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Proton pump inhibitors and all-cause mortality risk among cancer patients

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World Journal of Clinical Oncology 2025年第1期16卷 34-42页

作者： Arunkumar Krishnan Carolin victoria schneider Declan Walsh Department of Supportive Oncology Atrium Health Levine CancerCharlotteNC 28204United States Department of Medicine Section of Hematology and OncologyWake Forest University School of MedicineWinston-SalemNC 27101United States Department of Medicine Ⅲ GastroenterologyMetabolic Diseasesand Intensive CareUniversity Hospital RWTH AachenAachen 52074Germany

BACKGROUND Proton pump inhibitors(PPIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related *** evidence suggests associations between long-term PPI use and higher risks for various adverse health outcomes,including greater *** To investigate the association between PPI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize *** This retrospective cohort study used data from the TriNetX research network,with electronic health records from multiple healthcare *** study employed a new-user,active comparator design,which compared newly treated PPI users with non-users and newly treated histamine2 receptor antagonists(H2RA)users among adult cancer *** prescribed PPIs(esomeprazole,lansoprazole,omeprazole,pantoprazole,or rabeprazole)users were compared to non-users or newly prescribed H2RAs(cimetidine,famotidine,nizatidine,or ranitidine)*** primary outcome was all-cause *** patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding *** Cox regression models were used to estimate hazard ratios(HRs)and 95% confidence interval(CI).RESULTS During the follow-up period(median 5.4±1.8 years for PPI users and 6.5±1.0 years for non-users),PPI users demonstrated a higher all-cause mortality rate than non-users after 1 year,2 years,and at the end of follow up(HRs:2.34-2.72).Compared with H2RA users,PPI users demonstrated a higher rate of all-cause mortality HR:1.51(95%CI:1.41-1.69).Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure,confirming the robustness of these *** a sensitivity analysis,we analyzed all-cause mortality outcomes between former PPI users and individual

关键词： All-cause mortality Cancer Histamine-2 receptor antagonists Mortality Malignancy Proton pump inhibitors Carcinoma Outcome

Survival and growth of dominant tree seedlings in seasonally tropical dry forests of Yucatan: site and fertilization effects

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Journal of Plant Ecology 2014年第5期7卷 470-479页

作者： Luis Salinas-Peba víctor Parra-Tabla julio Campo Miguel A.Munguía-Rosas Departamento de Ecología Tropical Campus de Ciencias Biológicas y AgropecuariasUniversidad Autónoma de YucatánKm.15.5 Carretera Mérida-XmatkuilYucatán 97000México Instituto de Ecología Universidad Nacional Autónoma de MéxicoA.p.70-275México D.F.04510México Departamento de Ecología Humana Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAV)Km.6 Antigua carretera a ProgresoMérida 97310México

Aims Seasonally tropical dry forests of the Yucatan Peninsula are typically found in sites with nutrient-poor soils because of the recent geologi-cal origin of the *** landscape is dominated by extensive karstic plates that shape environments where vegetation regenera-tion through seed germination may be limited by the availability of suitable *** this study,we documented the survival and growth of seedlings from three dominant tree species(Bursera simaruba,Piscidia piscipula and Lysiloma latisiliquum)in seasonally tropical dry forests in ***,we evaluated the effect of nutrient addition(N and P,separately and in combination)on seedling survival and growth across three sites with differing levels of *** We conducted a nutrient addition experiment,whereby we estab-lished 12 plots of dimensions 10×10 m(100 m^(2))at each site,from which three plots were randomly selected to receive one of four treatments:N addition,P addition,N and P addition and no nutri-ent addition(controls).Prior to treatment application,in each plot,we planted 10 seedlings of each species in October 2010 and sub-sequently conducted surveys of plant growth and survival every 20 days from November 2010 to April *** Findings Overall,nutrient addition increased seedling survival and the mag-nitude of this effect was similar among *** did not observe an additive effect of the N+P treatment on ***,we observed a positive effect of nutrient addition on seedling growth,but this effect was contingent upon site;regarding survival,the effects of N and P on seedling growth were not *** results suggest that seedling recruitment and growth in the three dominant species of trees in Yucatan are limited by nutrient avail-ability but that the magnitude of this effect,particularly on seedling growth,is specific for species and site.

关键词： growth nitrogen nutrient addition phosphorus seedling survival seasonally tropical dry forest

Clinical heterogeneity in autoimmune acute liver failure

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World Journal of Gastroenterology 2007年第12期13卷 1824-1827页

作者： Norberto C Chavez-Tapia julio Martinez-Salgado julio Granados Misael Uribe Felix I Tellez-Avila Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City MexicoJulio Granados Department of Immunology and Rheumatology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico Department of Immunology and Rheumatology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico

AIM: To describe the outcome and prognosis in a cohort of patients with acute liver failure due to autoimmune hepatitis without liver transplantation. METHODS: A retrospective trial was conducted in 11 patients with acute liver failure due to autoimmune hepatitis who attended the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran. Demographic, biochemical and severity indexes, and treatment and outcome were assessed. RESULTS: Among the 11 patients, with a median age of 31 years, 72% had inflammatory response syndrome, and six patients received corticosteroids. The mortality rate within four weeks was 56%, and the one-year survival was 27%. In the survivors, severity indexes were lower and 83% received corticosteroids. CONCLUSION: We observed a relatively high survival rate in patients with acute liver failure due to autoimmune hepatitis. This survival rate could be influenced by severity of the disease and/or use of corticosteroids.

关键词： Autoimmune hepatitis Acute liver failure Corticosteroids

Cardiorespiratory fitness measured with cardiopulmonary exercise testing and mortality in patients with cardiovascular disease:A systematic review and meta-analysis

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Journal of Sport and Health Science 2021年第6期10卷 609-619,F0003页

作者： Yasmin Ezzatvar MikelIzquierdo julio Núñez Joaquín Calatayud Robinson Ramírez-vélez Antonio García-Hermoso Exercise Intervention for Health Research Group(EXINH-RG) Department of PhysiotherapyUniversitat de ValènciaValencia 46010Spain Navarrabiomed Navarra Hospital Complex(CHN)Public University of Navarra(UPNA)Navarra Medical Research Institute(IdiSNA)Pamplona 31008Spain CIBER of Frailty and Healthy Aging(CIBERFES) Instituto de Salud Carlos IIIMadrid 28029Spain Department of Cardiology Valencia University HospitalBiomedical Research Institute(INCLIVA)Valencia 46010Spain CIBER in Cardiovascular Diseases(CIBERCv) Madrid 28029Spain Sciences of Physical Activity Sports and Health SchoolUniversity of Santiago of Chile(USACH)Santiago 71783-5Chile

Background Cardiorespiratory fitness(CRF)is inversely associated with mortality in apparently healthy subjects and in some clinical populations,but evidence for the association between CRF and all-cause and/or cardiovascular disease(CvD)mortality in patients with established CvD is *** study aimed to quantify this *** We searched for prospective cohort studies that measured CRF with cardiopulmonary exercise testing in patients with CvD and that examined all-cause and CvD mortality with at least 6 months of *** hazard ratios(HRs)were calculated using random-effect inverse-variance *** Data were obtained from 21 studies and included 159,352 patients diagnosed with CvD(38.1%female).Pooled HRs for all-cause and CvD mortality comparing the highest *** category of CRF were 0.42(95%confidence interval(95%CI):0.28–0.61)and 0.27(95%CI:0.16–0.48),*** HRs per 1 metabolic equivalent(1-MET)increment were significant for all-cause mortality(HR=0.81;95%CI:0.74–0.88)but not for CvD mortality(HR=0.75;95%CI:0.48–1.18).Coronary artery disease patients with high CRF had a lower risk of all-cause mortality(HR=0.32;95%CI:0.26–0.41)than did their unfit *** 1-MET increase was associated with lower all-cause mortality risk among coronary artery disease patients(HR=0.83;95%CI:0.76–0.91)but not lower among those with heart failure(HR=0.69;95%CI:0.36–1.32).Conclusion A better CRF was associated with lower risk of all-cause mortality and *** study supports the use of CRF as a powerful predictor of mortality in this population.

关键词： Cardiopulmonary fitness Coronary artery disease Exercise capacity Heart failure Survival

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Surface-plasmonic sensor using a columnar thin film in the grating-coupled configuration [Invited]

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Chinese Optics Letters 2021年第8期19卷 121-129页

作者： Kiran Mujeeb Muhammad Faryad Akhlesh Lakhtakia julio v.Urbina Department of Electronics Quaid-i-Azam UniversityIslamabad 45320Pakistan Department of Physics Lahore University of Management SciencesLahore 54792Pakistan Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPennsylvania 16802USA Department of Electrical Engineering The Pennsylvania State UniversityUniversity ParkPennsylvania 16802USA

The excitation of a surface-plasmon-polariton(SPP) wave guided by a columnar thin film(CTF) deposited on a one-dimensional metallic surface-relief grating was investigated for sensing the refractive index of a fluid infiltrating that CTF. The Bruggemann homogenization formalism was used to determine the relative permittivity scalars of the CTF infiltrated by the fluid. The change in the refractive index of the fluid was sensed by determining the change in the incidence angle for which an SPP wave was excited on illumination by a p-polarized plane wave, when the plane of incidence was taken to coincide with the grating plane but not with the morphologically significant plane of the CTF. Multiple excitations of the same SPP wave were found to be possible, depending on the refractive index of the fluid, which can help increase the reliability of results by sensing the same fluid with more than one excitation of the SPP wave.

关键词： metal grating multiple excitation rigorous coupled-wave approach sensitivity surface-plasmon-polariton wave

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Synthesis and applications of lanthanoid complexes of pentadentate and hexadentate N_(5) and N_(6) macrocycles:A review

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Journal of Rare Earths 2024年第1期42卷 1-15,I0001页

作者： julio Corredoira-vázquez Cristina González-Barreira Paula Oreiro-Martínez Ana M.García-Deibe Jesús Sanmartín-Matalobos Matilde Fondo Departamento de Química Inorganica Facultade de QuímicaUniversidade de Santiago de CompostelaCampus Vida15782Santiago de CompostelaSpain Phantom-g CICECO-Aveiro Institute of MaterialsDepartment of PhysicsUniversity of Aveiro3810-193AveiroPortugal Institute of Materials(iMATUS) Universidade de Santiago de Compostela15782Santiago de CompostelaSpain

In this paper,the lanthanoid complexes of N_(5) and N_(6) macrocycle ligands,without pendant arms or additional heteroatoms,are *** review covers the period from 2015 to the current date,since in 2014 Schiff base macrocyclic ligands incorporating the pyridine moiety,and their complexes,were revised,and in 2015 the chemistry of pentaaza macrocycle ligands with rare earth metals was also *** and phthalocyanine ligands are not included in this review,which primarily focuses on complexes with Schiff bases and amines without pendant arms or any additional donor other than *** synthetic methods,structural characterization,based on single X-ray crystal data,and properties of the lanthanoid complexes,with special attention to magneto-structural correlations,are presented herein.

关键词： Lanthanoid N_(5),N_(6)macrocycle Coordination chemistry Chirality Biological activity Molecule magnet

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Methodology for ranking controllable parameters to enhance operation of a steam generator with a combined Artificial Neural Network and Design of Experiments approach

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Energy and AI 2021年第1期3卷 9-21页

作者： Lara Werncke vieira Augusto Delavald Marques Paulo Smith schneider Antônio Joseda Silva Neto Felipe Antonio Chegury viana Madhat Abdel-jawad Julian David Hunt julio Cezar Mairesse Siluk Federal University of Rio Grande do Sul-UFRGS Porto AlegreBrazil State University of Rio de Janeiro-UERJ Nova FriburgoBrazil University of Central Florida OrlandoUCFUnited States Advanced Analysis Australia-AAA PerthAustralia International Institute for Applied Systems Analysis-IIASA ViennaAustria Federal University of Santa Maria-UFSM Santa MariaBrazil

The operation of complex systems can drift away from the initial design conditions,due to environmental condi-tions,equipment wear or specific *** generators are complex equipment and their proper opera-tion relies on the identification of their most relevant *** approach to rank the operational parameters of a subcritical steam generator of an actual 360 MW power plant is *** Artificial Neural Network-ANN delivers a model to estimate the steam generator efficiency,electric power generation and flue gas outlet temperature as a function of seven input *** ANN is trained with a two-year long database,with training errors of 0.2015 and 0.2741(mean absolute and square error)and validation errors of 0.32%and 2.350(mean percent and square error).That ANN model is explored by means of a combination of situations proposed by a Design of Experiment-DoE *** seven controlled parameters showed to be relevant to express both steam generator efficiency and electric power generation,while primary air flow rate and speed of the dynamic classifier can be neglected to calculate flue gas temperature as they are not statistically *** also shows the prominence of the primary air pressure in respect to the steam generator efficiency,electric power generation and the coal mass flow rate for the calculation of the flue gas outlet *** ANN and DoE combined methodology shows to be promising to enhance complex system efficiency and helpful whenever a biased behavior must be brought back to stable operation.

关键词： Coal-fired power plant Artificial Neural Network Design of Experiments Response surface methodology Steam generator

Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis

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World Journal of Gastroenterology 2006年第40期12卷 6507-6514页

作者： Alexander schneider Stephan L Haas Ralf Hildenbrand Sren Siegmund Iris Reinhard Helmut Nakovics Manfred v Singer Peter Feick Department of Medicine II (Gastroenterology Hepatology and Infectious Diseases) Univer-sity Hospital of Heidelberg at Mannheim Mannheim Germany Institute of Pathology University Hospital of Heidelberg at Mannheim Mannheim Germany Central Institute of Mental Health Mannheim Germany

AIM： To investigate interleukin-18 （IL-18） in patients with chronic panreatitis （CP）. METHODS： We studied 29 patients with CP and 30 healthy controls. Peripheral blood mononuclear cells （PBMC） were isolated and incubated with 50 mmol/L ethanol, lipopolysaccharide （LPS）（doses 25 g/L, 250 g/L, 2500 g/L） and both agents for 24 h. Levels of IL-18 in the supernatants, and levels of IL-18, IL-12, interferon （IFN）-T and soluble CD14 in the serum were analysed by EI_ISA technique. Expression of IL-18 in PBMC was investigated by reverse-transcription （RT）-PCR. IL-18 protein levels in CP tissue and in normal pancreas were studied by ELISA technique. IL-18 levels in PBMC and pancreatic tissue were determined by Westernblot. Immunohistochemistry for pancreatic IL-18 expression was performed.RESULTS： In patients, IL-18 serum levels were significantly enhanced by 76% （mean： 289.9 ± 167.7 ng/L） compared with controls （mean： 165.2 ± 43.6 ng/L; P 〈 0.0005）. IL-12 levels were enhanced by 25% in patients （18.3 ± 7.3 ng/L） compared with controls （14.7 ± 6.8 ng/L, P = 0.0576） although not reaching the statistical significance. IFN-γ, and soluble CD14 levels were not increased. In vitro, LPS stimulated significantly and dosedependently IL-18 secretion from PBMC. Incubation with ethanol reduced LPS-stimulated IL-18 secretion by about 50%. The mRNA expression of IL-18 in PBMC and the response of PBMC to ethanol and LPS was similar in CP patients and controls. In PBMC, no significant differences in IL-18 protein levels were detected between patients and controls. IL-18 protein levels were increased in CP tissues compared to normal pancreatic tissues. IL-18 was expressed by pancreatic acinar cells and by infiltrating inflammatory cells within the pancreas. CONCLUSION： IL-18 originates from the chronically inflammed pancreas and appears to be involved in the fibrotic destruction of the organ.

关键词： Chronic pancreatitis Cytokines Interleukin- 18 Pancreatic fibrosis

Acupuncture treatment in gastrointestinal diseases: A systematic review

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World Journal of Gastroenterology 2007年第25期13卷 3417-3424页

作者： Antonius schneider Konrad Streitberger Stefanie Joos University Hospital Heidelberg Department of General Practice and Health Services Research Germany University Hospital Heidelberg Department of Anaesthesiology Germany

The purpose of this work was to assess the evidence for effectiveness of acupuncture （AC） treatment in gastrointestinal diseases. A systematic review of the Medline-cited literature for clinical trials was performed up to May 2006. Controlled trials assessing acupuncture point stimulation for patients with gastrointestinal diseases were considered for inclusion. The search identified 18 relevant trials meeting the inclusion criteria. Two irritable bowel syndrome （IBS） trials, 1 Crohn＇s disease and 1 colitis ulcerosa trial had a robust random controlled trial （RCT） design. In regard to other gastrointestinal disorders, study quality was poor. In all trials, quality of life （QoL） improved significantly independently from the kind of acupuncture, real or sham. Real AC was significantly superior to sham acupuncture with regard to disease activity scores in the Crohn and Colitis trials. Efficacy of acupuncture related to QoL in IBS may be explained by unspecific effects. This is the same for QoL in inflammatory bowel diseases （IBD）, whereas specific acupuncture effects may be found in clinical scores. Further trials for IBDs and in particular for all other gastrointestinal disorders would be necessary to evaluate the efficacy of acupuncture treatment. However, it must be discussed on what terms patients benefit when this harmless and obviously powerful therapy with regard to QoL is demystified by further placebo controlled trials.

关键词： Irritable bowel syndrome Inflammatorybowel disease Gastrointestinal disease Placebo Acupuncture