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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

Accretion in strong field gravity with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 45-73页

作者： Alessandra De Rosa Phil Uttley LiJun Gou Yuan Liu Cosimo Bambi Didier Barret Tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson Cristina Baglio Pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Ammando Thomas Dauser Melania Del Santo Barbara De Marco Tiziana Di Salvo Chris Done Michal Dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu Linares Zhu Liu Thomas J.Maccarone julien malzac Antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini Paul T.O'Brien Julian P.Osborne Pierre Olivier Petrucci Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Francesco Tombesi Gabriel Torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou INAF-Istituto di Astrofisica e Planetologie Spaziali Via Fosso del Cavaliere Anton Pannekoek Institute for Astronomy University of Amsterdam National Astronomical Observatories Chinese Academy of Science Institute of High Energy Physics Chinese Academy of Science Center for Field Theory and Particle Physics and Department of Physics Fudan University IRAP Universitéde ToulouseCNRSUPSCNES INAF-Osservatorio Astronomico di Brera Department of Physics and Astronomy The University of MississippiUniversity Dipartimento di Matematica e Fisica Universitàdegli studi Roma Tre University of British Columbia INAF-Osservatorio Astronomico di Roma INFN-Roma 2 c/o Dipartimento di Fisica II Universit?di Roma"Tor Vergata" Dipartimento di Fisica Universitàdegli Studi di Roma"La Sapienza"&Sezione INFN Roma1 Department of Physics University of OxfordClarendon Laboratory Astronomical Institute Academy of Sciences School of Astronomy and Space Science Nanjing University MIT Kavli Institute for Astrophysics and Space Research Institut für Astronomie und Astrophysik Eberhard Karls Universität Department of Physics Anhui Normal University Department of Astronomy and Institute of Theoretical Physics and Astrophysics Xiamen University CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of China Instituto de Astrofísica de Andalucia(CSIC) Glorieta de la Astronomía s/n INAF-Istituto di Astrofisica Spaziale e Fisica cosmica di Bologna Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Institute of Physics and Research Centre for Computational Physics and Data Processing Faculty of Philosophy&ScienceSilesian University in OpavaíBezru?ovo nám. Department of Physics Middle East Technical University Department of Astronomy and Astrophysics Tata Institute of Fundamental Research Dipartimento di Fisica Universit?di Pisa&INFN INAF-Osservatorio Astrofisico di Arcetri INAF-Osservatorio Astronomico di Padova INFN-TIFPA Trento Ins

In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced "spectral-timing-polarimetry" techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process.

关键词： X-ray black holes physics accretion

Origin of superconductivity in hole doped SrBiO_(3) bismuth oxide perovskite from parameter-free first-principles simulations

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npj Computational Materials 2023年第1期9卷 2044-2052页

作者： julien Varignon Laboratoire CRISMAT CNRS UMR 6508ENSICAENNormandie Université6 boulevard Maréchal JuinF-14050Caen Cedex 4France

The recent discovery of nickel oxide superconductors have highlighted the importance of first-principles simulations forunderstanding the formation of the bound electrons at the core of superconductivity. Nevertheless, superconductivity in oxides isoften ascribed to strong electronic correlation effects that density functional theory (DFT) cannot properly take into account,thereby disqualifying this technique. Being isostructural to nickel oxides, Sr_(1-x)K_(x)BiO_(3) superconductors form an ideal testbed forunveiling the lowest theory level needed to model complex superconductors and the underlying pairing mechanism yieldingsuperconductivity. Here I show that parameter-free DFT simulations capture all the experimental features and related quantities of Sr_(1-x)K_(x)BiO_(3) superconductors, encompassing the prediction of an insulating to metal phase transition upon increasing the K dopingcontent and of an electron-phonon coupling constant of 1.22 in sharp agreement with the experimental value of 1.3 ± 0.2. Theproximity of a disproportionated phase is further demonstrated to be a prerequisite for superconductivity in bismuthates.

关键词： superconductivity bismuth parameter

植物系统发生海报——以演化视角介绍植物多样性的科教资料项目

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生物多样性 2025年

作者：蒋陈焜郁文彬饶广远黎怀成 julien B.Bachelier Hartmut H.Hilger Theodor C.H.Cole 北京大学生命科学学院蛋白质与植物基因研究国家重点实验室北京大学前沿交叉学科研究院北京大学-清华大学生命科学联合中心中国科学院西双版纳热带植物园综合保护中心/云南省热带雨林与亚洲象保护重点实验室 Dahlem Centre of Plant Sciences (DCPS)， Institute of Biology， Structural and Functional Plant Diversity， Freie Universit?t Berlin

中国的植物多样性保护行动虽然提升了公众对多样性的认识，但这些努力往往未能深入到理解植物多样性演化及其保护的深层意义。从演化的视角进行植物多样性宣传教育，有利于促进对多样性的综合理解，增进对多样性保护的认可。然而， ... 详细信息

中国的植物多样性保护行动虽然提升了公众对多样性的认识，但这些努力往往未能深入到理解植物多样性演化及其保护的深层意义。从演化的视角进行植物多样性宣传教育，有利于促进对多样性的综合理解，增进对多样性保护的认可。然而，现有资料多集中于物种的识别、鉴定与分类，缺乏从生物演化角度对植物多样性进行系统性介绍的内容。本文介绍了一个具有全球影响力的科教资料案例——由美裔德国植物学家Theodor C. H. Cole发起的植物系统发生海报(Plant Phylogeny Posters)项目。该项目通过整合最新的系统与演化植物学研究成果，以系统发生为线索介绍植物多样性及其亲缘关系，旨在利用系统发生树所蕴含的丰富演化思想内涵，启发读者理解植物多样性与演化。海报以系统发生树结合植物类群的形态、地理分布、物种数量等数据信息，直观展示了多个分类等级的重要类群的演化历史。在数十所大学和科研机构的45位研究人员的努力下， 70张系统发生海报已被翻译成中文，并向所有人免费开放获取。这一科教项目有望为增进公众深入理解植物多样性及其保护行动提供宝贵的资源和帮助。

关键词：植物多样性演化系统发生科教资料

Necessary Optimality Conditions for Semi-vectorial Bi-level Optimization with Convex Lower Level:Theoretical Results and Applications to the Quadratic Case

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Journal of the Operations Research Society of China 2021年第3期9卷 691-712页

作者： julien Collonge University of New Caledonia New Caledonia 98800France

This paper explores related aspects to post-Pareto analysis arising from the multicriteria optimization *** consists of two main *** the first one,we give first-order necessary optimality conditions for a semi-vectorial bi-level optimization problem:the upper level is a scalar optimization problem to be solved by the leader,and the lower level is a multi-objective optimization problem to be solved by several followers acting in a cooperative way(greatest coalition multi-players game).For the lower level,we deal with weakly or properly Pareto(efficient)solutions and we consider the so-called optimistic problem,*** followers choose amongst Pareto solutions one which is the most favourable for the *** order to handle reallife applications,in the second part of the paper,we consider the case where each follower objective is expressed in a quadratic *** this setting,we give explicit first-order necessary optimality ***,some computational results are given to illustrate the paper.

关键词： Bi-level optimization Multi-objective optimization Post-Pareto optimization Multi-objective convex optimization Quadratic optimization

A NEW SIMPLE 2-D PIECEWISE LINEAR MAP

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Journal of Systems Science & Complexity 2010年第2期23卷 379-389页

作者： Zeraoulia ELHADJ julien Clinton SPROTT Department of Mathematics University of Tébessa Department of Physics University of Wisconsin

A new simple piecewise linear map of the plane is presented and analyzed, then a detailed study of its dynamical behaviour is described, along with some other dynamical phenomena, especially fixed points and their stability, observation of a new chaotic attractors obtained via border collision bifurcation. An important resuk about coexisting chaotic attractors is also numerically studied and discussed.

关键词： Border collision bifurcation new chaotic attractor piecewise linear map.

Large shear rate behavior for the Hebraud-Lequeux model Dedicated to the NSFC-CNRS Chinese-French summer institute on fluid mechanics in 2010

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Science China Mathematics 2012年第2期55卷 435-452页

作者： OLIVIER julien Archimedes Center for Modeling Analysis and Computation University of Crete Iraklio 71003 Greece

The H@braud-Lequeux model is a model describing the flow of soft glassy material in a simple shear flow configuration. It is given by a kinetic/Fokker-Planck-type equation whose coefficients depend on the shear rate of the experiment. In this paper we want to study what happens to the stationary solutions of this model when the shear rate is asymptotically large. In order to do that, we expand the solution of the equation using singular perturbation tools. In the end, we rigorously prove the estimate of Hebraud and Lequeux that the material asymptotically behaves as a Newtonian fluid.

关键词： singular limit non-Newtonian rheology kinetic equations

Comparing the terrain reversal effect in satellite images and in shaded relief maps:an examination of the effects of color and texture on 3D shape perception from shading

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International Journal of Digital Earth 2019年第4期12卷 442-459页

作者： Arzu Çöltekin julien Biland Department of Geography University of ZurichZurichSwitzerland Department of Geography University of BernBernSwitzerland

Terrain reversal effect(TRE)causes reversed 3D shape perception in satellite images and shaded relief maps(SRMs),and introduces difficulties in identifying landforms such as valleys and *** this paper,in a controlled laboratory experiment,we compare how well 27 participants could identify valleys and ridges over 33 locations using SRMs,color satellite images and grayscale satellite *** main depth cue is shadow both in vertical-view images and ***,the presence of texture and color in images also affect 3D shape *** our participants experience the illusion strongly:with the SRMs,it is very severe(2%accuracy),with grayscale images low but considerably better than SRMs(17.6%accuracy),and slightly worse with color imagery(15.3%accuracy).These differences between SRMs and imagery suggest that the participants who are able to bypass the illusion consciously or subconsciously interpret the photographic *** support this observation further with a cue-strength ***,we provide exploratory analyses of the effects of expertise,global convexity bias,and bistable *** original empirical observations serve towards a better understanding of this visual illusion,and contribute towards nuanced and appropriate solutions to correcting for TRE differently for satellite images and SRMs.

关键词： Terrain reversal relief inversion false topographic perception phenomenon photo interpretation visual illusion user study bistable perception global convexity bias

Pharmacological attenuation of blood pressure variability

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Acta Pharmacologica Sinica 2005年第11期26卷 1288-1289页

作者： Claude julien France Laboratoire de Physiologie Faculte de Pharmacie Lyon 69373 Universite Claude Bernard Lyon 1

Over the past few years, the research team of ProfessorDing-feng SU has reported an impressive quantity of experimental data about the relationships between blood pressurevariability (BPV) and end-organ damage, a topic of obviousclinical interest. This research work has been summarized ina paper that appeared in the August issue of the renownedjournal Trends in Pharmacological Sciences[1]. The studiesby Su et al provide convincing evidence that BPV is an independent cardiovascular risk factor that should be considered as such and, therefore, might become an important target for therapeutic interventions. Besides these exciting perspectives in the prevention and treatment of cardiovascular

关键词： BPV Pharmacological attenuation of blood pressure variability