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Phytochemical Screening and Toxicity Assessment of Imperata cylindrica (L.) P. Beauv. (Poaceae) Raw Extracts with Brine Shrimp (Artemia salina) Lethality Assay

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Journal of Biosciences and Medicines 2022年第8期10卷 153-171页

作者： Anne Marie Léticia Konan koffi julien golly Adou koffi Mathieu Kra Amissa Augustin Adima Essis Esmel Claude Lohoues Biochemistry Department Medical Sciences Faculty Felix Houphouet-Boigny University Abidjan C&ocirc te d’Ivoire Laboratory of the Biology of Immunity Center Pasteur Institute Abidjan C&ocirc te d’Ivoire Pharmacodynamics Biochemical Laboratory Felix Houphouet-Boigny University Abidjan C&ocirc te d’Ivoire Research Department Water Chemicals and Natural Substances INP-HB Yamoussoukro C&ocirc te d’Ivoire

Background: Herbal medicinal preparations are used as dietary supplements for disease prevention and as alternative/complementary medicine. The growing interest in herbal medicine raises the question of its safety and efficacy. Numerous recorded cases of intoxication and toxicological studies reveal that medicinal plants can be toxic, which hinders their safe use. Plant intoxications related to a variety of factors include plant organs and many extraction solvents. Little toxicological data on medicinal plants is available. The need to investigate is important for safe use. Imperata cylindrica, a poaceae, is one of the medicinal plants for which few toxicological data are available. Materials & Methods: To expand toxicological data, water, 70% ethanol, and 30% acetone extracts of the leaves and roots, obtained by maceration and reflux methods, were used for phytochemicals molecules qualitative detection and toxicity test by the brine shrimp lethality assay. Results: The qualitative analysis of the different extracts revealed the presence of alkaloids, polyphenolic compounds, saponins, and polyterpenoids. The toxicity endpoint was lethal concentration 50 (LC50). The leaves’ extracts LC50 was between 489.78 μg/mL and 1066.6 μg/mL. As for the root extracts, the LC50 was between 341.98 μg/mL and 1530 μg/mL. Discussion: The different compounds’ presence justifies the use of Imperata cylindrica as a medicinal plant. According to Clarkson classification the root extracts are moderately toxic (LC50: 168.47 μg/mL), and leaf extracts are weakly toxic (LC50: 527.25 μg/mL). The extrapolation made in relation to the Gosselin, Smith, and Hodge scale, allows us to characterize the Imperata cylindrica root and leaf extracts as non-toxic to humans by oral route. Conclusion: This result can be a base for more precise toxicological studies.

关键词： Imperata cylindrica Poaceae Phytochemical Analyses Cytotoxicity Artemia salina

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The Institut Pasteur of Côte D’Ivoire (Ivory Coast) in the Emergency Management of Air Travellers during the COVID-19 Pandemic: A Unique Experience in Supporting the Response Strategy in Côte D’Ivoire from 2021 to 2022

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Open Journal of Applied Sciences 2023年第5期13卷 739-745页

作者： Blessa Jean-Claude Anné Tchepé Flore Bernadette Diplo Kouassi Bernadin Kouame Serge Stéphane Yao koffi julien golly Arouna Sidibe Jacques Kouakou Kouakou Serge Aoussi Mireille Dosso Department of Bacteriology-Virology Institut Pasteur de C&#244te d’Ivoire (IPCI) Abidjan C&#244te d’Ivoire Molecular Genetics Platform of The Institut Pasteur de Cô te d’Ivoire (IPCI) Abidjan C&#244te d’Ivoire Environment and Health Department Institut Pasteur de C&#244te d’Ivoire (IPCI) Abidjan C&#244te d’Ivoire Department of Parasitology-Mycology Institut Pasteur de C&#244te d’Ivoire (IPCI) Abidjan C&#244te d’Ivoire Department of Immunology Institut Pasteur de C&#244te d’Ivoire (IPCI) Abidjan C&#244te d’Ivoire Technical and Technological Department (IPCI) Abidjan C&#244te d’Ivoire

Since its outbreak in December 2019 in Wuhan Province (China), the Coronavirus (COVID-19) disease quickly spread around the world in such a way that most response plans were outdated. There was an urgent need to change and adapt response strategies as the virus globally spread. Entire firms and economies were brought to a standstill in order to reduce the virus’ capacity to spread and to limit some of the short-term impacts in order to save time and find out solutions to come back to a more or less normal way of life. Thus, most of the countries that closed their air, sea and land borders had to reopen them progressively, with travel restrictions submitted to rigid controls. In Côte d’Ivoire, as in all other countries, air travellers leaving the territory were required to provide a certificate for a negative COVID-19 test, valid for 24 to 72 hours depending on the country of destination. However, the national system implemented could not provide a result before 48 hours. The objective of this work was to develop an alternative strategy to the system for air travellers who were in a hurry and those who had a computer bug in obtaining their result. A total of 38,444 air travellers benefited from this strategy implemented by the Institut Pasteur de Côte d’Ivoire during these two years.

关键词： COVID-19 Institut Pasteur de Côte D’Ivoire (IPCI) Air Travellers Emergencies Strategy Hurry Computer Bug

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Phytochemical Characterization of Three Plants and Their Antisickling Activity in the Management of Sickle Cell Disease

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Journal of Biosciences and Medicines 2020年第6期8卷 100-112页

作者： Tatiana Kangah Mireille Kplé Joel Akakpo-Akue julien koffi golly Yvette Fofie Marcel Gnamien Ahon Mattieu Adou Kra Ibrahime Sanogo Antoinette Chiayé C. Yapo-Crezoit Laboratory of Biology and Health UFR Biosciences Université Félix Houphou&#235 t-Boigny (UFHB) Abidjan C&#244 te d’Ivoire Immunity Biology Center Institut Pasteur de C&#244 te d’Ivoire Abidjan C&#244 te d’Ivoire UFR of Pharmaceutical and Biological Sciences Université Félix Houphou&#235 t-Boigny (UFHB) Abidjan C&#244 te d’Ivoire Clinical Haematology Department University Hospital of Yopougon Abidjan C&#244 te d’Ivoire

Natural plant products have been used by the population of the south-eastern part of Côte d’Ivoire in the management of sickle cell anemia. This study was aimed at investigating the antisickling activity of the hydro-ethanolic extract of a combination of the leaves of J. secunda, J. gossypiifolia and P. nigrescens. These three plants species were used in the Ivorian traditional herbal medicine. Preliminary phytochemistry was carried out using standard methods. As for the sickling reversal test, the Hb SS blood sickling was induced with 2% sodium metabisulfite. After 120 minutes of incubation, the plant extract was added. Every 30 minutes for a period of 120 minutes, a drop of the prepared solution was observed at (40×) magnification and the percentage of reversion calculated. The phytochemical analysis revealed the presence of Alkaloids, Flavonoids, Polyphenols, Catechic Tannins, Sterols and Polyterpenes. The results of the reversal test showed that the percentage of sickling reversal effect of the combination of the plants (75.00 ± 4.33b,c) was highly superior than the negative control (10.17 ± 0.55d) but was significantly (p J. secunda: 83.50 ± 2.33<

关键词： Sickle Cell Disease Antisickling Activity Hydro-Ethanolic Extract J. gossypiifolia P. nigrescens J. secunda Côte d’Ivoire

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Contribution of COVID-19 Pandemic on the Human Development of Young Researchers at Institut Pasteur de Côte d’Ivoire

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Advances in Infectious Diseases 2022年第4期12卷 646-655页

作者： Yao Serge Stéphane Kouamé Kouassi Bernadin Kragbe Daugbley Guy Roland golly koffi julien Diplo Tchepé Flore Bernadette Anné Bléssa Jean Claude Dosso Mireille Department of Parasitology-Mycology (IPCI) Institut Pasteur de C&#244 te d’Ivoire (IPCI) Abidjan C&#244 te d’Ivoire Department of Health Environment Institut Pasteur de C&#244 te d’Ivoire (IPCI) Abidjan C&#244 te d’Ivoire Reception and Collection Unit Institut Pasteur de C&#244 te d’Ivoire (IPCI) Abidjan C&#244 te d’Ivoire Department of Technique and Technology (IPCI) Institut Pasteur de C&#244 te d’Ivoire (IPCI) Abidjan C&#244 te d’Ivoire Department of Bacteriology and Virology (IPCI) Institut Pasteur de C&#244 te d’Ivoire (IPCI) Abidjan C&#244 te d’Ivoire

The response to the COVID-19 pandemic has compelled Institut Pasteur de Cote d’Ivoire (IPCI) to set up strategies for an outstanding mobilisation of human resources to fight against it. Among these strategies, we can quote the screening of people requesting COVID-19 tests at IPCI for emergency travel after the lifting of flight restrictions. Newly recruited Young researchers at IPCI, as well as Ph.D. students and trainees, were mobilised. This document describes firstly, the benefits, knowledge acquired, and difficulties encountered, and secondly, recommendations to be followed for a future large-scale epidemic. This study helped to outline some achievements, such as upgrading the talents of young researchers, strong collaboration between young researchers from different fields, and between IPCI and other institutions. The lessons learned are numerous, including mood and stress management. The difficulties encountered during this study are mainly misunderstandings, increased workload, and insufficient awareness of COVID-19 travel test procedures. These results are relevant for a possible pandemic management in our country, as well as in other African countries.

关键词： Pandemic COVID-19 Human Development Management Travelers

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