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Mexican Guidelines for the Diagnosis and Treatment of Chronic Myeloid Leukaemia

Journal of Cancer Therapy 2013年第3期4卷 747-764页

作者： Eduardo Cervera Federico Godínez rosa Sosa ramón rivas Carlos Best Juan Hernández Adrián Morales Hugo Zurita Ivette Carrasco Jorge Cruz álvaro Aguayo José Espinoza Juan Labardini Luis Valero Judith Cruz Diana Arcos Diego Limón Omar López-Navarro Daniela Gordillo-Bastidas Myrna Candelaria Francisco Torres Juan Kassack Oscar de Jesús Pérez ramírez Jorge Aquino Guillermo Díaz Mariela Cardiel Margarita rodríguez Patricia Montoya Juan Contreras María Chávez Sandra Chávez David Gómez Olga Cantú Jorge Duque Luis Pita Eduardo Lobato julio López Antonio López Pedro González Jorge Cortés Haematology and Oncology Department National Institute of Medical and Nutrition Sciences “Dr. Salvador Zubirán” Mexico City Mexico Haematology Deparment from Hospital Juárez Mexico City Mexico Haematology Department Blood Bank and Unit of Aphaeresis General Hospital of Culiacán Health Ministry Culiacán Mexico Haematology Department Bone Marrow Transplant and Blood Bank from Hospital Regional de Alta Especialidad “Dr. Juan Graham Casassus” Villahermosa Mexico Haematology Department Cancerology National Institute (INCan) Mexico City Mexico Haematology Department Cancerology National Institute (INCan) Mexico City Mexico 2Internal Medicine Haematology Hospital ISSSTECALI Tijuana Mexico Haematology Department Centenario Hospital Miguel Hidalgo Health Ministry Aguascalientes Mexico Haematology Department General Hospital of Sonora State Sonora Mexico Haematology Department Hospital Universitario UANL Monterrey Mexico Haematology Haematology Service Hospital General Regional SSG León Mexico Haematology Head of Haematology Service School of Medicine Autonomous University of San Luis Potosí San Luis Potosí Mexico Haematology Hospital “Aranda de la Parra” León Mexico Haematology Hospital General de Especialidades Campeche Mexico Haematology Hospital General de México Mexico City Mexico Haematology Hospital General de Occidente SSA Guadalajara Mexico Haematology Hospital Regional de Alta Especialidad de Oaxaca Oaxaca Mexico Haematology Mérida Clinic Yucatán Mexico Haematology Oncology Unit SSEP Puebla Mexico Hospital Betania Puebla Mexico Hospital of the Poblano Child Puebla Mexico Internal Medicine Haematology Hospital ISSSTECALI Tijuana Mexico Leukaemias Clinic at ISSEMyM Toluca Mexico Leukemia Department MD Anderson Cancer Center Houston Mexico Los Mochis General Hospital Sinaloa Mexico renaissance Clinic Morelia Mexico State Council for AIDS Prevention and Control Chihuahua Mexico Universidad Autónoma de Yucatán Mérida Mexico

Background: This document includes recommendations and guidelines issued by a group of Mexican researchers and specialists gathered in the First National Colloquium for the Diagnosis and Management of Chronic Myeloid Leukaemia (CML) by initiative of Instituto Nacional de Cancerología and with the support of the Leukaemia Department of the MD Anderson Cancer Center. Mexico lacks of updated information taken from its own reality on the diagnosis and treatment of CML and other haematological disorders;besides, there are no national guidelines. Aim: To publish a consensus document with guidelines for the management of CML adjusted to the national environment and overall characteristics. Method: The participants answered a DELPHI questionnaire about the overall aspects of the disease, aiming to target controversial topics, discuss them in the colloquium, and to agree on the best ones. After those meetings, a final document was drawn up. results: The group presents recommendations for definition, diagnosis, prognosis, monitoring, and treatment of CML in Mexico. Conclusions: Having consensus guidelines for the clinical management of CML in our country will enable the consensual practice of Mexican specialists regarding the clinical approach to CML, as well as optimize the resources which allow the rational planning of the medical care strategies.

关键词： Chronic Myeloid Leukaemia Management Guidelines Diagnosis Treatment.

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间接竞争酶联免疫吸附法应用于采后水果组织中葡萄孢菌的定量分析

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保鲜与加工 2012年第2期 56-56页

作者： Martín A Fernndez-Baldo Jorge G Fernández Sirley V Pereira Germn A Messina Eloy Salinas julio raba María I Sanz Ferramola INQUISAL Departamento de Química.Universidad Nacional de San Luis

灰霉病是导致水果采后巨大经济损失的主要病害,其致病菌为葡萄孢菌。葡萄孢菌通常以潜伏侵染的形式存在,一旦病原菌发展蔓延则引起健康果实的迅速腐烂变质。因此,开发快速、灵敏的葡萄孢菌检测和定量分析方法势在必行。本文介绍了一种... 详细信息

灰霉病是导致水果采后巨大经济损失的主要病害,其致病菌为葡萄孢菌。葡萄孢菌通常以潜伏侵染的形式存在,一旦病原菌发展蔓延则引起健康果实的迅速腐烂变质。因此,开发快速、灵敏的葡萄孢菌检测和定量分析方法势在必行。本文介绍了一种用于测定苹果(red Delicious)、鲜食葡萄(Pink Moscatel)和梨(William’s)组织中葡萄孢菌的间接竞争酶联免疫吸附法(ELISA)。该方法的原理是基于水果组织中葡萄孢菌抗原与交联固定在微量滴定板表面的葡萄孢菌纯化抗原对于单克隆抗体结合位点的竞争作用。为了验证该方法的有效性,进行了如选择性、线性分析、精密度、准确性、灵敏性等大量的参数测定。该方法对于葡萄孢菌抗原的检测限为0.97μ***-1,为了保证测定的稳定性,事先将纯化抗原固定长达4个月。应用该方法可以对尚未表现症状的任何水果中的葡萄孢菌进行检测定量分析。通过与一项DNA定量测试结果进行对比,表明ELISA法的测定结果与DNA分析结果具有很好的相关性。本研究结果表明,新开发的测试方法实现了对无发病症状的果实中葡萄孢菌的检测分析,具有成本低廉、操作简便、快捷等优点,可将其应用于世界各国对水果等植物的病害检疫领域。

关键词：采后间接竞争酶联免疫吸附法葡萄水果定量分析

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Early Paleozoic accretionary orogens along the Western Gondwana margin

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Geoscience Frontiers 2021年第1期12卷 109-130页

作者： Sebastián Oriolo Bernhard Schulz Silvana Geuna Pablo DGonzález Juan E.Otamendi JiíSláma Elena Druguet Siegfried Siegesmund CONICET-Universidad de Buenos Aires Instituto de Geociencias BasicasAplicadas y Ambientales de Buenos Aires(IGEBA)Intendente Güiraldes 2160C1428EHABuenos AiresArgentina Institute of Mineralogy Division of Economic Geology and PetrologyTU Bergakademie FreibergBrennhausgasse 14D-09596FreibergSaxonyGermany Instituto de Investigacion en Paleobiología y Geología(UNrN-CONICET) Avenida Julio A.Roca 1242R8332EXZGeneral RocaArgentina CONICET Departamento de GeologíaUniversidad Nacional de Río CuartoCampus UniversitarioX5804BYARío CuartoArgentina Institute of Geology The Czech Academy of SciencesRozvojova 269CZ-16500Prague 6Czech Republic Departament de Geologia Universitat Autonoma de Barcelona08193BellaterraBarcelonaSpain Geoscience Centre Georg-August-Universit€at G€ottingenGoldschmidtstraße 337077GottingenGermany

Early Paleozoic accretionary orogens dominated the Western Gondwana margin and were characterized by nearly continuous subduction associated with crustal extension and back-arc basin *** southwestern margin is represented by Famatinian and Pampean basement realms exposed in South America,both related to the protracted Paleozoic evolution of the Terra Australis Orogen,whereas the northwestern margin is mainly recorded in Cadomian domains of Europe and adjacent ***,no clear relationships between these regions were so far *** on a compilation and reevaluation of geological,paleomagnetic,petrological,geochronological and isotopic evidence,this contribution focuses on crustal-scale tectonic and geodynamic processes occurring in Western Gondwana accretionary orogens,aiming at disentangling their common Early Paleozoic *** show that accretionary orogens were dominated by high-temperature/lowpressure metamorphism and relatively high geothermal gradients,resulting from the development of extended/hyperextended margins and bulk transtensional *** this sense,retreating-mode accretionary orogens characterized the Early Paleozoic Gondwana margin,though short-lived pulses of compression/transpression also *** existence of retreating subduction zones favoured mantle-derived magmatism and mixing with relatively young(meta)sedimentary sources in a thin continental *** reworking of previous forearc sequences due to trenchward arc migration thus took place through assimilation and anatexis in the arc/back-arc ***,retreating-mode accretionary orogens were the locus of Early Paleozoic crustal growth in Western Gondwana,intimately associated with major flare-up events,such as those related to the Cadomian and Famatian *** roll back,probably resulting from decreasing convergence rates and plate velocities after Gondwana assembly,was a key factor for orogen-scale geodynamic ***

关键词： retreating accretionary orogen Lower Paleozoic Crustal growth Hf isotopic array Famatinian Cadomian

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提上唇肌切断术及上唇复位:矫正露龈笑的联合方法

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中国美容整形外科杂志 2014年第6期 393-395页

作者： Luis H.Ishida Luiz C.Ishida Jorge Ishida julio Grynglas Nivaldo Alonso Marcus C.Ferreira 魏峰高景恒张晨圣保罗大学整形外科中心《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

背景与目的对牙龈过度显露的治疗方法通常包括LeFort嵌入或上颌牙龈切除术。笔者提供一种新的方法,通过降低提上唇肌功能及复位上唇的方式来减少牙龈的显露程度。方法自2008年2月至2009年3月,我们对14例牙龈过度显露的女性患者进行了...

背景与目的对牙龈过度显露的治疗方法通常包括LeFort嵌入或上颌牙龈切除术。笔者提供一种新的方法,通过降低提上唇肌功能及复位上唇的方式来减少牙龈的显露程度。方法自2008年2月至2009年3月,我们对14例牙龈过度显露的女性患者进行了手术。分别于术前和术后6个月拍照记录。要求患者最大程度地笑,测量患者牙龈显露的最大值,并使用Image J软件进行分析。患者在局部麻醉下进行手术。利用骨膜剥离器,将牙龈黏膜从上颌骨上分离下来。钝性剥离上唇肌肉下方的皮肤和皮下组织。通过系带成形术延长上唇。切开双侧提上唇肌并分离。结果术后所有患者恢复良好。术前牙龈显露程度为(5.22±1.48)mm,而术后6个月为(1.91±1.50)mm。牙龈显露程度减少1.59～4.83mm,平均(1.59±4.83)mm。结论本方法可以有效减少笑时牙龈的显露程度,本组患者均取得满意疗效。

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