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Disaster Awareness and Preparedness Among Older Adults in Canada Regarding Floods, Wildfires, and Earthquakes

International Journal of Disaster Risk Science 2024年第2期15卷 198-212页

作者： Evalyna Bogdan Rachel Krueger julie wright Kyle Woods Shaieree Cottar School of Administrative Studies Disaster and Emergency Management ProgramYork UniversityTorontoOntario M3J 1P3Canada Department of Geography and Environmental Management University of WaterlooWaterlooOntario N2L 3G1Canada Partners for Action Faculty of EnvironmentUniversity of WaterlooWaterlooOntario N2L 3G1Canada

Older adults are significantly impacted by natural hazards and disasters that are exacerbated by climate change. Understanding their awareness and preparedness is essential for enhancing disaster resilience. This study investigated the attitudes, actions, and recommendations of older adults regarding natural hazards that pose risks in their geographic area—specifically floods, wildfires, and/or earthquakes in Canada. Methods for this study included survey and focus groups with older adults(n = 161 and n = 10, respectively) and other high-risk groups from across Canada, that are vulnerable to these natural hazards. The main findings from this study are that current awareness and preparedness among older adults is low, though stronger perceptions of risks are associated with risks specific to geographic locations where respondents live. Several barriers, such as hazard vulnerability misperceptions, cost-related reasons, and lack of hazard awareness have resulted in low awareness and preparedness among these populations. The two main recommendations arising from this research are:(1) improve awareness and preparedness with tailor-made emergency preparedness materials for older adults;and(2) adopt community-based approaches to disaster preparedness through existing community groups to strengthen social connections with a focus on locally specific hazards. The findings from this research can be applied to other hazards, including heatwaves and pandemics.

关键词： Canada Community-based disaster risk management Disaster awareness and preparedness Disaster resilience Natural hazards Older adults

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从支付者角度考察成人咽炎的经济负担

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中国药物经济学 2009年第2期4卷 64-73页

作者： Alan R Salkind julie M wright 李凌艳吴晶

目的:虽然临床治疗指南不提倡给患有病毒性咽炎的成人患者处方抗生素,但是内科医生还是经常这样做。从支付者角度考察这种医疗行为的经济负担还没有被研究过。本研究的目的就是评估这种行为所产生的费用。方法:从支付者角度研究咽炎管... 详细信息

目的:虽然临床治疗指南不提倡给患有病毒性咽炎的成人患者处方抗生素,但是内科医生还是经常这样做。从支付者角度考察这种医疗行为的经济负担还没有被研究过。本研究的目的就是评估这种行为所产生的费用。方法:从支付者角度研究咽炎管理的疾病负担(Cost-of-Illness)。利用美国国家流动医疗调查(National Ambulatory Medical Care Survey)的数据获得当前成人咽炎流动门诊和抗生素处方的模式。将直接成本和抗生素耐药成本汇总估计咽炎管理的总费用。耐药成本通过建立一个将抗生素使用量与耐药性肺炎链球菌感染相关联的模型计算。依照美国传染病学会(IDSA)临床治疗指南有关咽炎管理的相关规定,对当前医疗模式的成本产出与非抗生素治疗的成本产出进行了比较和敏感度分析。结果:在基础分析中,当前医疗模式的总费用为12亿美元,其中抗生素耐药的成本占总费用的36%(4.26亿美元)。如果遵从IDSA临床治疗指南,医疗成本可以降至5.59亿美元,其中抗生素耐药成本占6.8%(3790万美元)。遵从IDSA临床治疗指南并减少门诊次数的30%,可以降低成本至3.72亿美元,其中抗生素耐药成本占1.4%(530万美元)。采用非抗生素治疗策略可以节省额外的8800万美元成本。结论:当前的医疗模式表明在咽炎治疗中处方抗生素有着广泛的经济影响,给支付者带来很大的经济负担,然而遵从临床治疗指南可以减少耐药性,降低成本。利益相关者、支付者、内科医生和其它医疗提供者应该不断加强对临床治疗指南的依从性,从而降低医疗成本。

关键词：成人抗生素耐药疾病负担分析咽炎

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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels julie D.De Schutter Lies De Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

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动画片与明星身体

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当代动画 2022年第1期 121-128页

作者： [英]朱莉·洛巴佐·赖特吴晓宇(译) 英国华威大学影视研究系北京电影学院文学系

动画片在漫长的历史中,始终在征用电影明星,然而,有关电影明星与动画片之间关系的研究却很少。该文通过考察一个在动画片中使用电影明星形象的特例,即《海洋奇缘》中的道恩·"巨石"·强森,探讨借助电影明星个体与动画媒介呈现的白日梦... 详细信息

动画片在漫长的历史中,始终在征用电影明星,然而,有关电影明星与动画片之间关系的研究却很少。该文通过考察一个在动画片中使用电影明星形象的特例,即《海洋奇缘》中的道恩·"巨石"·强森,探讨借助电影明星个体与动画媒介呈现的白日梦与幻觉,并对人类和动画身体投以特殊的一瞥。

关键词：电影明星动画片道恩·强森身体《海洋奇缘》

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A MEASURE OF SUPPLY CHAIN COMPLEXITY INCORPORATING VIRTUAL ARCS

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Journal of Systems Science and Systems Engineering 2015年第4期24卷 486-499页

作者： julie Drzymalski Department of Industrial Engineering and Engineering Management Western New England University

Increased globalization, as well as the ability to have virtual supply chain partners, has had numerous effects on supply chains. While some of these effects are positive, making more resilient supply chains, there are also the negative effects of scale ~nd complexity, making these supply chains more challenging than ever to manage. Having a means to measure the complexity is crucial for today＇s managers to make more informed decisions. This measure must not only account for the number of arcs, but the amount of information and material carried on it, as well as incorporate the benefit that virtual arcs add to the network by increasing efficiency and reducing information, product and financial transfer costs and time. This research utilizes newer models in network clustering and complexity theory to make them applicable to supply chains and creates a new, practical approach to measuring supply chain complexity which can be easily implemented by practitioners.

关键词： Supply chain complexity clustering virtual networks

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Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms

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World Journal of Gastrointestinal Oncology 2016年第8期8卷 615-622页

作者： Vivian Weiss julie Dueber Jesse P wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi Department of Pathology Microbiology and Immunology Vanderbilt University Medical Center Department of Surgery Surgical Oncology Vanderbilt University Medical Center Department of Surgery Surgical Oncology University of Miami Hospital

AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC.

关键词： β-catenin Familial adenomatous polyposis Pancreatic neuroendocrine neoplasm Adenomatous polyposis coli E-cadherin

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γδ T cells,Tregs and epithelial cells interact with IL-33 in the lung

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Cellular & Molecular Immunology 2021年第4期18卷 790-791页

作者： julie Darrigues julie C.Ribot Institute de Medicina Molecular Joao Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisbonPortugal

Mucosal barriers are composed of an organized network of tightly joined cells that act as a critical first line of defense against *** their tissue hom ing properties and ability to sense environmental signals,gamma d... 详细信息

关键词： lung delta network

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Coagulation enhanced electrokinetic settling of mature fine oil sands tailings

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International Journal of Mining Science and Technology 2019年第2期29卷 199-208页

作者： Shriful Islam julie Q.Shang Department of Civil and Environmental Engineering The University of Western Ontario Department of Civil and Environmental Engineering Shahjalal University of Science and Technology

The mature fine oil sand tailings(MFT) remain as slurry in the tailings pond for long time. The dewatering and consolidation of MFT for sustainable management is an important task for the mining industry. The objective of this study is to accelerate electrokinetic settling of MFT solids in suspensions in presence of optimal coagulant. In the first phase, optimal coagulant and coagulant dosage for settling of suspension are identified, i.e., ferric chloride at 350 mg/L. It is found that the chemical treatment is not much effective; the final solid content of the sediment is only 6.48% from an initial of 5%. In the second phase,combined coagulation and electrokinetic treatment is carried out to enhance the settling effect. The direct electric current is applied in continuous and intermittent modes on MFT suspensions placed in electrokinetic cell. The results show the final solid content reaches 23.74% under the combined application of350 mg/L ferric chloride and 218.75 V/m applied voltage gradient in the continuous mode. The intermittent current mode with 40% save in power consumption produces a settled sediment having 20.84% final solid content.

关键词： Electrokinetics Electrophoresis Coagulation Settling Voltage gradient MFT

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Could serotonin play a role in abnormal brain outcomes in fetal growth restriction?

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Neural Regeneration Research 2023年第3期18卷 543-544页

作者： Kate Beecher julie A.Wixey UQ Centre for Clinical Research Faculty of MedicineThe University of QueenslandHerstonQLDAustralia

Fetal growth restriction(FGR)describes a fetus that has not grown to its expected biological potential in *** can result from maternal,fetal,or placental complications,though it is commonly caused by placental *** prolonged hypoxic environment the FGR fetus is exposed to has detrimental effects on the newborn,which extends to adverse long-term neurological outcomes in a significant proportion of FGR infants(Malhotra et al.,2019).Unfortunately,there are currently no therapies to reduce the adverse neurological outcomes in *** injury is evident in the FGR brain,and therefore understanding which neurons are lost and how they are lost will aid in the selection of treatment options for FGR.

关键词： fetal fetus insufficiency

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Understanding the timing of brain injury in fetal growth restriction:lessons from a model of spontaneous growth restriction in piglets

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Neural Regeneration Research 2023年第2期18卷 322-323页

作者： Hannah Musco julie A.Wixey UQ Centre for Clinical Research Faculty of MedicineUniversity of QueenslandQueenslandAustralia

Fetal growth restriction(FGR)is one of the most common contributors to increased risk of mortality in the fetal/neonatal period and long-term morbidity in the infant(Malhotra et al.,2019).FGR can arise from many pathophysiological processes associated with maternal,fetal,genetic,or placental compromise;however,placental insufficiency is the most common cause of *** insufficiency during pregnancy results in chronic fetal hypoxia where a lack of oxygen and nutrients supply to the developing fetus impacts normal development of the fetus.

关键词： fetal fetus insufficiency

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