic photoactive layer are of outmost importance for efficiency and stability in organic solar cells(OSCs).Tin oxide(SnO_(2))is one of the promising candidates for the electron transport layer(ETL)in high-performance inverted *** a solution-processed SnO_(2)ETL is employed,however,the presence of interfacial defects and suboptimal interfacial contact can lower the power conversion efficiency(PCE)and operational stability of ***,highly efficient and stable inverted OSCs by modification of the SnO_(2)surface with ultraviolet(UV)-curable acrylate oligomers(SAR and OCS)are *** highest PCEs of 16.6%and 17.0%are achieved in Pm6:Y6-BO OSCs with the SAR and OCS,respectively,outperforming a device with a bare SnO_(2)ETL(PCE 13.8%).The remarkable enhancement of PCEs is attributed to the optimized interfacial contact,leading to mitigated surface *** strikingly,improved light-soaking and thermal stability strongly correlated with the interfacial defects are demonstrated for OSCs based on SnO_(2)/UV cross-linked resins compared to OSCs utilizing bare SnO_(2).We believe that UV cross-linking oligomers will play a key role as interfacial modifiers in the future fabrication of large-area and flexible OSCs with high efficiency and stability.

关键词： Organic solar cells SnO_(2) Surface defects Ultraviolet resins Stability Cross-linking oligomers Non-halogenated solvent

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Growth, Development and Yield of Kenaf as Affected by Planting Dates and N Fertilization

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Open Journal of Applied Sciences 2024年第3期14卷 707-720页

作者： julius Yirzagla Peter Quandahor Iddrisu Yahaya Olivia Aguriboba Akanbelum Listowell Aditwin Akologo John Bokaligidi Lambon Abdul-Wahab m. Imoro Kwadwo Gyasi Santo CSIR-SARI Nyankpala Ghana St Vincent College of Education Yendi Ghana Gbewaah College of Education Pusiga-Bawku Ghana CSIR-Head Office Accra Ghana C.K. Tedam University of Technology and Applied Sciences Navrongo Ghana University of Energy and Natural Resources Sunyani Ghana

Kenaf (Hibiscus cannabinus L) consists of various beneficial components like stalks, seeds, leaves, fibers, oils, proteins, allelopathic chemicals, and fiber strands, among other things. Despite the numerous uses of the crop, there is little or no information on optimum agronomic practices such as planting date and N fertilization of the crop in the Upper East Region (UER) of Ghana where the crop is widely cultivated by smallholder farmers. Field experiments were therefore carried out in 2020 and repeated during the 2021 cropping season in the study area. The objective of the study was to determine appropriate planting date and N fertilization for increased kenaf productivity. In each year, the treatments consisted of 3 × 5 factorial combinations of three planting dates (1st July, 7th July and 14th July) and five levels of N (0, 20, 40, 60 and 80 kg/ha) replicated three times. The design of the experiment was a split-plot with the N fertilizer as the main plot and the planting date assigned to sub plot. The results showed that, planting kenaf in early (1st) July or N fertilization at the rate of 60 kg/ha increased plant density, stem height, stem diameter, dry bast and core yields in both cropping seasons.

关键词： Growth Fibres Bast Yield Core Yield

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Prevalence of Work-Aggravated Asthma among Bakery Workers in Abidjan (Cote d’Ivoire)

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Health 2024年第3期16卷 204-217页

作者： Loukou Leandre Konan Esme marie Laure Essis Brou michel Kouassi marius Kedote julius Fobil William Yavo Ossey Bernard Yapo Issaka Tiembre National Institute of Public Health Abidjan Cote d’Ivoire Interuniversity Doctoral Program Cotonou Benin medical Sciences Training and Research Unit Department of Public Health and Biostatistics Felix Houphouet Boigny University Abidjan C&#244te d’Ivoire Global Environmental Occupational Health (GEOHealth) Accra Ghana UFR of Pharmaceutical and Biological Sciences Department of Public Health Felix Houphou&#235t Boigny University Abidjan Cote d’Ivoire Nangui Abrogoua University Abidjan C&#244te d’Ivoire National Institute of Public Hygiene Abidjan C&#244te d’Ivoire

Introduction: Work-aggravated asthma is pre-existing or concomitant asthma whose symptoms are aggravated by the work environment. The aim of this study was to determine the prevalence of this pathology and its associated factors among bakery workers in Abidjan. materials and methods: This descriptive and analytical cross-sectional study was conducted over a period of four (4) months from 18 December 2019 to 18 April 2020. Two questionnaires were used, one on employees and the other on the indoor environment of bakeries. In addition, a spirometry test was performed on all bakery workers. Statistical analysis was performed using stata 15.1 software. Results: A total of 599 bakery employees, including bakers (59.73%), sales assistants/ cashiers (23.52%), cleaners (6.34%) and administrative staff (10.18%), were investigated. The mean age was 30.8 ± 8 years, with a sex ratio (m/F) = 2.2. Asthma symptoms were found in 95 (15.86%) employees, of whom 74 (77.9%) had work-related asthma and 11 (14.9%) had asthma aggravated by work. The factors associated with work-aggravated asthma were personal or family history of allergy or atopy [ORa = 3.75;CI95%: 1.56 - 8.93;p = 0.003], exposure to dust [ORa = 5.01;CI95%: 1.43 - 7.50;p = 0.011] and humidity level (60% - 70%) [ORa = 1.80;CI 95%: 0.99 - 3.28;p = 0.05]. Conclusion: Work-aggravated asthma is a reality in bakeries in Abidjan, with an estimated prevalence of 14.9%. Two of the three factors associated with this condition suggest a link with indoor air pollution. Combating air pollution in these establishments must therefore be a priority for the relevant authorities, in order to provide employees with a working environment that protects their health.

关键词： Work-Aggravated Asthma Occupational Asthma Work-Related Asthma Bakeries Abidjan Ivory Coast

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On the nonclassical dynamics of cavity-assisted four-channel nonlinear coupler

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Chinese Physics B 2018年第11期27卷 498-505页

作者： Rafael julius Abdel-Baset m A Ibrahim Pankaj Kumar Choudhury Hichem Eleuch Faculty of Applied Sciences Universiti Teknologi MARA (UiTM) Faculty of Applied Sciences Universiti Teknologi Mara (UiTM) Perak Tapah Campus Institute of microengineering and Nanoelectronics Universiti Kebangsaan Malaysia Department of Applied Sciences and mathematics College of Arts and Sciences Abu Dhabi University Institute for Quantum Science and Engineering Texas A&M University College Station

The non-classical properties of light propagating in four-channel Kerr waveguides, confined in an optical cavity, are studied. The solution to the Hamiltonian of field operators is obtained semi-analytically by using symmetrically ordered phase-space representation. Full quantum analysis of the input coherent fields displays a strong transition of photon property between the super-Poissonian and sub-Poissonian statistics. It is found that the cavity-assisted multichannel system exhibits enhanced squeezing both in single-and compound-mode. This multichannel system may be utilized as an efficient quantumlight generator.

关键词： squeezed states Kerr effects Langevin equation

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Collaborative Efforts and Strategies for Cholera Outbreak Control in Garissa County, Kenya: Implementation of Water Quality monitoring Interventions

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Journal of Water Resource and Protection 2024年第2期16卷 123-139页

作者： michael Habtu mark Nanyingi Ali A. Hassan Abdiwahid m. Noor Joel mutyandia muli Alan mwika julius Wekesa Ahmed Fidhow Diba Dulacha Landry Kabego Ishata Nannie Conteh Andre Arsene Bita Fouda Sonia Chene Aden H. Ibrahim Ahmed Nadhir Omar martins C. Livinus Abdourahmane Diallo World Health Organization Nairobi Kenya Department of Health Garissa County Government Garissa Kenya Water Resources Authority Garissa Kenya World Health Organization Regional Office for Africa Brazzaville Congo Regional Agency for Health Dijon France

A multi-faceted Case Area Targeted Intervention (CATI) approach emphasizing the integration of Water, Sanitation and Hygiene (WASH) interventions and Oral Cholera Vaccine (OCV) campaign was employed to respond to the outbreak of cholera in Garissa County. Drinking water sources in areas heavily impacted by cholera were systematically mapped and tested for microbiological quality. The quality assessment was carried out in April 2023 during an ongoing cholera outbreak in the county. A total of 109 samples were collected and tested for thermotolerant coliforms and other in situ parameters. The finding revealed that more than 87% of the samples did not meet the World Health Organization (WHO) standard for thermotolerant coliforms;and 30% had turbidity values above the recommended threshold values. None of the 109 samples had any traceable residual chlorine. Following these findings, the county government implemented the targeted interventions which resulted in a positive impact in the fight against cholera. The WHO supported key interventions which included capacity building in water quality monitoring and prepositioning of critical WASH commodities to the cholera affected areas.

关键词： Cholera Drinking Water Household Water Treatment Kenya

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Climate Change and Pastoral Economy in Kenya:A Blinking Future

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Acta Geologica Sinica(English Edition) 2009年第5期83卷 1017-1023页

作者： julius m.HUHO Josephine K.W.NGAIRA Harun O.OGINDO Geography Department Maseno UniversityMaseno 40105Kenya Department of Botany and Horticulture Maseno UniversityMaseno40105Kenya

The present paper examines the changing climatic scenarios and associated effects on livestock farming （pastoralism） in the arid and semi arid lands （ASAL） of Kenya, which cover over 80 % of the country. The study was carried out in the semi arid mukogodo Division of Laikipia District in Kenya. This division received a mean annual rainfall of approximately 507.8 nun and the main source of livelihood was pastoralism. Questionnaire, structured interview, observation and literature review were the main methods of data collection. Rainfall was used in delineating changes in climate. Standardized precipitation index （SPI） and markov process were used in analyzing drought severity and persistence, respectively. Approximately 38% of all droughts between 1975 and 2005 were prolonged and extremely severe, with cumulative severity indices ranging between -2.54 and -6.49. The probability that normal climatic conditions persisted for two or more consecutive years in mukogodo Division remained constant at approximately 52%. However, the probability of wet years persisting for two or more years showed a declining trend, while persistence of dry years increased with duration. A drying climatic trend was established. This drying trend in the area led to increased land degradation and encroachment of invasive nonpalatable bushes. The net effect on pastoralism was large-scale livestock loss through starvation, disease and cattle rustling. Proper drought monitoring and accurate forecasts, community participation in all government interventions, infrastructural development in the ASAL and allocation of adequate resources for livestock development are some of the measures necessary for mitigating the dwindling pastoral economy in Kenya and other parts of the world.

关键词： arid and semi arid lands pastoralism climate change drought Kenya

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