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Bone changes in alcoholic liver disease

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World Journal of Hepatology 2015年第9期7卷 1258-1264页

作者： Emilio gonzález-Reimers Geraldine Quintero-Platt Eva rodríguez-rodríguez Antonio Martínez-Riera julio Alvisa-Negrín Francisco Santolaria-Fernández Servicio de Medicina Interna Hospital Universitario de Canarias Universidad de La Laguna

Alcoholism has been associated with growth impairment, osteomalacia, delayed fracture healing, and aseptic necrosis(primarily necrosis of the femoral head), but the main alterations observed in the bones of alcoholic patients are osteoporosis and an increased risk of fractures. Decreased bone mass is a hallmark of osteoporosis, and it may be due either to decreased bone synthesis and/or to increased bone breakdown. Ethanol may affect both mechanisms. It is generally accepted that ethanol decreases bone synthesis, and most authors have reported decreased osteocalcin levels(a "marker" of bone synthesis), but some controversy exists regarding the effect of alcohol on bone breakdown, and, indeed, disparate results have been reported for telopeptide and other biochemical markers of bone resorption. In addition to the direct effect of ethanol, systemic alterations such as malnutrition, malabsorption, liver disease, increased levels of proinflammatory cytokines, alcoholic myopathy and neuropathy, low testosterone levels, and an increased risk of trauma, play contributory roles. The treatment of alcoholic bone disease should be aimed towards increasing bone formation and decreasing bone degradation. In this sense, vitamin D and calcium supplementation, together with biphosphonates are essential, but alcohol abstinence and nutritional improvement are equally important. In this review we study the pathogenesis of bone changes in alcoholic liver disease and discuss potential therapies.

关键词： Alcoholism Liver disease Osteoporosis Vitamin D Bone fractures

Neuroprotective effect of Neuro-EPO in neurodegenerative diseases:“Alea jacta est”

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Neural Regeneration Research 2019年第9期14卷 1519-1521页

作者： Ramón Rama Fernando Garzón Yamila rodríguez-Cruz Tangui Maurice julio-César García-rodríguez Department of Cell Biology Physiology and ImmunologyUniversity of BarcelonaBarcelonaSpain Department of Animal Health University of NarinoPastoNarinoColombia Department of Histology University of Medical SciencesHavanaCuba MMDN Univ MontpellierINSERMEPHEUMR_S1198MontpellierFrance CENPALAB National Center for Animals BreedingHavanaCuba

Our common home,planet Earth,is inhabited by more than 7 billion human *** average life expectancy currently estimated for men is^69 years,with strong differences among ***,neurodegenerative diseases are currently the leading cause of death and disability *** clinical use and neuroscience research,a solution for an effective diagnosis is in progress,but a prophylactic treatment to counteract this long-lasting plague for humanity is still unidentified.

关键词： Our common home neurodegenerative still unidentified

Drought and Spatiotemporal Variability of Forest Fires Across Mexico

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Chinese Geographical Science 2018年第1期28卷 25-37页

作者： Pompa-García MARíN Camarero J.julio rodríguez-Trejo DANTE ARTURO Vega-Nieva DANIEL JOSE Facultad de Ciencias Forestales Universidad Juarez del Estado de Durango Durango 34120 MExico Instituto Pirenaico de Ecologia IPE-CSIC 50059 Spain Divisian de Ciencias Forestales Universidad Autonoma Chapingo Chapingo 56230 MExico

Understanding the spatiotemporal links between drought and forest fire occurrence is crucial for improving decision-making in fire management under current and future climatic conditions. We quantified forest fire activity in Mexico using georeferenced fire records for the period of 2005–2015 and examined its spatial and temporal relationships with a multiscalar drought index, the Standardized Precipitation-Evapotranspiration Index(SPEI). A total of 47975 fire counts were recorded in the 11-year long study period, with the peak in fire frequency occurring in 2011. We identified four fire clusters, i.e., regions where there is a high density of fire records in Mexico using the Getis-Ord G spatial statistic. Then, we examined fire frequency data in the clustered regions and assessed how fire activity related to the SPEI for the entire study period and also for the year 2011. Associations between the SPEI and fire frequency varied across Mexico and fire-SPEI relationships also varied across the months of major fire occurrence and related SPEI temporal scales. In particular, in the two fire clusters located in northern Mexico(Chihuahua, northern Baja California), drier conditions over the previous 5 months triggered fire occurrence. In contrast, we did not observe a significant relationship between drought severity and fire frequency in the central Mexico cluster, which exhibited the highest fire frequency. We also found moderate fire-drought associations in the cluster situated in the tropical southern Chiapas where agriculture activities are the main causes of forest fire occurrence. These results are useful for improving our understanding of the spatiotemporal patterns of fire occurrence as related to drought severity in megadiverse countries hosting many forest types as Mexico.

关键词： cluster drought forest fires geostatistics spatial clusters Standardised Precipitation-Evapotranspiration Index (SPEI)

Inconsistencies in four-dimensional Einstein-Gauss-Bonnet gravity

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Chinese Physics C 2021年第1期45卷 89-96页

作者： julio Arrechea Adria Delhom alejandro Jimenez-Cano Instituto de Astrofisica de Andalucia(IAA-CSIC) Glorieta de la AstronomiaGranadaSpain Departamento de Fisica Teorica and IFIC Centro Mixto Universidad de Valencia-CSIC.Universidad de ValenciaBuijassot-46100ValenciaSpain Departamento de Fisica Teorica y del Cosmos and CAFPE Universidad de Granada18071 GranadaSpain

We attempt to clarify several aspects concemi ng the recently presented four-dimensional Ein stein-Gauss-Bonnet *** argue that the limiting procedure outlined in[***.124,081301(2020)]generally involves ill-defined terms in the four dimensional field *** ways to circumvent this issue are discussed,alongside remarks regarding specific solutions of the *** prove that,although linear perturbations are well behaved around maximally symmetric backgrounds,the equations for second-order perturbations are illdefined even around a Minkowskia n *** on ally,we perform a detailed analysis of the spherically symmetric solutions and find that the central curvature singularity can be reached within a finite proper time.

关键词： alternative theories of gravity singularities Einstein・Gauss-Bonnet

Synthesis and applications of lanthanoid complexes of pentadentate and hexadentate N_(5) and N_(6) macrocycles:A review

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Journal of Rare Earths 2024年第1期42卷 1-15,I0001页

作者： julio Corredoira-Vázquez Cristina gonzález-Barreira Paula Oreiro-Martínez Ana M.García-Deibe Jesús Sanmartín-Matalobos Matilde Fondo Departamento de Química Inorganica Facultade de QuímicaUniversidade de Santiago de CompostelaCampus Vida15782Santiago de CompostelaSpain Phantom-g CICECO-Aveiro Institute of MaterialsDepartment of PhysicsUniversity of Aveiro3810-193AveiroPortugal Institute of Materials(iMATUS) Universidade de Santiago de Compostela15782Santiago de CompostelaSpain

In this paper,the lanthanoid complexes of N_(5) and N_(6) macrocycle ligands,without pendant arms or additional heteroatoms,are *** review covers the period from 2015 to the current date,since in 2014 Schiff base macrocyclic ligands incorporating the pyridine moiety,and their complexes,were revised,and in 2015 the chemistry of pentaaza macrocycle ligands with rare earth metals was also *** and phthalocyanine ligands are not included in this review,which primarily focuses on complexes with Schiff bases and amines without pendant arms or any additional donor other than *** synthetic methods,structural characterization,based on single X-ray crystal data,and properties of the lanthanoid complexes,with special attention to magneto-structural correlations,are presented herein.

关键词： Lanthanoid N_(5),N_(6)macrocycle Coordination chemistry Chirality Biological activity Molecule magnet

Novel Tandem Three Consecutive Reactions: Aza-Wittig, Imine Condensation and Electrophilic Aromatic Substitution Strategy to Indolizine Synthesis

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International Journal of Organic Chemistry 2021年第2期11卷 55-71页

作者： julio C. gonzález-rodríguez Carlos gonzález-Romero Erick Cuevas-Yáñez Juan J. Mejía Vega Christopher K. Jankowski David Corona-Becerril Centro Conjunto de Investigación en Química Sustentable (CCIQS) UAEM-UNAM Universidad Autónoma del Estado de México Unidad San Cayetano Toluca de Lerdo México Departamento de Química Orgánica Facultad de Química Universidad Autónoma del Estado de México Paseo Colón/Paseo Tollocan s/n Toluca Estado de México México Department de Chimie et Biochimie Université de Moncton Moncton Canadá

Reaction of ethyl (Z)-3-(heteroaryl/aryl)-2-((triphenyl-λ5-phosphaneylidene) amino) acrylates intermediates with 2,3-thiophenedicarboxaldehyde was used in novel Tandem three consecutive reactions: aza-Wittig, imine condensation and electrophilic heteroaromatic cyclization to obtain a series of indolizines. A tentative mechanism of this reaction is proposed.

关键词： Iminophosphorane Tandem Reaction Indolizine Synthesis

Validity of autorefractor based screening method for irregular astigmatism compared to the corneal topography-a cross sectional study

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1412-1418页

作者： Alicia Galindo-Ferreiro Julita De Miguel-Gutierrez Manuel gonzález-Sagrado Alberto Galvez-Ruiz Rajiv Khandekar Silvana Schellini julio Galindo-Alonso King Khaled Eye Specialist Hospital Riyadh 12329SaudiArabia Department of Ophthalmology Rio-Hortega University HospitalValladolid 47012Spain Unit Research Support Rio-Hortega HospitalValladolid 47012Spain Faculdade de Medicina de Botucatu State University of SgoPauloUNESP 18618687Brazil Galindo Clinic Valladolid 47003Spain

AIM：To present a method of screening for irregular astigmatism with an autorefractor and its determinants compared to corneal ***：This cross-sectional validity study was conducted in 2013 at an eye hospital in Spain.A tabletop autorefractor（test 1）was used to measure the refractive status of the anterior surface of the cornea at two corneal meridians of each *** corneal topography（test 2）and Bogan’s classification was used to group eyes into those with regular or no astigmatism（GRI）and irregular astigmatism（GRII）.Test 1 provided a single absolute value for the greatest cylinder difference（Vr）.The receiver operating characteristic（ROC）were plotted for the Vr values measured by test 1 for GRI and GRII *** the basis a Vr value of 1.25 D as cut off,sensitivity,specificity were also ***：The study sample was comprised of 260 eyes（135 patients）.The prevalence of irregular astigmatism was 42%[95%confidence interval（CI）：36,48].Based on test 2,there were 151 eyes in GRI and 109 eyes in *** median Vr was 0.75 D（25%quartile,0.5 D）for GRI and1.75 D（25%quartile,1.25 D）for *** area under curve was 0.171 for GRI and 0.83 for *** sensitivity of test I was 78.1%and the specificity was 76.1%.CONCLUSION：A conventional autorefractor can be effective as a first level screening method to detect irregular corneal astigmatism in places where corneal topography facilities are not available.

关键词： screening irregular astigmatism autorefrac-tot corneal topography cornea validity

Shape Retrieval Using Fourier Descriptors Applied to Industrial Process

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Journal of Computer and Communications 2020年第3期8卷 43-52页

作者： julio-alejandro Romero-gonzález Rosamaría Romero-gonzález Marcela Herrera-Navarro Diana-Margarita Córdova-Esparza Hugo Jiménez-Hernández Faculty of Informatics Autonomous University of Queretaro Queretaro Mexico

Nowadays, manufacturing processes are carried out at speeds that they themselves demand and subject to rigorous standards to maintain the quality of materials. An important step to define the quality of products in metalworking is the casting process, which principal focus is seeking control and monitoring of properties of materials. Nevertheless, it is not easy due to the high temperatures and gas produced in the vessel. Although some researchers have been attempting to solve these problems, it is difficult to carry out due to hard conditions. This article proposes the analysis of the surface of the liquid metal, that is, the slag on the surface, which is considered as connected spaces characterized by the topology of their discrete surface. These spaces are described through Fast Fourier Transform, associating changes of intensities to the frequency domain and obtaining main features of these frequencies, these features are used to define an enveloping shape that represents the liquid metal. Finally, the results obtained are presented, which, according to them shows that it is possible to characterize the slag, and by which it is possible to spatially locate the molten metal liquid in the refractory. Therefore, this research serves as the basis for the development of new algorithms for level detection and measurement, preventing overflows and damage to refractories.

关键词： Convex Hull Shape Retrieval Features Detection Fourier Transform Vision Computing

Acute necrotizing pancreatitis: Surgical indications and technical procedures

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World Journal of Clinical Cases 2014年第12期2卷 840-845页

作者： José Manuel Aranda-Narváez Antonio Jesús gonzález-Sánchez María Custodia Montiel-Casado Alberto Titos-García julio Santoyo-Santoyo General Digestive and Transplantation Surgery Department University Regional Hospital 29010 Málaga Spain

Necrosis of pancreatic parenchyma or extrapancreatic tissues is present in 10%-20% of patients with acute pancreatitis, defining the necrotizing presentation frequently associated with high morbidity and mortality rates. During the initial phase of acute necrotizing pancreatitis the most important pillars of medical treatment are fluid resuscitation, early enteral nutrition, endoscopic retrograde colangiopancreatography if associated cholangitis and intensive care unit support. When infection of pancreatic or extrapancreatic necrosis occurs, surgical approach constitutes the most accepted therapeutic option. In this context, we have recently assited to changes in time for surgery(delaying the indication if possible to around 4 wk to deal with "walledoff" necrosis) and type of access for necrosectomy: from a classical open approach(with closure over large-bore drains for continued postoperative lavage or semiopen techniques with scheduled relaparotomies), trends have changed to a "step-up" philosophy with initial percutaneous drainage and posterior minimally invasive or endoscopic access to the retroperitoneal cavity for necrosectomy if no improvement has been previously achieved. These approaches are progressively gaining popularity and morbidity and mortality rates have decreased significantly. Therefore, a staged, multidisciplinary, step-up approach with minimally invasive or endoscopic access for necrosectomy is widely accepted nowadays for management of pancreatic necrosis.

关键词： Acute pancreatitis Necrotizing pancreatitis Surgery Open necrosectomy Minimal access retroperitoneal pancreatic necrosectomy Video-assisted retroperitoneal debridement