检索结果-南通市图书馆

New immune regulators of sciatic nerve regeneration?Lessons from the neighborhood

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第4期19卷 705-706页

作者： AndréL.Bombeiro Rodrigo G.Q.Fernandes julie c.ribot Instituto de Medicina Molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisbonPortugal

For decades,the immune system has been associated with host protection against infectious pathogens or tumors,while also contributing to ***,this paradigm is now changing,with recent studies highlighting novel roles for immune mediators in the maintenance of steady-state tissue *** this perspective,we review some of the latest findings featuring immune modulators of the nervous system pathophysiology,with a special focus on interleukin(IL)-17.

关键词： homeostasis neighborhood finding

Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels julie D.De Schutter Lies De Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

corneal injection track: an unusual complication of intraocular lens implantation and review

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2015年第3期8卷 631-633页

作者： julie Y.c.Lok Alvin L.Young Department of Ophthalmology & Visual Sciences the Chinese University of Hong Kong Prince of Wales Hospital Alice Ho Miu Ling Nethersole Hospital

Phacoemulsification is the main gold standard for cataract operation in the developed world together with foldable intraocular lens(IOL) implantation by injection,allowing for stable wound construction and less postoperative astigmatism. It is a safe procedure with high success rate with the advancement in machines,improvement of IOL injection systems and further maturation of surgeons’ techniques. Despite the large number of operations performed every day, foldable IOL injection leading to an intra-stromal corneal track is a very rare complication. We report a case of this unusual finding in a 70-year-old gentleman who has undergone cataract operation in November 2011 in our hospital and will review on the complications related to foldable IOL injection.

关键词： foldable intraocular lens phacoemulsification cornea complications

Hypoxia-inducible factor-1a restricts the anabolic actions of parathyroid hormone

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2014年第1期2卷 33-42页

作者： julie L Frey David P Stonko Marie-claude Faugere Ryan c Riddle Department of Orthopaedic Surgery Johns Hopkins University School of Medicine Division of Nephrology Bone & Mineral Metabolism University of Kentucky Veterans Administration Medical center

The hypoxia inducible factors （Hifs） are evolutionarily conserved transcriptional factors that control homeostatic responses to low oxygen. In developing bone, Hif-1 generated signals induce angiogenesis necessary for osteoblast specification, but in mature bone, loss of Hif-1 in osteoblasts resulted in a more rapid accumulation of bone. These findings suggested that Hif-1 exerts distinct developmental functions and acts as a negative regulator of bone formation. To investigate the function of Hif-1a in osteoanabolic signaling, we assessed the effect of Hif-1a loss-of-function on bone formation in response to intermittent parathyroid hormone （PTH）. Mice lacking Hif-1a in osteoblasts and osteocytes form more bone in response to PTH, likely through a larger increase in osteoblast activity and increased sensitivity to the hormone. consistent with this effect, exposure of primary mouse osteoblasts to PTH resulted in the rapid induction of Hif-1a protein levels via a post-transcriptional mechanism. The enhanced anabolic response appears to result from the removal of Hif-1a-mediated suppression of β-catenin transcriptional activity. Together, these data indicate that Hif-1a functions in the mature skeleton to restrict osteoanabolic signaling. The availability of pharmacological agents that reduce Hif-1a function suggests the value in further exploration of this pathway to optimize the therapeutic benefits of PTH.

关键词： PTH Hypoxia-inducible factor-1a restricts the anabolic actions of parathyroid hormone Figure

Emergent interactions influence functional traits and success of dune building ecosystem engineers

在线全文

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2018年第4期11卷 524-532页

作者： Joseph K.Brown julie c.Zinnert Donald R.Young Department of Biology Virginia Commonwealth University1000 West Cary Street RichmondVA 23284USA

Aims Dune building processes are affected by interactions between the growth of ecosystem engineering dune grasses and environmen-tal factors associated with disturbance such as sand burial and sea *** investigating how species interactions influence dune community structure and functional trait responses in high abiotic stress environments is *** investigated how spe-cies interactions influence the functional trait responses of three dominant dune grasses to common abiotic *** We performed a multi-factorial greenhouse experiment by plant-ing three common dune grasses(Ammophila breviligulata Fern.,Uniola paniculata *** Spartina patens Muhl.)in different interspecific combinations,using sand burial and sea spray as abiotic *** burial was applied once at the beginning of the *** spray was applied three times per week using a calibrated spray *** functional trait meas-urements(leaf elongation,maximum root length,aboveground biomass and belowground biomass)were collected at the end of the *** experiment continued from May 2015 to August *** Findings Species interactions between *** and *** negatively affected dune building function traits of ***,indicating that interactions with *** could alter dune community ***,*** had a negative interaction with ***,which decreased *** functional trait responses to abiotic *** all species occurred together,the interactions among species brought about coexistence of all three *** data suggest that species interactions can change traditional functional trait responses of dominant species to abiotic stress.

关键词： competition coastal dunes facilitation intransitivity

Suppressor of Runnerless Encodes a DELLA Protein that controls Runner Formation for A=sexual Reproduction in Strawberry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2018年第1期11卷 230-233页

作者： julie c. caruana John W. Sittmann Wanpeng Wang Zhongchi Liu Department of cell Biology and Molecular Genetics University of Maryland College Park MD 20742 USA

Dear Editor, Strawberry is an economically important fruit crop contributing to human nutrition and agricultural output. The commercial success of this fruit crop is due in part to its asexual propagation through runn...

关键词：

Effects of improved amino acid balance diet on lysine mammary utilization, whole body protein turnover and muscle protein breakdown on lactating sows

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2024年第5期15卷 2031-2043页

作者： Sai Zhang Juan c.Marini Vengai Mavangira Andrew claude julie Moore Mahmoud A.Mohammad Nathalie L.Trottier Department of Animal Science Michigan State UniversityEast Lansing 48824USA State Key Laboratory of Swine and Poultry Breeding Industry Key Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640PR China USDA/ARS children’s Nutrition Research center and Pediatric critical care Medicine Department of PediatricsBaylor College of MedicineHoustonTX 77030USA Department of Large Animal clinical Sciences Michigan State UniversityEast LansingMI 48824USA Present address:Department of Animal Science Cornell UniversityFrank Morrison Hall507 Tower RoadIthacaNY 14853‑4801USA

Background The study objective was to test the hypothesis that low crude protein(cP)diet with crystalline amino acids(cAA)supplementation improves Lys utilization efficiency for milk production and reduces protein turnover and muscle protein *** lactating multiparous Yorkshire sows were allotted to 1 of 2 isocaloric diets(10.80 MJ/kg net energy):control(cON;19.24%cP)and reduced cP with“optimal”AA profile(OPT;14.00%cP).Sow body weight and backfat were recorded on d 1 and 21 of lactation and piglets were weighed on d 1,14,18,and 21 of *** d 14 and 18,a subset of 9 sows(cON=4,OPT=5)was infused with a mixed solution of 3-[methyl-2H3]histidine(bolus injection)and[13c]bicarbonate(priming dose)first,then a constant 2-h[13c]bicarbonate infusion followed by a 6-h primed constant[1-13c]lysine *** blood and milk sampling were performed to determine plasma and milk Lys enrichment,Lys oxidation rate,whole body protein turnover,and muscle protein *** Over the 21-d lactation period,compared to cON,sows fed OPT had greater litter growth rate(Pcompared to cON,sows fed OPT had greater efficiency of Lys(Pciency(Pcompared to cON,sows fed OPT tended to have lower whole body protein breakdown rate(P=0.069).Muscle protein breakdown rate did not differ between OPT and cON(P=0.197).conclusion Feeding an improved AA balance diet increased efficiency of Lys and reduced whole-body protein turnover and protein *** results imply that the lower maternal N retention observed in lactating sows fed improved AA balance diets in previous studies may be a result of greater partitioning of AA towards milk rather than greater body protein breakdown.

关键词： Amino acid Efficiency Lactating sows Protein breakdown Protein turnover Reduced protein diet

Dual regulatory role for phosphatase and tensin homolog in specification of intestinal endocrine cell subtypes

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第14期18卷 1579-1589页

作者： Sébastien AB Roy Marie-Josée Langlois julie c carrier Franois Boudreau Nathalie Rivard Nathalie Perreault canadian Institutes of Health Research Team on Digestive Epithelium Department of Anatomy and Cell BiologyFaculty of Medicine and Health SciencesUniversité de SherbrookeSherbrooke J1H 5N4QCCanada canadian Institutes of Health Research Team on Digestive Epithelium Service of GastroenterologyFaculty of Medicine and Health SciencesUniversité de SherbrookeSherbrooke J1H 5N4QCCanada

AIM:To investigate the impact of phosphatase and tensin homolog(Pten) in the specification of intestinal enteroendocrine ***:Using the cre/loxP system,a mouse with conditional intestinal epithelial Pten deficiency was *** mutant mice and controls were sacrificed and small intestines collected for immunofluorescence and quantitative real-time polymerase chain *** was collected on 16 h fasted mice by cardiac ***-linked immunosorbent assay was used to measure blood circulating ghrelin,somatostatin(SST) and glucose-dependent insulinotropic peptide(GIP) ***:Results show an unexpected dual regulatory role for epithelial Pten signalling in the specification/differentiation of enteroendocrine cell subpopulations in the small *** data indicate that Pten positively regulates chromogranin A(cgA) expressing subpopulations,including cells expressing secretin,ghrelin,gastrin and cholecystokinin(ccK).In contrast,Pten negatively regulates the enteroendocrine subtype specification of non-expressing cgA cells such as GIP and SST expressing ***:The present results demonstrate that Pten signalling favours the enteroendocrine progenitor to specify into cells expressing cgA including those producing ccK,gastrin and ghrelin.

关键词： Phosphatase and tensin homolog Enteroendocrine cells Intestinal epithelial cell specification chromogranin A

The diagnostic and prognostic utility of the dual-task tandem gait test for pediatric concussion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2021年第2期10卷 131-137页

作者： Katie A.Van Deventer corrine N.Seehusen Gregory A.Walker julie c.Wilson David R.Howell University of colorado School of Medicine AuroraCO 80045USA Sports Medicine center Children’s Hospital ColoradoAuroraCO 80045USA Department of Orthopedics University of Colorado School of MedicineAuroraCO 80045USA Department of Pediatrics University of Colorado School of MedicineAuroraCO 80045USA

Background:The tandem gait test has gained interest recently for assessment of concussion *** purpose of our study was to determine the prognostic and diagnostic use of the single-and dual-task tandem gait test,alongside other clinical measures,within 10 days of pediatric ***:We assessed 126 patients post-concussion(6.3§2.3 days post-injury,mean§SD)at a pediatric sports medicine clinic and compared them to 58 healthy controls(age:15.6§1.3 years;43%female).We also compared the 31 patients with concussion who developed persistent post-concussion symptoms(PPcS)(age=14.9§2.0 years;48%female)to the 81 patients with concussion who did not develop PPcS following the initial assessment(age:14.1§3.0 years;41%female).All subjects completed a test battery,and concussion patients were monitored until they experienced concussion-symptom *** test battery included tandem gait(single-task,dual-task(performing tandem gait while concurrently completing a cognitive test)conditions),modified Balance Error Scoring System(mBESS),and concussion symptom assessment(Health and Behavior Inventory).We defined PPcS as symptom resolution time>28 days post-concussion for the concussion *** outcomes included tandem gait time(single-and dual-task),dual-task cognitive accuracy,mBESS errors(single/double/tandem stances),and symptom ***:The concussion group completed the single-task(mean difference=9.1 s,95%confidential interval(95%cI):6.1-12.1)and dual-task(mean difference=12.7 s,95%cI:8.716.8)tandem gait test more slowly than the control *** to those who recovered within 28 days of concussion,the PPcS group had slower dual-task tandem gait test times(mean difference=7.9 s,95%cI:2.0-13.9),made more tandem-stance mBESS errors(mean difference=1.3 errors,95%cI:0.2-2.3),and reported more severe symptoms(mean difference=26.6 Health and Behavior Inventory rating,95%cI:21.1-32.6).conclusion:Worse dual-task tandem gait test time and mB

关键词： Adolescent Balance Mild traumatic brain injury Postural stability Prognosis