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New immune regulators of sciatic nerve regeneration?Lessons from the neighborhood

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Neural Regeneration Research 2024年第4期19卷 705-706页

作者： AndréL.Bombeiro Rodrigo G.q.Fernandes julie C.Ribot Instituto de Medicina Molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisbonPortugal

For decades,the immune system has been associated with host protection against infectious pathogens or tumors,while also contributing to ***,this paradigm is now changing,with recent studies highlighting novel roles for immune mediators in the maintenance of steady-state tissue *** this perspective,we review some of the latest findings featuring immune modulators of the nervous system pathophysiology,with a special focus on interleukin(IL)-17.

关键词： homeostasis neighborhood finding

Plant-derived nanovesicles as an emerging platform for cancer therapy

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Acta Pharmaceutica Sinica B 2024年第1期14卷 133-154页

作者： Hanzhe Liu Guo-Feng Luo Zhengjun shang The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhan 430079China

Plant-derived nanovesicles(PDNVs)derived from natural green products have emerged as an attractive nanoplatform in biomedical *** are usually characterized by unique structural and biological functions,such as the bioactive lipids/proteins/nucleic acids as therapeutics and targeting groups,immune-modulation,and long-term *** the rapid development of nanotechnology,materials,and synthetic chemistry,PDNVs can be engineered with multiple functions for efficient drug delivery and specific killing of diseased cells,which represent an innovative biomaterial with high biocompatibility for fighting against *** this review,we provide an overview of the state-of-theart studies concerning the development of PDNVs for cancer *** original sources,methods for obtaining PDNVs,composition and structure are introduced *** an emphasis on the featured application,the inherent anticancer properties of PDNVs as well as the strategies in constructing multifunctional PDNVs-based nanomaterials will be discussed in ***,some scientific issues and technical challenges of PDNVs as promising options in improving anticancer therapy will be discussed,which are expected to promote the further development of PDNVs in clinical translation.

关键词： Naturally occurring nanovesicles Plant Nanotechnology Drug delivery Cancer therapy

Taiji-Tianqin-LISA network:Precisely measuring the Hubble constant using both bright and dark sirens

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 59-77页

作者： shang-Jie Jin Ye-Zhu Zhang Ji-Yu Song Jing-Fei Zhang Xin Zhang Key Laboratory of Cosmology and Astrophysics(Liaoning)&College of Sciences Northeastern UniversityShenyang 110819China Key Laboratory of Data Analytics and Optimization for Smart Industry(Ministry of Education) Northeastern UniversityShenyang 110819China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityShenyang 110819China

In the coming decades,the space-based gravitational-wave(GW)detectors such as Taiji,Tianqin,and LISA are expected to form a network capable of detecting millihertz GWs emitted by the mergers of massive black hole binaries(MBHBs).In this work,we investigate the potential of GW standard sirens from the Taiji-Tianqin-LISA network in constraining cosmological *** the optimistic scenario in which electromagnetic(EM)counterparts can be detected,we predict the number of detectable bright sirens based on three different MBHB population models,i.e.,popⅢ,q3d,and *** results show that the TaijiTianqin-LISA network alone could achieve a constraint precision of 0.9%for the Hubble constant,meeting the standard of precision ***,the Taiji-Tianqin-LISA network could effectively break the cosmological parameter degeneracies generated by the CMB data,particularly in the dynamical dark energy *** combined with the CMB data,the joint CMB+Taiji-Tianqin-LISA data offerσ(w)=0.036 in the wCDM model,which is close to the latest constraint result obtained from the CMB+SN *** also consider a conservative scenario in which EM counterparts are not *** to the precise sky localizations of MBHBs by the Taiji-Tianqin-LISA network,the constraint precision of the Hubble constant is expected to reach 1.2%.In conclusion,the GW standard sirens from the Taiji-Tianqin-LISA network will play a critical role in helping solve the Hubble tension and shedding light on the nature of dark energy.

关键词： space-based gravitational wave detection standard sirens the Taiji-Tianqin-LISA network the Hubble constant dark energy

Investigation on photonic crystal nanobeam cavity based on mixed diamond–circular holes

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Nanotechnology and Precision Engineering 2024年第1期7卷 63-70页

作者： Jingtong Bin Kerui Feng shang Ma Ke Liu Yong Cheng Jing Chen qifa Liu College of Telecommunication and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210003China State Key Laboratory of Advanced Optical Communication Systems and Networks Shanghai Jiao Tong UniversityShanghai 200240China

A photonic crystal nanobeam cavity(M-PCNC)with a structure incorporating a mixture of diamond-shaped and circular air holes is *** performance of the cavity is simulated and studied *** theﬁnite-difference time-domain method,the parameters of the M-PCNC,including cavity thickness and width,lattice constant,and radii and numbers of holes,are optimized,with the quality factor q and mode volume Vm as performance *** modulation of the lattice constant and hole radius enable the proposed M-PCNC to realize outstanding *** optimized cavity possesses a high quality factor q 1.45105 and an ultra-small mode=×volume Vm 0.01(λ/n)[Zeng et al.,Opt Lett 2023:48;3981–3984]in the telecommunications wavelength *** can be progres-=sively squeezed in both the propagation direction and the perpendicular in-plane direction by a series of interlocked anti-slots and slots in the diamond-shaped hole ***,the energy can be conﬁned within a small mode volume to achieve an ultra-high q/Vm ratio.

关键词： Photonic crystal nanobeam cavity Mixed diamond–circular holes Slots and anti-slots FDTD simulation quality factor Mode volume

Composition characterization and transformation mechanism of dissolved organic phosphorus in wastewater treatment using 31P NMR spectroscopy

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 103-113页

作者： Yuting Zhang Wei shang SoonThiam Khu Xingcan Zheng Yongli Sun Pengfeng Li Miao Gu Wen-an Zhang Huanmei Ma National Engineering Research Center For Urban Water&Wastewater North China Municipal Engineering Design&Research Institute Co.Ltd.Tianjin 300381China School of Environment Science&Engineering Tianjin UniversityTianjin 300350China

The migration and transformation of phosphorus components in wastewater treatment plants(WWTPs)play a crucial role in the convergence and circulation of ***,the composition and variation of dissolved organic phosphorus(DOP)in WWTPs were unclear because of its complex nature,hindering its efficient *** this study,the DOP species and their transformation during the treatment process in WWTP were comprehensively ***,two enrichment methods were assessed for their effectiveness at facilitating wastewater analysis:lyophilization and aluminum salt *** salt precipitation was found to be better because its application allowed 31P nuclear magnetic resonance(31P NMR)spectroscopy to identify more species in the secondary effluent:orthophosphate(Ortho-P)(81.1%–89.3%of the dissolved total phosphorus),pyrophosphates(Pyro-P)(0%–2.3%),orthophosphate monoesters(Mono-P)(7.0%–10.77%),orthophosphate diesters(Di-P)(1.0%–2.96%),and phosphonate(Phos-P)(1.7%–5.16%).Furthermore,the variation and transformation mechanism of phosphorus,particularly those of DOP,during the entire sewage-treatment process were *** the treatment steps,biological treatment combined tertiary treatment achieved better DOP removal ***,biological treatment mainly removed Mono-P and Di-P with removal efficiencies of 33.3%and 41.7%compared with the effluent of the grit ***-P has higher bioavailability and is more easily converted and utilized by microorganisms than ***,Phos-P,with low bioavailability,was hardly utilized by microorganisms,which showed only 18.4%removal efficiency in biological *** tertiary treatment,coagulation process exhibited higher removal ability of Ortho-P(69.1%)and partial removal efficiencies of DOP,resulting in an increase in the DOP proportion in *** addition,Phos-P could not be effectively removed through the biological treatment and was only partially reduced via the adsorption pro

关键词： Municipal wastewater Dissolved organic phosphorus Composition Transformation 31P nuclear magnetic resonance

Spatiotemporal Variability and Environmental Controls of Temperature Sensitivity of Ecosystem Respiration across the Tibetan Plateau

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Advances in Atmospheric Sciences 2024年第9期41卷 1821-1842页

作者： Danrui SHENG Xianhong MENG Shaoying WANG Zhaoguo LI Lunyu shang Hao CHEN Lin ZHAO Mingshan DENG Hanlin NIU Pengfei XU Xiaohu WEN Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Zoige Plateau Wetlands Ecosystem Research Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

Warming-induced carbon loss via ecosystem respiration(R_(e))is probably intensifying in the alpine grassland ecosystem of the Tibetan Plateau owing to more accelerated warming and the higher temperature sensitivity of R_(e)(q_(10)).However,little is known about the patterns and controlling factors of q_(10)on the plateau,impeding the comprehension of the intensity of terrestrial carbon-climate feedbacks for these sensitive and vulnerable ***,we synthesized and analyzed multiyear observations from 14 sites to systematically compare the spatiotemporal variations of q_(10)values in diverse climate zones and ecosystems,and further explore the relationships between q_(10)and environmental ***,structural equation modeling was utilized to identify the direct and indirect factors predicting q_(10)values during the annual,growing,and non-growing *** results indicated that the estimated q_(10)values were strongly dependent on temperature,generally,with the average q_(10)during different time periods increasing with air temperature and soil temperature at different measurement depths(5 cm,10 cm,20 cm).The q_(10)values differentiated among ecosystems and climatic zones,with warming-induced q_(10)declines being stronger in colder regions than elsewhere based on spatial *** was the most cardinal factor in predicting annual q_(10)values,significantly and positively correlated with q_(10).Soil temperature(Ts)was identified as the other powerful predictor for q_(10),and the negative q_(10)-Ts relationship demonstrates a larger terrestrial carbon loss potentiality in colder than in warmer regions in response to global *** that the interpretations of the effect of soil moisture on q_(10)were complicated,reflected in a significant positive relationship between q_(10)and soil moisture during the growing season and a strong quadratic correlation between the two during the annual and non-growing *** findings are conducive to imp

关键词： carbon cycle eddy covariance measurements ecosystem respiration q_(10)value Tibetan Plateau climate change

Predictive performance of the variation rate of the driving pressure on the outcome of invasive mechanical ventilation in patients with acute respiratory distress syndrome

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Chinese Journal of Traumatology 2024年第2期27卷 107-113页

作者： Hui-Dan Jing Jun-Ying Tian Wei Li Bing-Ling He Hong-Chao Li Fu-Xia Jian Cui shang Feng Shen Department of Intensive Care Unit The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Intensive Care Unit Army Medical Center of PLAChongqing400042China College of Foreign Languges Chongqing Medical UniversityChongqing400016China

Purpose:To assess the value of the driving pressure variation rate(ΔP%)in predicting the outcome of weaning from invasive mechanical ventilation in patients with acute respiratory distress ***:In this case-control study,a total of 35 patients with moderate-severe acute respiratory distress syndrome were admitted to the intensive care unit between January 2022 and December 2022 and received invasive mechanical ventilation for at least 48 h were *** were divided into successful weaning group and failed weaning group depending on whether they could be removed from ventilator support within 14 *** measures including driving pressure,PaO2:FiO2,and positive end-expiratory pressure,*** assessed every 24 h from day 0 to day 14 until successful weaning was *** measurement data of non-normal distribution were presented as median(q1,q3),and the differences between groups were compared by Wilcoxon rank sum *** categorical data use the Chi-square test or Fisher's exact test to *** predictive value ofΔP%in predicting the outcome of weaning from the ventilator was analyzed using receiver operating characteristic ***:Of the total 35 patients included in the study,17 were successful vs.18 failed in weaning from a ventilator after 14 days of mechanical *** cut-off values of the medianΔP%measured by Operator 1 *** 2 in the first 4 days were≥4.17%and 4.55%,respectively(p<0.001),with the area under curve of 0.804(sensitivity of 88.2%,specificity of 64.7%)and 0.770(sensitivity of 88.2%,specificity of 64.7%),*** was a significant difference in mechanical ventilation duration between the successful weaning group and the failure weaning group(8(6,13)vs.12(7.5,17.3),p=0.043).The incidence of ventilator-associated pneumonia in the successful weaning group was significantly lower than in the failed weaning group(0.2‰vs.2.3‰,p=0.001).There was a significant difference noted between these

关键词： Driving pressure Driving pressure variation rate Acute respiratory distress syndrome Mechanical ventilation

Bi-layered coded metasurface for multi-functional hologram with broadband transmission and efficient reflection

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Chinese Optics Letters 2024年第5期22卷 8-16页

作者：朱磊李绪胜董亮谢文静尚关玉 Shah Nawaz Burokur 丁旭旻 School of Computer and Control Engineering Qiqihar UniversityQiqihar 161006China Communication and Electronics Engineering Institute Qiqihar UniversityQiqihar 161006China Heilongjiang Key Laboratory of Big Data Network Security Detection and Analysis Qiqihar UniversityQiqihar 161000China Department of Microwave Engineering Harbin Institute of TechnologyHarbin 150001China LEME UPLUniversitéParis NanterreF92410 Ville d’AvrayFrance Advanced Microscopy and Instrumentation Research Center Harbin Institute of TechnologyHarbin 150080China Key Laboratory of Millimeter Waves Southeast UniversityNanjing 210096China

A multi-functional full-space metasurface based on frequency and polarization multiplexing is *** metasurface unit consists of metallic patterns printed on the two faces of a single-layered dielectric *** unit cell can control electromagnetic wavefronts to achieve a broadband transmission with amplitudes greater than 0.4 from 4.4 to 10.4 ***,at 11.7 GHz and 15.4 GHz,four high-efficiency reflection channels with a reflection amplitude greater than 0.8 are also *** illuminated by linearly polarized waves,five different functions can be realized at five different frequencies,which are demonstrated by theoretical calculations,full-wave simulations,and experimental measurements.

关键词： multi-functional metasurface broadband transmission efficient reflection full space

农业社会化服务对农业碳排放的影响及其空间特征

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中国生态农业学报（中英文） 2024年第8期32卷 1288-1301页

作者：朱美荣王淦秋向文凯尚杰东北林业大学经济管理学院哈尔滨150040

农业碳排放是中国实现“双碳”目标和高质量发展的重要议题,农业社会化服务充当了衔接小农与现代农业的重要角色,能显著抑制农业碳排放的增加。本文以2007—2021年省级面板数据为基础,综合利用因子测算法、拉开档次法、双向固定效应模... 详细信息

农业碳排放是中国实现“双碳”目标和高质量发展的重要议题,农业社会化服务充当了衔接小农与现代农业的重要角色,能显著抑制农业碳排放的增加。本文以2007—2021年省级面板数据为基础,综合利用因子测算法、拉开档次法、双向固定效应模型、中介效应模型、空间计量分析等方法测算中国各省份(除中国香港、中国澳门、中国台湾外)农业碳排放和农业社会化服务水平,检验了农业社会化服务对农业碳排放的影响机制、影响路径、空间溢出效应和效应溢出范围。研究发现:1)从总体上来看,随时间推移各地区农业碳排放量整体呈先上升后下降的趋势,而农业社会化服务水平则逐年提高,并对农业碳排放表现出显著抑制作用,但这种作用存在显著的地区差异性,呈由东向西逐渐减弱的态势;2)在农业社会化服务抑制农业碳排放的不同路径中,农地流转和农业经营规模均能发挥部分中介效应,分别达到总效应的13%和18%;3)从空间效应上来看,邻近地区的农业社会化服务作用具有空间溢出效应,并显著地抑制本地农业碳排放,其空间溢出效应随经济距离的增加而增强,2 d以上经济距离的空间溢出效应可达全部溢出效应的26.2%。基于以上结果,地方政府应因地制宜建设农业社会化服务体系;适度提高农地流转,降低农业经营规模,完善土地全程托管服务;发挥地区产业优势,鼓励跨区农业社会化服务,加强地区间经济一体化合作,推动资源的跨区高效配置。

关键词：农业社会化服务农业碳排放并行中介效应空间溢出效应空间溢出范围