检索结果-南通市图书馆

Simultaneous occurrence of autoimmune pancreatitis and pancreatic cancer in patients resected for focal pancreatic mass

引用

World Journal of Gastroenterology 2017年第12期23卷 2185-2193页

作者： Peter Macinga Adela Pulkertova Lukas Bajer Jana Maluskova martin Oliverius martin Smejkal Maria Heczkova julius spicak Tomas Hucl Department of Gastroenterology and Hepatology Institute for Clinical and Experimental Medicine Department of Pathology Institute for Clinical and Experimental Medicine Department of Transplant Surgery Institute for Clinical and Experimental Medicine Department of Radiodiagnostics and Interventional Radiology Institute for Clinical and Experimental Medicine Center for Experimental Medicine Institute for Clinical and Experimental Medicine

AIM To assess the occurrence of autoimmune pancreatitis(AIP) in pancreatic resections performed for focal pancreatic *** We performed a retrospective analysis of medical records of all patients who underwent pancreatic resection for a focal pancreatic enlargement at our tertiary center from January 2000 to July 2013. The indication for surgery was suspicion of a tumor based on clinical presentation, imaging findings and laboratory evaluations. The diagnosis of AIP was based on histology findings. An experienced pathologist specialized in pancreatic disease reviewed all the cases and confirmed the diagnosis in pancreatic resection specimens suggestive of AIP. The histological diagnosis of AIP was set according to the international consensus diagnostic *** Two hundred ninety-five pancreatic resections were performed in 201 men and 94 women. AIP was diagnosed in 15 patients(5.1%, 12 men and 3 women) based on histology of the resected specimen. Six of them had AIP type 1, nine were diagnosed with AIP type 2. Pancreatic adenocarcinoma(PC) was also present in six patients with AIP(40%), all six were men. Patients with AIP + PC were significantly older(60.5 vs 49 years of age, P = 0.045), more likely to have been recently diagnosed with diabetes(67% vs 11%, P = 0.09), and had experienced greater weight loss(15.5 kg vs 8.5 kg, P = 0.03) than AIP patients without PC. AIP was not diagnosed in any patients prior to surgery; however, the diagnostic algorithm was not fully completed in every case. CONCLUSION The possible co-occurrence of PC and AIP suggests that preoperative diagnosis of AIP does not rule out simultaneous presence of PC.

关键词： Chronic pancreatitis Pancreatic cancer Ig G4related disease Autoimmune pancreatitis Malignancy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis

引用

World Journal of Gastroenterology 2017年第25期23卷 4548-4558页

作者： Lukas Bajer Miloslav Kverka martin Kostovcik Peter Macinga Jiri Dvorak Zuzana Stehlikova Jan Brezina Pavel Wohl julius spicak Pavel Drastich Department of Gastroenterology and Hepatology Institute for Clinical and Experimental Medicine Institute of Microbiology the Czech Academy of Sciences Institute of Experimental Medicine the Czech Academy of Sciences Department of Genetics and Microbiology Faculty of ScienceCharles University BIOCEV Institute of Microbiologythe Czech Academy of Sciences

To characterize the gut bacterial microbiota of patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). METHODSStool samples were collected and relevant clinical data obtained from 106 study participants, 43 PSC patients with (n = 32) or without (n = 11) concomitant inflammatory bowel disease, 32 UC patients, and 31 healthy controls. The V3 and V4 regions of the 16S ribosomal RNA gene were sequenced on Illumina MiSeq platform to cover low taxonomic levels. Data were further processed in QIIME employing MaAsLin and LEfSe tools for analysis of the output data. RESULTSMicrobial profiles in both PSC and UC were characterized by low bacterial diversity and significant change in global microbial composition. Rothia, Enterococcus, Streptococcus, Veillonella, and three other genera were markedly overrepresented in PSC regardless of concomitant inflammatory bowel disease (IBD). Rothia, Veillonella and Streptococcus were tracked to the species level to identify Rothia mucilaginosa, Streptococcus infantus, S. alactolyticus, and S. equi along with Veillonella parvula and V. dispar. PSC was further characterized by decreased abundance of Adlercreutzia equolifaciens and Prevotella copri. Decrease in genus Phascolarctobacterium was linked to presence of colonic inflammation regardless of IBD phenotype. Akkermansia muciniphila, Butyricicoccus pullicaecorum and Clostridium colinum were decreased in UC along with genus Roseburia. Low levels of serum albumin were significantly correlated with enrichment of order Actinomycetales. CONCLUSIONPSC is associated with specific gut microbes independently of concomitant IBD and several bacterial taxa clearly distinguish IBD phenotypes (PSC-IBD and UC).

关键词： Dysbiosis Inflammatory bowel disease Ulcerative colitis Gut microbiota Primary sclerosing cholangitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Epithelial markers of colorectal carcinogenesis in ulcerative colitis and primary sclerosing cholangitis

引用

World Journal of Gastroenterology 2013年第14期19卷 2234-2241页

作者： Pavel Wohl Tomas Hucl Pavel Drastich David Kamenar julius spicak Eva Honsova Eva Sticova Alena Lodererova Jan Matous martin Hill Petr Wohl Milos Kucera Department of Hepatogastroenterology Institute for Clinical and Experimental MedicineVidenska 195814021 Prague 4Czech Republic Department of Pathology Institute for Clinical and Experimental Medicine(IKEM)Videnska 195814021 Prague 4Czech Republic 2~(nd) Department of Internal Medicine Third Faculty of MedicineCharles University11640 Prague 1Czech Republic Department of Biostatistics Institute of EndocrinologyCharles University11640 Prague 1Czech Republic Institute for Clinical and Experimental Medicine(IKEM) Videnska 195814021 Prague 4Czech Republic

AIM:To evaluate the expression of epithelial markers of colorectal carcinogenesis in patients with long-term ulcerative colitis(UC) and primary sclerosing cholangitis(PSC) before and after ***:Eight patients with UC and PSC prior to liver transplantation(PSC-UC),22 patients with UC after liver transplantation for PSC(OLT),9 patients with active ulcerative colitis without PSC(UCA),7 patients withUC in remission(UCR) and 10 controls(N) underwent colonoscopy with multiple *** were analysed histologically and semi-quantitatively immunohistochemically for p53,Bcl-2 and cyclooxygenase-2(COX-2) *** analysis was performed by Kruskal-Wallis and Fisher's exact ***:PSC-UC had a statistically significantly higher expression of p53 in the nondysplastic mucosa as compared to OLT,UCA,UCR and N(P < 0.05).We also found a statistically significant positive correlation between the incidence of PSC and the expression of p53(P < 0.001).UCA had a higher p53 expression as compared to *** had a significantly lower expression of p53 as compared with PSC-UC(P < 0.001).Bcl-2 had a significant higher bcl-2 expression as compared with *** difference in COX-2 expression between PSC-UC,UCR and UCA was *** had higher COX-2 expression as compared to *** also found a statistically significant positive correlation between the expression of COX-2 and *** after liver transplantation for PSC had a statistically significantly lower expression of the p53 compared with PSCUC(P < 0.001).PSC-UC had the same inflammatory endoscopic activity as OLT and UCR when evaluated with the Mayo ***:Our study shows that the nondysplatic mucosa of UC patients with PSC is characterised by a higher expression of the tumour suppressor gene p53,suggesting a higher susceptibility of *** p53 overexpression correlates with the presence of PSC whilst it is not present in patients with UC after liver transplantation for

关键词： Imunohistochemistry Ulcerative colitis Primary sclerosing cholangitis Colorectal carcinoma Liver transplantation p53 bcl2 Cyclooxygenase-2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Patient and physician perception of natural orifice transluminal endoscopic appendectomy

引用

World Journal of Gastroenterology 2012年第15期18卷 1800-1805页

作者： Tomas Hucl Adela Saglova Marek Benes Matej Kocik martin Oliverius Zdenek Valenta julius spicak Department of Gastroenterology and Hepatology Institute for Clinical and Experimental Medicine14021 PragueCzech Republic Department of Transplantation Surgery Institute for Clinical and Experimental Medicine14021 PragueCzech Republic Department of Medical Informatics Institute of Computer Science AS CR18207 PragueCzech Republic

AIM:To investigate perception of natural orifice transluminal endoscopic surgery(NOTES)as a potential technique for ***:One hundred patients undergoing endoscopy and 100 physicians were given a questionnaire describing in detail the techniques of NOTES and laparoscopic *** were asked about the reasons for their preference,choice of orifice,and extent of complication risk they were willing to ***:Fifty patients(50%)and only 21 physicians(21%)preferred NOTES(P<0.001).Patients had previously heard of NOTES less frequently(7%vs73%,P<0.001)and had undergone endoscopy more frequently(88%vs 36%,P<0.001)than *** of hernia was the most common reason for NOTES preference in physicians(80%vs 44%,P= 0.003),whereas reduced pain was the most common reason in patients(66%vs 52%).Physicians were more likely to refuse NOTES as a novel and unsure technique(P<0.001)and having an increased risk of infection(P<0.001).The preferred access site in both groups was colon followed by stomach,with vagina being rarely *** multivariable modeling,those with high-school education[odds ratio(OR):2.68,95% confidence interval(CI):1.23-5.83]and prior colonoscopy(OR:2.10,95%CI:1.05-4.19)were more likely to prefer NOTES over laparoscopic *** was a steep decline in NOTES preference with increased rate of procedural *** patients were more likely to consent to their wives vaginal NOTES appendectomy than male physicians(P=0.02).CONCLUSION:The preference of NOTES for appendectomy was greater in patients than physicians and was related to reduced pain and absence of hernia rather than lack of scarring.

关键词： Natural orifice transluminal endoscopic surgery Patient perception Physician perception Appendectomy Laparoscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Limited validity of Mayo endoscopic subscore in ulcerative colitis with concomitant primary sclerosing cholangitis

引用

World Journal of Gastrointestinal Endoscopy 2024年第11期16卷 607-616页

作者： Pavel Wohl Alzbeta Krausova Petr Wohl Ondrej Fabian Lukas Bajer Jan Brezina Pavel Drastich Mojmir Hlavaty Petra Novotna Michal Kahle julius spicak.martin gregor Department of Gastroenterology Institute for Clinical and Experimental MedicinePrague 14021Czech Republic Department of Integrative Biology Institute of Molecular Genetics of the Czech Academy of SciencesPrague 14220Czech Republic Department of Metabolism and Diabetes Institute for Clinical and Experimental MedicinePrague 14021Czech Republic Clinical and Transplant Pathology Centre Institute for Clinical and Experimental MedicinePrague 14021Czech Republic Department of Data Analysis Statistics and Artificial IntelligenceInstitute for Clinical and Experimental MedicinePrague 14021Czech Republic

BACKGROUND Ulcerative colitis(UC)with concomitant primary sclerosing cholangitis(PSC)represents a distinct disease entity(PSC-UC).Mayo endoscopic subscore(MES)is a standard tool for assessing disease activity in UC but its relevance in PSC-UC remains *** To assess the accuracy of MES in UC and PSC-UC patients,we performed histological scoring using Nancy histological index(NHI).METHODS MES was assessed in 30 PSC-UC and 29 UC adult patients during *** and inflammation were evaluated in biopsies from the cecum,rectum,and terminal *** addition,perinuclear anti-neutrophil cytoplasmic antibodies,fecal calprotectin,body mass index,and other relevant clinical characteristics were *** The median MES and NHI were similar for UC patients(MES grade 2 and NHI grade 2 in the rectum)but were different for PSC-UC patients(MES grade 0 and NHI grade 2 in the cecum).There was a correlation between MES and NHI for UC patients(Spearman's r=0.40,P=0.029)but not for PSC-UC *** examination revealed persistent microscopic inflammation in 88%of PSC-UC patients with MES grade 0(46%of all PSC-UC patients).Moreover,MES overestimated the severity of active inflammation in an additional 11%of PSCUC *** MES insufficiently identifies microscopic inflammation in *** indicates that histological evaluation should become a routine procedure of the diagnostic and grading system in both PSC-UC and PSC.

关键词： Primary sclerosing cholangitis Ulcerative colitis Diagnosis Nancy histological index Mayo endoscopic subscore

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Post-testing measurement of freely movable and diffusible hydrogen in context of WEC formation at cylindrical roller thrust bearings from 100Cr6

引用

Friction 2021年第4期9卷 876-890页

作者： martin LINZMAYER Francisco GUTIÉRREZ GUZMÁN gregor MANKE Georg JACOBS Christopher SOUS Michael POHL Institute for Machine Elements and System Engineering RWTH Aachen UniversitySchinkelstrasse 10Aachen 52062Germany Institute for Materials Material TestingRuhr University BochumUniversitatsstr 150Bochum 44801Germany

Sub-surface crack networks in areas of altered microstructure are a common cause for bearing *** to its appearance under light microscopy,the damage pattern is referred to as White Etching Cracks(WEC).The root causes leading to the formation of WEC are still under ***,it has already been shown that atomic hydrogen can have an accelerating effect on the formation and propagation of *** addition to hydrogen pre-charging,hydrogen can be released and absorbed during rolling/sliding due to the decomposing of the lubricant and *** current work focuses on the analysis of the hydrogen content of cylindrical roller thrust bearings after testing in a FE8 type test rig using two different *** the framework of this work,two different hydrogen analysis methods were used and assessed regarding their *** results show that the so-called Hydrogen Collecting Analysis(HCA)is more suitable to investigate the correlation between lubricant chemistry and hydrogen content in the test bearings than the Local Hydrogen Analysis(LHA).The measurements with the HCA show a continuously increasing freely movable and diffusible hydrogen content under tribological conditions,which leads to the formation of *** tests with an oil without hydrogen showed that the tendency of the system to fail as a result of WEC can be reduced by using a lubricant without hydride compounds.

关键词： White Etching Crack(WEC) White Etching Areas(WEA) hydrogen content Hydrogen Collecting Analysis(HCA) freely movable hydrogen diffusible hydrogen cylindrical roller thrust bearing roller bearings roller contact fatigue

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simplified modeling of electromagnets for dynamic simulation of transient effects for a synchronous electric motor

引用

International Journal of Mechanical System Dynamics 2021年第1期1卷 89-95页

作者： Florian Bechler julius Kesten Florian Wittemann Frank Henning martin Doppelbauer Peter Eberhard Institute of Engineering and Computational Mechanics University of StuttgartStuttgartGermany Institute of Electrical Engineering Karlsruhe Institute of Technology(KIT)KarlsruheGermany Institute of Vehicle System Technology Karlsruhe Institute of Technology(KIT)KarlsruheGermany

This study aims to show an approach for the dynamic simulation of a synchro-nous *** magnetic forces in the air gap are calculated efficiently using simplified approaches without neglecting important *** the modeling of the magnetic forces,an equivalent magnetic circuit is constructed in which the magnetic saturation and the leakage flux are taken into account and coupled with the electrical circuit at the *** calculated magnetic forces are then passed to a mechanical model of the *** with a predefinable load torque,the resulting motor rotation and the forces in the bearings are *** presented model is then investigated in a small *** novel ap-proach is intended to provide a method of calculating dynamically the forces transmitted from the shaft to the motor housing and to create the basis for evaluating electric motors for vibrations,noise,and harshness under varying loads and input voltages.

关键词： dynamic simulation electromagnet electromagnet modeling magnetomotive forces

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Irritable bowel syndrome and organic diseases: A comparative analysis of esophageal motility

引用

World Journal of Gastroenterology 2013年第38期19卷 6408-6415页

作者： Thomas Thomaidis martin Goetz Sebastian Paul gregor Arthur Hoffman Elias Kouroumalis Markus Moehler Peter Robert Galle Andreas Schwarting Ralf Kiesslich Medical Clinic Johannes-Gutenberg University55131 MainzRheinland-PfalzGermany Medical Clinic University of Tuebingen72076 TuebingenBaden-WürttembergGermany Medical Clinic SHG-Hospital55743 Idar-ObersteinRheinland-PfalzGermany Medical Clinic 60318 Frankfurt am MainHessenGermany Clinic of Gastroenterology Medical School of Crete71110 HeraklionCreteGreece Sana Rheumatology Centre 55543 Bad KreuznachRheinland-PfalzGermany

AIM:To assess the esophageal motility in patients with irritable bowel syndrome(IBS)and to compare those with patients with autoimmune ***:15 patients with IBS,22 with systemic lupus erythematosus(SLE)and 19 with systemic sclerosis(SSc)were prospectively selected from a total of 115patients at a single university centre and esophageal motility was analysed using standard manometry(Mui Scientific PIP-4-8SS).All patients underwent esophagogastro-duodenoscopy before entering the study so that only patients with normal endoscopic findings were included in the current *** patients underwent a complete physical,blood biochemistry and urinary *** grade of dysphagia was determined for each patient in accordance to the intensity and frequency of the presented esophageal ***,disease activity scores(SLEDAI and modified Rodnan score)were obtained for patients with autoimmune *** parameter:A correlation coefficient was calculated between amplitudes,velocity and duration of the peristaltic waves throughout esophagus and patients’dysphagia for all three ***:There was no statistical difference in the standard blood biochemistry and urinary analysis in all three *** with IBS showed similar pathologic dysphagia scores compared to patients with SLE and *** mean value of dysphagia score was in IBS group 7.3,in SLE group 6.73 and in SSc group7.56 with a P-value>***,the manometric patterns were *** patients showed during esophageal manometry peristaltic amplitudes at the proximal part of esophagus greater than 60 mmHg in46%of the patients,which was significant higher in comparison to the SLE(11.8%)and SSc-Group(0%,P=0.003).Furthermore,IBS patients showed lower mean resting pressure of the distal esophagus sphincter(Lower esophageal sphincter,22 mmHg)when compared with SLE(28 mmHg,P=0.037)and SSc(26 mmHg,P=0.052).23.5%of patients with SLE showed amplitudes greater as 160 mmHg in the

关键词： Irritable bowel syndrome Systemic lupus erythematosus Systemic sclerosis Esophageal manometry Dysphagia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A survey on deep learning in medical image reconstruction

引用

Intelligent Medicine 2021年第3期1卷 118-127页

作者： Emmanuel Ahishakiye martin Bastiaan Van Gijzen julius Tumwiine Ruth Wario Johnes Obungoloch Department of Computer Science Kyambogo UniversityP.O Box 1KyambogoKampalaUganda Delft University of Technology Delft Institute of Applied MathematicsMekelweg 42628 CDthe Netherlands Department of Mathematics Mbarara University of Science and TechnologyMbarara 1410Uganda Department of Informatics University of Free StateSouth Africa Department of Biomedical Sciences and Engineering Mbarara University of Science and TechnologyMbarara 1410Uganda

Medical image reconstruction aims to acquire high-quality medical images for clinical usage at minimal cost and risk to the *** learning and its applications in medical imaging,especially in image reconstruction have received considerable attention in the literature in recent *** study reviews records obtained elec-tronically through the leading scientific databases(Magnetic Resonance Imaging journal,Google Scholar,Scopus,Science Direct,Elsevier,and from other journal publications)searched using three sets of keywords:(1)Deep learning,image reconstruction,medical imaging;(2)Medical imaging,Deep learning,Image reconstruction;(3)Open science,Open imaging data,Open *** articles reviewed revealed that deep learning-based re-construction methods improve the quality of reconstructed images qualitatively and ***,deep learning techniques are generally computationally expensive,require large amounts of training datasets,lack decent theory to explain why the algorithms work,and have issues of generalization and *** challenge of lack of enough training datasets is currently being addressed by using transfer learning techniques.

关键词： Deep learning Open science Image reconstruction Medical imaging Machine Learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ga_(2)O_(3)/γ-Al_(2)O_(3)表面丙烷选择性还原NO的反应机理研究

引用

石油化工 2004年第Z1期33卷 768-770页

作者：何川华 martin Paulus julius A Nickl Josef Find 储伟 Department of Chemistry TU MünchenLichtenbergstr.4D-85747 GarchingGermany Gesellschaft für Werkstoffprüfung mbH Georg-Wimmer-Ring 25D-85604 ZornedingGermany 四川大学化学工程学院

对不同催化剂的制备方法及催化剂中镓含量对催化剂活性的影响进行了研究,对Ga2O3/γ-Al2O3催化剂中的活性中心进行了讨论;用原位红外技术、暂态反应技术、程序升温脱附和程序升温表面反应等方法对Ga2O3/γ-Al2O3表面丙烷选择性还原NO的... 详细信息

对不同催化剂的制备方法及催化剂中镓含量对催化剂活性的影响进行了研究,对Ga2O3/γ-Al2O3催化剂中的活性中心进行了讨论;用原位红外技术、暂态反应技术、程序升温脱附和程序升温表面反应等方法对Ga2O3/γ-Al2O3表面丙烷选择性还原NO的反应机理进行了研究.对催化剂表面各吸附物种的形成和反应性能、NO对丙烷氧化的影响进行了详细的研究,实验结果与化学计量学计算结果相结合可以推测出哪些吸附物种涉及NO的选择性还原,哪些吸附物种没有参与NO的还原反应,从而推断出在Ga2O3/γ-Al2O3催化剂表面丙烷选择性还原NO的反应机理.

关键词：选择催化还原(SCR) NOx消除反应氧化铝氧化镓原位红外光谱研究反应机理

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：