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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels julie d.de schutter Lies de Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

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Hunting for a viral proxy in bioaerosols of swine buildings using molecular detection and metagenomics

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Journal of Environmental Sciences 2025年第2期148卷 69-78页

作者： Valérie Létourneau Marie-Josée Gagné Jonathan M.Vyskocil Vincent Brochu Kim Robitaille Martin Gauthier julie Brassard Caroline duchaine Quebec Heart and Lung Institute Research Centre-UniversitéLaval 2725 Chemin Sainte-FoyQuebecG1V 4G5Canada Saint-Hyacinthe Research and.development Centre Agriculture and Agri-Food Canada3600 Casavant Boulevard WestSaint-HyacintheJ2S 8E3Canada department of Biochemistry Microbiologyand Bio-informaticsFaculty of Science and EngineeringUniversitéLaval1045 Avenue de la MédecineQuebecG1V 0A6Canada The Swine and Poultry Infectious diseases Research Centre Faculty of Veterinary Medicine of Universitéde Montréal3200 Rue SicotteSaint-HyacintheJ2S 2M2Canada

There are limited biosecurity measures directed at preventing airborne transmission of viruses in *** effectiveness of dust mitigation strategies such as oil sprinkling,to decrease risk of airborne virus transmission are *** and qPCR for common fecal viruses were used to hunt for a ubiquitous virus to serve as a proxy when evaluating the efficiency of mitigation strategies against airborne viral infectious *** particles were collected from swine buildings using high-volume air *** dNA and RNA were used to perform specific RT-qPCR and qPCR and analyzed by highthroughput *** astroviruses group 2 were common(from 102 to 105 genomic copies per cubic meter of air or gc/m^(3),93%positivity)while no norovirus genogroup II was recovered from air *** torque teno sus virus were detected by qPCR in low concentrations(from 101 to 102 gc/m^(3),47%positivity).Among the identified viral families by metagenomics analysis,Herelleviridae,Microviridae,Myoviridae,Podoviridae,and Siphoviridae were *** phage vB_AviM_AVP of Aerococcus was present in all air samples and a newly designed qPCR revealed between 101 and 105 gc/m^(3) among the samples taken for the present study(97%positivity)and banked samples from5-and 15-year old studies(89%positivity).According to the present study,both the porcine astrovirus group 2 and the phage vB_AviM_AVP of Aerococcus could be proxy for airborne viruses of swine buildings.

关键词： Bioaerosols Viral metagenomics Astrovirus Aerococcus phage Swine buildings

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Establishment of goat mammary organoid cultures modeling the mammary gland.development and lactation

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Journal of Animal Science and Biotechnology 2025年第1期16卷 193-205页

作者： Lei Jia Wenying Zhang Tao Luo Yongtao Li Jianhong Shu julie Strand Yuan Yue Stig Purup Jianxin Liu Hengbo Shi Zhejiang Key Laboratory of Cow Genetic Improvement&Milk Quality Research Institute of Dairy ScienceCollege of Animal SciencesZhejiang UniversityHangzhou 310058China College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018China department of Animal and Veterinary Sciences Aarhus UniversityTjele DK‑8830Denmark Ministry of Education Key Laboratory of Molecular Animal Nutrition Zhejiang UniversityHangzhou 310058China

Background Although several cell culture systems have been developed to investigate the function of the mam-mary gland in dairy livestock,they have potential limitations,such as the loss of alveolar structure or genetic and phe-notypic differences from their native *** these challenges is crucial for lactation *** of protocols to establish lactating organoid of livestock represents a promising goal for the *** this study,we developed a protocol to establish a culture system for mammary organoids in dairy goats to model the mammary gland.development and lactation *** The organoids cultured within an extracellular matrix gel maintained a bilayer structure that closely resem-bled the native architecture of mammary *** expansion of mammary organoids was significantly promoted by growth factors containing epidermal growth factor and fibroblast growth factor 2 whereas the proliferative index of the organoids was significantly inhibited by the treatment with WNT *** stimulation with a lactogenic medium containing prolactin,the mammary organoids exhibited efficient lactation,characterized by the accumu-lation of lipid droplets in the lumen *** lactation could be sustained for more than 3 ***,the expression patterns of genes related to fatty acid synthesis and milk proteins in lactating organoids closely mirrored those observed in mammary *** observations were confirmed by data from proteomic analysis that the bulk of milk proteins was produced in the lactating *** This study is the first to establish a mammary organoid culture system modeling the mammary gland.development and lactation process in *** efficient induction of lactation in ruminant mammary organoids holds promises for advancing the field of cell-based milk bio-manufacture in the food industry.

关键词： Cell-based milk production Lactation Mammary gland Organoid

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Altered microRNA composition in the uterine lumen fluid in cattle(Bos taurus)pregnancies initiated by artificial insemination or transfer of an in vitro produced embryo

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Journal of Animal Science and Biotechnology 2025年第1期16卷 76-91页

作者： Fernando H.Biase Sarah E.Moorey julie G.Schnuelle Soren Rodning Martha Sofia Ortega Thomas E.Spencer School of Animal Sciences Virginia Polytechnic Institute and State University175 W Campus DrBlacksburgVA 24061USA department of Animal Science University of TennesseeKnoxvilleTN 37996USA department of Clinical Sciences Auburn UniversityAuburnAL 36849USA department of Animal Science Auburn UniversityAuburnAL 36849USA department of Animal and dairy Sciences University of Wisconsin MadisonMadisonWI 53706USA division of Animal Sciences University of MissouriColumbiaMO 65211USA

Background MicroRNAs(miRNAs)are presented in the uterine lumen of many mammals,and in vitro experiments have determined that several miRNAs are important for the regulation of endometrial and trophoblast *** aim was to identify and contrast the miRNAs present in extracellular vesicles(EVs)in the uterine lumen fluid(ULF)at the onset of attachment in cattle pregnancies(gestation d 18)initiated by artificial insemination(AI)or by the trans-fer of an in vitro-produced blastocyst(IVP-ET).A third group had no conceptus after the transfer of an IVP *** The abundance of 263 annotated miRNAs was quantified in the EVs collected from *** was an increase in the transcript abundance of 20 miRNAs in the ULF EVs from the AI pregnant group,while 4 miRNAs had a lower abundance relative to the group not containing a ***,4 miRNAs were more abun-dant in ULF EVs in the AI pregnant group relative to IVP-ET group(bta-mir-17,bta-mir-7-3,MIR7-1,MIR18A).Specific miRNAs in the ULF EVs were co-expressed with messenger RNAs expressed in extra-embryonic tissues and endome-trium,including genes that are known to be their *** The results provide biological insights into the participation of miRNAs in the regulation of trophoblast proliferation and differentiation,as well as in endometrium *** knowledge that in vitro cultured embryos can contribute to the altered abundance of specific miRNAs in the uterine lumen can lead to the development of cor-rective approaches to reduce conceptus losses during the first month of pregnancy in cattle.

关键词： Artificial reproductive technology Cattle Conceptus Embryos Endometrium Small RNA

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Fever without source in infants aged 22–60 days:how laboratory tests perform at identifying bacterial infections and predicting the need for a lumbar puncture?

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World Journal of Emergency Medicine 2025年第1期16卷 74-77页

作者： Keven Vachon Geneviève Gravel Samuel Leduc Alexandra Larouche Myriam Mallet david Simonyan Mahukpe Narcisse Ulrich Singbo julie Ouellet-Pelletier Simon Berthelot Centre de Recherche du CHU de Québec-UniversitéLaval Population Health and Optimal Health Practices AxisQuébec G1V 4G2Canada Faculty of Medicine UniversitéLavalQuébec G1V 0A6Canada Centre Hospitalier de l’UniversitéLaval(CHUL) Québec G1V 4G2Canada

Febrile infants are at greater risk of invasive bacterial infections (IBI),which include bacterial meningitis and *** bacterial meningitis is uncommon,^([1-2])it remains a concern for clinicians treating infants younger than 90 *** for investigating fever without a source(meaning without an apparent source of infection,or of nonobvious origin) are numerous around the world but remain conflicting,particularly on whether to perform a lumbar puncture for cerebrospinal fluid (CSF) analysis in infants older than 22 d and hence at lower risk than younger infants.

关键词： puncture infections lumbar

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The Potential of Wacapou (Vouacapoua americana) Extracts to develop New Biobased Protective Solutions for Low-durability Wood Species

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Journal of Renewable Materials 2025年第1期13卷 79-100页

作者： Emma Kieny Kévin Candelier Louis Milhe Yannick Estevez Cyrielle Sophie Romain Lehnebach Jérémie damay daniela Florez Emeline Houël Marie-France Thévenon julie Bossu CIRAd Ecologie de Forêts de Guyane(EcoFoG)AgroparisTechCNRSINRAEUniversitéde GuyaneKourou97379France CIRAd UPR BioWooEBMontpellierF-34398France BioWooEB Universitéde MontpellierCIRADMontpellierF-34398France CNRS Ecologie de Forêts de Guyane(EcoFoG)AgroparisTechCIRADINRAEUniversitéde GuyaneKourouGuyane Française97379France Sorbonne Université CNRSLaboratoire de Biodiversitéet Biotechnologies MicrobiennesLBBMObservatoire OcéanologiqueBanyuls-sur-Mer66650France

The valorization of Amazonian wood residues into active chemical compounds could be an eco-friendly,cost-effective and valuable way to develop wood preservative formulations to enhance the decay and termite resistance of low-durable wood ***(Vouacapoua americana.,Fabaceae)is a well-known Guianese wood spe-cies commonly used in local wood construction due to its outstanding natural durability,which results from the presence of a large panel of extractives *** addition,its industrial processing generates large amounts of *** residues were extracted by maceration using four different solvents(water/ethanol,ethyl acetate,hexane and dichloromethane/methanol),separately and *** yield of each extractive fraction was determined,and their chemical compositions were analyzed by Liquid Chromatography-Mass Spectrometry(LC-MS).Ethyl acetate led to the highest extraction yield,and the active compounds were identiﬁed in the obtained extractive *** this sense,the fungicidal and termite-repellent properties of these extractives were then tested using a screening laboratory(with temperate and tropical microorganisms),according to the solution concentration(1%,2.5%,5%,8%and 10%).Finally,Virola michelii Heckel wood samples(low durable species)were impregnated with the 8%concentration *** impregnated wood samples were then exposed to a soil bed *** results highlighted that the nature of the solvent used during wood maceration affects the con-tent of the obtained extractive ***-Performance Liquid Chromatography–High-Resolution Mass Spectrometry(UHPLC-HRMS)analyses showed the inﬂuence of extraction parameters on the nature of the extracted *** extracts(from ethyl acetate maceration)showed good anti-fungal and anti-termite ***,the concentration in extractives had an impact on the anti-termite activity level for Reti-culitermesﬂavipes and Cryptotermes *** based on W

关键词： Anti-fungal and anti-termite activities conferred durability extractives French Guiana impregnation guianese species wood by-products

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Management of inflammatory bowel disease with Clostridium difficile infection

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World Journal of Gastroenterology 2017年第27期23卷 4986-5003页

作者： julie d’Aoust Robert Battat Talat Bessissow division of Internal Medicine Jewish General Hospital division of Gastroenterology Jewish General Hospital division of Gastroenterology Mc Gill University Health Centre

To address the management of Clostridium difficile (C. difficile) infection (CdI) in the setting of suspected inflammatory bowel disease (IBd)-flare. METHOdSA systematic search of the Ovid MEdLINE and EMBASE databases by independent reviewers identified 70 articles including a total of 932141 IBd patients or IBd-related hospitalizations. RESULTSIn those with IBd, CdI is associated with increased morbidity, including subsequent escalation in IBd medical therapy, urgent colectomy and increased hospitalization, as well as excess mortality. Vancomycin-containing regimens are effective first-line therapies for CdI in IBd inpatients. No prospective data exists with regards to the safety or efficacy of initiating or maintaining corticosteroid, immunomodulator, or biologic therapy to treat IBd in the setting of CdI. Corticosteroid use is a risk factor for the development of CdI, while immunomodulators and biologics are not. CONCLUSIONStrong recommendations regarding when to initiate IBd specific therapy in those with CdI are precluded by a lack of evidence. However, based on expert opinion and observational data, initiation or resumption of immunosuppressive therapy after 48-72 h of targeted antibiotic treatment for CdI may be considered.

关键词： Biologic therapy Clostridium difficile Inflammatory bowel disease Ulcerative colitis Crohn’s disease Corticosteroids

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Onsite strength determination for early-opening decision making of high early strength concrete pavement

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Journal of Traffic and Transportation Engineering(English Edition) 2023年第2期10卷 291-303页

作者： Katelyn Kosar Lucio Salles de Salles Naser Pourakbar Sharifi julie Vandenbossche Lev Khazanovich department of Civil and Environmental Engineering University of PittsburghPittsburghPA 15261USA department of Civil Engineering Technology Environmental Management and SafetyRochester Institute of TechnologyRochesterNY 14623USA

High early strength(HES)concrete pavements are commonly opened to traffic within the first 24 h after construction,making early-opening decisions critical for pavement quality and traffic ***,most state departments of transportation rely on compressive strength testing for early-opening decision ***,there laboratory tests are labor intensive,costly and not always representative of field strength *** this study,non-destructive testing(maturity and ultrasonic tomography)was explored for faster and reliable in-situ strength *** experimental section constructed using HES concrete was routinely monitored using compressive testing,maturity,and ultrasonic tomography in the first 24 h after *** shear wave velocity,measured using ultrasonic tomography,was able to capture the strength-gain variability within a single slab and between different slabs due to the ability to monitor several locations in a short period of *** results were consistently conservative in the first 24 h of *** show that both maturity testing and ultrasonic tomography are able to replace or add to conventional strength testing for HES concrete pavements to facilitate making the opening decision within the first 24 *** tomography proved more beneficial as a result of the device's portability,increased speed of testing,and accurate estimations of HES concrete strength for the entire pavement length.

关键词： Road engineering High early strength concrete pavement Traffic early-opening Strength Maturity Ultrasonic tomography

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Current management of fecal incontinence:Choosing amongst treatment options to optimize outcomes

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World Journal of Gastroenterology 2013年第48期19卷 9216-9230页

作者： julie Ann M Van Koughnett Steven d Wexner departmen of Colorectal Surgery Cleveland Clinic Florida Weston FL 33331 United States

The severity of fecal incontinence widely varies and can have dramatic devastating impacts on a person’s *** incontinence is common,though it is often underreported by *** addition to standard treatment options,new treatments have been developed during the past decade to attempt to effectively treat fecal incontinence with minimal ***-operative treatments include dietary modifications,medications,and biofeedback *** used surgical treatments include repair(sphincteroplasty),stimulation(sacral nerve stimulation or posterior tibial nerve stimulation),replacement(artificial bowel sphincter or muscle transposition)and diversion(stoma formation).Newer augmentation treatments such as radiofrequency energy delivery and injectable materials,are minimally invasive tools that may be good options before proceeding to surgery in some patients with mild fecal *** general,more invasive surgical treatments are now reserved for moderate to severe fecal *** and quality of life related outcomes,as well as potential complications of the treatment must be considered and the treatment of fecal incontinence must be individualized to the *** indications,techniques,and outcomes profiles for the various treatments of fecal incontinence are discussed in *** the most effective treatment for the individual patient is essential to achieve optimal outcomes in the treatment of fecal incontinence.

关键词： Fecal incontinence Treatment Sacral nerve stimulation Sphincteroplasty Artificial bowel Sphincter Biofeedback

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Integrated ab initio modelling of atomic ordering and magnetic anisotropy for design of FeNi-based magnets

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npj Computational Materials 2024年第1期10卷 303-316页

作者： Christopher d.Woodgate Laura H.Lewis julie B.Staunton department of Physics University of WarwickCoventryCV47ALUK H.H.Wills Physics Laboratory University of BristolRoyal FortBristolBS81TLUK department of Chemical Engineering Northeastern UniversityBostonMA02115USA department of Mechanical and Industrial Engineering Northeastern UniversityBostonMA02115USA

We describe an integrated modelling approach to accelerate the search for novel,single-phase,multicomponent materials with high magnetocrystalline anisotropy(MCA).For a given system we predict the nature of atomic ordering,its dependence on the magnetic state,and then proceed to describe the consequentMCA,magnetisation,and magnetic critical temperature(Curie temperature).Crucially,within our modelling framework,the same ab initio description of a material’s electronic structure determines all aspects.

关键词： anisotropy magnetic atomic

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