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Improving brain outcomes in the growth restricted newborn: treating after birth

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Neural Regeneration Research 2021年第5期16卷 978-979页

作者： julie A.Wixey Stella Tracey Bjorkman UQ Centre for Clinical Research Faculty of MedicineThe University of QueenslandHerstonQueenslandAustralia

Intrauterine growth restriction(IUGR)occurs when a baby is unable to grow normally due to receiving inadequate nutrients while developing in the *** is a leading cause of perinatal death and longterm *** fetal brain is particularly vulnerable to IUGR conditions and adverse outcomes range from learning,attention and behavioral difficulties,to cerebral *** to medical advancements,more IUGR babies now survive,resulting in an even greater burden of disability.

关键词： restricted IUGR advancement

Successful Peripartum Use of an Intrathecal Morphine Pump

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Open Journal of Anesthesiology 2012年第5期2卷 224-225页

作者： julie T. Vuong Jill M. Eckert Department of Anesthesiology Penn State Hershey Medical Center Hershey USA.

As intrathecal pumps are now widely used for management of pain and spasticity, there are more women of child-bearing age who have intrathecal pumps already implanted at time of conception of their children. There is little in the way of guidelines for how to manage these women, especially those with intrathecal pumps infusing analgesics, throughout pregnancy and after birth. We present a woman who presented at 19 weeks of gestation for consultation of long term pain management, with 3 years of postpartum follow up.

关键词： Intrathecal Pump Pain Pump

Current management of fecal incontinence:Choosing amongst treatment options to optimize outcomes

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World Journal of Gastroenterology 2013年第48期19卷 9216-9230页

作者： julie Ann M Van koughnett Steven D Wexner Departmen of Colorectal Surgery Cleveland Clinic Florida Weston FL 33331 United States

The severity of fecal incontinence widely varies and can have dramatic devastating impacts on a person’s *** incontinence is common,though it is often underreported by *** addition to standard treatment options,new treatments have been developed during the past decade to attempt to effectively treat fecal incontinence with minimal ***-operative treatments include dietary modifications,medications,and biofeedback *** used surgical treatments include repair(sphincteroplasty),stimulation(sacral nerve stimulation or posterior tibial nerve stimulation),replacement(artificial bowel sphincter or muscle transposition)and diversion(stoma formation).Newer augmentation treatments such as radiofrequency energy delivery and injectable materials,are minimally invasive tools that may be good options before proceeding to surgery in some patients with mild fecal *** general,more invasive surgical treatments are now reserved for moderate to severe fecal *** and quality of life related outcomes,as well as potential complications of the treatment must be considered and the treatment of fecal incontinence must be individualized to the *** indications,techniques,and outcomes profiles for the various treatments of fecal incontinence are discussed in *** the most effective treatment for the individual patient is essential to achieve optimal outcomes in the treatment of fecal incontinence.

关键词： Fecal incontinence Treatment Sacral nerve stimulation Sphincteroplasty Artificial bowel Sphincter Biofeedback

Prevalence of historical and replacement brominated flame retardant chemicals in New York City homes

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Emerging Contaminants 2017年第1期3卷 32-39页

作者： Whitney J.Cowell Heather M.Stapleton Darrell Holmes Lehyla Calero Catherine Tobon Matthew Perzanow.ki julie B.Herbstman Department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Columbia Center for Children's Environmental Health Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Nicholas School of the Environment Duke UniversityDurhamNC 27708United States

Background:Until their phase-out between 2005 and 2013,polybrominated diphenyl ethers(PBDEs)were added to household products including furniture,rugs,and electronics to meet flammability *** brominated flame retardant(BFR)chemicals,including 2-ethylhexyl-2,3,4,5-tetrabromobenzoate(TBB)and bis(2-ethylhexyl)2,3,4,5-tetrabromophthalate(TBPH),which are components of the Firemaster 550®commercial mixture,are now being used to meet some flammability standards in *** objective of this analysis was to evaluate the extent to which mothers and their children living in New York City are exposed to PBDEs,TBB,and ***:We measured PBDEs,TBB,and TBPH using gas chromatography mass spectrometry in dust(n=25)and handwipe(n?11)samples collected between 2012 and 2013 from mothers and children living in New York *** defined dust as enriched if the proportional distribution for a given BFR exceeded two-thirds of the total BFR ***:We detected PBDEs and TBPH in 100%of dust and handwipe samples and TBB in 100%of dust samples and 95%of handwipe *** from approximately two-thirds of households was enriched for either PBDEs(n?9)or for TBB t TBPH(n=8).Overall,the median house dust concentration of TBB+TBPH(1318 ng/g dust)was higher than that of SPentaBDE(802 ng/g dust)and BDE-209(1171 ng/g dust).Children generally had higher BFR handwipe concentrations compared to mothers(SPentaBDE:73%,BDE-209:64%,TBB t TBPH:55%)and within households,BFR concentrations from paired maternalchild handwipes were highly *** mothers,we found a significant positive relation between house dust and handwipe BDE-209 and TBB t TBPH ***:PBDEs,TBB and TBPH are ubiquitous in house dust and handwipes in a sample of motherchild pairs residing in New York City.

关键词： Flame retardants PBDEs TBB TBPH Dust Handwipe Children

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旅游与历史:概念、挑战及新的研究路径

宁波大学学报（人文科学版） 2016年第6期29卷 1-9页

作者： Manfredini julie 赵冉巴黎第一大学社会史研究中心法国巴黎75004 宁波大学人文与传媒学院浙江宁波315211

20世纪80年代是法国旅游史研究的转折期,法国的历史学者通过其第一批旅游史研究成果,革新了旅游领域的某些定义,开始阐释旅游现象并为其划分周期。借助多学科交叉研究,历史学者在旅游研究中引入了"文化研究"等新思想。旅游迁徙引出的特... 详细信息

20世纪80年代是法国旅游史研究的转折期,法国的历史学者通过其第一批旅游史研究成果,革新了旅游领域的某些定义,开始阐释旅游现象并为其划分周期。借助多学科交叉研究,历史学者在旅游研究中引入了"文化研究"等新思想。旅游迁徙引出的特性/身份问题、区域旅游发展、旅游地类型的开创与扩散等话题也受到其关注。与此同时,还有很多领域值得历史学者深入钻研,如旅游经济,如长期被忽视的法国政府在旅游发展中发挥中的作用,等等。

关键词：历史旅游周期划分特性概念法国

Sieving characteristics of cytokine-and peroxide-induced epithelial barrier leak:Inhibition by berberine

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World Journal of Gastrointestinal Pathophysiology 2016年第2期7卷 223-234页

作者： katherine M DiGuilio Christina M Mercogliano Jillian Born Brendan Ferraro julie To Brittany Mixson Allison Smith Mary Carmen Valenzano James M Mullin Lankenau Institute for Medical Research Lankenau Medical Center Departments of Biology and Biomedical Engineering Drexel University

AIM: To study whether the inflammatory bowel disease (IBD) colon which exhibits varying severity and cytokine levels across its mucosa create varying types of transepithelial leak. METHODS: We examined the effects of tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1-β (IL1β) and hydrogen peroxide (H2O2) - singly and in combinations - on barrier function of CACO-2 cell layers. Our focus was on the type (not simply the magnitude) of transepithelial leak generated by these agents as measured by transepithelial electrical resistance (TER) and transepithelial flux of 14C-D-mannitol, 3H-Lactulose and 14C-Polyethylene glycol as radiolabeled probe molecules. The isoquinoline alkaloid, berberine, was then examined for its ability to reduce specific types of transepithelial leak. RESULTS: Exposure to TNF-α alone (200 ng/mL; 48 h) induced a 50% decrease in TER, i.e., increased leak of Na+ and Cl- - with only a marginal but statistically significant increase in transepithelial leak of 14C-mannitol (Jm). Exposure to TNF-α + IFN-γ (200 ng/mL; 48 h) + IL1β (50 ng/mL; 48 h) did not increase the TER change (from TNF-α alone), but there was now a 100% increase in Jm. There however was no increase in transepithelial leak of two larger probe molecules, 3H-lactulose and 14C-polyethylene glycol (PEG). However, exposure to TNF-α + IFN-γ + IL1β followed by a 5 h exposure to 2 mmol/L H2O2 resulted in a 500% increase in 14C-PEG leak as well as leak to the luminal mitogen, epidermal growth factor. CONCLUSION: This model of graded transepithelial leak is useful in evaluating therapeutic agents reducing IBD morbidity by reducing barrier leak to various luminal substances.

关键词： Intestine Crohn’s disease Tight junction Ulcerative colitis CACO-2 Berberine Micronutrient Cytokine

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法国国家图书馆的中文典藏与法中学术交流

民俗典籍文字研究 2019年第1期 82-93,288-289页

作者：罗栖霞法国国家图书馆法国巴黎75008

法国国家图书馆是举世闻名的世界图书资源宝库,也是法国汉学研究的重镇。14世纪国王查理五世(Charles V)颁布敕令,将历代皇家保存的近千种文献,集中收藏于罗浮宫图书馆,由此诞生法国皇家图书馆,至今已有650年的历史。该馆收藏中文图书逾... 详细信息

法国国家图书馆是举世闻名的世界图书资源宝库,也是法国汉学研究的重镇。14世纪国王查理五世(Charles V)颁布敕令,将历代皇家保存的近千种文献,集中收藏于罗浮宫图书馆,由此诞生法国皇家图书馆,至今已有650年的历史。该馆收藏中文图书逾300年,超过15万册,尤以收藏敦煌文献著名,为法国汉学和中国学术界的海外汉学研究提供了独特的学术文化舞台。了解法国国家图书馆馆藏的中文图书,认识它的存藏历史与利用现状,讨论它与中法学者研究工作的联系,是当今方兴未艾的跨文化研究与交流必须开展的一项工作。

关键词：法国国家图书馆黎世留馆中文典藏跨文化

Gut microbiota imbalance and colorectal cancer

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World Journal of Gastroenterology 2016年第2期22卷 501-518页

作者： Johan Gagnière Jennifer Raisch julie Veziant Nicolas Barnich Richard Bonnet Emmanuel Buc Marie-Agnès Bringer Denis Pezet Mathilde Bonnet Clermont Université UMR 1071 Inserm/Universitéd’Auvergne63000 Clermont-FerrandFrance INRA USC-201863000 Clermont-FerrandFrance Chirurgie Digestive Centre Hospitalier Universitaire63000 Clermont-FerrandFrance Bactériologie Centre Hospitalier Universitaire63000 Clermont-FerrandFrance Laboratoire d’Immunologie Institut Armand FrappierLaval H7V 1B7Canada INRA UMR 1324 CNRS UMR 6265Universitéde BourgogneCentre des Sciences du Goût et de l’AlimentationEye Nutrition and Signalling Research Group21000 DijonFrance

The gut microbiota acts as a real organ. The symbiotic interactions between resident micro-organisms and the digestive tract highly contribute to maintain the gut homeostasis. However, alterations to the microbiome caused by environmental changes(e.g., infection, diet and/or lifestyle) can disturb this symbiotic relationship and promote disease, such as inflammatory bowel diseases and cancer. Colorectal cancer is a complex association of tumoral cells, non-neoplastic cells and a large amount of micro-organisms, and the involvement of the microbiota in colorectal carcinogenesis is becoming increasingly clear. Indeed, many changes in the bacterial composition of the gut microbiota have been reported in colorectal cancer, suggesting a major role of dysbiosis in colorectal carcinogenesis. Some bacterial species have been identified and suspected to play a role in colorectal carcinogenesis, such as Streptococcus bovis, Helicobacter pylori, Bacteroides fragilis, Enterococcus faecalis, Clostridium septicum, Fusobacterium spp. and Escherichia coli. The potential pro-carcinogenic effects of these bacteria are now better understood. In this review, we discuss the possible links between the bacterial microbiota and colorectal carcinogenesis, focusing on dysbiosis and the potential pro-carcinogenic properties of bacteria, such as genotoxicity and other virulence factors, inflammation, host defenses modulation, bacterial derived metabolism, oxidative stress and anti-oxidative defenses modulation. We lastly describe how bacterial microbiota modifications could represent novel prognosis markers and/or targets for innovative therapeutic strategies.

关键词： Colorectal cancer Gut microbiota Dysbiosis Cyclomodulin Oxidative stress

Erratum:The problem and promise of scale in multilayer animal social networks

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Current Zoology 2023年第2期69卷 225-225页

作者： Alec L.Robitaille Quinn M.R.Webber julie W.Turner Eric Vander Wal 不详

Current Zoology,2021,67(1):113-123,https://***/10.1093/cz/zoaa052 In the originally published version of this manuscript,the order of the following co-author's name should read:"Eric Vander Wal"instead of"Vander Wal E... 详细信息

关键词： ipt multilayer