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Achievement of high rate nitritation with aerobic granular sludge reactors enhanced by sludge recirculation events

Frontiers of Environmental Science & Engineering 2015年第3期9卷 528-533页

作者： Zulkifly JEMAAT Josep Anton TORA Albert BARTROLI Julian CARRERA julio PEREZ Department of Chemical Engineering School of Engineering Universitat Autbnoma de Barcelona Barcelona 08193 Spain Aeris Tecnologias Ambientales Ed. Eureka-Campus UAB Barcelona 08193 Spain Present address: Faculty of Chemical & Natural Resources Engineering Universiti Malaysia Pahang Lebuhraya Tun Razak Kuantan 26300 Malaysia

A ratio control strategy has been used to demonstrate the feasibility of this automatic control procedure for the achievement of stable full and partial nitritation. The control strategy assured constant ratio between the dissolved oxygen （DO） and the total ammonia nitrogen （TAN） concentrations in the bulk liquid of aerobic granular sludge reactors operating in continuous mode. Three different set-ups with different reactor capacities were used （3, 110, and 150L）. High strength synthetic wastewaters and reject water were tested with similar performance. Achieved nitrogen loading rates ranged between 0.4 and 6.1 kgN· m^-3·d^-1, at temperatures between 20℃ and 30℃. 1Granular sludge and nitritation were stable in the long term continuous operation of the reactors. Suitable stable effluent for Anammox has been obtained using the desired TAN setpoint （i.e. 50% of influent ammonium oxidation）. An existing biofilm model devel- oped incorporating the implemented control loops and validated in a previous publication was used to investigate the effects of the ammonium concentration of the influent and the biofilm density on the achievement of full nitritation. The model demonstrated how sludge recirculation events led to a stable and significant increase of the biomass concentration in the reactor, which in turn resulted in the achievement of high nitrogen loading rates, due to the action of the control strategy. The model predicted an enhancement of stable full nitritation at higher ammonium concentrations in the influent. Poor influence of the biofilm density in the achievement of full nitritation was predicted with the model.

关键词： partial nitrification reject water high strength ammonium wastewater closed-loop control

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Optimizing urban traffic control using a rational agent

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第12期15卷 1123-1137页

作者： Salvador IBARRA-MARTíNEZ José A.CASTN-ROCHA julio LARIA-MENCHACA Engineering School Autonomous University of Tamaulipas

This paper is devoted to developing and evaluating a set of technologies with the objective of designing a methodology for the implementation of sophisticated traffic lights by means of rational agents. These devices would be capable of optimizing the behavior of a junction with multiple traffic signals, reaching a higher level of autonomy without losing reliability, accuracy, or efficiency in the offered services. In particular, each rational agent in a traffic signal will be able to analyze the requirements and constraints of the road, in order to know its level of demand. With such information, the rational agent will adapt its light cycles with the view of accomplishing more fluid traffic patterns and minimizing the pollutant environmental emissions produced by vehicles while they are stopped at a red light, through using a case-based reasoning(CBR) adaptation. This paper also integrates a microscopic simulator developed to run a set of tests in order to compare the presented methodology with traditional traffic control methods. Two study cases are shown to demonstrate the efficiency of the introduced approach, increasing vehicular mobility and reducing harmful activity for the environment. For instance, in the first scenario, taking into account the studied traffic volumes, our approach increases mobility by 23% and reduces emissions by 35%. When the roads are managed by sophisticated traffic lights, a better level of service and considerable environmental benefits are achieved, demonstrating the utility of the presented approach.

关键词： Rational agents Traffic light control Optimization Traffic mobility

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Usefulness of the CONUT index upon hospital admission as a potential prognostic indicator of COVID-19 health outcomes

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Chinese Medical Journal 2022年第2期135卷 187-193页

作者： Adrian K.Bengelloun Guillermo J.Ortega julio Ancochea Ancor Sanz-Garcia Diego A.Rodriguez-Serrano Guillermo Fernandez-Jimenez Rosa Giron Elena Avalos Joan B.Soriano J.Ignacio de Ulibarri Facultad de Medicina Universidad Autónoma de MadridMadridSpain Unidad de Análisis de Datos Instituto de Investigación Sanitaria del Hospital de la PrincesaMadridSpain Servicios de Neumología Admisión y Documentación ClínicaCuidados Intensivos y Nutrición y DietéticaHospital Universitario de La PrincesaMadridSpain Centro de Investigación en Red de Enfermedades Respiratorias(CIBERES) Instituto de Salud Carlos III(ISCIII)MadridEspañaSpain

Background:In-hospital mortality in patients with coronavirus disease 2019(COVID-19)is *** prognostic indices are needed to identify patients at high-risk of COVID-19 health *** aimed to determine the usefulness of the CONtrolling NUTritional status(CONUT)index as a potential prognostic indicator of mortality in COVID-19 patients upon hospital ***:Our study design is of a retrospective observational study in a large cohort of COVID-19 *** addition to descriptive statistics,a Kaplan-Meier mortality analysis and a Cox regression were performed,as well as receiver operating curve(ROC).Results:From February 5,2020 to January 21,2021,there was a total of 2969 admissions for COVID-19 at our hospital,corresponding to 2844 ***,baseline(within 4 days of admission)CONUT index could be scored for 1627(57.2%)***’age was 67.3±16.5 years and 44.9%were *** CONUT severity distribution was:194(11.9%)normal(0-1);769(47.2%)light(2-4);585(35.9%)moderate(5-8);and 79(4.9%)severe(9-12).Mortality of 30 days after admission was 3.1%in patients with normal risk CONUT,9.0%light,22.7%moderate,and 40.5%in those with severe CONUT(P<0.05).An increased risk of death associated with a greater baseline CONUT stage was sustained in a multivariable Cox regression model(P<0.05).An increasing baseline CONUT stage was associated with a longer duration of admission,a greater requirement for the use of non-invasive and invasive mechanical ventilation,and other clinical outcomes(all P<0.05).The ROC of CONUT for mortality had an area under the curve(AUC)and 95%confidence interval of 0.711(0.676-0746).Conclusion:The CONUT index upon admission is potentially a reliable and independent prognostic indicator of mortality and length of hospitalization in COVID-19 patients.

关键词： Admission Clinical risk CONUT COVID-19 Prognosis Score

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A T follicular helper cell origin for T regulatory type 1 cells

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Cellular & Molecular Immunology 2023年第5期20卷 489-511页

作者： Patricia Solé Jun Yamanouchi Josep Garnica Muhammad Myn Uddin Robert Clarke Joel Moro Nahir Garabatos Shari Thiessen Mireia Ortega Santiswarup Singha Debajyoti Mondal César Fandos julio Saez-Rodriguez Yang Yang Pau Serra Pere Santamaria Institut D'investigacions Biomediques August Pi i Sunyer BarcelonaSpain Department of Microbiology Immunology and Infectious DiseasesSnyder Institute for Chronic DiseasesCumming School of MedicineUniversity of CalgaryCalgaryABCanada Institute of Computational Biomedicine Faculty of MedicineHeidelberg University HeidelbergGermany Department of Biochemistry and Molecular Biology Cumming School of MedicineUniversity of CalgaryCalgaryABCanada.

Chronic antigenic stimulation can trigger the differentiation of antigen-experienced CD4+T cells into T regulatory type 1(TR1)cells,a subset of interleukin-10-producing Treg cells that do not express *** identities of the progenitor(s)and transcriptional regulators of this T-cell subset remain ***,we show that the peptide-major histocompatibility complex class Il(pMHCll)monospecific immunoregulatory T-cell pools that arise in vivo in different genetic backgrounds in response to pMHCll-coated nanoparticles(pMHCll-NPs)are invariably comprised of oligoclonal subpools of T follicular helper(TFH)and TR1 cells with a nearly identical clonotypic composition but different functional properties and transcription factor expression *** analyses of scRNAseq data and multidimensional mass cytometry revealed progressive downregulation and upregulation of TFH and TR1 markers,***,pMHCIl-NPs trigger cognate TR1 cell formation in TFH cell-transfused immunodeficient hosts,and T-cell-specific deletion of Bcl6 or Irf4 blunts both the TFH expansion and TR1 formation induced by *** contrast,deletion of Prdm1 selectively abrogates the TFH-to-TR1 ***6 and Prdm1 are also necessary for anti-CD3 mAbinduced TR1 ***,TFH cells can differentiate into TR1 cells in vivo,and BLIMP1 is a gatekeeper of this cellular reprogramming event.

关键词： T-regulatory type 1(TR1)cells autoimmunity T follicular helper(TFH)cells transdifferentiation nanomedicine

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Mobility Habitus in the Literature From 2020 to 2024

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Journalism and Mass Communication 2024年第2期14卷 53-62页

作者： María del Rosario Molina González Cruz García Lirios julio E Crespo Isabel Cristina Rincón Rodríguez Jorge Enrique Chaparro Medina Francisco Rubén Sandoval Vázquez Enrique Martínez Muñoz JoséAlfonso Aguilar Fuentes Alfredo Barrera Escobar Universidad de Sonora NavojoaMéxico Universidad de la Salud Ciudad de MexicoMéxico Universidad de Los Lagos OsornoChile Universidad de Santander UDES BucaramangaColombia Universidad de Investigación y Desarrollo UDI BucaramangaColombia Universidad Autónoma del Estado de Morelos CuernavacaMéxico Universidad Autónoma del Estado de Hidalgo PachucaMéxico Universidad Autónoma del Estado de México HuehuetocaMéxico Universidad Fidel Velazquez EdomexMéxico

The objective of the present work is modeling the mobility habitus in the public transport system with low Co2 emission mechanics in the center of *** this sense,a documentary work was carried out with a review of sources indexed to national repositories,using the Delphi technique for the content analysis and the specification of the model.A study was conducted with a selection of 100 students to establish the reliability,linearity,sphericity,adequacy,and validity of an instrument from which a relationship of dependence between income and mobility habitus was *** limits of the search,selection,and processing of information are recognized,and it is recommended to extend the research to international repositories,as well as to employ a more sophisticated technique.

关键词： spatiality habitus capacities model complexity

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Evaluation of Early Action Mechanisms in Peru Regarding Preparedness for El Nino

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International Journal of Disaster Risk Science 2019年第4期10卷 493-510页

作者： julio Aguirre Daniel De La Torre Ugarte Juan Bazo Paulo Quequezana Mauricio Collado Department of Economics Universidad del Pacifico15072 LimaPeru Red Cross Red Crescent Climate Centre 2502 KC The HagueThe Netherlands Centro de Investigacion de Riesgo Resiliencia y Cambio Climatico(CIRCA)Universidad Tecnologica del Peru(UTP)15046 LimaPeru

In this article,we provide an impact evaluation of an intervention in Peru regarding preparedness for El Nino impacts in Picsi District of Chiclayo Province in Peru’s northwestern coastal Lambayeque *** effort involved the provision of special kits that reduce the potential damage to homes as a consequence of rainfall and floods associated with an El Nino-Southern Oscillation *** was collected in 2016 when this Forecast-based Financing early action was activated by an El Nino forecast,and after a coastal El Nino actually struck in *** dual database permits us to estimate the impact of the intervention on the damage level of homes by comparing those homes supported by the program with those homes not receiving pilot-program *** comparison is achieved by using propensity score matching techniques,which identify the most comparable homes to the ones that were supported by the *** main findings of the study suggest a positive impact of the program in terms of its effectiveness in mitigating the damage caused by the 2017 El Ni?*** results suggest a drop in the scale of house damage(less damage)by around 63%for a home that received the modular kit *** considering other specifications of the model,the decrease in the scale of house damage improves up to approximately 66%.

关键词： Early warning Early action El NinoSouthern Oscillation Forecast-based Financing Matching propensity score Perú Red Cross

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Prefoldins Negatively Regulate Cold Acclimation in Arabidopsis thaliana by Promoting Nuclear Proteasome-Mediated HY5 Degradation

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Molecular Plant 2017年第6期10卷 791-804页

作者： Carlos Perea-Resa Miguel A. Rodriguez-Milla Elisa Iniesto Vicente Rubio julio Salinas Departamento de Biologia Medioambiental Centro de Investigaciones Biologicas CSIC 28040 Madrid Spain Departamento de Genetica Molecular de Plantas Centro Nacional de Biotecnologia CSIC 28049 Madrid Spain present address: Department of Molecular Biology Massachusetts General Hospital Boston MA 02214 USA Present address: Unidad de Biotecnologia Celular Instituto de Salud Garlos Ⅲ 28222 Madrid Spain

The process of cold acclimation is an important adaptive response whereby many plants from temperate regions increase their freezing tolerance after being exposed to low non-freezing temperatures. The correct development of this response relies on proper accumulation of a number of transcription factors that regulate expression patterns of cold-responsive genes. Multiple studies have revealed a variety of molecular mechanisms involved in promoting the accumulation of these transcription factors. Interestingly, however, the mechanisms implicated in controlling such accumulation to ensure their adequate levels remain largely unknown. In this work, we demonstrate that prefoldins （PFDs） control the levels of HY5, an Arabidopsis transcription factor with a key role in cold acclimation by activating anthocyanin biosynthesis, in response to low temperature. Our results show that, under cold conditions, PFDs accumulate into the nucleus through a DELLA-dependent mechanism, where they interact with HY5, triggering its ubiquitination and subsequent degradation. The degradation of HY5 would result, in turn, in anthocyanin biosynthesis attenuation, ensuring the accurate development of cold acclimation. These findings uncover an unanticipated nuclear function for PFDs in plant responses to abiotic stresses.

关键词： prefoldins cold acclimation Arabidopsis HY5 anthocyanin DELLAs

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Electrochemical reduction of Cr(Ⅵ)in the presence of sodium alginate and its application in water purification

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Journal of Environmental Sciences 2021年第3期33卷 304-312页

作者： Bryan Butter Paola Santander Guadalupe del CPizarro Diego POyarzún Federico Tasca julio Sánchez Facultad de Química y Biología Universidad de Santiago de ChileUSACHCasilla 40Correo 33SantiagoChile Departamento de Química Universidad Tecnológica MetropolitanaJ.P.Alessandri 1242SantiagoChile Laboratorio de Nanotecnología Recursos Naturales y Sistemas ComplejosFacultad de Ciencias NaturalesUniversidad de AtacamaCopayapu 485CopiapóChile

Chromium(Cr)is used in many manufacturing processes,and its release into natural waters is a major environmental problem *** concentrations of Cr(Ⅵ)are toxic to human health and living organisms due to the carcinogenic and mutagenic nature of this *** work examined the conversion of Cr(Ⅵ)to Cr(Ⅲ)via electrochemical reduction using gold electrode in an acidic sodium alginate(SA)solution and subsequent removal of the produced Cr(Ⅲ)-SA by the polymer-enhanced ultrafiltration(PEUF)technique.A solution of SA in nitric acid was used both as an electrolytic medium during the voltammetric measurements and bulk electrolysis and as an extracting agent during the PEUF *** electroanalysis of Cr(Ⅵ)was performed by linear sweep voltammetry in the presence of acidic SA solution to study its voltammetric behavior as a function of the Cr(Ⅵ)concentration,pH,presence of Cr(Ⅲ),SA concentration and scan *** addition,the quantitative reduction of Cr(Ⅵ)to Cr(Ⅲ)was studied through the bulk electrolysis *** results showed efficient reduction with well-defined peaks at approximately 0.3 V ***/AgCl,using a gold working *** the pH increased,the reduction signal strongly decreased until its *** optimum SA concentration was 10 mmol/L,and it was observed that the presence of Cr(Ⅲ)did not interfere in the Cr(Ⅵ)*** the quantitative reduction by bulk electrolysis in the presence of acidic SA solution,it was possible to reduce all Cr(Ⅵ)to Cr(Ⅲ)followed by its removal via PEUF.

关键词： Alginate solution Chromium Electroanalytical chemistry Ultrafiltration Water purification

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Growth phenology adjusts to seasonal changes in water availability in coexisting evergreen and deciduous mediterranean oaks

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Forest Ecosystems 2023年第5期10卷 535-546页

作者： Filipe Campelo Alvaro Rubio-Cuadrado Fernando Montes Michele Colangelo Cristina Valeriano J.julio Camarero Department of Life Sciences University of CoimbraCalçada Martim de FreitasCoimbra3000-456Portugal Departamento de Sistemas y Recursos Naturales Escuela Tecnica Superior de Ingeniería de MontesForestal y Del Medio NaturalUniversidad Politecnica de MadridCiudad Universitaria S/n28040MadridSpain Instituto Pirenaico de Ecología(IPE-CSIC) Avda.Montanana 1005E-50192ZaragozaSpain Departamento de Dinamica y Gestion Forestal Instituto de Ciencias Forestales(ICIFOR-INIA-CSIC)Ctra.La Coruna Km 7.528040MadridSpain Scuola di Scienze Agrarie ForestaliAlimentari e AmbientaliUniversita Della BasilicataViale Dell’Ateneo Lucano 1085100PotenzaItaly

Different leaf(evergreen *** habit)and xylem(***-porous wood)traits represent contrasting strategies to face seasonal changes in water availability and ***,how contrasting leaf and xylem habits of coexisting tree species affect stem wood formation and tree-ring development remains poorly ***,we investigated the spatio-temporal patterns of wood formation in two deciduous oaks(Quercus faginea and Quercus petraea)and two evergreen oaks(Quercus ilex and Quercus suber)coexisting in seasonally dry Mediterranean forests along an aridity gradient in *** hypothesized that growth responses to drought and intra-and inter-annual growth patterns would differ between functional *** simulated intra-and interannual growth using a modified version of the Vaganov-Shashkin(VS)process-based,growth *** VS model simulations were used to estimate growth changes under a high emission scenario(RCP 8.5)for the current distribution of the study oak species and to forecast their future performance under warm(4.8℃)conditions in the Iberian *** simulations indicate that climate warming would induce a shortening of the ringgrowth season and a reduction of radial growth in evergreen and deciduous Mediterranean oaks,particularly in dry sites from southern and eastern Iberia currently occupied by *** and *** oaks may better recover after dry periods than deciduous oaks by resuming growth after the summer *** soil water availability in spring would be more detrimental to growth of deciduous ***-based growth models should be refined and validated to better forecast changes in tree growth as a function of climate.

关键词： Process-based growth model Quercus ilex Quercus suber Quercus faginea Quercus petraea Tree-ring growth

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Domain adversarial training for classification of cracking in images of concrete surfaces

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AI in Civil Engineering 2022年第1期1卷 119-132页

作者： Bruno Oliveira Santos Jónatas Valença João P.Costeira Eduardo julio CERIS Instituto Superior TécnicoUniversity of LisbonLisbonPortugal ISR Instituto Superior TécnicoUniversity of LisbonLisbonPortugal

The development of automatic methods to recognize cracks in surfaces of concrete has been under focus in recent years,firstly through computer vision methods and more recently focusing on convolutional neural networks that are delivering promising *** are still persisting in crack recognition,namely due to the confusion added by the myriad of elements commonly found on concrete *** robustness of these methods would deal with these elements if access to correspondingly heterogeneous datasets was *** so,this would be a cumbersome methodology,since training would be needed for each particular case and models would be case ***,efforts from the scientific community are focusing on generalizing neural network models to achieve high per-formance in images from different domains,slightly different from those in which they were effectively *** generalization of networks can be achieved by domain adaptation techniques at the training *** adapta-tion enables finding a feature space in which features from both domains are invariant,and thus,classes become *** work presented here proposes the DA-Crack method,which is a domain adversarial training method,to generalize a neural network for recognizing cracks in images of concrete *** domain adversarial method uses a convolutional extractor followed by a classifier and a discriminator,and relies on two datasets:a source labeled dataset and a target unlabeled small *** classifier is responsible for the classification of images randomly chosen,while the discriminator is dedicated to uncovering to which dataset each image *** from the discriminator reverses the gradient used to update the *** enables fighting the convergence promoted by the updating backpropagated from the classifier,and thus generalizing the extractor enabling it for crack recognition of images from both source and target *** show that

关键词： DA-Crack method Domain-adaptation Adversarial training network Crack detection Concrete surfaces Computer vision

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