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Recombinogenic Effect of the Ternary Complex of Copper（II） with Doxycycline and 1,10-Phenanthroline on Somatic Cells of Drosophila melanogaster

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Journal of Pharmacy and Pharmacology 2018年第5期6卷 531-540页

作者： Jeyson cesary Lopes Luisa Mariana Melo Guimaraes julio cesar nepomuceno Sandra Morelli Robson Jose de Oliveira Junior Laboratory of Cytogenetics Federal University of Uberldndia (UFU) Uberlandia 38700-000 M.G. Brazil Laboratory of Cvtogenetics and Mutagenesis University Center of Paros de Minas-UNIPAM Paros de Minas 38700-000 M.G.Brazil

In the search for new anti-tumor agents, exploiting features such as the flexibility of coordination modes of metals have become an alternative strategy for synthesizing pharmaceuticals. It has been shown that the CuDP （copper（II）, doxycycline, and 1,10-phenanthroline） complex cleaves DNA strands by an oxidative mechanism and by intercalating the major groove, resulting in a cytotoxic action. The objective of this study was to assess the mutageinc/recombinogenic effects of the CuDP complex in vivo using the SMART （Somatic Mutation and Recombination Test） in Drosophila melanogaster. Treatments were carried out with third instar larvae at the standard cross and high bioactivation cross using three concentrations of CuDP （6.92, 13.84 or 27.67 mM）. The mutagenic doxorubicin （0.4 mM） was used as a positive control and reverse osmosis water as a negative control. For each compound, marked trans-heterozygous and balanced heterozygous individuals were analyzed to determine the mutational and recombinogenic events occurring in the cells, We found that CuDP significantly increased the frequencies of mutant cells in both standard and high bioactivation crosses, mostly by induction of recombination. These data show that CuDP is a direct recombinogenic agent that is independent of bioactivation,

关键词： Copper recombination mutation Drosophila melanogaster.

Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases

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Neural Regeneration Research 2024年第3期19卷 571-577页

作者： Sonia Irais Gonzalez-Cano Gonzalo Flores Jorge Guevara julio cesar Morales-Medina Samuel Treviño Alfonso Diaz Faculty of Chemical Sciences Benemerita Autonomous University of PueblaPueblaMexico Institute of Physiology Benemerita Autonomous University of PueblaPueblaMexico Department of Biochemistry Faculty of MedicineNational Autonomous University of MexicoMexico CityMexico Animal Reproduction Research Center CINVESTAV-Autonomous University of TlaxcalaTlaxcalaMexico

Aging is a natural phenomenon characterized by a progressive decline in physiological integrity,leading to a deterioration of cognitive function and increasing the risk of suffering from chronic-degenerative diseases,including cardiovascular diseases,osteoporosis,cancer,diabetes,and *** is considered the major risk factor for Parkinson’s and Alzheimer’s disease ***,diabetes and insulin resistance constitute additional risk factors for developing neurodegenerative ***,no treatment can effectively reverse these neurodegenerative ***,some antidiabetic drugs have opened the possibility of being used against neurodegenerative *** the previous framework,Vanadium species have demonstrated a notable antidiabetic *** research group evaluated polyoxidovanadates such as decavanadate and metforminium-decavanadate with preventive and corrective activity on neurodegeneration in brain-specific areas from rats with metabolic *** results suggest that these polyoxidovanadates induce neuronal and cognitive restoration *** review aims to describe the therapeutic potential of polyoxidovanadates as insulin-enhancer agents in the brain,constituting a therapeutic alternative for aging and neurodegenerative diseases.

关键词： Alzheimer’s disease antidiabetic brain cognition diabetes insulin neurodegeneration neuroinflammation oxidative stress Vanadium species

Influence of Data Clouds Fusion From 3D RealTime Vision System on Robotic Group Dead Reckoning in Unknown Terrain

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IEEE/CAA Journal of Automatica Sinica 2020年第2期7卷 368-385页

作者： Mykhailo Ivanov Oleg Sergyienko Vera Tyrsa Lars Lindner Wendy Flores-Fuentes julio cesar Rodriguez-Quinonez Wilmar Hernandez Paolo Mercorelli Universidad Autónoma de Baja California MexicaliB.C.21100Mexico Universidad de Las Américas Quito 170125Equador Leuphana University of Lueneburg Lüneburg 21335Germany

This paper proposes the solution of tasks set required for autonomous robotic group behavior optimization during the mission on a distributed area in a cluttered hazardous *** navigation scheme uses the benefits of the original real-time technical vision system(TVS)based on a dynamic triangulation *** method uses TVS output data with fuzzy logic rules processing for resolution *** on previous researches,the dynamic communication network model is modified to implement the propagation of information with a feedback method for more stable data exchange inside the robotic *** to the comparative analysis of approximation methods,in this paper authors are proposing to use two-steps post-processing path planning aiming to get a smooth and energy-saving *** article provides a wide range of studies and computational experiment results for different scenarios for evaluation of common cloud point influence on robotic motion planning.

关键词： Data transfer group behavior machine vision navigation robotic group(RG) vision system

Red pigment production by Penicillium purpurogenum GH2 is influenced by pH and temperature

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第12期12卷 961-968页

作者： Alejandro MéNDEZ Catalina PéREZ julio cesar MONTAéZ Gabriela MARTíNEZ Cristóbal Noé AGUILAR Department of Food Science and Technology School of Chemistry Universidad Autónoma de Coahuila Saltillo 25280 Coahuila Mexico Department of Organic Chemistry School of Chemistry Universidad Autónoma de Coahuila Saltillo 25280 Coahuila Mexico Department of Chemical Engineering School of Chemistry Universidad Autónoma de Coahuila Saltillo 25280 Coahuila Mexico

The combined effects of pH and temperature on red pigment production and fungal morphology were evaluated in a submerged culture of Penicillium purpurogenum GH2, using Czapek-Dox media with D-xylose as a carbon source. An experimental design with a factorial fix was used: three pH values (5, 7, and 9) and two temperature levels (24 and 34 °C) were evaluated. The highest production of red pigment (2.46 g/L) was reached with a pH value of 5 and a temperature of 24 °C. Biomass and red pigment production were not directly associated. This study demon- strates that P. purpurogenum GH2 produces a pigment of potential interest to the food industry. It also shows the feasibility of producing and obtaining natural water-soluble pigments for potential use in food industries. A strong combined effect (p<0.05) of pH and temperature was associated with maximal red pigment production (2.46 g/L).

关键词： Penicillium purpurogenum Food colorants Combined effects Water-soluble pigment

Safety of the Patient from the Medication

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Journal of Pharmacy and Pharmacology 2017年第1期5卷 13-19页

作者： julio cesar Garcia Casallas Clinical Pharmacology Department Clinica Universidad de La Sabana Investigation Group Evidencia Terapeutica Universidad de La Sabana Chia 250001 Colombia

Currently, more than 7% of admissions to acute care hospitals am related with AEMs （adverse events to medications）. AEMs are the sixth cause of death, causing a cost of over $5.6 million dollars （USD） per hospital per year. There is an estimate that between 19% and 23% of hospitalized patients will have an adverse effect within the first 30 days after being discharged, 14.3% will be re-admitted and 70% of these events will be related to a medication prescription. Fortunately, at least 58% of these AEMs are preventable, since they result from a lack of information on the medication, prescription and dosage errors and from the abuse and underuse of the same. Polymedicated patients, especially the elderly with multiple pathologies and/or chronic patients that need to be admitted into the hospital more frequently, usually to internal medicine, neurology, psychiatry, rehabilitation and intensive care, are precisely the most liable to suffer from medication errors. It must be the objective to aim for the increase in the patient safety standards when it comes to medications.

关键词： Medication patient's safety pharmacological conciliation polymedication.

Ayahuasca:Uses,Phytochemical and Biological Activities

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Natural Products and Bioprospecting 2019年第4期9卷 251-265页

作者： Edgar Antonio Estrella‑Parra julio cesar Almanza‑Pérez Francisco Javier Alarcón‑Aguilar Laboratorio de Farmacología.Dpto.Ciencias de la Salud.Div.C.B.S.Universidad Autónoma Metropolitana Unidad Iztapalapa.Av.San Rafael Atlixco No.186Col.Vicentina09340 Mexico CDMXMexico Laboratorio de Fitoquímica Laboratorio de FarmacognosiaLaboratorio de Fisiología VegetalUnidad UBIPROFES-IztacalaUNAMTlalnepantla de Baz54090 Mexico CDMXMexico

Ayahuasca(caapi,yajé),is a psychoactive brew from the Amazon Basin region of South America traditionally considered a“master plant.”It is prepared as a decoction from Banisteriopsis caapi and Psychotria viridis,which it is thought that it stimulates creative thinking and visual *** healers of the Orinoco and Amazon basins have used traditionally ayahuasca as a healing tool for multiple purposes,particularly to treat psychological disorders in the patients,with some beneficial effects experimentally and clinically ***,several syncretic religions,as the“Uniao de Vegetal”(UDV)group in Brazil,have been spread around the *** use of ayahuasca has been popularized by internet and smart-shops,bringing the psychoactive substance to new highs,emerging new“ayahuasqueros.”Ayahuasca has alkaloids asβ-carbolines and dimethyltryptamines,which inhibit the monoamine oxidase and active the 5-HT_(2A)(5-hydroxytryptamine)receptor,respectively,resulting in hallucinations in the *** induces a psychedelic change in the anteroposterior coupling of the electrophysiological brain oscillations in *** ayahuasca beverage is generating pharmacological,commercial and spiritual interest among the scientific community,government people,and different populations *** goal of this article is to report about the uses,chemistry and biological activities of ayahuasca.

关键词： Ayahuasca Banisteriopsis caapi Psychotria viridis-dimethyltryptamine β-carbolines Psychotherapy

Leaching kinetics in cyanide media of Ag contained in the industrial mining-metallurgical wastes in the state of Hidalgo, Mexico

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International Journal of Mining Science and Technology 2014年第5期24卷 689-694页

作者： Juan Hernandez Francisco Patino Isauro Rivera Iván Alejandro Reyes Misrael Uriel Flores julio cesar Juarez Martín Reyes Research Centre in Materials and Metallurgy Autonomous University of Hidalgo Pachuca 42184 Mexico

The leaching kinetics in cyanide media of the silver contained in the Dos Carlos waste tailings at the City of Pachuca de Soto, Hidalgo State, Mexico were carried out. The used material contained the following chemical composition: 56 10-6of Ag, 0.6 10 6of Au and 70.43%(by weight) of SiO2; 7.032%(by weight) of Al2O3; 2.69%(by weight) of Fe; 0.46%(by weight) of Mn; 3.98%(by weight) of K2O; 3.34%(by weight) of CaO; 2.50%(by weight) of Na2O; 0.04%(by weight) of Zn; 0.026%(by weight) of Pb. The mineralogical phases present were the following: Silica, albite, argentite, berlinite, orthoclase, potassium jarosite, and natrojarosite. In the leaching kinetics in cyanide media, and under the studied conditions,the effect of the CN concentration on the reaction rate has no effect on the whole process of alkaline cyanidation, of which the reaction order is n 0. Temperature has an effect on the cyanidation rate of the reaction, with an activation energy of 47.9 KJ/mol. At the same time, when the particle size decreases there is an increase in the reaction rate, which is inversely proportional to the particle diameter; when increasing the NaOH concentration there is an increase in the reaction rate Kexp, with a reaction order(n) of 0.215 under the studied ranges.

关键词： Silver Waste tailings Cyanidation Leaching

Gastrointestinal tuberculosis:An autopsy-based study

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Infectious Medicine

Infectious Medicine 2023年第2期2卷 122-127页

作者： julio cesar Mantilla Juan JoséChaves Ferney Africano-Lopez Néstor Blanco-Barrera Marta Juliana Mantilla Department of Pathology Universidad Industrial de SantanderBucaramanga 680002Colombia Department of Pathology Hospital Universitario de SantanderBucaramanga 680002Colombia Department of Pathology Fundación Universitaria de Ciencias de la SaludBogotá111411Colombia Department of Gastroenterology Gastrocenter and Medical SpecialitiesIpiales 524061Colombia Department of Gastroenterology Universidad Militar Nueva GranadaBogotá250240Colombia Department of Rheumatology Universidad de la SabanaChía 250001Colombia

Background:Tuberculosis is a disease of great relevance since it is one of the leading causes of morbidity and mortality *** tuberculosis is an unusual *** is defined as the involvement of any segment of the digestive tract,associated viscera,and *** study’s main objective is to collect information from autopsies of patients diagnosed with gastrointestinal tuberculosis in a Pathology reference center in ***:This is a retrospective and descriptive study of autopsy reports.A total of 4,500 autopsies were performed between January 2004 and December *** inclusion criteria were authorization of a family member following local law regulations and a final autopsy diagnosis of gastrointestinal tuberculosis using microscopic ***:Forty-eight patients with gastrointestinal tuberculosis autopsies were included in our *** of the patients were male(n=35,72.9%)with a median age of 40.5 years *** immunodeficiency virus infection history was reported in 28 cases(58.33%).The most affected gastrointestinal tract site was the terminal *** and thickened epithelium were common autopsies macroscopic *** multiorgan compromise was a relevant finding in patients with gastrointestinal ***:Gastrointestinal tuberculosis is a disease of great importance,being its diagnosis a clinical *** can be reported in a high percentage of cases,so autopsy diagnosis can help reveal more accurate data about this condition.

关键词： Gastrointestinal tuberculosis Autopsy Forensic pathology Infections Colombia

Emerging Timber Bridge Program to Sao Paulo State： A Five-Year Report

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Journal of Civil Engineering and Architecture 2011年第5期5卷 459-464页

作者： Carlito Carlil Jtmior julio cesar Molina Department of Structural Engineering Sao Carlos School of Engineering University of Sao Paulo Brazil

The Emerging Timber Bridge Program to Sao Paulo state （ETBPSP） was started in 2001 with the main objective of research and development of new technologies for timber bridge construction. After five years of this program eleven demonstration timber bridges were constructed in the State of Sao Paulo, whereas eight composite timber/concrete bridges, one log timber girder bridge with transversal sawn deck, one transversal lumber prestressed timber bridge and one transversal cellular plywood box prestressed bridge. As a final objective is the divulgation of the constructive and structural systems in extension courses to municipal engineers and in a complete publication of timber bridges project plans with the different structural and constructional systems. This paper describes the goals of the MTBPSP, the accomplishments of the program in the first five years, the information sheet of the bridges and outlines some obstacles and opportunities.

关键词： Bridge decks Brazil testing timber-concrete timber.