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Omics-based biomarkers as useful tools in metabolic dysfunctionassociated steatotic liver disease clinical practice:How far are we?

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World Journal of Gastroenterology 2024年第14期30卷 1982-1989页

作者： julieta tr.nks María F Mascardi Adrián Gadano Sebastián Marciano Instituto de Medicina traslacional e Ingeniería Biomédica-Consejo Nacional de Investigaciones Científicas y Técnicas-Instituto Universitario del Hospital Italiano-Hospital Italiano de Buenos Aires Ciudad Autónoma de Buenos Aires C1199ACLArgentina Consejo Nacional de Investigaciones Científicas y Técnicas Ciudad Autónoma de Buenos Aires C1425FQBArgentina Liver Unit Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina Department of Research Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina

Unmet needs exist in metabolic dysfunction-associated steatotic liver disease(MASLD)risk *** ability to identify patients with MASLD with advanced fibrosis and at higher risk for adverse outcomes is still *** novel biomarkers could represent a meaningful improvement to current risk *** this aim,omics technologies have revolutionized the process of MASLD biomarker discovery over the past *** the research in this field is thriving,much of the publication has been haphazard,often using single-omics data and specimen sets of convenience,with many identified candidate biomarkers but lacking clinical validation and *** we incorporate these biomarkers to direct patients’management,it should be considered that the roadmap for translating a newly discovered omics-based signature to an actual,analytically valid test useful in MASLD clinical practice is rigorous and,therefore,not easily *** article presents an overview of this area’s current state,the conceivable opportunities and challenges of omics-based laboratory diagnostics,and a roadmap for improving MASLD biomarker research.

关键词： Metabolic dysfunction-associated steatotic liver disease Non-alcoholic steatohepatitis Biomarker Risk stratification Omics

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Mitochondrial dysfunction as a target in spinal cord injury:intimate correlation between pathological processes and therapeutic approaches

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Neural Regeneration Research 2023年第10期18卷 2161-2166页

作者： julieta Schmidt Héctor Ramiro Quintá Universidad de Buenos Aires CABAArgentina Laboratorio de Medicina Experimental“Dr.J.Toblli” Hospital AlemánCABAArgentina Consejo Nacional de Investigaciones Científicas y Técnicas-CONICET CABAArgentina Rehabilitation Medicine Department University of MinnesotaTwin CitiesMINUSA

traumatic spinal cord injuries interrupt the connection of all axonal projections with their neuronal targets below and above the lesion site. This interruption results in either temporary or permanent alterations in the locomotor, sensory, and autonomic functions. Damage in the spinal tissue prevents the re-growth of severed axons across the lesion and their reconnection with neuronal targets. Therefore, the absence of spontaneous repair leads to sustained impairment in voluntary control of movement below the injury. For decades, axonal regeneration and reconnection have been considered the opitome of spinal cord injury repair with the goal being the repair of the damaged long motor and sensory tracts in a complex process that involves:(1) resealing injured axons;(2) reconstructing the cytoskeletal structure inside axons;(3) re-establishing healthy growth cones;and(4) assembling axonal cargos. These biological processes require an efficient production of adenosine triphosphate, which is affected by mitochondrial dysfunction after spinal cord injury. From a pathological standpoint, during the secondary stage of spinal cord injury, mitochondrial homeostasis is disrupted, mainly in the distal segments of severed axons. This result in a reduction of adenosine triphosphate levels and subsequent inactivation of adenosine triphosphate-dependent ion pumps required for the regulation of ion concentrations and reuptake of neurotransmitters, such as glutamate. The consequences are calcium overload, reactive oxygen species formation, and excitotoxicity. These events are intimately related to the activation of necrotic and apoptotic cell death programs, and further exacerbate the secondary stage of the injury, being a hallmark of spinal cord injury. This is why restoring mitochondrial function during the early stage of secondary injury could represent a potentially effective therapeutic intervention to overcome the motor and sensory failure produced by spinal cord injury. This

关键词： adenosine triphosphate axonal regeneration creatine mitochondria dysfunction mitochondria spinal cord injury

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Aspects of forest restoration and hydrology:the hydrological function of litter

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Journal of Forestry Research 2022年第2期33卷 543-552页

作者： Luara Castilho Pereira Leonardo Balbinot Marcelle Teodoro Lima julieta Bramorski Kelly Cristina Tonello Hydrology in Forest Ecosystems Lab.(Hidrolef) Department of Environmental SciencesFederal University of São Carlos(UFSCar)SorocabaSão PauloBrazil Hydrology in Forest Ecosystems Lab.(Hidrolef) Department of Environmental SciencesFederal University of Amapá(UNIFAP)MacapáAmapáBrazil

Although forests play important roles in the hydrological cycle,there is little information that relates the water retention capacity of litter in areas under passive restoration,especially in Cerrado *** study relates litter levels to water holding capacity and effective water retention among forest fragments under different passive restoration stages:46,11,and 8 years to better understand litter hydrological functions in the *** retention capacity and effective water retention capacity of litters(unstructured materials,branches and leaves)in the field were monitored on a monthly *** litter accumulation at 46 years was significantly higher than that of the other succession *** litter mass was significantly higher than that of leaves and *** 46-year stage had the highest water holding capacity in the leaf fraction,followed by unstructured material and *** the water holding capacity was lower in the oldest resto-ration,this site showed the highest efficiency under field *** process was quickly reestablished,as the 11-year restoration showed results closer to that for the 46-year stage in comparison to the area at 8 ***,passive restoration plays a key role in soil water mainte-nance due to the influence of litter in Cerrado *** and the imminent need of restoring degraded sites,highlight the need for further studies focused on bet-ter understanding of the process of forest restoration and its temporal effect on soil water recovery dynamics.

关键词： Forest hydrology Litter interception Stemflow Cerrado Águas Perenes Forest Water holding capacity

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Elemental Assessments in Paddy Soil for Geographical traceability of Rice from Peninsular Malaysia

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Rice science 2023年第5期30卷 486-498页

作者： Nazaratul Ashifa Abdullah SALIM Norlida Mat DAUD julieta GRIBOFF Abdul Rahim HARUN Department of Food Sciences Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia Malaysian Nuclear Agency 43000 KajangSelangorMalaysia Innovation Centre for Confectionery Technology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia National Council for Scientific and Technical Research/Centre for Research in Clinical Biochemistry Immunology/Clinical Biochemistry Department Faculty of Chemical ScienceNational University of Córdoba/Ciudad UniversitariaMedina Allende esq.Haya de la Torre s/n5000 CórdobaArgentina

This investigation aimed to establish the geographical traceability of Malaysian rice by assessing the elemental composition in paddy ***-element determination in combination with a chemometric approach was applied to evaluate the elemental concentrations of paddy soil from granaries cultivated with the same rice variety and to assess the relationship between elements in the soil and rice(SAR) system.A total of 29 elements(aluminum,arsenic,barium,bromine,calcium,chlorine,cobalt,chromium,cesium,europium,iron,gallium,hafnium,potassium,lanthanum,lutetium,magnesium,manganese,sodium,rubidium,antimony,scandium,samarium,thorium,titanium,uranium,vanadium,ytterbium and zinc) were successfully determined in paddy soil from Kedah,Selangor and Langkawi by neutron activation analysis.A significant difference(P tric approaches of principal component and linear discriminant analyses demonstrated clear discrimination and highly corrected classification(100%) of the soil samples.A high classification(98.1%) was also achieved by assessing 10 elements(aluminum,arsenic,bromine,chlorine,potassium,magnesium,manganese,sodium,rubidium and zinc),which similarly applied to rice geographical origin *** elements in SAR were also observed for differences in the pattern of correlation and bioaccumulation factor between the ***,the generalized Procrustes analysis showed a 98% consensus between SAR and clear differences between the studied *** canonical correlation analysis demonstrated a significant correlation between the chemical profile of SAR(r~2 = 0.88,P < 0.001).Therefore,the current work model provides a reliable assessment to establish rice provenance.

关键词： soil rice multi-element correlation geographical origin

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High-throughput metabarcoding of SAR11 assemblages from the southwest Atlantic shelf and arid Patagonia:richness and associated rank abundance distributions

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Quantitative Biology 2023年第3期11卷 332-342页

作者： Leandro R.Jones julieta M.Manrique Laboratorio de Virología y Genética Molecular Universidad Nacional dela Patagonia San Juan BoscoTrelew CP 9100Argentina

Background:Massively parallel sequencing of environmental DNA allows microbiological studies to be performed in greater detail than was possible with first-generation *** example,it facilitates the use of approaches hitherto largely applied to flora and fauna,such as rank abundance distribution(RAD)***:Here,we set out to advance the knowledge on ***(SAR11)communities from southern South America using environmental sequences from the open ocean in the Argentine sea,the uncharted Engaño Bay,as well as a river and an oligohaline shallow lake from the Patagonian Steppe *** structures of the SAR11 assemblages present in these ecosystems were dissected by direct and rarefaction-based estimates of species richness,and evaluations of the corresponding abundance distributions(ADs),which was addressed by RAD ***:Microbial community composition analyses revealed that the studied SAR11 assemblages coexist with 27 bacterial ***11 richness was in general very high,but ADs turned out to be highly *** results were compatible with prior knowledge,and similar to that derived from point estimates of ***,our comprehensive dissection allowed for more detailed quantitative comparisons to be made between the environments surveyed,and revealed differences regarding both richness and the underlying ***:Despite SAR11 assemblages being extremely rich,their ADs are very *** and ADs can vary,not only between fresh and salt water,but also between oceanic and coastal marine *** obtained results provide insights on general topics such as adaptation and the contrast between marine and freshwater radiations.

关键词： SAR11 richness species abundance distribution rank abundance distribution Patagonia Argentina

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Amphibian richness along modified riparian areas of central Mexico:conservation priorities

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Ecological Processes 2022年第1期11卷 902-915页

作者： Marco Tulio Oropeza‑Sánchez Ireri Suazo‑Ortuño julieta Benítez‑Malvido Erandi Monroy‑Hernández Roberto Munguía‑Steyer Instituto de Investigaciones en Ecosistemas y Sustentabilidad(IIES) Universidad Nacional Autónoma de MéxicoAntigua Carretera a Pátzcuaro 8701CP 58190 MoreliaMichoacánMexico Instituto de Investigaciones Sobre los Recursos Naturales(INIRENA) Universidad Michoacana de San Nicolás de HidalgoAv.San Juanito Itzícuaro S/NCP 58330 MoreliaMichoacánMexico Facultad de Estudios Superiores Iztacala(FES‑Iztacala) Universidad Nacional Autónoma de MéxicoAv.de los Barrios No.1CP 54090 Tlalnepantla de BazEstado de MéxicoMexico.

Background:Land‑use change frequently affects faunistic populations and *** achieve successful conservation strategies,we need suitable information about species distribution and the causes of extinction *** amphibian species depend on riparian vegetation to complete their life *** 41%of amphibian species are globally threatened,and accurate estimations of population size,species richness and the identification of critical habitats are urgently needed *** evaluate the magnitude of changes in species richness and demography,estimations that include detection probability are *** this study,we employed multi‑species occupancy models to estimate detection probability and the effect of land cover type(i.e.,cropland,artificial pasture,secondary and mature forest)in a 500‑m radius on the occupancy probability and richness of diurnal amphibians in 60 riparian zones in the state of Michoacán in central ***,we evaluated the potential of the endemic salamander Ambystoma ordinarium as a flagship species for the conservation of other native amphibian ***:We registered a total of 20 amphibian species in the diurnal assemblage,of which 10 species are considered at risk of *** found that cropland was the most important land‑use type for explaining amphibian distribu‑tion in riparian zones,with negative effects on most amphibian *** found no differences in species richness between zones with and without *** riparian zones occupied by ***,however,we found a higher number of species at risk of ***:Our findings showed negative effects of croplands on the distribution of most amphibian *** riparian zones are important for the maintenance of native diurnal amphibian communities and *** can act as a flagship species for the conservation of threatened amphibian species.

关键词： Flagship species Habitat quality Occupancy models Salamanders Threatened species

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Sex estimation in a Turkish population using Purkait’s triangle:a virtual approach by 3-dimensional computed tomography(3D-CT)

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Forensic Sciences Research 2022年第2期7卷 97-105页

作者： julieta G.García-Donas Suna Ors Ercan Inci Elena F.Kranioti Oguzhan Ekizoglu Negahnaz Moghaddam Silke Grabherr Centre for anatomy and human identification school of science and engineeringUniversity of DundeescotlandUK Department of radiology Bakirkoy Training and research hospitalistanbulTurkey Department of Forensic science University of cretecreteGreece University center of Legal Medicine Lausanne-Geneva Lausanneswitzerland Unit of Forensic imaging and anthropology University center of Legal Medicine Lausanne-GenevaLausanneswitzerland Swiss human institute of Forensic Taphonomy University center of Legal Medicine Lausanne-GenevaLausanneswitzerland

Sex estimation is considered one of the first steps in the forensic identification *** and morphometrical differences between males and females have been used as means for morphoscopic and metric methods on both cranial and postcranial skeletal *** dry skeletal elements are not available,virtual data can be used as a *** present research explores 3-dimensional(3D)scans from a Turkish population to test a sex estimation method developed by Purkait(2005).Overall,296 individuals were used in this study(158 males and 138 females).Purkait’s triangle parameters were measured on computed tomography(CT)scans obtained from both right and left femora of each patient at the Bakirkoy *** Konuk training Research Hospital(Istanbul,Turkey).Intra-and inter-observer errors were assessed for all variables through technical error of measurements *** asymmetry and sex differences were evaluated using parametric and non-parametric statistical *** and multivariate discriminant function analyses were then *** errors demonstrated an overall agreement within and between experts,as indicated by technical error of measurement(TEM)*** bilateral asymmetries were reported,and all parameters demonstrated a statistically significant difference between males and *** discriminant models were generated by applying single and combined parameters,producing a total correct sex classification ranging from 78.4%to 92.6%.In addition,over 67%of the total sample was accurately classified,with 95%or greater posterior *** study demonstrates the feasibility of 3D sex estimation using Purkait’s triangle on a Turkish population,with accuracy rates comparable to those reported in other *** is the first attempt to apply this method on virtual data and although further validation and standardisation are recommended for its application on dry bone,this research constitutes a signif

关键词： Forensic sciences forensic anthropology sex estimation computed tomography Purkait’s triangle

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The technical and the social:challenges in the conservation of earthen vernacular architecture in a changing world(Jujuy,Argentina)

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Built Heritage 2021年第3期5卷 36-48页

作者： Jorge Tomasi julieta Barada CONICET‑Laboratorio de Arquitecturas Andinas y Construcción con Tierra Instituto de Investigaciones sobre la Naturaleza y la Cultura“Rodolfo Kusch”Universidad Nacional de JujuyRivadavia 642TilcaraProvincia de JujuyArgentina

Vernacular earthen architecture presents a series of relevant conservation challenges that involve designing solutions for diferent kinds of alterations and *** challenges of a social nature simultaneously arise and are related,among other factors,to the participation of local communities and the actions of diferent institutional *** these phenomena has generally been approached from perspectives that take technical considera‑tions and social dynamics as separate *** current global context has resulted in an acceleration of changes in these dynamics,in terms of both techniques and management models,giving rise to the need to develop compre‑hensive conceptual and methodological approaches through which these challenges should be addressed jointly by recombining the technical and the *** paper will analyse the main problems afecting vernacular architectures in three communities in northern Argentina,where earthen techniques have been very *** will refect on various potentially useful theoretical frameworks,incorporating concepts from the anthropology of technology and methodological approaches from an ethnography of conservation as a way to work with multiple ontologies.

关键词： Heritage ethnography Vernacular architecture Anthropology of techniques

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International Collaboration in Brazilian Higher Education

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Frontiers of Education in China 2015年第1期10卷 7-22页

作者： Creso SÁ julieta GRIECO Ontario Institute for Studies in Education University of TorontoTorontoOntario M5S 1V6Canada

This paper examines the approach Brazil has taken to promote the internationalization of higher education over the last *** key areas are identified:human resources development,institution building,and international *** analyses of initiatives in these areas demonstrate that Brazil does not follow global trends such as the creation of world-class universities or the pursuit of“excellence initiatives”to help universities reach higher positions in global ***,recent strategies for international collaboration in higher education follow variegated domestic goals that encompass the logics of foreign policy and the internal priorities of federal research and education *** nature and limitations of these strategies are discussed.

关键词： Brazilian higher education internationalization higher education policy international collaboration

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The spectrum of building block conformers sustains the biophysical properties of clinically-oriented self-assembling protein nanoparticles

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Science China Materials 2022年第6期65卷 1662-1670页

作者： Eric Voltà-Durán julieta M Sánchez Hèctor-López-Laguna Eloi Parladé Laura Sánchez-García Alejandro Sánchez-Chardi Ario de Marco Ugutz Unzueta Esther Vázquez Antonio Villaverde Institut de Biotecnologia i de Biomedicina Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain Departament de Genètica i de Microbiologia Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain CIBER de Bioingeniería Biomateriales y Nanomedicina(CIBER-BBN) Bellaterra 08193BarcelonaSpain Instituto de Investigaciones Biológicas y Tecnológicas(IIBYT)(CONICET-Universidad Nacional de Córdoba) ICTA&Cátedra de Química BiológicaDepartamento de QuímicaFCEFyNUNC.Av.Velez Sarsfield 1611X 5016GCA CórdobaArgentina Servei de Microscòpia Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain Departament de Biologia Evolutiva Ecologia i Ciències AmbientalsFacultat de BiologiaUniversitat de Barcelona08028 BarcelonaSpain Laboratory for Environmental and Life Sciences University of Nova GoricaNova Gorica 5000Slovenia Biomedical Research Institute Sant Pau(IIB Sant Pau) Sant Antoni Ma Claret 16708025 BarcelonaSpain

Histidine-rich peptides confer self-assembling properties to recombinant proteins through the supramolecular coordination with divalent *** fact allows the cost-effective,large-scale generation of microscopic and macroscopic protein materials with intriguing biomedical *** such materials,resulting from the simple bioproduction of protein building blocks,homomeric nanoparticles are of special value as multivalent interactors and drug ***,we have here identified that the assembly of a given His-tagged protein might render distinguishable categories of self-assembling protein *** fact has been scrutinized through the nanobody-containing fusion proteins EM1-GFP-H6 and A3C8-GFP-H6,whose biosynthesis results in two distinguishable populations of building *** one of them,the assembling and disassembling is controllable by ***,a second population immediately self-assembles upon purification through a non-regulatable pathway,rendering larger nanoparticles with specific biological *** structural analyses of both model proteins and nanoparticles revealed important conformational variability in the building *** fact renders different structural and functional categories of the final soft materials resulting from the participation of energetically unstable intermediates in the oligomerization *** data illustrate the complexity of the Hismediated protein assembling in recombinant proteins but they also offer clues for a better design and refinement of protein-based nanomedicines,which,resulting from biological fabrication,show an architectonic flexibility unusual among biomaterials.

关键词： recombinant proteins self-assembling protein materials nanoparticles biomaterials

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