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Willingness to pay to reduce future risk:a fundamental issue to invest in prevention behaviour

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Economic and Political Studies 2021年第1期9卷 17-36页

作者： Jim Engle-Warnick julie Héroux Claude Montmarquette Department of Economics McGill UniversityMontrealCanada Centre for Interuniversity Research and Analysis on Organisation(CIRANO) MontrealCanada Department of Economics University of MontrealMontrealCanada

At the core of the decision to invest in prevention are individuals who face immediate real costs against future and uncertain *** this paper,we elicit subjects’willingness to pay to reduce future *** our experiments,subjects are given a cash endowment and a risky *** report their willingness to pay to exchange the risky lottery for a safe *** play the lottery either immediately,eight weeks later,or 25 weeks ***,both the lottery and the future are sources of uncertainty in our *** two additional treatments,we control for future uncertainty with a continuation probability(a stopping rule),constant and independent across periods,that simulates the chances of not being able to return to play the lottery after 8 and 25 *** find evidence for a present bias in both the time-delay sessions and the continuation probability sessions,suggesting that this bias robustly persists in environments including both risk and future ***,eliciting prevention behaviour is a major challenge.

关键词： Hyperbolic discounting uncertainty risk experiments present bias prevention behaviour

Two awn-development-related peptides,GAD1 and OsEPFL2,promote seed dispersal and germination in rice

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Molecular Plant 2023年第3期16卷 485-488页

作者： Jing Jin Luling Xiong julie E.Gray Bin Hu Chengcai Chu Guangdong Laboratory for Lingnan Modern Agriculture State Key Laboratory for Conservation and Utilization of Subtropical Agro-BioresourcesCollege of AgricultureSouth China Agricultural UniversityGuangzhou 510642China Key Laboratory for Enhancing Resource Use Eficiency of Crops in South China Ministry of Agriculture and Rural AffairsSouth China Agricultural UniversityGuangzhou510642China Guangdong Provincial Key Laboratory of Plant Molecular Breeding South China Agricultural UniversityGuangzhou 510642China Plants Photosynthesis and SoilSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK

In nature,seed dispersal and germination are crucial for plant survival and *** mechanisms have evolved that enhance the success of these events(Peart,1981;Bewley,1997),and the widespread distribution of grass species has been associated with the evolution of these *** of these mechanisms are associated with characteristics that are intrinsic to the seed,such as awn development,seed shattering,and germination(Ntakirutimana et al.,2019).Awns and/or other seed appendages often help mature seeds to disperse widely and germinate under various challenging environments(Elbaum et al.,2007).

关键词： dispersal traits germination

Local buckling of thin plate on tensionless elastic foundations under interactive uniaxial compression and shear

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Theoretical & Applied Mechanics Letters 2018年第2期8卷 75-82页

作者： Iianghui Dong Xing Ma Yan Zhuge julie E.Mills School of Natural and Built Environments University of South AustraliaAdelaideSA 5095Australia

This paper uses a mathematical method to develop an analytical solution to the local buckling behaviour of long rectangular plates resting on tensionless elastic Winkler foundations and under combined uniform longitudinal uniaxial compressive and uniform in-plane shear loads. Fitted formulas are derived for plates with clamped edges and simplified supported edges. Two examples are given to demonstrate the application of the current method： one is a plate on tensionless spring foundations and the other is the contact between the steel sheet and elastic solid foundation. Finite element （FE） analysis is also conducted to validate the analytical results. Good agreement is obtained between the current method and FE analysis.

关键词： Buckling coefficient Contact buckling Winkler foundation Interaction curve Finite element analysis

Non-ischemic complications of dermal fillers

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Plastic and Aesthetic Research 2023年第1期10卷 171-194页

作者： Preeya Mehta Joy Li julie Woodward Sandy Zhang-Nunes Ophthalmology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Ophthalmology Duke University Eye CenterDurhamNC 27710USA Ophthalmology Roski Eye InstituteUniversity of Southern CaliforniaLos AngelesCA 90033USA

Dermal fillers have been commonly used for the filling of facial *** the use of dermal fillers has grown,so has the incidence of non-ischemic *** complications range from edema,bruising,and erythema to more complex conditions such as delayed hypersensitivity nodules and *** article sought to review the causes of various non-ischemic complications,discuss their risk factors,and review management *** predisposing factors to delayed hypersensitivity nodules,such as Vycross technology,a history of viral illness,or coronavirus disease 19(COVID-19)infections,are discussed in detail in this *** techniques such as patient counseling,elucidating certain patient history(viral illness,dental procedures),the use of aseptic technique,and procedural factors are also *** appropriate management for these complications can also help in ***,such as ultrasound,computed tomography(CT)and magnetic resonance imaging(MRI),has taken on a larger role in the management of non-ischemic complications.

关键词： Non-ischemic complications delayed hypersensitivity nodules COVID-19 hypersensitivity nodules prevention techniques granulomas biofilms imaging

Myosin *** Regulates Protonemal Patterning and Developmental Timing in the Moss Physcomitrella patens

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Molecular Plant 2011年第5期4卷 909-921页

作者： Shu-Zon Wu julie A. Ritchie Ai-Hong Pan Ralph S. Quatrano Magdalena Bezanilla Department of Biology University of Massachusetts Amherst MA 01003 USA Department of Biology Washington University in St Louis St Louis MO 63130 USA

Plants have two classes of myosins. While recent work has focused on class XI myosins showing that myosin XI is responsible for organelle motility and cytoplasmic streaming, much less is known about the role of myosin VIII in plant growth and development. We have used a combination of RNAi and insertional knockouts to probe myosin VIII function in the moss Physcomitrella patens. We isolated Amyo8ABCDE plants demonstrating that myosin VIII is not required for plant viability. However, myosin VIII mutants are smaller than wild-type plants in part due to a defect in cell size. Additionally, Amyo8ABCDE plants produce more side branches and form gametophores much earlier than wild-type plants. In the ab- sence of nutrient media, Amyo8ABCDE plants exhibit significant protonemal patterning defects, including highly curved protonemal filaments, morphologically defective side branches, as well as an increase in the number of branches. Exogenous auxin partially rescues protonemal defects in Amyo8ABCDE plants grown in the absence of nutrients. This result, together with defects in protonemal branching, smaller caulonemal ceils, and accelerated development in the Amyo8ABCDE plants, suggests that myosin VIII is involved in hormone homeostasis in P patens.

关键词： Cell division cell expansion cell morphogenesis cytoskeleton development.

Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells

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World Journal of Gastroenterology 2006年第12期12卷 1859-1864页

作者： Audrey Ferrand Aline Kowalski-Chauvel Claudine Bertrand Daniel Fourmy Marlene Dufresne Catherine Seva julie Pannequin INSERM U.531 Groupe de Recherche de Biologie et Pathologie DigestivesIFR31Institut Louis BugnardBP 8422531432 toulouse Cedex 4France University of Melbourne Department of Surgery Austin CampusARMCHeidelbergVictoria 3084Australia

AIM： To investigate whether Src, JAK2 and phosphatidylinositol 3-kinase （PI3K） pathways are involved in the proliferation of human colonic tumour cells induced by glycine-extended gastrin （G-gly）, the precursor of the mature amidated gastrin and to elucidate the molecular interaction between these three kinases in response to this peptide. METHODS： Using the human colonic tumour cell line HCT116 as a model, we first measured the activation of PI3K, p60-Src and JAK2 in response to G-gly by in vitro kinase assays. Then we investigated the involvement of these kinases in G-gly-induced cell proliferation by MTT test. RESULTS： G-gly stimulation induced p60-Src, JAK2 and PI3K activation in HCT116. The different pathways were involved in proliferation of human colon cancer cells induced by G-gly. Furthermore, we found that both Src and JAK2 were necessary to PI3K regulation by this peptide. However, we did not find any cross-talk between the two tyrosine kinases. CONCLUSION： Our results suggest that the p60-Src/ PI3K and JAK2/PI3K pathways act independently to mediate G-gly proliferative effect on human colonic tumour cells.

关键词： Colon cancer Src JAK2 Phosphatidylinositol 3-kinase Glycine-extended gastrin

Glycosylation-related gene expression in HT29-MTX-E12 cells upon infection by Helicobacter pylori

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World Journal of Gastroenterology 2017年第37期23卷 6817-6832页

作者： Michael T Cairns Ananya Gupta julie A Naughton Marian Kane Marguerite Clyne Lokesh Joshi Glycoscience Group National Centre for Biomedical Engineering ScienceNational University of Ireland Galway School of Natural Sciences National University of Ireland Galway Conway Institute of Biomolecular and Biomedical Research School of Medicine and Medical Sciences University College Dublin

AIM To identify glycosylation-related genes in the HT29 derivative cell line, HT29-MTX-E12, showing differential expression on infection with Helicobacter pylori(H. pylori).METHODS Polarised HT29-MTX-E12 cells were infected for 24 h with H. pylori strain 26695. After infection RNA was isolated from both infected and non-infected host cells. Sufficient infections were carried out to provide triplicate samples for microarray analysis and for q RTPCR analysis. RNA was isolated and hybridised to Affymetrix arrays. Analysis of microarray data identified genes significantly differentially expressed upon infection. Genes were grouped into gene ontology functional categories. Selected genes associated with host glycan structure(glycosyltransferases, hydrolases, lectins, mucins) were validated by real-time q RT-PCR *** Infection of host cells was confirmed by the isolation of live bacteria after 24 h incubation and by PCR amplification of bacteria-specific genes from the host cell RNA. H. pylori do not survive incubation under the adopted culture conditions unless they associate with the adherent mucus layer of the host cell. Microarray analysis identified a total of 276 genes that were significantly differentially expressed(P < 0.05) upon H. pylori infection and where the fold change in expression was greater than 2. Six of these genes are involved in glycosylation-related processes. Real-time q RT-PCR demonstrated significant downregulation(1.8-fold, P < 0.05) of the mucin MUC20. REG4 was heavily expressed and significantly downregulated(3.1-fold, P < 0.05) upon infection. Gene ontology analysis was consistent with previous studies on H. pylori *** Gene expression data suggest that infection with H. pylori causes a decrease in glycan synthesis, resulting in shorter and simpler glycan structures.

关键词： Glycosylation Adherent mucus Gastric HT29-MTX-E12 H pylori strain 26695 Transcriptomics

Considerations for the clinical use of stem cells in genitourinary regenerative medicine

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World Journal of Stem Cells 2021年第10期13卷 1480-1512页

作者： Christophe Caneparo Luis Sorroza-Martinez Stéphane Chabaud julie Fradette Stéphane Bolduc Centre de Recherche en Organogénèse Expérimentale de l'UniversitéLaval/LOEX Centre de Recherche du CHU de Québec-UniversitéLavalAxe Médecine RégénératriceQuebec G1J1Z4Canada Department of Surgery Faculty of MedicineUniversitéLavalQuebec G1V0A6Canada

The genitourinary tract can be affected by several pathologies which require repair or replacement to recover biological *** therapeutic strategies are challenged by a growing shortage of adequate ***,new options must be considered for the treatment of patients,with the use of stem cells(SCs)being *** different strategies can be derived from stem cell use:Cell therapy and tissue therapy,mainly through tissue *** recent advances using these approaches are described in this review,with a focus on stromal/mesenchymal cells found in adipose ***,the accessibility,high yield at harvest as well as anti-fibrotic,immunomodulatory and proangiogenic properties make adipose-derived stromal/SCs promising alternatives to the therapies currently offered to ***,an innovative technique allowing tissue reconstruction without exogenous material,the self-assembly approach,will be *** advances,more studies are needed to translate such approaches from the bench to clinics in *** the 21st century,cell and tissue therapies based on SCs are certainly the future of genitourinary regenerative medicine.

关键词： Genitourinary tract Cell therapy Tissue engineering Stem cells

Influence of primary tumor location and resection on survival in metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2020年第11期12卷 1296-1310页

作者： ZoéTharin julie Blanc Ikram Charifi Alaoui Aurélie Bertaut François Ghiringhelli Department of Medical Oncology Centre Georges-François LeclercDijon 21000France Department of Bioastatistics Centre Georges-François LeclercDijon 21000France

BACKGROUND Patients with right sided colorectal cancer are known to have a poorer prognosis than patients with left sided colorectal cancer, whatever the cancer stage. To this day, primary tumor resection(PTR) is still controversial in a metastatic, non resectable *** To explore the survival impact of PTR in patients with metastatic colorectal cancer(mCRC) depending on *** We retrospectively collected data from all consecutive patients treated for mCRC at the Centre Georges Francois Leclerc Hospital. Univariate and multivariate Cox proportional hazard regression models were used to assess the influence of PTR on survival. We then evaluated the association between PTL and overall survival among patients who previously underwent or did not undergo PTR. A propensity score was performed to match *** Four hundred and sixty-six patients were included. A total of 153(32.8%) patients had unresected synchronous mCRC and 313(67.2%) patients had resected synchronous mCRC. The number of patients with right colic cancer, left colic cancer and rectal cancer was respectively 174(37.3%), 203(43.6%) and 89(19.1%). In the multivariate analysis only PTL, PTR, resection of hepatic and or pulmonary metastases and the use of oxaliplatin, EGFR inhibitors or bevacizumab throughout treatment were associated to higher overall survival rates. Survival evaluation depending on PTR and PTL found that PTR improved the prognosis of both left and right sided mCRC. Results were confirmed by using a weighted propensity *** In mCRC, PTR seems to confer a higher survival rate to patients whatever the PTL.

关键词： Colorectal cancer Metastatic Primary tumor resection Chemotherapy Primary tumor location Synchronous