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Non-ischemic complications of dermal fillers

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Plastic and Aesthetic research 2023年第1期10卷 171-194页

作者： Preeya Mehta Joy Li julie Woodward Sandy Zhang-Nunes Ophthalmology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Ophthalmology Duke University Eye CenterDurhamNC 27710USA Ophthalmology Roski Eye InstituteUniversity of Southern CaliforniaLos AngelesCA 90033USA

Dermal fillers have been commonly used for the filling of facial *** the use of dermal fillers has grown,so has the incidence of non-ischemic *** complications range from edema,bruising,and erythema to more complex conditions such as delayed hypersensitivity nodules and *** article sought to review the causes of various non-ischemic complications,discuss their risk factors,and review management *** predisposing factors to delayed hypersensitivity nodules,such as Vycross technology,a history of viral illness,or coronavirus disease 19(COVID-19)infections,are discussed in detail in this *** techniques such as patient counseling,elucidating certain patient history(viral illness,dental procedures),the use of aseptic technique,and procedural factors are also *** appropriate management for these complications can also help in ***,such as ultrasound,computed tomography(CT)and magnetic resonance imaging(MrI),has taken on a larger role in the management of non-ischemic complications.

关键词： Non-ischemic complications delayed hypersensitivity nodules COVID-19 hypersensitivity nodules prevention techniques granulomas biofilms imaging

Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone

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Bone research 2018年第2期6卷 189-196页

作者： julie E.Pickett John M.Thompson Agnieszka Sadowska Christine Tkaczyk Bret r.Sellman Andrea Minola Davide Corti Antonio Lanzavecchia Lloyd S.Miller Daniel LJ Thorek Division of Nuclear Medicine and Molecular Imaging Department of Radiology and Radiological ScienceJohns Hopkins University School of MedicineGaithersburgMDUSA Department of Orthopaedic Surgery Johns Hopkins University School of MedicineBaltimoreMD 21205USA Department of Infectious Disease MedImmune LLCGaithersburgMDUSA Humabs Bio Med SA BellinzonaSwitzerland Institute for research in Biomedicine Universitàdella Svizzera italianaBellinzonaSwitzerland Department of Dermatology Johns Hopkins University School of MedicineBaltimoreMD 21205USA Division of Infectious Disease Department of MedicineJohns Hopkins University School of MedicineBaltimoreMDUSA Cancer Molecular and Functional Imaging Program Department of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21205USA

Discriminating sterile inflammation from infection, especially in cases of aseptic loosening versus an actual prosthetic joint infection, is challenging and has significant treatment implications. Our goal was to evaluate a novel human monoclonal antibody（mAb） probe directed against the Gram-positive bacterial surface molecule lipoteichoic acid（LTA）. Specificity and affinity were assessed in vitro. We then radiolabeled the anti-LTA mAb and evaluated its effectiveness as a diagnostic imaging tool for detecting infection via immuno PET imaging in an in vivo mouse model of prosthetic joint infection（PJI）. In vitro and ex vivo binding of the anti-LTA mAb to pathogenic bacteria was measured with Octet, ELISA, and flow cytometry. The in vivo PJI mouse model was assessed using traditional imaging modalities, including positron emission tomography（PET） with [^（18）F]FDG and [^（18）F]Na F as well as X-ray computed tomography（CT）, before being evaluated with the zirconium-89-labeled antibody specific for LTA（[^（89）Zr]SAC55）.The anti-LTA mAb exhibited specific binding in vitro to LTA-expressing bacteria. results from imaging showed that our model could reliably simulate infection at the surgical site by bioluminescent imaging, conventional PET tracer imaging, and bone morphological changes by CT. One day following injection of both the radiolabeled anti-LTA and isotype control antibodies, the anti-LTA antibody demonstrated significantly greater（P 〈 0.05） uptake at S. aureus-infected prosthesis sites over either the same antibody at sterile prosthesis sites or of control non-specific antibody at infected prosthesis sites. Taken together, the radiolabeled anti-LTA mAb, [^（89）Zr]SAC55, may serve as a valuable diagnostic molecular imaging probe to help distinguish between sterile inflammation and infection in the setting of PJI. Future studies are needed to determine whether these findings will translate to human PJI.

关键词： Zr Molecularly specific detection bacterial lipoteichoic acid diagnosis prosthetic infection bone LTA SAC PET FDG tracer

Myosin *** regulates Protonemal Patterning and Developmental Timing in the Moss Physcomitrella patens

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Molecular Plant 2011年第5期4卷 909-921页

作者： Shu-Zon Wu julie A. ritchie Ai-Hong Pan ralph S. Quatrano Magdalena Bezanilla Department of Biology University of Massachusetts Amherst MA 01003 USA Department of Biology Washington University in St Louis St Louis MO 63130 USA

Plants have two classes of myosins. While recent work has focused on class XI myosins showing that myosin XI is responsible for organelle motility and cytoplasmic streaming, much less is known about the role of myosin VIII in plant growth and development. We have used a combination of rNAi and insertional knockouts to probe myosin VIII function in the moss Physcomitrella patens. We isolated Amyo8ABCDE plants demonstrating that myosin VIII is not required for plant viability. However, myosin VIII mutants are smaller than wild-type plants in part due to a defect in cell size. Additionally, Amyo8ABCDE plants produce more side branches and form gametophores much earlier than wild-type plants. In the ab- sence of nutrient media, Amyo8ABCDE plants exhibit significant protonemal patterning defects, including highly curved protonemal filaments, morphologically defective side branches, as well as an increase in the number of branches. Exogenous auxin partially rescues protonemal defects in Amyo8ABCDE plants grown in the absence of nutrients. This result, together with defects in protonemal branching, smaller caulonemal ceils, and accelerated development in the Amyo8ABCDE plants, suggests that myosin VIII is involved in hormone homeostasis in P patens.

关键词： Cell division cell expansion cell morphogenesis cytoskeleton development.

Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells

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World Journal of Gastroenterology 2006年第12期12卷 1859-1864页

作者： Audrey Ferrand Aline Kowalski-Chauvel Claudine Bertrand Daniel Fourmy Marlene Dufresne Catherine Seva julie Pannequin INSErM U.531 Groupe de Recherche de Biologie et Pathologie DigestivesIFR31Institut Louis BugnardBP 8422531432 toulouse Cedex 4France University of Melbourne Department of Surgery Austin CampusARMCHeidelbergVictoria 3084Australia

AIM： To investigate whether Src, JAK2 and phosphatidylinositol 3-kinase （PI3K） pathways are involved in the proliferation of human colonic tumour cells induced by glycine-extended gastrin （G-gly）, the precursor of the mature amidated gastrin and to elucidate the molecular interaction between these three kinases in response to this peptide. METHODS： Using the human colonic tumour cell line HCT116 as a model, we first measured the activation of PI3K, p60-Src and JAK2 in response to G-gly by in vitro kinase assays. Then we investigated the involvement of these kinases in G-gly-induced cell proliferation by MTT test. rESULTS： G-gly stimulation induced p60-Src, JAK2 and PI3K activation in HCT116. The different pathways were involved in proliferation of human colon cancer cells induced by G-gly. Furthermore, we found that both Src and JAK2 were necessary to PI3K regulation by this peptide. However, we did not find any cross-talk between the two tyrosine kinases. CONCLUSION： Our results suggest that the p60-Src/ PI3K and JAK2/PI3K pathways act independently to mediate G-gly proliferative effect on human colonic tumour cells.

关键词： Colon cancer Src JAK2 Phosphatidylinositol 3-kinase Glycine-extended gastrin

revisiting the Electron radius in Light of Length Contraction

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第4期10卷 1743-1748页

作者： julie Marty Independent researcher New Hope USA

In previous work, the electron radius was identified as the “actual electron radius.” However, this is more accurately described as the electron radius at rest. This study reexamines the electron with an emphasis on the electron radius under motion, incorporating the effects of length contraction. The findings suggest that the radius is subject to Lorentz contraction, which has interesting implications for relativistic effects at the subatomic level.

关键词： Electron radius Length Contraction Lorentz Factor relativistic Effects Subatomic Particles Compton Scattering

Considerations for the clinical use of stem cells in genitourinary regenerative medicine

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World Journal of Stem Cells 2021年第10期13卷 1480-1512页

作者： Christophe Caneparo Luis Sorroza-Martinez Stéphane Chabaud julie Fradette Stéphane Bolduc Centre de recherche en Organogénèse Expérimentale de l'UniversitéLaval/LOEX Centre de Recherche du CHU de Québec-UniversitéLavalAxe Médecine RégénératriceQuebec G1J1Z4Canada Department of Surgery Faculty of MedicineUniversitéLavalQuebec G1V0A6Canada

The genitourinary tract can be affected by several pathologies which require repair or replacement to recover biological *** therapeutic strategies are challenged by a growing shortage of adequate ***,new options must be considered for the treatment of patients,with the use of stem cells(SCs)being *** different strategies can be derived from stem cell use:Cell therapy and tissue therapy,mainly through tissue *** recent advances using these approaches are described in this review,with a focus on stromal/mesenchymal cells found in adipose ***,the accessibility,high yield at harvest as well as anti-fibrotic,immunomodulatory and proangiogenic properties make adipose-derived stromal/SCs promising alternatives to the therapies currently offered to ***,an innovative technique allowing tissue reconstruction without exogenous material,the self-assembly approach,will be *** advances,more studies are needed to translate such approaches from the bench to clinics in *** the 21st century,cell and tissue therapies based on SCs are certainly the future of genitourinary regenerative medicine.

关键词： Genitourinary tract Cell therapy Tissue engineering Stem cells

A Novel Model for Elementary Particles: Light Charges and Their Motion in 5D Space-Time

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Journal of High Energy Physics, Gravitation and Cosmology 2023年第3期9卷 725-742页

作者： julie Marty Independent researcher New Hope MN USA

This paper proposes a novel model for elementary particles, introducing the concept of “light charges”, as fundamental entities that exhibit intriguing behavior in 5-dimensional space-time. Light charges are postulated to possess two velocity vectors: one moving at variable velocity, and one moving at the speed of light, that remain fixed relative to each other at perpendicular angles. These light charges interact with each other based on their charges, leading to changes in their motion over time. This paper derives equations based on the proposed model to investigate the behavior of light charges in various scenarios. remarkably, the model is capable of reproducing known properties of elementary particles, including values for their charge, mass, and spin. This paper further discusses the implications of this model for our understanding of fundamental particles, including the potential connections to quantum mechanics and relativity. The proposed light charge model offers a new perspective on the behavior of elementary particles. While further research and validation are needed, this model may pave the way for a deeper understanding of the fundamental nature of matter and energy in the universe.

关键词： Quantum Gravity Black Holes

Influence of primary tumor location and resection on survival in metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2020年第11期12卷 1296-1310页

作者： ZoéTharin julie Blanc Ikram Charifi Alaoui Aurélie Bertaut François Ghiringhelli Department of Medical Oncology Centre Georges-François LeclercDijon 21000France Department of Bioastatistics Centre Georges-François LeclercDijon 21000France

BACKGrOUND Patients with right sided colorectal cancer are known to have a poorer prognosis than patients with left sided colorectal cancer, whatever the cancer stage. To this day, primary tumor resection(PTr) is still controversial in a metastatic, non resectable *** To explore the survival impact of PTr in patients with metastatic colorectal cancer(mCrC) depending on *** We retrospectively collected data from all consecutive patients treated for mCrC at the Centre Georges Francois Leclerc Hospital. Univariate and multivariate Cox proportional hazard regression models were used to assess the influence of PTr on survival. We then evaluated the association between PTL and overall survival among patients who previously underwent or did not undergo PTr. A propensity score was performed to match *** Four hundred and sixty-six patients were included. A total of 153(32.8%) patients had unresected synchronous mCrC and 313(67.2%) patients had resected synchronous mCrC. The number of patients with right colic cancer, left colic cancer and rectal cancer was respectively 174(37.3%), 203(43.6%) and 89(19.1%). In the multivariate analysis only PTL, PTr, resection of hepatic and or pulmonary metastases and the use of oxaliplatin, EGFr inhibitors or bevacizumab throughout treatment were associated to higher overall survival rates. Survival evaluation depending on PTr and PTL found that PTr improved the prognosis of both left and right sided mCrC. results were confirmed by using a weighted propensity *** In mCrC, PTr seems to confer a higher survival rate to patients whatever the PTL.

关键词： Colorectal cancer Metastatic Primary tumor resection Chemotherapy Primary tumor location Synchronous

Glycosylation-related gene expression in HT29-MTX-E12 cells upon infection by Helicobacter pylori

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World Journal of Gastroenterology 2017年第37期23卷 6817-6832页

作者： Michael T Cairns Ananya Gupta julie A Naughton Marian Kane Marguerite Clyne Lokesh Joshi Glycoscience Group National Centre for Biomedical Engineering ScienceNational University of Ireland Galway School of Natural Sciences National University of Ireland Galway Conway Institute of Biomolecular and Biomedical research School of Medicine and Medical Sciences University College Dublin

AIM To identify glycosylation-related genes in the HT29 derivative cell line, HT29-MTX-E12, showing differential expression on infection with Helicobacter pylori(H. pylori).METHODS Polarised HT29-MTX-E12 cells were infected for 24 h with H. pylori strain 26695. After infection rNA was isolated from both infected and non-infected host cells. Sufficient infections were carried out to provide triplicate samples for microarray analysis and for q rTPCr analysis. rNA was isolated and hybridised to Affymetrix arrays. Analysis of microarray data identified genes significantly differentially expressed upon infection. Genes were grouped into gene ontology functional categories. Selected genes associated with host glycan structure(glycosyltransferases, hydrolases, lectins, mucins) were validated by real-time q rT-PCr *** Infection of host cells was confirmed by the isolation of live bacteria after 24 h incubation and by PCr amplification of bacteria-specific genes from the host cell rNA. H. pylori do not survive incubation under the adopted culture conditions unless they associate with the adherent mucus layer of the host cell. Microarray analysis identified a total of 276 genes that were significantly differentially expressed(P ri infection and where the fold change in expression was greater than 2. Six of these genes are involved in glycosylation-related processes. real-time q rT-PCr demonstrated significant downregulation(1.8-fold, P rEG4 was heavily expressed and significantly downregulated(3.1-fold, P revious studies on H. pylori *** Gene expression data suggest that infection with H. pylori causes a decrease in glycan synthesis, resulting in shorter and simpler glycan structures.

关键词： Glycosylation Adherent mucus Gastric HT29-MTX-E12 H pylori strain 26695 Transcriptomics