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Clinical usefulness of adherence to gastro-esophageal reflux disease guideline by Spanish gastroenterologists

World Journal of Gastroenterology 2012年第35期18卷 4885-4891页

作者： Fermín Mearin julio ponce Marta ponce Agustín Balboa Miguel A González Javier Zapardiel Service of Gastroenterology Centro Medico Teknon Digestive Disease Unit Hospital Quiron Centro de Investigacion Biomedica en Red:Enfermedades Hepaticasy Digestivas Service of Gastroenterology Hospital Universitario La Fe Biostatistics Innovex-Grupo Quintiles Espana Medical Department AstraZeneca Farmaceutica

AIM:To investigate usefulness of adherence to gastroesophageal reflux disease(GERD) guideline established by the Spanish Association of ***:Prospective,observational and multicentre study of 301 patients with typical symptoms of GERD who should be managed in accordance with guidelines and were attended by gastroenterologists in daily ***(aged > 18 years) were eligible for inclusion if they had typical symptoms of GERD(heartburn and/or acid regurgitation) as the major complaint in the presence or absence of accompanying atypical symptoms,such as dyspeptic symptoms and/or supraesophageal *** and therapeutic decisions should be made based on specific recommendations of the Spanish clinical practice guideline for GERD which is a widely disseminated and well known instrument among Spanish in digestive disease ***:Endoscopy was indicated in 123(41%) patients:50 with alarm symptoms,32 with age > 50 years without alarm ***-two patients(58.5%) had esophagitis(grade A,23,grade B,28,grade C,18,grade D,3).In the presence of alarm symptoms,endoscopy was indicated consistently with recommendations in 98% of ***,in the absence of alarm symptoms,endoscopy was indicated in 33% of patients > 50 years(not recommended by the guideline).Adherence for proton pump inhibitors(PPIs) therapy was 80%,but doses prescribed were lower(half) in 5% of cases and higher(double) in 15%.Adherence regarding duration of PPI therapy was 69%;duration was shorter than recommended in 1%(4 wk in esophagitis grades C-D) or longer in 30%(8 wk in esophagitis grades A-B or in patients without endoscopy).Treatment response was higher when PPI doses were consistent with guidelines,although differences were not significant(95% vs 85%).CONCLUSION:GERD guideline compliance was quite good although endoscopy was over indicated in patients > 50 years without alarm symptoms;PPIs were prescribed at higher doses and longer duration.

关键词： Gastro-esophageal reflux disease Clinicalpractice guidelines Adherence to guidelines Treatmentof gastro-esophageal reflux disease

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Small intestinal bacterial overgrowth in inactive Crohn's disease:Influence of thiopurine and biological treatment

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World Journal of Gastroenterology 2014年第38期20卷 13999-14003页

作者： Cristina Sánchez-Montes Vicente Ortiz Guillermo Bastida Ester Rodríguez María Yago Belén Beltrán Mariam Aguas Marisa Iborra Vicente Garrigues julio ponce Pilar Nos Gastroenterology Unit Hospital Universitari i Politécnic La Fe

AIM: To investigate the influence of thiopurines and biological drugs on the presence of small intestinal bacterial overgrowth (SIBO) in patients with inactive Crohn’s disease (CD).

关键词： Crohn’ s disease Bacterial overgrowth Thiopurines Biologics Inflammatory bowel disease

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Do assortative mating and immigrant inviability help maintain population genetic structuring of an herbivore on a crop and a wild relative?

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Insect Science 2019年第2期26卷 283-296页

作者： Ricardo Ramirez-Romero Delia Garibay-Benitez Ofelia Vargas-ponce Andrea Joyce julio S. Bernal Departamento de Produccion Agricola CUCBA Universidad de Guadalajara Zapopan Jalisco Mexico Departamento de Botanica y Zoologia CUCBA Universidad de Guadalajara Zapopan Jalisco Mexico Sierra Nevada Research Institute University of California Merced California USA Department of Entomology Texas A&M University College Station. Texas USA

Population genetic structuring is common among herbivorous insects and frequently is associated with divergent host plants, such as crops and their wild relatives. Previous studies showed population genetic structuring in corn leafhopper Dulbulus maidis in Mexico, such that the species consists of two sympatric, host plant-associated populations: an abundant and widespread "pestiferous” population on maize (Zea mays mays), and a small and localized "wild" population on perennial teosinte (Zea diploperennis). a maize wild relative with a limited distribution. This study addressed whether assortative mating and immigrant inviability mediate genetic structuring of corn leafliopper by comparing the mating and reproductive successes of pestiferous and wild females that colonize their nonassociated host plants against the successes of females colonizing their associated host plants. Assortative mating was assessed by comparing mating frequencies and premating and mating times among females of each population on each host plant: immigrant inviability was assessed by comparing, across two generations, the fecundity, survival, development time, sex ratio, and population growth rate among leafhopper populations and host plants. Our results showed that on maize, and compared to resident, pestiferous females, wild females were more likely to mate, and greater proportions of their offspring survived to adult stage and were daughters;consequently, the per-generation population growth rate on maize was greater for immigrant, wild leafhoppers compared to resident, pestiferous leafhoppers. Our results suggested that wild leafhoppers emigrating to maize have a fitness advantage over resident, pestiferous leafhoppers, while immigrant pestiferous and resident wild leafhoppers on teosinte have similar fitnesses.

关键词： crop domestication Dalbulus maidis ecological speciation host associated differentiation Zea diploperennis Zea mays mays

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Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients

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World Journal of Gastroenterology 2006年第48期12卷 7762-7767页

作者： Roberto Herrera-Goepfert Jesús K Yamamoto-Furusho Luis F Oate-Ocaa Margarita Camorlinga-ponce Leopoldo Muoz Jorge A Ruiz-Morales Gilberto Vargas-Alarcón julio Granados Cellular Biology Section Department of Pathology Institute Nacional de Cancerologia (INCan) Mexico City Mexico Department of Immunology and Rheumatology Institute Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Mexico City Mexico Department of Gastroenterology Institute Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Mexico City Mexico Department of Gastroenterology (INCan) Mexico City Mexico Medical Research Unit on Infectious and Parasitic Diseases Hospital de Pediatria Centro Medico Nacional Siglo XXI (CMN-SXXI) Institute Mexicano del Seguro Social (IMSS) Mexico City Mexico Department of Immunology and Rheumatology Institute Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Mexico City Mexico Department of Physiology Institute Nacional de Cardiologia Ignacio Chavez Mexico City Mexico

AIM： To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma.METHODS： Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosorbent assay （EUSA） method. RESULTS： We found a significant increased frequency of HLA-DQBI＊0401 allele in Hpylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P = 1 × 10^-7, odds ratio （OR） = 4.96; 95% confidence interval （95% CI）, 3.87-6.35]. We also found a significant increased frequency of HLA-DQBI＊0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals （P = 1 × 10^4, OR = 13.07; 95% CI, 2.82-85.14）.CONCLUSION： HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and difffuse-type gastric adenocarcinoma in the Mexican Mestizo population.

关键词： HLA-DQ HLA-DQ5 HLA-DQBI*0501 Hpy/or/ Chronic gastritis Gastric cancer Diffuse-type adenocarcinoma

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Food-derived peptides with inhibitory capacity for HMG-CoA reductase activity: a potential nutraceutical for hypercholesterolemia

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Food Science and Human Wellness 2024年第6期13卷 3083-3094页

作者： Guillermo Santos-Sánchez Ana IsabelÁlvarez-López Eduardo ponce-España Patricia Judith Lardone Antonio Carrillo-Vico Ivan Cruz-Chamorro Instituto de Biomedicina de Sevilla Instituto de Biomedicina de Sevilla(IbiS)Hospital Universitario Virgen del RocíoConsejo Superior de Investigaciones Científi cas(CSIC)Universidad de SevillaSeville 41013Spain Departamento de Bioquímica Médica y Biología Molecular e Inmunología Facultad de MedicinaUniversidad de SevillaSeville 41009Spain

Cardiovascular diseases(CVDs)are the leading global cause of mortality and disease *** are the most prescribed lipid-lowering drugs to treat hypercholesterolemia and prevent *** biochemical mechanism of statins consists of competitive inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase enzyme(HMG-CoAR),the limiting enzyme in cholesterol *** to statin intolerance in some patient groups,the search for new inhibitors is a field of great *** review focusses on the studies reporting the inhibitory effect of protein hydrolysates and biopeptides on the HMG-CoAR enzyme *** analysis of the action mechanism and physicochemical characteristics of the HMG-CoAR inhibitory peptides revealed that the molecular weight,amino acid composition,charge,and polarity are key aspects of the interaction with the HMG-CoAR *** conclusion,this review reveals the potential of using food peptides as new cholesterol-lowering agents and opens a new interesting field of ***,clinical approaches are mandatory to confirm their therapeutic hypercholesterolemic effect.

关键词： Functional foods Cholesterol Cardiovascular diseases Statins 3-Hydroxy-3-methylglutaryl-coenzyme A

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